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Low Grade Corneal Squamous Intraepithelial Neoplasia

MedGen UID:: 232705
•Concept ID:: C1334422
•: Neoplastic Process

Synonyms:

Grade 1 Corneal Intraepithelial Neoplasia; Grade I Corneal Intraepithelial Neoplasia; Low Grade Corneal Intraepithelial Neoplasia

Definition

A precancerous neoplastic intraepithelial process with low-grade dysplastic features involving the corneal epithelium. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLow Grade Corneal Squamous Intraepithelial Neoplasia

Disease
- Disorder by Site
  - Disorder of orbital region
    - Corneal disorder
      - Cornea neoplasm
        Corneal intraepithelial neoplasm
        Low Grade Corneal Squamous Intraepithelial Neoplasia

Recent clinical studies

Diagnosis

Invasive squamous cell carcinoma of the conjunctiva.

Iliff WJ, Marback R, Green WR
Arch Ophthalmol 1975 Feb;93(2):119-22. doi: 10.1001/archopht.1975.01010020125005. PMID: 1115670

Therapy

Efficacy and safety of topical 5-fluorouracil in conjunctival intraepithelial neoplasia refractory to interferon alpha-2b.

Pérez-García P, Burgos-Blasco B, Gómez-Calleja V, Vidal-Villegas B, Méndez-Fernández R, Gegúndez-Fernández JA, Díaz-Valle D
J Oncol Pharm Pract 2023 Jun;29(4):975-979. Epub 2022 Sep 21 doi: 10.1177/10781552221125763. PMID: 36131486

Prognosis

Efficacy and safety of topical 5-fluorouracil in conjunctival intraepithelial neoplasia refractory to interferon alpha-2b.

Pérez-García P, Burgos-Blasco B, Gómez-Calleja V, Vidal-Villegas B, Méndez-Fernández R, Gegúndez-Fernández JA, Díaz-Valle D
J Oncol Pharm Pract 2023 Jun;29(4):975-979. Epub 2022 Sep 21 doi: 10.1177/10781552221125763. PMID: 36131486

Invasive squamous cell carcinoma of the conjunctiva.

Iliff WJ, Marback R, Green WR
Arch Ophthalmol 1975 Feb;93(2):119-22. doi: 10.1001/archopht.1975.01010020125005. PMID: 1115670

Clinical prediction guides

Efficacy and safety of topical 5-fluorouracil in conjunctival intraepithelial neoplasia refractory to interferon alpha-2b.

Pérez-García P, Burgos-Blasco B, Gómez-Calleja V, Vidal-Villegas B, Méndez-Fernández R, Gegúndez-Fernández JA, Díaz-Valle D
J Oncol Pharm Pract 2023 Jun;29(4):975-979. Epub 2022 Sep 21 doi: 10.1177/10781552221125763. PMID: 36131486

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Low Grade Corneal Squamous Intraepithelial Neoplasia
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