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Major Salivary Gland Non-Hodgkin Lymphoma

MedGen UID:
233140
•Concept ID:
C1334552
•
Neoplastic Process
Synonyms: Major Salivary Gland Non-Hodgkin's Lymphoma; Non-Hodgkin's Lymphoma of Major Salivary Gland; Non-Hodgkin's Lymphoma of the Major Salivary Gland; Primary Major Salivary Gland Non-Hodgkin's Lymphoma

Definition

A non-Hodgkin lymphoma that arises from the parotid gland, submandibular gland, or sublingual gland. Representative examples include mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma. [from NCI]

Professional guidelines

PubMed

Pulmonary nodules in patients with primary Sjögren's syndrome: Causes, clinico-radiologic features, and outcomes.
Casal Moura M, Navin PJ, Johnson GB, Hartman TE, Baqir M, Yi ES, Ryu JH
Respir Med 2020 Nov-Dec;174:106200. Epub 2020 Oct 22 doi: 10.1016/j.rmed.2020.106200. PMID: 33147563
Malignant lymphoma in primary Sjögren's syndrome: an update on the pathogenesis and treatment.
Routsias JG, Goules JD, Charalampakis G, Tzima S, Papageorgiou A, Voulgarelis M
Semin Arthritis Rheum 2013 Oct;43(2):178-86. Epub 2013 Jun 29 doi: 10.1016/j.semarthrit.2013.04.004. PMID: 23816048
Mucosa-associated lymphoid tissue lymphoma in Sjögren's syndrome: risks, management, and prognosis.
Voulgarelis M, Moutsopoulos HM
Rheum Dis Clin North Am 2008 Nov;34(4):921-33, viii. doi: 10.1016/j.rdc.2008.08.006. PMID: 18984412

Recent clinical studies

Etiology

Non- Hodgkin lymphoma of the lips: A rare entity.
Kaplan I, Shuster A, Frenkel G, Avishai G, Allon I, Raiser V
Acta Histochem 2019 Nov;121(8):151449. Epub 2019 Sep 27 doi: 10.1016/j.acthis.2019.151449. PMID: 31570207
Prognostic markers of lymphoma development in primary Sjögren syndrome.
Retamozo S, Brito-Zerón P, Ramos-Casals M
Lupus 2019 Jul;28(8):923-936. Epub 2019 Jun 19 doi: 10.1177/0961203319857132. PMID: 31215845
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224
Predictors for the development of non-Hodgkin lymphoma in primary Sjögren's syndrome.
Jonsson MV, Theander E, Jonsson R
Presse Med 2012 Sep;41(9 Pt 2):e511-6. Epub 2012 Aug 3 doi: 10.1016/j.lpm.2012.05.025. PMID: 22867948
Hepatitis c and lymphoma.
Silvestri F, Sperotto A, Fanin R
Curr Oncol Rep 2000 Mar;2(2):172-5. doi: 10.1007/s11912-000-0090-0. PMID: 11122840

Diagnosis

Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification.
Kapsogeorgou EK, Voulgarelis M, Tzioufas AG
J Autoimmun 2019 Nov;104:102316. Epub 2019 Aug 17 doi: 10.1016/j.jaut.2019.102316. PMID: 31431317
Prognostic markers of lymphoma development in primary Sjögren syndrome.
Retamozo S, Brito-Zerón P, Ramos-Casals M
Lupus 2019 Jul;28(8):923-936. Epub 2019 Jun 19 doi: 10.1177/0961203319857132. PMID: 31215845
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224
IgG4-related disease in the head and neck.
Ferry JA, Deshpande V
Semin Diagn Pathol 2012 Nov;29(4):235-44. doi: 10.1053/j.semdp.2012.07.008. PMID: 23068303
Hepatitis c and lymphoma.
Silvestri F, Sperotto A, Fanin R
Curr Oncol Rep 2000 Mar;2(2):172-5. doi: 10.1007/s11912-000-0090-0. PMID: 11122840

Therapy

Mantle Cell Lymphoma Involving Major and Minor Salivary Glands With Parotid Sparing.
Abukhiran I, Jasser J, Hoffman HT, Syrbu S
JAMA Otolaryngol Head Neck Surg 2020 Mar 1;146(3):309-311. doi: 10.1001/jamaoto.2019.4116. PMID: 31895458
Extrahepatic Manifestations of Hepatitis C Virus.
Viganò M, Colombo M
Gastroenterol Clin North Am 2015 Dec;44(4):775-91. Epub 2015 Aug 12 doi: 10.1016/j.gtc.2015.07.006. PMID: 26600219
A systematic overview of radiation therapy effects in non-Hodgkin's lymphoma.
Gustavsson A, Osterman B, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):605-19. doi: 10.1080/02841860310014435. PMID: 14596518
Hepatitis c and lymphoma.
Silvestri F, Sperotto A, Fanin R
Curr Oncol Rep 2000 Mar;2(2):172-5. doi: 10.1007/s11912-000-0090-0. PMID: 11122840
Hodgkin's disease: complications of therapy and excess mortality.
Hoppe RT
Ann Oncol 1997;8 Suppl 1:115-8. PMID: 9187444

Prognosis

Non- Hodgkin lymphoma of the lips: A rare entity.
Kaplan I, Shuster A, Frenkel G, Avishai G, Allon I, Raiser V
Acta Histochem 2019 Nov;121(8):151449. Epub 2019 Sep 27 doi: 10.1016/j.acthis.2019.151449. PMID: 31570207
Predicting lymphoma development in patients with Sjögren's syndrome.
De Vita S, Gandolfo S
Expert Rev Clin Immunol 2019 Sep;15(9):929-938. Epub 2019 Sep 12 doi: 10.1080/1744666X.2019.1649596. PMID: 31347413
Prognostic markers of lymphoma development in primary Sjögren syndrome.
Retamozo S, Brito-Zerón P, Ramos-Casals M
Lupus 2019 Jul;28(8):923-936. Epub 2019 Jun 19 doi: 10.1177/0961203319857132. PMID: 31215845
Predictors for the development of non-Hodgkin lymphoma in primary Sjögren's syndrome.
Jonsson MV, Theander E, Jonsson R
Presse Med 2012 Sep;41(9 Pt 2):e511-6. Epub 2012 Aug 3 doi: 10.1016/j.lpm.2012.05.025. PMID: 22867948
Hepatitis c and lymphoma.
Silvestri F, Sperotto A, Fanin R
Curr Oncol Rep 2000 Mar;2(2):172-5. doi: 10.1007/s11912-000-0090-0. PMID: 11122840

Clinical prediction guides

Clinical picture, outcome and predictive factors of lymphoma in primary Sjögren's syndrome: results from a harmonized dataset (1981-2021).
Chatzis LG, Stergiou IE, Goules AV, Pezoulas V, Tsourouflis G, Fotiadis D, Tzioufas AG, Voulgarelis M
Rheumatology (Oxford) 2022 Aug 30;61(9):3576-3585. doi: 10.1093/rheumatology/keab939. PMID: 34940812
Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification.
Kapsogeorgou EK, Voulgarelis M, Tzioufas AG
J Autoimmun 2019 Nov;104:102316. Epub 2019 Aug 17 doi: 10.1016/j.jaut.2019.102316. PMID: 31431317
Predicting lymphoma development in patients with Sjögren's syndrome.
De Vita S, Gandolfo S
Expert Rev Clin Immunol 2019 Sep;15(9):929-938. Epub 2019 Sep 12 doi: 10.1080/1744666X.2019.1649596. PMID: 31347413
Predictors for the development of non-Hodgkin lymphoma in primary Sjögren's syndrome.
Jonsson MV, Theander E, Jonsson R
Presse Med 2012 Sep;41(9 Pt 2):e511-6. Epub 2012 Aug 3 doi: 10.1016/j.lpm.2012.05.025. PMID: 22867948
Clinical, immunologic, and molecular factors predicting lymphoma development in Sjogren's syndrome patients.
Voulgarelis M, Skopouli FN
Clin Rev Allergy Immunol 2007 Jun;32(3):265-74. doi: 10.1007/s12016-007-8001-x. PMID: 17992593

Recent systematic reviews

A systematic overview of radiation therapy effects in non-Hodgkin's lymphoma.
Gustavsson A, Osterman B, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):605-19. doi: 10.1080/02841860310014435. PMID: 14596518

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