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Poorly Differentiated Prostate Adenocarcinoma

MedGen UID:
233333
•Concept ID:
C1335446
•
Neoplastic Process

Definition

An invasive prostate adenocarcinoma characterized by the presence of poorly differentiated malignant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoorly Differentiated Prostate Adenocarcinoma

Professional guidelines

PubMed

An orthotopic prostate cancer model for new treatment development using syngeneic or patient-derived tumors.
Chaudary N, Wiljer E, Foltz W, Thapa P, Hill RP, Milosevic M
Prostate 2024 Jun;84(9):823-831. Epub 2024 Apr 12 doi: 10.1002/pros.24701. PMID: 38606933
The NANETS consensus guidelines for the diagnosis and management of poorly differentiated (high-grade) extrapulmonary neuroendocrine carcinomas.
Strosberg JR, Coppola D, Klimstra DS, Phan AT, Kulke MH, Wiseman GA, Kvols LK; North American Neuroendocrine Tumor Society (NANETS)
Pancreas 2010 Aug;39(6):799-800. doi: 10.1097/MPA.0b013e3181ebb56f. PMID: 20664477Free PMC Article
Cytotoxic treatment of aggressive prostate tumors with or without neuroendocrine elements.
Steineck G, Reuter V, Kelly WK, Frank R, Schwartz L, Scher HI
Acta Oncol 2002;41(7-8):668-74. doi: 10.1080/028418602321028292. PMID: 14651212

Recent clinical studies

Etiology

Pathology of the prostate in radical cystectomy specimens: a critical review.
Autorino R, Di Lorenzo G, Damiano R, Giannarini G, De Sio M, Cheng L, Montironi R
Surg Oncol 2009 Mar;18(1):73-84. Epub 2008 Aug 29 doi: 10.1016/j.suronc.2008.07.006. PMID: 18760917
Prostate-specific antigen, high-molecular-weight cytokeratin (clone 34betaE12), and/or p63: an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma.
Kunju LP, Mehra R, Snyder M, Shah RB
Am J Clin Pathol 2006 May;125(5):675-81. doi: 10.1309/V1RY-91NK-X5AR-W2Q5. PMID: 16707367
Immunohistochemical profile of high-grade urothelial bladder carcinoma and prostate adenocarcinoma.
Mhawech P, Uchida T, Pelte MF
Hum Pathol 2002 Nov;33(11):1136-40. doi: 10.1053/hupa.2002.129416. PMID: 12454820

Diagnosis

The 99mTc-MIP-1404 PSMA Uptake in the Isolated Paratracheal Lymph Node From the Prostate Adenocarcinoma.
Jonusas J, Tiskevicius S, Janulionis E
Clin Nucl Med 2022 Dec 1;47(12):1101-1102. Epub 2022 Sep 6 doi: 10.1097/RLU.0000000000004384. PMID: 36342797Free PMC Article
Cytological findings of metastatic poorly differentiated prostate adenocarcinoma to Virchow's node with immunohistochemical positivity for CD10 and negativity for PSA.
Kobayashi G, Sentani K, Uraoka N, Oue N, Sasaki N
Cytopathology 2022 Nov;33(6):749-753. Epub 2022 May 26 doi: 10.1111/cyt.13149. PMID: 35557476
Prostate-specific antigen, high-molecular-weight cytokeratin (clone 34betaE12), and/or p63: an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma.
Kunju LP, Mehra R, Snyder M, Shah RB
Am J Clin Pathol 2006 May;125(5):675-81. doi: 10.1309/V1RY-91NK-X5AR-W2Q5. PMID: 16707367
Orbital metastasis from prostate cancer: an atypical case of neuroendocrine dedifferentiation during progression from hormone-sensitive to refractory stage.
Challagundla S, Gokden M, Viswamitra S, Kohli M
Clin Prostate Cancer 2005 Sep;4(2):134-7. doi: 10.3816/cgc.2005.n.023. PMID: 16197616
Immunohistochemical profile of high-grade urothelial bladder carcinoma and prostate adenocarcinoma.
Mhawech P, Uchida T, Pelte MF
Hum Pathol 2002 Nov;33(11):1136-40. doi: 10.1053/hupa.2002.129416. PMID: 12454820

Prognosis

Pathology of the prostate in radical cystectomy specimens: a critical review.
Autorino R, Di Lorenzo G, Damiano R, Giannarini G, De Sio M, Cheng L, Montironi R
Surg Oncol 2009 Mar;18(1):73-84. Epub 2008 Aug 29 doi: 10.1016/j.suronc.2008.07.006. PMID: 18760917

Clinical prediction guides

The 99mTc-MIP-1404 PSMA Uptake in the Isolated Paratracheal Lymph Node From the Prostate Adenocarcinoma.
Jonusas J, Tiskevicius S, Janulionis E
Clin Nucl Med 2022 Dec 1;47(12):1101-1102. Epub 2022 Sep 6 doi: 10.1097/RLU.0000000000004384. PMID: 36342797Free PMC Article

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