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Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

MedGen UID:: 233397
•Concept ID:: C1335711
•: Neoplastic Process

Synonyms:

Recurrent Mature T- and NK-Cell Lymphoma; Recurrent Mature T- and NK-Cell Non-Hodgkin's Lymphoma; Recurrent Peripheral T-cell Lymphoma; Relapsed Peripheral T-cell Lymphoma

Definition

The reemergence of mature T-cell and NK-cell non-Hodgkin lymphoma after a period of remission. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRecurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

Hematologic disorder
- Hematopoietic and lymphoid cell neoplasm
  - Lymphoid neoplasm
    - T-cell and NK-cell neoplasm
      - Neoplasm of mature T-cells or NK-cells
        Mature T-cell and NK-cell non-Hodgkin lymphoma
        Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
        Recurrent Adult T-Cell Leukemia/Lymphoma
        Recurrent Anaplastic Large Cell Lymphoma
        Recurrent Breast Implant-Associated Anaplastic Large Cell Lymphoma
        Recurrent Childhood Anaplastic Large Cell Lymphoma
        Recurrent Primary Cutaneous Anaplastic Large Cell Lymphoma
        Recurrent Systemic Anaplastic Large Cell Lymphoma
        Recurrent Systemic Anaplastic Large Cell Lymphoma, ALK-Positive
        Recurrent Enteropathy-Associated T-Cell Lymphoma
        Recurrent Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type
        Recurrent Follicular Helper T-Cell Lymphoma, Follicular-Type
        Recurrent Hepatosplenic T-Cell Lymphoma
        Recurrent Monomorphic Epitheliotropic Intestinal T-cell Lymphoma
        Recurrent Mycosis Fungoides and Sezary Syndrome
        Recurrent Mycosis Fungoides
        Recurrent Transformed Mycosis Fungoides
        Recurrent Sezary Syndrome
        Recurrent Nasal Type Extranodal NK/T-Cell Lymphoma
        Recurrent NK-Cell Lymphoma, Unclassifiable
        Recurrent Peripheral T-Cell Lymphoma, Not Otherwise Specified
        Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
        Recurrent Subcutaneous Panniculitis-Like T-Cell Lymphoma
        Recurrent Transformed T-cell Non-Hodgkin Lymphoma

Professional guidelines

PubMed

A genetic profiling guideline to support diagnosis and clinical management of lymphomas.

Sánchez-Beato M, Méndez M, Guirado M, Pedrosa L, Sequero S, Yanguas-Casás N, de la Cruz-Merino L, Gálvez L, Llanos M, García JF, Provencio M
Clin Transl Oncol 2024 May;26(5):1043-1062. Epub 2023 Sep 6 doi: 10.1007/s12094-023-03307-1. PMID: 37672206 Free PMC Article

Mantle Cell Lymphoma: the Role of Risk-Adapted Therapy and Treatment of Relapsed Disease.

Tarockoff M, Gonzalez T, Ivanov S, Sandoval-Sus J
Curr Oncol Rep 2022 Oct;24(10):1313-1326. Epub 2022 May 31 doi: 10.1007/s11912-022-01297-x. PMID: 35639332

Advances in the treatment of extranodal NK/T-cell lymphoma, nasal type.

Yamaguchi M, Suzuki R, Oguchi M
Blood 2018 Jun 7;131(23):2528-2540. Epub 2018 Mar 30 doi: 10.1182/blood-2017-12-791418. PMID: 29602763

See all (15)

Recent clinical studies

Etiology

A genetic profiling guideline to support diagnosis and clinical management of lymphomas.

Mechanisms of antigen escape from BCMA- or GPRC5D-targeted immunotherapies in multiple myeloma.

Lee H, Ahn S, Maity R, Leblay N, Ziccheddu B, Truger M, Chojnacka M, Cirrincione A, Durante M, Tilmont R, Barakat E, Poorebrahim M, Sinha S, McIntyre J, M Y Chan A, Wilson H, Kyman S, Krishnan A, Landgren O, Walter W, Meggendorfer M, Haferlach C, Haferlach T, Einsele H, Kortüm MK, Knop S, Alberge JB, Rosenwald A, Keats JJ, Rasche L, Maura F, Neri P, Bahlis NJ
Nat Med 2023 Sep;29(9):2295-2306. Epub 2023 Aug 31 doi: 10.1038/s41591-023-02491-5. PMID: 37653344 Free PMC Article

Follicular lymphoma.

Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.

Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, McCastlain K, Edmonson M, Pounds SB, Shi L, Zhou X, Ma X, Sioson E, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Auvil JG, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino BP, Downing JR, Loh ML, Hunger SP, Zhang J, Mullighan CG
Nat Genet 2017 Aug;49(8):1211-1218. Epub 2017 Jul 3 doi: 10.1038/ng.3909. PMID: 28671688 Free PMC Article

Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype.

Jain N, Lamb AV, O'Brien S, Ravandi F, Konopleva M, Jabbour E, Zuo Z, Jorgensen J, Lin P, Pierce S, Thomas D, Rytting M, Borthakur G, Kadia T, Cortes J, Kantarjian HM, Khoury JD
Blood 2016 Apr 14;127(15):1863-9. Epub 2016 Jan 8 doi: 10.1182/blood-2015-08-661702. PMID: 26747249 Free PMC Article

See all (66)

Diagnosis

A genetic profiling guideline to support diagnosis and clinical management of lymphomas.

Mechanisms of antigen escape from BCMA- or GPRC5D-targeted immunotherapies in multiple myeloma.

T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness.

Bardelli V, Arniani S, Pierini V, Di Giacomo D, Pierini T, Gorello P, Mecucci C, La Starza R
Genes (Basel) 2021 Jul 23;12(8) doi: 10.3390/genes12081118. PMID: 34440292 Free PMC Article

Follicular lymphoma.

Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752

Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype.

See all (71)

Therapy

Durable Responses With Mosunetuzumab in Relapsed/Refractory Indolent and Aggressive B-Cell Non-Hodgkin Lymphomas: Extended Follow-Up of a Phase I/II Study.

Budde LE, Assouline S, Sehn LH, Schuster SJ, Yoon SS, Yoon DH, Matasar MJ, Bosch F, Kim WS, Nastoupil LJ, Flinn IW, Shadman M, Diefenbach C, Cheah CY, Ma CY, Huang H, Kwan A, Wei MC, Yin S, Bartlett NL
J Clin Oncol 2024 Jul 1;42(19):2250-2256. Epub 2024 Mar 28 doi: 10.1200/JCO.23.02329. PMID: 38547425 Free PMC Article

Antitumor efficacy and safety of unedited autologous CD5.CAR T cells in relapsed/refractory mature T-cell lymphomas.

Hill LC, Rouce RH, Wu MJ, Wang T, Ma R, Zhang H, Mehta B, Lapteva N, Mei Z, Smith TS, Yang L, Srinivasan M, Burkhardt PM, Ramos CA, Lulla P, Arredondo M, Grilley B, Heslop HE, Brenner MK, Mamonkin M
Blood 2024 Mar 28;143(13):1231-1241. doi: 10.1182/blood.2023022204. PMID: 38145560 Free PMC Article

Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial.

Laetsch TW, Maude SL, Rives S, Hiramatsu H, Bittencourt H, Bader P, Baruchel A, Boyer M, De Moerloose B, Qayed M, Buechner J, Pulsipher MA, Myers GD, Stefanski HE, Martin PL, Nemecek E, Peters C, Yanik G, Khaw SL, Davis KL, Krueger J, Balduzzi A, Boissel N, Tiwari R, O'Donovan D, Grupp SA
J Clin Oncol 2023 Mar 20;41(9):1664-1669. Epub 2022 Nov 18 doi: 10.1200/JCO.22.00642. PMID: 36399695 Free PMC Article

Follicular lymphoma.

Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752

Mature T-cell leukemias.

Ravandi F, Kantarjian H, Jones D, Dearden C, Keating M, O'Brien S
Cancer 2005 Nov 1;104(9):1808-18. doi: 10.1002/cncr.21405. PMID: 16136598

See all (62)

Prognosis

Durable Responses With Mosunetuzumab in Relapsed/Refractory Indolent and Aggressive B-Cell Non-Hodgkin Lymphomas: Extended Follow-Up of a Phase I/II Study.

Antitumor efficacy and safety of unedited autologous CD5.CAR T cells in relapsed/refractory mature T-cell lymphomas.

A genetic profiling guideline to support diagnosis and clinical management of lymphomas.

Peripheral T-Cell Lymphoma, not Otherwise Specified (PTCL-NOS).

Oluwasanjo A, Kartan S, Johnson W, Alpdogan O, Gru A, Mishra A, Haverkos BM, Gong J, Porcu P
Cancer Treat Res 2019;176:83-98. doi: 10.1007/978-3-319-99716-2_4. PMID: 30596214

Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype.

See all (72)

Clinical prediction guides

Durable Responses With Mosunetuzumab in Relapsed/Refractory Indolent and Aggressive B-Cell Non-Hodgkin Lymphomas: Extended Follow-Up of a Phase I/II Study.

Antitumor efficacy and safety of unedited autologous CD5.CAR T cells in relapsed/refractory mature T-cell lymphomas.

Teclistamab Improves Patient-Reported Symptoms and Health-Related Quality of Life in Relapsed or Refractory Multiple Myeloma: Results From the Phase II MajesTEC-1 Study.

Martin TG, Moreau P, Usmani SZ, Garfall A, Mateos MV, San-Miguel JF, Oriol A, Nooka AK, Rosinol L, Chari A, Karlin L, Krishnan A, Bahlis N, Popat R, Besemer B, Martínez-López J, Delforge M, Trancucci D, Pei L, Kobos R, Fastenau J, Gries KS, van de Donk NWCJ
Clin Lymphoma Myeloma Leuk 2024 Mar;24(3):194-202. Epub 2023 Nov 14 doi: 10.1016/j.clml.2023.11.001. PMID: 38052709

A genetic profiling guideline to support diagnosis and clinical management of lymphomas.

Development of new agents for peripheral T-cell lymphoma.

Ito Y, Makita S, Tobinai K
Expert Opin Biol Ther 2019 Mar;19(3):197-209. Epub 2019 Jan 29 doi: 10.1080/14712598.2019.1572746. PMID: 30658046

See all (41)

Recent systematic reviews

Systematic review of survival outcomes for relapsed or refractory adult T-cell leukemia-lymphoma.

Nosaka K, Crawford B, Yi J, Kuan W, Matsumoto T, Takahashi T
Eur J Haematol 2022 Mar;108(3):212-222. Epub 2021 Dec 8 doi: 10.1111/ejh.13728. PMID: 34862665 Free PMC Article

Evolving Strategies for the Treatment of T-Cell Lymphoma: A Systematic Review and Recent Patents.

Laribi K, Alani M, Truong C, de Materre AB
Recent Pat Anticancer Drug Discov 2018;13(3):308-340. doi: 10.2174/1574892813666180517102801. PMID: 29769011

See all (2)

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Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity