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Microinvasive Malignant Neoplasm

MedGen UID:
233707
•Concept ID:
C1334755
•
Neoplastic Process

Definition

A malignant neoplasm that has minimal stromal invasion. [from NCI]

Professional guidelines

PubMed

AIRO Breast Cancer Group Best Clinical Practice 2022 Update.
Ciabattoni A, Gregucci F, De Rose F, Falivene S, Fozza A, Daidone A, Morra A, Smaniotto D, Barbara R, Lozza L, Vidali C, Borghesi S, Palumbo I, Huscher A, Perrucci E, Baldissera A, Tolento G, Rovea P, Franco P, De Santis MC, Grazia AD, Marino L, Meduri B, Cucciarelli F, Aristei C, Bertoni F, Guenzi M, Leonardi MC, Livi L, Nardone L, De Felice F, Rosetto ME, Mazzuoli L, Anselmo P, Arcidiacono F, Barbarino R, Martinetti M, Pasinetti N, Desideri I, Marazzi F, Ivaldi G, Bonzano E, Cavallari M, Cerreta V, Fusco V, Sarno L, Bonanni A, Mangiacotti MG, Prisco A, Buonfrate G, Andrulli D, Fontana A, Bagnoli R, Marinelli L, Reverberi C, Scalabrino G, Corazzi F, Doino D, Di Genesio-Pagliuca M, Lazzari M, Mascioni F, Pace MP, Mazza M, Vitucci P, Spera A, Macchia G, Boccardi M, Evangelista G, Sola B, La Porta MR, Fiorentino A, Levra NG, Ippolito E, Silipigni S, Osti MF, Mignogna M, Alessandro M, Ursini LA, Nuzzo M, Meattini I, D'Ermo G
Tumori 2022 Jul;108(2_suppl):1-144. doi: 10.1177/03008916221088885. PMID: 36112842
The Management of Colorectal Cancer Liver Metastases: The Interventional Radiology Viewpoint.
Rice SL, Bale R, Breen DJ, de Baere T, Denys A, Guiu B, Goldberg N, Kim E, Lewandowski RJ, Helmberger T, Mejerjink M, Pereira PL, Solbiati L, Solomon SB, Sofocleous CT
Int J Radiat Oncol Biol Phys 2019 Mar 1;103(3):537-539. doi: 10.1016/j.ijrobp.2018.08.069. PMID: 30722965
Management of borderline ovarian tumours.
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698

Recent clinical studies

Etiology

ACR Appropriateness Criteria® Ductal Carcinoma in Situ.
Kaufman SA, Harris EE, Bailey L, Chadha M, Dutton SC, Freedman GM, Goyal S, Halyard MY, Horst KC, Novick KL, Park CC, Suh WW, Toppmeyer D, Zook J, Haffty BG
Oncology (Williston Park) 2015 Jun;29(6):446-58, 460-1. PMID: 26089220
The pathology of cervical tumours.
Tiltman AJ
Best Pract Res Clin Obstet Gynaecol 2005 Aug;19(4):485-500. Epub 2005 Mar 23 doi: 10.1016/j.bpobgyn.2005.02.003. PMID: 16150389
Current issues in the pathology of ovarian cancer.
Rabban JT, Bell DA
J Reprod Med 2005 Jun;50(6):467-74. PMID: 16050571
Microinvasive cervix cancer.
Schink JC, Lurain JR
Int J Gynaecol Obstet 1991 Sep;36(1):5-11. doi: 10.1016/0020-7292(91)90170-a. PMID: 1683303
Minimal breast carcinoma.
Nevin JE, Pinzón G, Morán TJ, Baggerly JT
Am J Surg 1980 Mar;139(3):357-9. doi: 10.1016/0002-9610(80)90293-7. PMID: 6244748

Diagnosis

KRT15 in early breast cancer screening and correlation with HER2 positivity, pathological grade and N stage.
Zhang Z, Wang H, Jin Y, Zhou J, Chu C, Tang F, Zou L, Zou Q
Biomark Med 2023 Jun;17(12):553-562. Epub 2023 Oct 10 doi: 10.2217/bmm-2023-0130. PMID: 37814985
Clinical characteristics of breast ductal carcinoma in situ with microinvasion: a narrative review.
Zheng J, Yu J, Zhou T
J Int Med Res 2020 Nov;48(11):300060520969304. doi: 10.1177/0300060520969304. PMID: 33179556Free PMC Article
Is it ductal carcinoma in situ with microinvasion or "Ductogenesis"? The role of myoepithelial cell markers.
Masood S
Breast J 2020 Jun;26(6):1138-1147. Epub 2020 May 23 doi: 10.1111/tbj.13897. PMID: 32447817
Vulvar cancer.
Nash JD, Curry S
Surg Oncol Clin N Am 1998 Apr;7(2):335-46. PMID: 9537980
Microinvasive cervix cancer.
Schink JC, Lurain JR
Int J Gynaecol Obstet 1991 Sep;36(1):5-11. doi: 10.1016/0020-7292(91)90170-a. PMID: 1683303

Therapy

Management of borderline ovarian tumours.
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698
ACR Appropriateness Criteria® Ductal Carcinoma in Situ.
Kaufman SA, Harris EE, Bailey L, Chadha M, Dutton SC, Freedman GM, Goyal S, Halyard MY, Horst KC, Novick KL, Park CC, Suh WW, Toppmeyer D, Zook J, Haffty BG
Oncology (Williston Park) 2015 Jun;29(6):446-58, 460-1. PMID: 26089220
Stereotactic radiofrequency ablation.
Bale R, Widmann G, Haidu M
Cardiovasc Intervent Radiol 2011 Aug;34(4):852-6. Epub 2010 Aug 24 doi: 10.1007/s00270-010-9966-z. PMID: 20734193
Tumour ablation: technical aspects.
Widmann G, Bodner G, Bale R
Cancer Imaging 2009 Oct 2;9 Spec No A(Special issue A):S63-7. doi: 10.1102/1470-7330.2009.9026. PMID: 19965296Free PMC Article
Minimal breast carcinoma.
Nevin JE, Pinzón G, Morán TJ, Baggerly JT
Am J Surg 1980 Mar;139(3):357-9. doi: 10.1016/0002-9610(80)90293-7. PMID: 6244748

Prognosis

More microinvasive foci in larger tumours of breast ductal carcinoma in situ.
Chen XY, Thike AA, Lim JX, Bay BH, Tan PH
Singapore Med J 2023 Aug;64(8):493-496. doi: 10.11622/smedj.2022089. PMID: 35846408Free PMC Article
Clinical characteristics of breast ductal carcinoma in situ with microinvasion: a narrative review.
Zheng J, Yu J, Zhou T
J Int Med Res 2020 Nov;48(11):300060520969304. doi: 10.1177/0300060520969304. PMID: 33179556Free PMC Article
NEN: Advancement in Diagnosis and Minimally Invasive Therapy.
Putzer D, Schullian P, Jaschke W, Bale R
Rofo 2020 May;192(5):422-430. Epub 2019 Nov 20 doi: 10.1055/a-1030-4631. PMID: 31747704
Pathology of preinvasive and excellent-prognosis breast cancer.
Page DL, Simpson JF
Curr Opin Oncol 2000 Nov;12(6):526-31. doi: 10.1097/00001622-200011000-00003. PMID: 11085451
Microinvasive cervix cancer.
Schink JC, Lurain JR
Int J Gynaecol Obstet 1991 Sep;36(1):5-11. doi: 10.1016/0020-7292(91)90170-a. PMID: 1683303

Clinical prediction guides

The Utility of Myoepithelial Cell Layer Identification in Adnexal Carcinomas.
Plaza JA, Chung C, Wick M, Sangueza M, Gru A
Am J Dermatopathol 2022 Mar 1;44(3):155-162. doi: 10.1097/DAD.0000000000001844. PMID: 35171883
IMP3 Expression in Borderline Tumors of the Ovary.
El-Balat A, Sänger N, Karn T, Becker S, Holtrich U, Muallem Z, Arsenic R
Anticancer Res 2017 Feb;37(2):583-588. doi: 10.21873/anticanres.11351. PMID: 28179304
Prognostic significance of substage and WHO classification systems in T1 urothelial carcinoma of the bladder.
Fransen van de Putte EE, Behrendt MA, Pigot GL, van der Kwast TH, van Rhijn BW
Curr Opin Urol 2015 Sep;25(5):427-35. doi: 10.1097/MOU.0000000000000202. PMID: 26125511
Sentinel lymph node biopsy in patients with microinvasive breast cancer: a systematic review and meta-analysis.
Gojon H, Fawunmi D, Valachis A
Eur J Surg Oncol 2014 Jan;40(1):5-11. Epub 2013 Nov 5 doi: 10.1016/j.ejso.2013.10.020. PMID: 24238761
Borderline ovarian tumour: pathological diagnostic dilemma and risk factors for invasive or lethal recurrence.
Morice P, Uzan C, Fauvet R, Gouy S, Duvillard P, Darai E
Lancet Oncol 2012 Mar;13(3):e103-15. doi: 10.1016/S1470-2045(11)70288-1. PMID: 22381933

Recent systematic reviews

The role of sentinel lymph node biopsy in extramammary paget disease: a systematic review.
Faisel L, Swanson A, Sheridan C, Walker T, Carr DR, Shahwan KT
Arch Dermatol Res 2023 Nov;315(9):2513-2518. Epub 2023 Jun 2 doi: 10.1007/s00403-023-02649-8. PMID: 37266674
Survival Impact of Ovarian Preservation on Women With Early-Stage Endometrial Cancer: A Systematic Review and Meta-analysis.
Gu H, Li J, Gu Y, Tu H, Zhou Y, Liu J
Int J Gynecol Cancer 2017 Jan;27(1):77-84. doi: 10.1097/IGC.0000000000000857. PMID: 27922977
Vulvar cancer: initial management and systematic review of literature on currently applied treatment approaches.
Sznurkowski JJ
Eur J Cancer Care (Engl) 2016 Jul;25(4):638-46. Epub 2016 Feb 16 doi: 10.1111/ecc.12455. PMID: 26880231
Cervical cancer.
Martin-Hirsch PL, Wood NJ
BMJ Clin Evid 2011 Jul 27;2011 PMID: 21791123Free PMC Article
Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients.
van Seters M, van Beurden M, de Craen AJ
Gynecol Oncol 2005 May;97(2):645-51. doi: 10.1016/j.ygyno.2005.02.012. PMID: 15863172

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