U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Non-Neoplastic Dental Disorder

MedGen UID:
233769
•Concept ID:
C1335005
•
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the teeth and/or the periodontal tissues. Representative examples include odontoma, enamel hypoplasia, and periodontitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Dental Disorder

Professional guidelines

PubMed

Medication-related osteonecrosis of the jaw: Surgical or non-surgical treatment?
Favia G, Tempesta A, Limongelli L, Crincoli V, Maiorano E
Oral Dis 2018 Mar;24(1-2):238-242. doi: 10.1111/odi.12764. PMID: 29480596
Diagnosis and surgical management of nasopalatine duct cysts.
Aldelaimi TN, Khalil AA
J Craniofac Surg 2012 Sep;23(5):e472-4. doi: 10.1097/SCS.0b013e318258764b. PMID: 22976713
Sialoendoscopy for diagnosis and treatment of non-neoplastic obstruction in the salivary glands.
Danquart J, Wagner N, Arndal H, Homøe P
Dan Med Bull 2011 Feb;58(2):A4232. PMID: 21299921

Recent clinical studies

Etiology

Salivary gland tumours: an epidemiological review of non-neoplastic and neoplastic pathology.
Mckenzie J, Lockyer J, Singh T, Nguyen E
Br J Oral Maxillofac Surg 2023 Jan;61(1):12-18. Epub 2022 Dec 9 doi: 10.1016/j.bjoms.2022.11.281. PMID: 36623970
Neoplasms and non-neoplastic pathologies in the oral and maxillofacial regions in children and adolescents of a Brazilian population.
da Silva Barros CC, da Silva LP, Gonzaga AKG, de Medeiros AMC, de Souza LB, da Silveira ÉJD
Clin Oral Investig 2019 Apr;23(4):1587-1593. Epub 2018 Aug 24 doi: 10.1007/s00784-018-2581-0. PMID: 30143900
Cystic lesions of the parotid gland: radiologic-pathologic correlation according to the latest World Health Organization 2017 Classification of Head and Neck Tumours.
Takita H, Takeshita T, Shimono T, Tanaka H, Iguchi H, Hashimoto S, Kuwae Y, Ohsawa M, Miki Y
Jpn J Radiol 2017 Nov;35(11):629-647. Epub 2017 Aug 23 doi: 10.1007/s11604-017-0678-z. PMID: 28836142
Salivary gland carcinomas.
Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859
Non-neoplastic salivary gland diseases.
Arduino PG, Carrozzo M, Pentenero M, Bertolusso G, Gandolfo S
Minerva Stomatol 2006 May;55(5):249-70. PMID: 16688102

Diagnosis

Top 10 Clear Cell Head and Neck Lesions to Contemplate.
Cipriani NA, Kakkar A
Head Neck Pathol 2023 Mar;17(1):33-52. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01518-6. PMID: 36928734Free PMC Article
CT and MR imaging findings of non-neoplastic cystic lesions of the parotid gland.
Kato H, Kawaguchi M, Ando T, Aoki M, Kuze B, Matsuo M
Jpn J Radiol 2019 Sep;37(9):627-635. Epub 2019 Jul 27 doi: 10.1007/s11604-019-00858-8. PMID: 31352657
Black and Brown: Non-neoplastic Pigmentation of the Oral Mucosa.
Rosebush MS, Briody AN, Cordell KG
Head Neck Pathol 2019 Mar;13(1):47-55. Epub 2019 Jan 22 doi: 10.1007/s12105-018-0980-9. PMID: 30671761Free PMC Article
Cystic lesions of the parotid gland: radiologic-pathologic correlation according to the latest World Health Organization 2017 Classification of Head and Neck Tumours.
Takita H, Takeshita T, Shimono T, Tanaka H, Iguchi H, Hashimoto S, Kuwae Y, Ohsawa M, Miki Y
Jpn J Radiol 2017 Nov;35(11):629-647. Epub 2017 Aug 23 doi: 10.1007/s11604-017-0678-z. PMID: 28836142
Salivary gland carcinomas.
Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859

Therapy

KRAS mutations in implant-associated peripheral giant cell granuloma.
Martins-Chaves RR, Guimarães LM, Pereira TDSF, Pereira NB, Chrcanovic BR, Fonseca FP, Lafuente-Ibáñez de Mendoza I, Aguirre-Urizar JM, Gomes CC, Gomez RS
Oral Dis 2020 Mar;26(2):334-340. Epub 2019 Dec 19 doi: 10.1111/odi.13241. PMID: 31758745
Medication-related osteonecrosis of the jaw: Surgical or non-surgical treatment?
Favia G, Tempesta A, Limongelli L, Crincoli V, Maiorano E
Oral Dis 2018 Mar;24(1-2):238-242. doi: 10.1111/odi.12764. PMID: 29480596
Quantifying the outcome of surgical treatment of temporomandibular joint ankylosis: A systematic review and meta-analysis.
De Roo N, Van Doorne L, Troch A, Vermeersch H, Brusselaers N
J Craniomaxillofac Surg 2016 Jan;44(1):6-15. Epub 2015 Sep 10 doi: 10.1016/j.jcms.2015.08.019. PMID: 26433770
Non-neoplastic salivary gland diseases.
Arduino PG, Carrozzo M, Pentenero M, Bertolusso G, Gandolfo S
Minerva Stomatol 2006 May;55(5):249-70. PMID: 16688102
Folate intake and risk of oral and pharyngeal cancer.
Pelucchi C, Talamini R, Negri E, Levi F, Conti E, Franceschi S, La Vecchia C
Ann Oncol 2003 Nov;14(11):1677-81. doi: 10.1093/annonc/mdg448. PMID: 14581278

Prognosis

Stimulated Raman histology for histological evaluation of oral squamous cell carcinoma.
Steybe D, Poxleitner P, Metzger MC, Rothweiler R, Beck J, Straehle J, Vach K, Weber A, Enderle-Ammour K, Werner M, Schmelzeisen R, Bronsert P
Clin Oral Investig 2023 Aug;27(8):4705-4713. Epub 2023 Jun 22 doi: 10.1007/s00784-023-05098-9. PMID: 37349642Free PMC Article
Salivary Gland Fine Needle Aspiration and Introduction of the Milan Reporting System.
Pusztaszeri M, Rossi ED, Baloch ZW, Faquin WC
Adv Anat Pathol 2019 Mar;26(2):84-92. doi: 10.1097/PAP.0000000000000224. PMID: 30601148
Salivary gland carcinomas.
Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859
Human papilloma virus detection in neoplastic and non-neoplastic nasopharyngeal tissues in Taiwan.
Huang CC, Hsiao JR, Yang MW, Wu YH, Hsu KF, Chang Y, Chen CW, Tsai ST, Wei HP, Jin YT
J Clin Pathol 2011 Jul;64(7):571-7. Epub 2011 Apr 21 doi: 10.1136/jcp.2010.087742. PMID: 21512108
Matrix metalloproteinases and their inhibitors in non-neoplastic otorhinolaryngological disease.
De S, Fenton JE, Jones AS
J Laryngol Otol 2005 Jun;119(6):436-42. doi: 10.1258/0022215054273269. PMID: 15992468

Clinical prediction guides

Stimulated Raman histology for histological evaluation of oral squamous cell carcinoma.
Steybe D, Poxleitner P, Metzger MC, Rothweiler R, Beck J, Straehle J, Vach K, Weber A, Enderle-Ammour K, Werner M, Schmelzeisen R, Bronsert P
Clin Oral Investig 2023 Aug;27(8):4705-4713. Epub 2023 Jun 22 doi: 10.1007/s00784-023-05098-9. PMID: 37349642Free PMC Article
Salivary Gland Fine Needle Aspiration and Introduction of the Milan Reporting System.
Pusztaszeri M, Rossi ED, Baloch ZW, Faquin WC
Adv Anat Pathol 2019 Mar;26(2):84-92. doi: 10.1097/PAP.0000000000000224. PMID: 30601148
Neoplasms and non-neoplastic pathologies in the oral and maxillofacial regions in children and adolescents of a Brazilian population.
da Silva Barros CC, da Silva LP, Gonzaga AKG, de Medeiros AMC, de Souza LB, da Silveira ÉJD
Clin Oral Investig 2019 Apr;23(4):1587-1593. Epub 2018 Aug 24 doi: 10.1007/s00784-018-2581-0. PMID: 30143900
Agreement between clinical and histopathologic diagnoses and completeness of oral biopsy forms.
Mendez M, Haas AN, Rados PV, Sant'ana M Filho, Carrard VC
Braz Oral Res 2016 Aug 22;30(1):e94. doi: 10.1590/1807-3107BOR-2016.vol30.0094. PMID: 27556681
The role of intrinsic epithelial activation in the pathogenesis of Sjögren's syndrome.
Manoussakis MN, Kapsogeorgou EK
J Autoimmun 2010 Nov;35(3):219-24. Epub 2010 Aug 4 doi: 10.1016/j.jaut.2010.06.011. PMID: 20685080

Recent systematic reviews

Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review.
Feola T, Gianno F, De Angelis M, Colonnese C, Esposito V, Giangaspero F, Jaffrain-Rea ML
J Endocrinol Invest 2021 Oct;44(10):2103-2122. Epub 2021 May 3 doi: 10.1007/s40618-021-01577-6. PMID: 33939106Free PMC Article
Peripheral giant cell granuloma associated with dental implants: a systematic review.
Chrcanovic BR, Gomes CC, Gomez RS
J Stomatol Oral Maxillofac Surg 2019 Nov;120(5):456-461. Epub 2019 Jan 21 doi: 10.1016/j.jormas.2019.01.010. PMID: 30677564
Quantifying the outcome of surgical treatment of temporomandibular joint ankylosis: A systematic review and meta-analysis.
De Roo N, Van Doorne L, Troch A, Vermeersch H, Brusselaers N
J Craniomaxillofac Surg 2016 Jan;44(1):6-15. Epub 2015 Sep 10 doi: 10.1016/j.jcms.2015.08.019. PMID: 26433770
Fine-needle aspiration cytology of salivary gland lesions: a systematic review.
Colella G, Cannavale R, Flamminio F, Foschini MP
J Oral Maxillofac Surg 2010 Sep;68(9):2146-53. Epub 2010 Jul 1 doi: 10.1016/j.joms.2009.09.064. PMID: 20580145
Surgical approaches to the submandibular gland: a review of literature.
Beahm DD, Peleaz L, Nuss DW, Schaitkin B, Sedlmayr JC, Rivera-Serrano CM, Zanation AM, Walvekar RR
Int J Surg 2009 Dec;7(6):503-9. Epub 2009 Sep 24 doi: 10.1016/j.ijsu.2009.09.006. PMID: 19782158

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...