U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant Neoplasm with Regional Lymph Node Involvement

MedGen UID:
234094
•Concept ID:
C1332837
•
Neoplastic Process
Synonym: Cancer with Regional Lymph Node Involvement

Definition

A malignant neoplasm that has spread to nearby lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Neoplasm with Regional Lymph Node Involvement

Professional guidelines

PubMed

AIRO Breast Cancer Group Best Clinical Practice 2022 Update.
Ciabattoni A, Gregucci F, De Rose F, Falivene S, Fozza A, Daidone A, Morra A, Smaniotto D, Barbara R, Lozza L, Vidali C, Borghesi S, Palumbo I, Huscher A, Perrucci E, Baldissera A, Tolento G, Rovea P, Franco P, De Santis MC, Grazia AD, Marino L, Meduri B, Cucciarelli F, Aristei C, Bertoni F, Guenzi M, Leonardi MC, Livi L, Nardone L, De Felice F, Rosetto ME, Mazzuoli L, Anselmo P, Arcidiacono F, Barbarino R, Martinetti M, Pasinetti N, Desideri I, Marazzi F, Ivaldi G, Bonzano E, Cavallari M, Cerreta V, Fusco V, Sarno L, Bonanni A, Mangiacotti MG, Prisco A, Buonfrate G, Andrulli D, Fontana A, Bagnoli R, Marinelli L, Reverberi C, Scalabrino G, Corazzi F, Doino D, Di Genesio-Pagliuca M, Lazzari M, Mascioni F, Pace MP, Mazza M, Vitucci P, Spera A, Macchia G, Boccardi M, Evangelista G, Sola B, La Porta MR, Fiorentino A, Levra NG, Ippolito E, Silipigni S, Osti MF, Mignogna M, Alessandro M, Ursini LA, Nuzzo M, Meattini I, D'Ermo G
Tumori 2022 Jul;108(2_suppl):1-144. doi: 10.1177/03008916221088885. PMID: 36112842
Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline - Update 2022.
Gauci ML, Aristei C, Becker JC, Blom A, Bataille V, Dreno B, Del Marmol V, Forsea AM, Fargnoli MC, Grob JJ, Gomes F, Hauschild A, Hoeller C, Harwood C, Kelleners-Smeets N, Kaufmann R, Lallas A, Malvehy J, Moreno-Ramirez D, Peris K, Pellacani G, Saiag P, Stratigos AJ, Vieira R, Zalaudek I, van Akkooi ACJ, Lorigan P, Garbe C, Lebbé C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Aug;171:203-231. Epub 2022 Jun 19 doi: 10.1016/j.ejca.2022.03.043. PMID: 35732101
Australasian Gastrointestinal Trials Group (AGITG) contouring atlas and planning guidelines for intensity-modulated radiotherapy in anal cancer.
Ng M, Leong T, Chander S, Chu J, Kneebone A, Carroll S, Wiltshire K, Ngan S, Kachnic L
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):1455-62. Epub 2012 Mar 6 doi: 10.1016/j.ijrobp.2011.12.058. PMID: 22401917

Recent clinical studies

Etiology

Systematic endoscopic staging of mediastinum to guide radiotherapy planning in patients with locally advanced non-small-cell lung cancer (SEISMIC): an international, multicentre, single-arm, clinical trial.
Steinfort DP, Kothari G, Wallace N, Hardcastle N, Rangamuwa K, Dieleman EMT, Lee P, Li P, Simpson JA, Yo S, Bashirdazeh F, Nguyen P, Jennings BR, Fielding D, Crombag L, Irving LB, Yasufuku K, Annema JT, Ost DE, Siva S
Lancet Respir Med 2024 Jun;12(6):467-475. Epub 2024 Mar 12 doi: 10.1016/S2213-2600(24)00010-9. PMID: 38490228
Internal mammary node involvement in patients with axilla-negative early breast cancer: a narrative review.
Braue K, Baker C, Lippey J
ANZ J Surg 2023 Jan;93(1-2):59-64. Epub 2022 Aug 23 doi: 10.1111/ans.17982. PMID: 35997283
Internal mammary and medial supraclavicular lymph node chain irradiation in stage I-III breast cancer (EORTC 22922/10925): 15-year results of a randomised, phase 3 trial.
Poortmans PM, Weltens C, Fortpied C, Kirkove C, Peignaux-Casasnovas K, Budach V, van der Leij F, Vonk E, Weidner N, Rivera S, van Tienhoven G, Fourquet A, Noel G, Valli M, Guckenberger M, Koiter E, Racadot S, Abdah-Bortnyak R, Van Limbergen EF, Engelen A, De Brouwer P, Struikmans H, Bartelink H; European Organisation for Research and Treatment of Cancer Radiation Oncology and Breast Cancer Groups
Lancet Oncol 2020 Dec;21(12):1602-1610. Epub 2020 Nov 2 doi: 10.1016/S1470-2045(20)30472-1. PMID: 33152277
Neoadjuvant chemotherapy for lymph node-positive penile cancer: current evidence and knowledge.
Bandini M, Pederzoli F, Necchi A
Curr Opin Urol 2020 Mar;30(2):218-222. doi: 10.1097/MOU.0000000000000719. PMID: 31913205
Contemporary management of the axilla in breast cancer.
Nurudeen S, Hunt KK
Clin Adv Hematol Oncol 2018 Dec;16(12):823-831. PMID: 30843891

Diagnosis

Post-mastectomy radiotherapy for women with early breast cancer and one to three positive lymph nodes.
Verma R, Chandarana M, Barrett J, Anandadas C, Sundara Rajan S
Cochrane Database Syst Rev 2023 Jun 16;6(6):CD014463. doi: 10.1002/14651858.CD014463.pub2. PMID: 37327075Free PMC Article
Detection of cancer metastasis: past, present and future.
Alix-Panabieres C, Magliocco A, Cortes-Hernandez LE, Eslami-S Z, Franklin D, Messina JL
Clin Exp Metastasis 2022 Feb;39(1):21-28. Epub 2021 May 7 doi: 10.1007/s10585-021-10088-w. PMID: 33961169
Contemporary management of the axilla in breast cancer.
Nurudeen S, Hunt KK
Clin Adv Hematol Oncol 2018 Dec;16(12):823-831. PMID: 30843891
Lymph nodal metastases: diagnosis and treatment.
Di Muzio N, Fodor A, Berardi G, Mapelli P, Gianolli L, Messa C, Picchio M
Q J Nucl Med Mol Imaging 2012 Oct;56(5):421-9. PMID: 23069921
Endoscopic ultrasonography.
Pollack BJ, Chak A, Sivak MV Jr
Semin Oncol 1996 Jun;23(3):336-46. PMID: 8658217

Therapy

The addition of androgen deprivation therapy and pelvic lymph node treatment to prostate bed salvage radiotherapy (NRG Oncology/RTOG 0534 SPPORT): an international, multicentre, randomised phase 3 trial.
Pollack A, Karrison TG, Balogh AG, Gomella LG, Low DA, Bruner DW, Wefel JS, Martin AG, Michalski JM, Angyalfi SJ, Lukka H, Faria SL, Rodrigues GB, Beauchemin MC, Lee RJ, Seaward SA, Allen AM, Monitto DC, Seiferheld W, Sartor O, Feng F, Sandler HM
Lancet 2022 May 14;399(10338):1886-1901. doi: 10.1016/S0140-6736(21)01790-6. PMID: 35569466Free PMC Article
Internal mammary and medial supraclavicular lymph node chain irradiation in stage I-III breast cancer (EORTC 22922/10925): 15-year results of a randomised, phase 3 trial.
Poortmans PM, Weltens C, Fortpied C, Kirkove C, Peignaux-Casasnovas K, Budach V, van der Leij F, Vonk E, Weidner N, Rivera S, van Tienhoven G, Fourquet A, Noel G, Valli M, Guckenberger M, Koiter E, Racadot S, Abdah-Bortnyak R, Van Limbergen EF, Engelen A, De Brouwer P, Struikmans H, Bartelink H; European Organisation for Research and Treatment of Cancer Radiation Oncology and Breast Cancer Groups
Lancet Oncol 2020 Dec;21(12):1602-1610. Epub 2020 Nov 2 doi: 10.1016/S1470-2045(20)30472-1. PMID: 33152277
European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 2. Treatment.
Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, Bataille V, Bastholt L, Dreno B, Concetta Fargnoli M, Forsea AM, Frenard C, Harwood CA, Hauschild A, Hoeller C, Kandolf-Sekulovic L, Kaufmann R, Kelleners-Smeets NWJ, Malvehy J, Del Marmol V, Middleton MR, Moreno-Ramirez D, Pellecani G, Peris K, Saiag P, van den Beuken-van Everdingen MHJ, Vieira R, Zalaudek I, Eggermont AMM, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2020 Mar;128:83-102. Epub 2020 Feb 26 doi: 10.1016/j.ejca.2020.01.008. PMID: 32113942
Standardization of pathologic evaluation and reporting of postneoadjuvant specimens in clinical trials of breast cancer: recommendations from an international working group.
Provenzano E, Bossuyt V, Viale G, Cameron D, Badve S, Denkert C, MacGrogan G, Penault-Llorca F, Boughey J, Curigliano G, Dixon JM, Esserman L, Fastner G, Kuehn T, Peintinger F, von Minckwitz G, White J, Yang W, Symmans WF; Residual Disease Characterization Working Group of the Breast International Group-North American Breast Cancer Group Collaboration
Mod Pathol 2015 Sep;28(9):1185-201. Epub 2015 Jul 24 doi: 10.1038/modpathol.2015.74. PMID: 26205180
Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.
Galimberti V, Cole BF, Zurrida S, Viale G, Luini A, Veronesi P, Baratella P, Chifu C, Sargenti M, Intra M, Gentilini O, Mastropasqua MG, Mazzarol G, Massarut S, Garbay JR, Zgajnar J, Galatius H, Recalcati A, Littlejohn D, Bamert M, Colleoni M, Price KN, Regan MM, Goldhirsch A, Coates AS, Gelber RD, Veronesi U; International Breast Cancer Study Group Trial 23-01 investigators
Lancet Oncol 2013 Apr;14(4):297-305. Epub 2013 Mar 11 doi: 10.1016/S1470-2045(13)70035-4. PMID: 23491275Free PMC Article

Prognosis

Internal mammary node involvement in patients with axilla-negative early breast cancer: a narrative review.
Braue K, Baker C, Lippey J
ANZ J Surg 2023 Jan;93(1-2):59-64. Epub 2022 Aug 23 doi: 10.1111/ans.17982. PMID: 35997283
Detection of cancer metastasis: past, present and future.
Alix-Panabieres C, Magliocco A, Cortes-Hernandez LE, Eslami-S Z, Franklin D, Messina JL
Clin Exp Metastasis 2022 Feb;39(1):21-28. Epub 2021 May 7 doi: 10.1007/s10585-021-10088-w. PMID: 33961169
Neoadjuvant chemotherapy for lymph node-positive penile cancer: current evidence and knowledge.
Bandini M, Pederzoli F, Necchi A
Curr Opin Urol 2020 Mar;30(2):218-222. doi: 10.1097/MOU.0000000000000719. PMID: 31913205
Lymphangiogenesis and Anti-lymphangiogenesis in Cutaneous Melanoma.
Raica M, Jitariu AA, Cimpean AM
Anticancer Res 2016 Sep;36(9):4427-35. doi: 10.21873/anticanres.10986. PMID: 27630278
Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.
Galimberti V, Cole BF, Zurrida S, Viale G, Luini A, Veronesi P, Baratella P, Chifu C, Sargenti M, Intra M, Gentilini O, Mastropasqua MG, Mazzarol G, Massarut S, Garbay JR, Zgajnar J, Galatius H, Recalcati A, Littlejohn D, Bamert M, Colleoni M, Price KN, Regan MM, Goldhirsch A, Coates AS, Gelber RD, Veronesi U; International Breast Cancer Study Group Trial 23-01 investigators
Lancet Oncol 2013 Apr;14(4):297-305. Epub 2013 Mar 11 doi: 10.1016/S1470-2045(13)70035-4. PMID: 23491275Free PMC Article

Clinical prediction guides

Systematic endoscopic staging of mediastinum to guide radiotherapy planning in patients with locally advanced non-small-cell lung cancer (SEISMIC): an international, multicentre, single-arm, clinical trial.
Steinfort DP, Kothari G, Wallace N, Hardcastle N, Rangamuwa K, Dieleman EMT, Lee P, Li P, Simpson JA, Yo S, Bashirdazeh F, Nguyen P, Jennings BR, Fielding D, Crombag L, Irving LB, Yasufuku K, Annema JT, Ost DE, Siva S
Lancet Respir Med 2024 Jun;12(6):467-475. Epub 2024 Mar 12 doi: 10.1016/S2213-2600(24)00010-9. PMID: 38490228
Melanoma trials that defined surgical management.
Faries MB
J Surg Oncol 2022 Jan;125(1):34-37. doi: 10.1002/jso.26744. PMID: 34897707
Detection of cancer metastasis: past, present and future.
Alix-Panabieres C, Magliocco A, Cortes-Hernandez LE, Eslami-S Z, Franklin D, Messina JL
Clin Exp Metastasis 2022 Feb;39(1):21-28. Epub 2021 May 7 doi: 10.1007/s10585-021-10088-w. PMID: 33961169
Attention Guided Lymph Node Malignancy Prediction in Head and Neck Cancer.
Chen L, Dohopolski M, Zhou Z, Wang K, Wang R, Sher D, Wang J
Int J Radiat Oncol Biol Phys 2021 Jul 15;110(4):1171-1179. Epub 2021 Feb 6 doi: 10.1016/j.ijrobp.2021.02.004. PMID: 33561508
Clinical impact of lymph node status in rectal cancer.
Colombo PE, Patani N, Bibeau F, Assenat E, Bertrand MM, Senesse P, Rouanet P
Surg Oncol 2011 Dec;20(4):e227-33. Epub 2011 Sep 10 doi: 10.1016/j.suronc.2011.08.004. PMID: 21911287

Recent systematic reviews

European clinical practice guidelines for the definition, diagnosis, and treatment of oligometastatic esophagogastric cancer (OMEC-4).
Kroese TE, Bronzwaer S, van Rossum PSN, Schoppman SF, Deseyne PRAJ, van Cutsem E, Haustermans K, Nafteux P, Thomas M, Obermannova R, Mortensen HR, Nordsmark M, Pfeiffer P, Elme A, Adenis A, Piessen G, Bruns CJ, Lordick F, Gockel I, Moehler M, Gani C, Liakakos T, Reynolds JV, Morganti AG, Rosati R, Castoro C, Cellini F, D'Ugo D, Roviello F, Bencivenga M, de Manzoni G, van Berge Henegouwen MI, Hulshoff MCCM, van Dieren J, Vollebergh M, van Sandick JW, Jeene P, Muijs C, Slingerland M, Voncken FEM, Hartgrink H, Creemers GJ, van der Sangen MJC, Nieuwenhuijzen GAP, Berbee M, Verheij M, Wijnhoven B, Beerepoot LV, Mohammad NH, Mook S, Ruurda JP, Kolodziejczyk P, Polkowski WP, Wyrwicz L, Alsina M, Tabernero J, Pera M, Kanonnikoff TF, Cervantes A, Nilsson M, Monig S, Wagner AD, Guckenberger M, Griffiths EA, Smyth E, Hanna GB, Markar S, Chaudry MA, Hawkins MA, Cheong E, van Laarhoven HWM, van Hillegersberg R; OMEC collaborators
Eur J Cancer 2024 Jun;204:114062. Epub 2024 Apr 16 doi: 10.1016/j.ejca.2024.114062. PMID: 38678762
Post-mastectomy radiotherapy for women with early breast cancer and one to three positive lymph nodes.
Verma R, Chandarana M, Barrett J, Anandadas C, Sundara Rajan S
Cochrane Database Syst Rev 2023 Jun 16;6(6):CD014463. doi: 10.1002/14651858.CD014463.pub2. PMID: 37327075Free PMC Article
Prophylactic supraclavicular lymph node dissection for esophageal squamous cell carcinoma: a systematic review and meta-analysis.
Tsunoda S, Hoshino N, Yoshida S, Obama K
Surg Today 2023 Jun;53(6):647-654. Epub 2022 Jul 7 doi: 10.1007/s00595-022-02544-1. PMID: 35798906
Prognostic value and management of regional lymph nodes in locoregional breast cancer recurrence: a systematic review of the literature.
Ge I, Erbes T, Juhasz-Böss I
Arch Gynecol Obstet 2022 Oct;306(4):943-957. Epub 2022 Feb 4 doi: 10.1007/s00404-021-06352-9. PMID: 35122159Free PMC Article
Is sentinel lymph node biopsy warranted for desmoplastic melanoma? A systematic review.
Dunne JA, Wormald JC, Steele J, Woods E, Odili J, Powell BW
J Plast Reconstr Aesthet Surg 2017 Feb;70(2):274-280. Epub 2016 Nov 16 doi: 10.1016/j.bjps.2016.11.003. PMID: 28017261

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...