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Central Nervous System Teratoma with Malignant Transformation

MedGen UID:
234418
Concept ID:
C1336704
Neoplastic Process
Synonyms: CNS Teratoma with Malignant Transformation; Teratoma of Central Nervous System with Malignant Transformation; Teratoma of CNS with Malignant Transformation; Teratoma of the Central Nervous System with Malignant Transformation; Teratoma of the CNS with Malignant Transformation

Definition

A central nervous system teratoma characterized by the presence of a malignant component. The malignant component most often is sarcomatous (rhabdomyosarcoma or undifferentiated sarcoma) or carcinomatous (squamous cell carcinoma or adenocarcinoma). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Teratoma with Malignant Transformation

Professional guidelines

PubMed

Wang Y, Zhang W, Yin J, Lu Q, Yin F, He F, Peng J
J Neuroimmunol 2017 Nov 15;312:59-65. Epub 2017 Sep 11 doi: 10.1016/j.jneuroim.2017.09.005. PMID: 28935354
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431

Recent clinical studies

Etiology

Ravindra N, Rao S, Arivazhagan A, Santosh V
Childs Nerv Syst 2021 Dec;37(12):3769-3775. Epub 2021 Oct 5 doi: 10.1007/s00381-021-05335-0. PMID: 34611764
Nolan A, Buza N, Margeta M, Rabban JT
Am J Surg Pathol 2019 Jul;43(7):949-964. doi: 10.1097/PAS.0000000000001249. PMID: 31021857
Wang Y, Zhang W, Yin J, Lu Q, Yin F, He F, Peng J
J Neuroimmunol 2017 Nov 15;312:59-65. Epub 2017 Sep 11 doi: 10.1016/j.jneuroim.2017.09.005. PMID: 28935354
Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S
Neurol India 2010 Nov-Dec;58(6):841-6. doi: 10.4103/0028-3886.73740. PMID: 21150046
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330

Diagnosis

Surana A, Aggarwal A, Krishnan V, Malik A, Misra RN
World Neurosurg 2020 Jul;139:286-288. Epub 2020 Apr 2 doi: 10.1016/j.wneu.2020.03.156. PMID: 32247796
Georgiu C, Opincariu I, Cebotaru CL, Mirescu ŞC, Stănoiu BP, Domşa TA, Şovrea AS
Rom J Morphol Embryol 2016;57(4):1389-1395. PMID: 28174809
Vasiljevic A, Szathmari A, Champier J, Fèvre-Montange M, Jouvet A
Neurochirurgie 2015 Apr-Jun;61(2-3):130-7. Epub 2014 Apr 13 doi: 10.1016/j.neuchi.2013.06.006. PMID: 24726316
Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S
Neurol India 2010 Nov-Dec;58(6):841-6. doi: 10.4103/0028-3886.73740. PMID: 21150046
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431

Therapy

Sugai K, Fukuzawa R, Shofuda T, Fukusumi H, Kawabata S, Nishiyama Y, Higuchi Y, Kawai K, Isoda M, Kanematsu D, Hashimoto-Tamaoki T, Kohyama J, Iwanami A, Suemizu H, Ikeda E, Matsumoto M, Kanemura Y, Nakamura M, Okano H
Mol Brain 2016 Sep 19;9(1):85. doi: 10.1186/s13041-016-0265-8. PMID: 27642008Free PMC Article
Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M
PLoS One 2015;10(2):e0116413. Epub 2015 Feb 23 doi: 10.1371/journal.pone.0116413. PMID: 25706286Free PMC Article
El-Bahy K, Kotb A, Galal A, El-Hakim A
Acta Neurochir (Wien) 2006 Apr;148(4):457-62. Epub 2006 Jan 27 doi: 10.1007/s00701-005-0722-0. PMID: 16437187
Kon H, Kumabe T, Jokura H, Shirane R
Acta Neurochir (Wien) 2002 Jun;144(6):611-6. doi: 10.1007/s00701-002-0951-4. PMID: 12111494

Prognosis

Ravindra N, Rao S, Arivazhagan A, Santosh V
Childs Nerv Syst 2021 Dec;37(12):3769-3775. Epub 2021 Oct 5 doi: 10.1007/s00381-021-05335-0. PMID: 34611764
Asmaro K, Arshad M, Massie L, Griffith B, Lee I
World Neurosurg 2019 Mar;123:e31-e38. Epub 2018 Nov 4 doi: 10.1016/j.wneu.2018.10.198. PMID: 30404057
Yokoyama T, Takehara K, Yamamoto Y, Okame S, Shiroyama Y, Yokoyama T, Nogawa T, Sugawara Y
Int J Clin Oncol 2015 Oct;20(5):960-6. Epub 2015 Feb 15 doi: 10.1007/s10147-015-0800-0. PMID: 25681878
Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S
Neurol India 2010 Nov-Dec;58(6):841-6. doi: 10.4103/0028-3886.73740. PMID: 21150046
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330

Clinical prediction guides

Ravindra N, Rao S, Arivazhagan A, Santosh V
Childs Nerv Syst 2021 Dec;37(12):3769-3775. Epub 2021 Oct 5 doi: 10.1007/s00381-021-05335-0. PMID: 34611764
Wang Y, Zhang W, Yin J, Lu Q, Yin F, He F, Peng J
J Neuroimmunol 2017 Nov 15;312:59-65. Epub 2017 Sep 11 doi: 10.1016/j.jneuroim.2017.09.005. PMID: 28935354
Serrano-Arévalo ML, Lino-Silva LS, Domínguez Malagón HR
Ultrastruct Pathol 2017 Jan-Feb;41(1):62-66. Epub 2016 Dec 28 doi: 10.1080/01913123.2016.1261975. PMID: 28029275
Yokoyama T, Takehara K, Yamamoto Y, Okame S, Shiroyama Y, Yokoyama T, Nogawa T, Sugawara Y
Int J Clin Oncol 2015 Oct;20(5):960-6. Epub 2015 Feb 15 doi: 10.1007/s10147-015-0800-0. PMID: 25681878
Trojanowski JQ, Lee VM, Schlaepfer WW
Hum Pathol 1984 Mar;15(3):248-57. doi: 10.1016/s0046-8177(84)80188-4. PMID: 6538179

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