U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Central nervous system germ cell tumor

MedGen UID:
232040
Concept ID:
C1332880
Neoplastic Process
Synonyms: Central Nervous System Germ Cell Neoplasm; central nervous system germ cell neoplasm; Central Nervous System Germ Cell Tumor; central nervous system germ cell tumor; central nervous system rare germ cell tumor; central nervous system rare germ cell tumour; CNS germ cell neoplasm; CNS Germ Cell Tumor; CNS germ cell tumor; CNS germ cell tumour; Germ Cell Neoplasm of Central Nervous System; germ cell neoplasm of central nervous system; Germ Cell Neoplasm of CNS; germ cell neoplasm of CNS; Germ Cell Neoplasm of the Central Nervous System; germ cell neoplasm of the central nervous system; Germ Cell Neoplasm of the CNS; germ cell neoplasm of the CNS; Germ Cell Tumor of Central Nervous System; germ cell tumor of central nervous system; Germ Cell Tumor of CNS; germ cell tumor of CNS; Germ Cell Tumor of the Central Nervous System; germ cell tumor of the central nervous system; Germ Cell Tumor of the CNS; germ cell tumor of the CNS; germ cell tumour of central nervous system; germ cell tumour of CNS; germ cell tumour of the central nervous system; germ cell tumour of the CNS
 
Monarch Initiative: MONDO:0003000

Definition

A unique group of rare tumors of the central nervous system that affect mainly children and adolescents. Their morphologic and biologic profile corresponds to that of homologous germ cell tumors that arise in the gonads and in other extragonadal sites. Representative examples include: germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system germ cell tumor

Professional guidelines

PubMed

Yao DC, Ye BK, Yao DJ, Guo CC
Clin Neurol Neurosurg 2024 Jan;236:108081. Epub 2023 Dec 7 doi: 10.1016/j.clineuro.2023.108081. PMID: 38091701
Hong KT, Lee DH, Kim BK, An HY, Choi JY, Phi JH, Cheon JE, Kang HJ, Kim SK, Kim JY, Park SH, Kim IH, Shin HY
BMC Cancer 2020 Oct 9;20(1):979. doi: 10.1186/s12885-020-07484-y. PMID: 33036578Free PMC Article

Recent clinical studies

Etiology

Takano M, Kinoshita Y, Sugiyama K, Kolakshyapati M, Takayasu T, Yonezawa U, Taguchi A, Akiyama Y, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
Eur J Radiol 2021 Mar;136:109523. Epub 2021 Jan 7 doi: 10.1016/j.ejrad.2021.109523. PMID: 33460957
Hong KT, Lee DH, Kim BK, An HY, Choi JY, Phi JH, Cheon JE, Kang HJ, Kim SK, Kim JY, Park SH, Kim IH, Shin HY
BMC Cancer 2020 Oct 9;20(1):979. doi: 10.1186/s12885-020-07484-y. PMID: 33036578Free PMC Article
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Coutinho V, Dellatolas G, Castaignede-Lalande C, Longaud-Vales A, Kieffer V, Guerrini-Rousseau L, Grill J, Valteau-Couanet D, Dufour C
J Pediatr Hematol Oncol 2018 Oct;40(7):e424-e428. doi: 10.1097/MPH.0000000000001200. PMID: 29746441
Weiner HL, Lichtenbaum RA, Wisoff JH, Snow RB, Souweidane MM, Bruce JN, Finlay JL
Neurosurgery 2002 Apr;50(4):727-33; discussion 733-4. doi: 10.1097/00006123-200204000-00008. PMID: 11904022

Diagnosis

Takano M, Kinoshita Y, Sugiyama K, Kolakshyapati M, Takayasu T, Yonezawa U, Taguchi A, Akiyama Y, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
Eur J Radiol 2021 Mar;136:109523. Epub 2021 Jan 7 doi: 10.1016/j.ejrad.2021.109523. PMID: 33460957
Hong KT, Lee DH, Kim BK, An HY, Choi JY, Phi JH, Cheon JE, Kang HJ, Kim SK, Kim JY, Park SH, Kim IH, Shin HY
BMC Cancer 2020 Oct 9;20(1):979. doi: 10.1186/s12885-020-07484-y. PMID: 33036578Free PMC Article
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y
J Child Neurol 2018 Aug;33(9):610-620. Epub 2018 May 30 doi: 10.1177/0883073818772470. PMID: 29848146
Coutinho V, Dellatolas G, Castaignede-Lalande C, Longaud-Vales A, Kieffer V, Guerrini-Rousseau L, Grill J, Valteau-Couanet D, Dufour C
J Pediatr Hematol Oncol 2018 Oct;40(7):e424-e428. doi: 10.1097/MPH.0000000000001200. PMID: 29746441

Therapy

Weiner HL, Lichtenbaum RA, Wisoff JH, Snow RB, Souweidane MM, Bruce JN, Finlay JL
Neurosurgery 2002 Apr;50(4):727-33; discussion 733-4. doi: 10.1097/00006123-200204000-00008. PMID: 11904022
Balmaceda C, Heller G, Rosenblum M, Diez B, Villablanca JG, Kellie S, Maher P, Vlamis V, Walker RW, Leibel S, Finlay JL
J Clin Oncol 1996 Nov;14(11):2908-15. doi: 10.1200/JCO.1996.14.11.2908. PMID: 8918487

Prognosis

Yao DC, Ye BK, Yao DJ, Guo CC
Clin Neurol Neurosurg 2024 Jan;236:108081. Epub 2023 Dec 7 doi: 10.1016/j.clineuro.2023.108081. PMID: 38091701
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Hong KT, Lee DH, Kim BK, An HY, Choi JY, Phi JH, Cheon JE, Kang HJ, Kim SK, Kim JY, Park SH, Kim IH, Shin HY
BMC Cancer 2020 Oct 9;20(1):979. doi: 10.1186/s12885-020-07484-y. PMID: 33036578Free PMC Article
Balmaceda C, Heller G, Rosenblum M, Diez B, Villablanca JG, Kellie S, Maher P, Vlamis V, Walker RW, Leibel S, Finlay JL
J Clin Oncol 1996 Nov;14(11):2908-15. doi: 10.1200/JCO.1996.14.11.2908. PMID: 8918487

Clinical prediction guides

Yao DC, Ye BK, Yao DJ, Guo CC
Clin Neurol Neurosurg 2024 Jan;236:108081. Epub 2023 Dec 7 doi: 10.1016/j.clineuro.2023.108081. PMID: 38091701
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Coutinho V, Dellatolas G, Castaignede-Lalande C, Longaud-Vales A, Kieffer V, Guerrini-Rousseau L, Grill J, Valteau-Couanet D, Dufour C
J Pediatr Hematol Oncol 2018 Oct;40(7):e424-e428. doi: 10.1097/MPH.0000000000001200. PMID: 29746441
Balmaceda C, Heller G, Rosenblum M, Diez B, Villablanca JG, Kellie S, Maher P, Vlamis V, Walker RW, Leibel S, Finlay JL
J Clin Oncol 1996 Nov;14(11):2908-15. doi: 10.1200/JCO.1996.14.11.2908. PMID: 8918487

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...