U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stage II Pharyngeal Cancer

MedGen UID:
237183
•Concept ID:
C1378108
•
Neoplastic Process
Synonyms: Pharyngeal Cancer Stage II; Stage II Carcinoma of Pharynx; Stage II Carcinoma of the Pharynx; Stage II Pharyngeal Carcinoma; Stage II Pharynx Carcinoma

Definition

Stage II carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions. [from NCI]

Professional guidelines

PubMed

Radiation Treatment Deintensification for HPV-Associated Oropharyngeal Cancer.
Dagan R, Galloway TJ
Semin Radiat Oncol 2021 Oct;31(4):324-331. doi: 10.1016/j.semradonc.2021.02.010. PMID: 34455987
Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline.
Chen YP, Ismaila N, Chua MLK, Colevas AD, Haddad R, Huang SH, Wee JTS, Whitley AC, Yi JL, Yom SS, Chan ATC, Hu CS, Lang JY, Le QT, Lee AWM, Lee N, Lin JC, Ma B, Morgan TJ, Shah J, Sun Y, Ma J
J Clin Oncol 2021 Mar 1;39(7):840-859. Epub 2021 Jan 6 doi: 10.1200/JCO.20.03237. PMID: 33405943
Nasopharyngeal carcinoma: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up(†).
Bossi P, Chan AT, Licitra L, Trama A, Orlandi E, Hui EP, Halámková J, Mattheis S, Baujat B, Hardillo J, Smeele L, van Herpen C, Castro A, Machiels JP; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; EURACAN
Ann Oncol 2021 Apr;32(4):452-465. Epub 2020 Dec 25 doi: 10.1016/j.annonc.2020.12.007. PMID: 33358989

Recent clinical studies

Etiology

Treatment Options in Early Stage (Stage I and II) of Oropharyngeal Cancer: A Narrative Review.
Meccariello G, Catalano A, Cammaroto G, Iannella G, Vicini C, Hao SP, De Vito A
Medicina (Kaunas) 2022 Aug 4;58(8) doi: 10.3390/medicina58081050. PMID: 36013517Free PMC Article
Effect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Tang LL, Guo R, Zhang N, Deng B, Chen L, Cheng ZB, Huang J, Hu WH, Huang SH, Luo WJ, Liang JH, Zheng YM, Zhang F, Mao YP, Li WF, Zhou GQ, Liu X, Chen YP, Xu C, Lin L, Liu Q, Du XJ, Zhang Y, Sun Y, Ma J
JAMA 2022 Aug 23;328(8):728-736. doi: 10.1001/jama.2022.13997. PMID: 35997729Free PMC Article
Nasopharyngeal carcinoma: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up(†).
Bossi P, Chan AT, Licitra L, Trama A, Orlandi E, Hui EP, Halámková J, Mattheis S, Baujat B, Hardillo J, Smeele L, van Herpen C, Castro A, Machiels JP; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; EURACAN
Ann Oncol 2021 Apr;32(4):452-465. Epub 2020 Dec 25 doi: 10.1016/j.annonc.2020.12.007. PMID: 33358989
Tumor Staging and HPV-Related Oropharyngeal Cancer.
Wittekindt C, Klussmann JP
Recent Results Cancer Res 2017;206:123-133. doi: 10.1007/978-3-319-43580-0_9. PMID: 27699534
Chemotherapy for Nasopharyngeal Cancer: Neoadjuvant, Concomitant, and/or Adjuvant.
Ng WT, Chang AT, Lee SW, Sze HC, Lee AW
Curr Treat Options Oncol 2015 Sep;16(9):44. doi: 10.1007/s11864-015-0361-5. PMID: 26187796

Diagnosis

Nasopharyngeal carcinoma: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up(†).
Bossi P, Chan AT, Licitra L, Trama A, Orlandi E, Hui EP, Halámková J, Mattheis S, Baujat B, Hardillo J, Smeele L, van Herpen C, Castro A, Machiels JP; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; EURACAN
Ann Oncol 2021 Apr;32(4):452-465. Epub 2020 Dec 25 doi: 10.1016/j.annonc.2020.12.007. PMID: 33358989
Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer.
Chan KCA, Woo JKS, King A, Zee BCY, Lam WKJ, Chan SL, Chu SWI, Mak C, Tse IOL, Leung SYM, Chan G, Hui EP, Ma BBY, Chiu RWK, Leung SF, van Hasselt AC, Chan ATC, Lo YMD
N Engl J Med 2017 Aug 10;377(6):513-522. doi: 10.1056/NEJMoa1701717. PMID: 28792880
Multimodality Treatment of Early-Stage Tonsil Cancer.
Roden DF, Schreiber D, Givi B
Otolaryngol Head Neck Surg 2017 Jul;157(1):62-68. Epub 2017 Mar 7 doi: 10.1177/0194599817696290. PMID: 28669307
Screening for and diagnosis of oral premalignant lesions and oropharyngeal squamous cell carcinoma: role of primary care physicians.
Epstein JB, Gorsky M, Cabay RJ, Day T, Gonsalves W
Can Fam Physician 2008 Jun;54(6):870-5. PMID: 18556495Free PMC Article
Nasopharyngeal cancer.
Ali H, al-Sarraf M
Hematol Oncol Clin North Am 1999 Aug;13(4):837-47. doi: 10.1016/s0889-8588(05)70096-4. PMID: 10494517

Therapy

Effect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Tang LL, Guo R, Zhang N, Deng B, Chen L, Cheng ZB, Huang J, Hu WH, Huang SH, Luo WJ, Liang JH, Zheng YM, Zhang F, Mao YP, Li WF, Zhou GQ, Liu X, Chen YP, Xu C, Lin L, Liu Q, Du XJ, Zhang Y, Sun Y, Ma J
JAMA 2022 Aug 23;328(8):728-736. doi: 10.1001/jama.2022.13997. PMID: 35997729Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Phase II Randomized Trial of Transoral Surgery and Low-Dose Intensity Modulated Radiation Therapy in Resectable p16+ Locally Advanced Oropharynx Cancer: An ECOG-ACRIN Cancer Research Group Trial (E3311).
Ferris RL, Flamand Y, Weinstein GS, Li S, Quon H, Mehra R, Garcia JJ, Chung CH, Gillison ML, Duvvuri U, O'Malley BW Jr, Ozer E, Thomas GR, Koch WM, Gross ND, Bell RB, Saba NF, Lango M, Méndez E, Burtness B
J Clin Oncol 2022 Jan 10;40(2):138-149. Epub 2021 Oct 26 doi: 10.1200/JCO.21.01752. PMID: 34699271Free PMC Article
Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).
Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT
J Clin Oncol 2021 Mar 20;39(9):956-965. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03128. PMID: 33507809Free PMC Article
Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline.
Chen YP, Ismaila N, Chua MLK, Colevas AD, Haddad R, Huang SH, Wee JTS, Whitley AC, Yi JL, Yom SS, Chan ATC, Hu CS, Lang JY, Le QT, Lee AWM, Lee N, Lin JC, Ma B, Morgan TJ, Shah J, Sun Y, Ma J
J Clin Oncol 2021 Mar 1;39(7):840-859. Epub 2021 Jan 6 doi: 10.1200/JCO.20.03237. PMID: 33405943

Prognosis

Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).
Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT
J Clin Oncol 2021 Mar 20;39(9):956-965. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03128. PMID: 33507809Free PMC Article
Nasopharyngeal carcinoma: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up(†).
Bossi P, Chan AT, Licitra L, Trama A, Orlandi E, Hui EP, Halámková J, Mattheis S, Baujat B, Hardillo J, Smeele L, van Herpen C, Castro A, Machiels JP; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; EURACAN
Ann Oncol 2021 Apr;32(4):452-465. Epub 2020 Dec 25 doi: 10.1016/j.annonc.2020.12.007. PMID: 33358989
Multimodality Treatment of Early-Stage Tonsil Cancer.
Roden DF, Schreiber D, Givi B
Otolaryngol Head Neck Surg 2017 Jul;157(1):62-68. Epub 2017 Mar 7 doi: 10.1177/0194599817696290. PMID: 28669307
Tumor Staging and HPV-Related Oropharyngeal Cancer.
Wittekindt C, Klussmann JP
Recent Results Cancer Res 2017;206:123-133. doi: 10.1007/978-3-319-43580-0_9. PMID: 27699534
Chemotherapy for Nasopharyngeal Cancer: Neoadjuvant, Concomitant, and/or Adjuvant.
Ng WT, Chang AT, Lee SW, Sze HC, Lee AW
Curr Treat Options Oncol 2015 Sep;16(9):44. doi: 10.1007/s11864-015-0361-5. PMID: 26187796

Clinical prediction guides

Effect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
Tang LL, Guo R, Zhang N, Deng B, Chen L, Cheng ZB, Huang J, Hu WH, Huang SH, Luo WJ, Liang JH, Zheng YM, Zhang F, Mao YP, Li WF, Zhou GQ, Liu X, Chen YP, Xu C, Lin L, Liu Q, Du XJ, Zhang Y, Sun Y, Ma J
JAMA 2022 Aug 23;328(8):728-736. doi: 10.1001/jama.2022.13997. PMID: 35997729Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Phase II Randomized Trial of Transoral Surgery and Low-Dose Intensity Modulated Radiation Therapy in Resectable p16+ Locally Advanced Oropharynx Cancer: An ECOG-ACRIN Cancer Research Group Trial (E3311).
Ferris RL, Flamand Y, Weinstein GS, Li S, Quon H, Mehra R, Garcia JJ, Chung CH, Gillison ML, Duvvuri U, O'Malley BW Jr, Ozer E, Thomas GR, Koch WM, Gross ND, Bell RB, Saba NF, Lango M, Méndez E, Burtness B
J Clin Oncol 2022 Jan 10;40(2):138-149. Epub 2021 Oct 26 doi: 10.1200/JCO.21.01752. PMID: 34699271Free PMC Article
Improved survival prediction for oropharyngeal cancer beyond TNMv8.
Price JM, West CM, Mistry HB, Betts G, Bishop P, Kennedy J, Dixon L, Homer JJ, Garcez KP, Lee LW, McPartlin A, Sykes AJ, Thomson DJ
Oral Oncol 2021 Apr;115:105140. Epub 2021 Feb 3 doi: 10.1016/j.oraloncology.2020.105140. PMID: 33548862
Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).
Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT
J Clin Oncol 2021 Mar 20;39(9):956-965. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03128. PMID: 33507809Free PMC Article

Recent systematic reviews

Characteristics of human papillomavirus infection among oropharyngeal cancer patients: A systematic review and meta-analysis.
Cui M, Cheng J, Cheng H, Zhao M, Zhou D, Zhang M, Jia J, Luo L
Arch Oral Biol 2024 Jan;157:105830. Epub 2023 Oct 31 doi: 10.1016/j.archoralbio.2023.105830. PMID: 37924712
Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline.
Chen YP, Ismaila N, Chua MLK, Colevas AD, Haddad R, Huang SH, Wee JTS, Whitley AC, Yi JL, Yom SS, Chan ATC, Hu CS, Lang JY, Le QT, Lee AWM, Lee N, Lin JC, Ma B, Morgan TJ, Shah J, Sun Y, Ma J
J Clin Oncol 2021 Mar 1;39(7):840-859. Epub 2021 Jan 6 doi: 10.1200/JCO.20.03237. PMID: 33405943
The role of concurrent chemotherapy for stage II nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A systematic review and meta-analysis.
Liu F, Jin T, Liu L, Xiang Z, Yan R, Yang H
PLoS One 2018;13(3):e0194733. Epub 2018 Mar 22 doi: 10.1371/journal.pone.0194733. PMID: 29566078Free PMC Article
Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small-volume primary oropharyngeal carcinoma.
Howard J, Masterson L, Dwivedi RC, Riffat F, Benson R, Jefferies S, Jani P, Tysome JR, Nutting C
Cochrane Database Syst Rev 2016 Dec 11;12(12):CD010963. doi: 10.1002/14651858.CD010963.pub2. PMID: 27943254Free PMC Article
Systematic review of the platysma myocutaneous flap for head and neck reconstruction.
Szudek J, Taylor SM
Arch Otolaryngol Head Neck Surg 2007 Jul;133(7):655-61. doi: 10.1001/archotol.133.7.655. PMID: 17638777

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...