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Mucinous Tubular and Spindle Cell Carcinoma of the Kidney

MedGen UID:
270843
•Concept ID:
C1513719
•
Neoplastic Process

Definition

A low grade carcinoma of the kidney characterized by the presence of tubules which are separated by mucinous stroma. Often the tubular structures have a spindle cell appearance. Patients are usually asymptomatic and occasionally they may present with hematuria or flank pain. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucinous Tubular and Spindle Cell Carcinoma of the Kidney

Professional guidelines

PubMed

Mucinous Tubular and Spindle-Cell Carcinoma of the Kidney: Clinical Features, Genomic Profiles, and Treatment Outcomes.
Ged Y, Chen YB, Knezevic A, Donoghue MTA, Carlo MI, Lee CH, Feldman DR, Patil S, Hakimi AA, Russo P, Voss MH, Motzer RJ
Clin Genitourin Cancer 2019 Aug;17(4):268-274.e1. Epub 2019 May 2 doi: 10.1016/j.clgc.2019.04.006. PMID: 31151928Free PMC Article

Recent clinical studies

Etiology

Mucinous tubular and spindle cell carcinoma of the kidney: a report of seven cases.
Ling C, Tan R, Li J, Feng J
BMC Cancer 2023 Aug 30;23(1):815. doi: 10.1186/s12885-023-11252-z. PMID: 37649003Free PMC Article
Mucinous Tubular and Spindle-Cell Carcinoma of the Kidney: Clinical Features, Genomic Profiles, and Treatment Outcomes.
Ged Y, Chen YB, Knezevic A, Donoghue MTA, Carlo MI, Lee CH, Feldman DR, Patil S, Hakimi AA, Russo P, Voss MH, Motzer RJ
Clin Genitourin Cancer 2019 Aug;17(4):268-274.e1. Epub 2019 May 2 doi: 10.1016/j.clgc.2019.04.006. PMID: 31151928Free PMC Article
Distinct Genomic Copy Number Alterations Distinguish Mucinous Tubular and Spindle Cell Carcinoma of the Kidney From Papillary Renal Cell Carcinoma With Overlapping Histologic Features.
Ren Q, Wang L, Al-Ahmadie HA, Fine SW, Gopalan A, Sirintrapun SJ, Tickoo SK, Reuter VE, Chen YB
Am J Surg Pathol 2018 Jun;42(6):767-777. doi: 10.1097/PAS.0000000000001038. PMID: 29462091Free PMC Article

Diagnosis

Mucinous tubular and spindle cell carcinoma of the kidney: a report of seven cases.
Ling C, Tan R, Li J, Feng J
BMC Cancer 2023 Aug 30;23(1):815. doi: 10.1186/s12885-023-11252-z. PMID: 37649003Free PMC Article
Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney.
Xu H, Li W, Zhu C, Cheng N, Li X, Hao F, Zhu J, Huang L, Wang R, Wang L, Luo Z, Wang F
J Pathol 2022 May;257(1):53-67. Epub 2022 Mar 10 doi: 10.1002/path.5869. PMID: 35043389Free PMC Article
Mucinous tubular and spindle cell carcinoma of the kidney: A case series with a brief review of the literature.
Adamane SA, Menon S, Prakash G, Bakshi G, Joshi A, Popat P, Desai SB
Indian J Cancer 2020 Jul-Sep;57(3):267-281. doi: 10.4103/ijc.IJC_642_18. PMID: 32675442
Mucinous Tubular and Spindle-Cell Carcinoma of the Kidney: Clinical Features, Genomic Profiles, and Treatment Outcomes.
Ged Y, Chen YB, Knezevic A, Donoghue MTA, Carlo MI, Lee CH, Feldman DR, Patil S, Hakimi AA, Russo P, Voss MH, Motzer RJ
Clin Genitourin Cancer 2019 Aug;17(4):268-274.e1. Epub 2019 May 2 doi: 10.1016/j.clgc.2019.04.006. PMID: 31151928Free PMC Article
Mucinous tubular and spindle cell carcinoma of the kidney: imaging features.
Sahni VA, Hirsch MS, Sadow CA, Silverman SG
Cancer Imaging 2012 Mar 5;12(1):66-71. doi: 10.1102/1470-7330.2012.0008. PMID: 22391478Free PMC Article

Therapy

Cytoreductive Nephrectomy After Combination of Nivolumab Plus Ipilimumab for Mucinous Tubular and Spindle Cell Carcinoma of the Kidney With Bone Metastases: A Case Report.
Furubayashi N, Taguchi K, Negishi T, Miura A, Sato Y, Miyoshi M, Nakamura M
In Vivo 2022 Jan-Feb;36(1):510-521. doi: 10.21873/invivo.12732. PMID: 34972756Free PMC Article

Prognosis

Mucinous tubular and spindle cell carcinoma of the kidney: a report of seven cases.
Ling C, Tan R, Li J, Feng J
BMC Cancer 2023 Aug 30;23(1):815. doi: 10.1186/s12885-023-11252-z. PMID: 37649003Free PMC Article
Distinct Genomic Copy Number Alterations Distinguish Mucinous Tubular and Spindle Cell Carcinoma of the Kidney From Papillary Renal Cell Carcinoma With Overlapping Histologic Features.
Ren Q, Wang L, Al-Ahmadie HA, Fine SW, Gopalan A, Sirintrapun SJ, Tickoo SK, Reuter VE, Chen YB
Am J Surg Pathol 2018 Jun;42(6):767-777. doi: 10.1097/PAS.0000000000001038. PMID: 29462091Free PMC Article
Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid transformation.
Arafah M, Zaidi SN
Saudi J Kidney Dis Transpl 2013 May;24(3):557-60. doi: 10.4103/1319-2442.111066. PMID: 23640631
Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid change.
Dhillon J, Amin MB, Selbs E, Turi GK, Paner GP, Reuter VE
Am J Surg Pathol 2009 Jan;33(1):44-9. doi: 10.1097/PAS.0b013e3181829ed5. PMID: 18941398
Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects.
Kuroda N, Toi M, Hiroi M, Shuin T, Enzan H
Histol Histopathol 2005 Jan;20(1):221-4. doi: 10.14670/HH-20.221. PMID: 15578440

Clinical prediction guides

Mucinous tubular and spindle cell carcinoma of the kidney: a report of seven cases.
Ling C, Tan R, Li J, Feng J
BMC Cancer 2023 Aug 30;23(1):815. doi: 10.1186/s12885-023-11252-z. PMID: 37649003Free PMC Article
Distinct Genomic Copy Number Alterations Distinguish Mucinous Tubular and Spindle Cell Carcinoma of the Kidney From Papillary Renal Cell Carcinoma With Overlapping Histologic Features.
Ren Q, Wang L, Al-Ahmadie HA, Fine SW, Gopalan A, Sirintrapun SJ, Tickoo SK, Reuter VE, Chen YB
Am J Surg Pathol 2018 Jun;42(6):767-777. doi: 10.1097/PAS.0000000000001038. PMID: 29462091Free PMC Article
Chromosomal abnormalities of high-grade mucinous tubular and spindle cell carcinoma of the kidney.
Sadimin ET, Chen YB, Wang L, Argani P, Epstein JI
Histopathology 2017 Nov;71(5):719-724. Epub 2017 Sep 8 doi: 10.1111/his.13298. PMID: 28656700
Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects.
Kuroda N, Toi M, Hiroi M, Shuin T, Enzan H
Histol Histopathol 2005 Jan;20(1):221-4. doi: 10.14670/HH-20.221. PMID: 15578440

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