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Testicular trophoblastic tumor

MedGen UID:
272844
•Concept ID:
C1515301
•
Neoplastic Process
Synonyms: Testicular Trophoblastic Tumor; testicular trophoblastic tumor
 
Monarch Initiative: MONDO:0002871

Definition

A tumor that arises from the testis and is composed of neoplastic trophoblastic cells. The vast majority of cases are choriocarcinomas. [from NCI]

Professional guidelines

PubMed

Testicular choriocarcinoma: a rare variant that requires a unique treatment approach.
Reilley MJ, Pagliaro LC
Curr Oncol Rep 2015 Feb;17(2):2. doi: 10.1007/s11912-014-0430-0. PMID: 25645112
The use of immunohistochemistry in the differential diagnosis of tumors of the testis and paratestis.
Emerson RE, Ulbright TM
Semin Diagn Pathol 2005 Feb;22(1):33-50. doi: 10.1053/j.semdp.2005.11.003. PMID: 16512598
Tumor markers: value and limitations in the management of cancer patients.
Bates SE, Longo DL
Cancer Treat Rev 1985 Sep;12(3):163-207. doi: 10.1016/0305-7372(85)90037-4. PMID: 2416441

Recent clinical studies

Etiology

Recently Described and Clinically Important Entities in Testis Tumors: A Selective Review of Changes Incorporated Into the 2016 Classification of the World Health Organization.
Ulbright TM
Arch Pathol Lab Med 2019 Jun;143(6):711-721. Epub 2018 Jun 27 doi: 10.5858/arpa.2017-0478-RA. PMID: 29949388
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396
Curative cancer chemotherapy.
Frei E 3rd
Cancer Res 1985 Dec;45(12 Pt 1):6523-37. PMID: 2998603
Testicular tumors: oncologic imaging and diagnosis.
Heiken JP, Balfe DM, McClennan BL
Int J Radiat Oncol Biol Phys 1984 Feb;10(2):275-87. doi: 10.1016/0360-3016(84)90014-2. PMID: 6200463

Diagnosis

Choriocarcinoma syndrome.
Medina A, Ramos M, Amenedo M, París L
Arch Esp Urol 2014 Oct;67(8):711-4. PMID: 25306991
Hyperglycosylated hCG.
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790
Scrotal ultrasound.
Krone KD, Carroll BA
Radiol Clin North Am 1985 Mar;23(1):121-39. PMID: 2858113
Testicular carcinoma.
Paulson DF
Curr Probl Cancer 1982 May;6(11):1-44. doi: 10.1016/s0147-0272(82)80013-5. PMID: 6179719
Testicular tumors.
Markland C
Curr Probl Surg 1968 Sep:3-51. doi: 10.1016/s0011-3840(68)80001-2. PMID: 4386486

Therapy

A 20-Year-Old-Man With New Onset of Melena.
Yang XY, Bégin LR, Tamaz R
Gastroenterology 2022 Jan;162(1):e14-e15. Epub 2021 Jun 17 doi: 10.1053/j.gastro.2021.05.065. PMID: 34146570
Testicular choriocarcinoma: a rare variant that requires a unique treatment approach.
Reilley MJ, Pagliaro LC
Curr Oncol Rep 2015 Feb;17(2):2. doi: 10.1007/s11912-014-0430-0. PMID: 25645112
Testicular tumors: oncologic imaging and diagnosis.
Heiken JP, Balfe DM, McClennan BL
Int J Radiat Oncol Biol Phys 1984 Feb;10(2):275-87. doi: 10.1016/0360-3016(84)90014-2. PMID: 6200463
Testicular germ cell neoplasms.
Hainsworth JD, Greco FA
Am J Med 1983 Nov;75(5):817-32. doi: 10.1016/0002-9343(83)90413-8. PMID: 6195919
Testicular carcinoma.
Paulson DF
Curr Probl Cancer 1982 May;6(11):1-44. doi: 10.1016/s0147-0272(82)80013-5. PMID: 6179719

Prognosis

Recent advances in the regulation of testicular germ cell tumors by microRNAs.
Batool A, Liu XM, Zhang CL, Hao CF, Chen SR, Liu YX
Front Biosci (Landmark Ed) 2019 Mar 1;24(4):765-776. doi: 10.2741/4749. PMID: 30844711
Hyperglycosylated hCG.
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790
Human chorionic gonadotropin in cancer.
Stenman UH, Alfthan H, Hotakainen K
Clin Biochem 2004 Jul;37(7):549-61. doi: 10.1016/j.clinbiochem.2004.05.008. PMID: 15234236
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653
Testicular tumors: oncologic imaging and diagnosis.
Heiken JP, Balfe DM, McClennan BL
Int J Radiat Oncol Biol Phys 1984 Feb;10(2):275-87. doi: 10.1016/0360-3016(84)90014-2. PMID: 6200463

Clinical prediction guides

Recently Described and Clinically Important Entities in Testis Tumors: A Selective Review of Changes Incorporated Into the 2016 Classification of the World Health Organization.
Ulbright TM
Arch Pathol Lab Med 2019 Jun;143(6):711-721. Epub 2018 Jun 27 doi: 10.5858/arpa.2017-0478-RA. PMID: 29949388
Hyperglycosylated hCG.
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790
Human chorionic gonadotropin in cancer.
Stenman UH, Alfthan H, Hotakainen K
Clin Biochem 2004 Jul;37(7):549-61. doi: 10.1016/j.clinbiochem.2004.05.008. PMID: 15234236
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396
Tumor markers: value and limitations in the management of cancer patients.
Bates SE, Longo DL
Cancer Treat Rev 1985 Sep;12(3):163-207. doi: 10.1016/0305-7372(85)90037-4. PMID: 2416441

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