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Testicular trophoblastic tumor

MedGen UID:
272844
•Concept ID:
C1515301
•
Neoplastic Process
Synonyms: Testicular Trophoblastic Tumor; testicular trophoblastic tumor
 
Monarch Initiative: MONDO:0002871

Definition

A tumor that arises from the testis and is composed of neoplastic trophoblastic cells. The vast majority of cases are choriocarcinomas. [from NCI]

Professional guidelines

PubMed

Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Testicular choriocarcinoma: a rare variant that requires a unique treatment approach.
Reilley MJ, Pagliaro LC
Curr Oncol Rep 2015 Feb;17(2):2. doi: 10.1007/s11912-014-0430-0. PMID: 25645112
Tumor markers: value and limitations in the management of cancer patients.
Bates SE, Longo DL
Cancer Treat Rev 1985 Sep;12(3):163-207. doi: 10.1016/0305-7372(85)90037-4. PMID: 2416441

Recent clinical studies

Etiology

Recently Described and Clinically Important Entities in Testis Tumors: A Selective Review of Changes Incorporated Into the 2016 Classification of the World Health Organization.
Ulbright TM
Arch Pathol Lab Med 2019 Jun;143(6):711-721. Epub 2018 Jun 27 doi: 10.5858/arpa.2017-0478-RA. PMID: 29949388
New discoveries on the biology and detection of human chorionic gonadotropin.
Cole LA
Reprod Biol Endocrinol 2009 Jan 26;7:8. doi: 10.1186/1477-7827-7-8. PMID: 19171054Free PMC Article
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253
Curative cancer chemotherapy.
Frei E 3rd
Cancer Res 1985 Dec;45(12 Pt 1):6523-37. PMID: 2998603
Testicular tumors: oncologic imaging and diagnosis.
Heiken JP, Balfe DM, McClennan BL
Int J Radiat Oncol Biol Phys 1984 Feb;10(2):275-87. doi: 10.1016/0360-3016(84)90014-2. PMID: 6200463

Diagnosis

Choriocarcinoma syndrome.
Medina A, Ramos M, Amenedo M, París L
Arch Esp Urol 2014 Oct;67(8):711-4. PMID: 25306991
Ten testicular trapdoors.
Rajab R, Berney DM
Histopathology 2008 Dec;53(6):728-39. Epub 2008 Mar 12 doi: 10.1111/j.1365-2559.2008.03001.x. PMID: 18336561
Hyperglycosylated hCG.
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790
Scrotal ultrasound.
Krone KD, Carroll BA
Radiol Clin North Am 1985 Mar;23(1):121-39. PMID: 2858113
Testicular tumors: oncologic imaging and diagnosis.
Heiken JP, Balfe DM, McClennan BL
Int J Radiat Oncol Biol Phys 1984 Feb;10(2):275-87. doi: 10.1016/0360-3016(84)90014-2. PMID: 6200463

Therapy

Pitfalls in Diagnosis and Management of Testicular Choriocarcinoma Metastatic to the Brain: Report of 2 Cases and Review of Literature.
Hoffman HA, Toshkezi G, Fullmer JM, Hall W, Chin LS
World Neurosurg 2017 Oct;106:536-542. Epub 2017 Jul 13 doi: 10.1016/j.wneu.2017.07.023. PMID: 28712904
Testicular choriocarcinoma: a rare variant that requires a unique treatment approach.
Reilley MJ, Pagliaro LC
Curr Oncol Rep 2015 Feb;17(2):2. doi: 10.1007/s11912-014-0430-0. PMID: 25645112
Testicular tumors: oncologic imaging and diagnosis.
Heiken JP, Balfe DM, McClennan BL
Int J Radiat Oncol Biol Phys 1984 Feb;10(2):275-87. doi: 10.1016/0360-3016(84)90014-2. PMID: 6200463
Testicular germ cell neoplasms.
Hainsworth JD, Greco FA
Am J Med 1983 Nov;75(5):817-32. doi: 10.1016/0002-9343(83)90413-8. PMID: 6195919
Testicular carcinoma.
Paulson DF
Curr Probl Cancer 1982 May;6(11):1-44. doi: 10.1016/s0147-0272(82)80013-5. PMID: 6179719

Prognosis

Recent advances in the regulation of testicular germ cell tumors by microRNAs.
Batool A, Liu XM, Zhang CL, Hao CF, Chen SR, Liu YX
Front Biosci (Landmark Ed) 2019 Mar 1;24(4):765-776. doi: 10.2741/4749. PMID: 30844711
Hyperglycosylated hCG.
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790
Classification and pathology of testicular germ cell and sex cord-stromal tumors.
Cheville JC
Urol Clin North Am 1999 Aug;26(3):595-609. doi: 10.1016/s0094-0143(05)70201-9. PMID: 10494291
Testicular tumors: oncologic imaging and diagnosis.
Heiken JP, Balfe DM, McClennan BL
Int J Radiat Oncol Biol Phys 1984 Feb;10(2):275-87. doi: 10.1016/0360-3016(84)90014-2. PMID: 6200463
Testicular germ cell neoplasms.
Hainsworth JD, Greco FA
Am J Med 1983 Nov;75(5):817-32. doi: 10.1016/0002-9343(83)90413-8. PMID: 6195919

Clinical prediction guides

Recently Described and Clinically Important Entities in Testis Tumors: A Selective Review of Changes Incorporated Into the 2016 Classification of the World Health Organization.
Ulbright TM
Arch Pathol Lab Med 2019 Jun;143(6):711-721. Epub 2018 Jun 27 doi: 10.5858/arpa.2017-0478-RA. PMID: 29949388
New discoveries on the biology and detection of human chorionic gonadotropin.
Cole LA
Reprod Biol Endocrinol 2009 Jan 26;7:8. doi: 10.1186/1477-7827-7-8. PMID: 19171054Free PMC Article
Hyperglycosylated hCG.
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396
Tumor markers: value and limitations in the management of cancer patients.
Bates SE, Longo DL
Cancer Treat Rev 1985 Sep;12(3):163-207. doi: 10.1016/0305-7372(85)90037-4. PMID: 2416441

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