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Wolffian duct adenocarcinoma

MedGen UID:
273908
•Concept ID:
C1516419
•
Neoplastic Process
Synonyms: Cervical Mesonephric Adenocarcinoma; cervical mesonephric adenocarcinoma; HPV- Independent Cervical Adenocarcinoma, Mesonephric Type; HPV- Independent Cervical Adenocarcinoma, Mesonephric-Type; Human Papillomavirus-Independent Cervical Adenocarcinoma, Mesonephric Type; Human Papillomavirus-Independent Cervical Adenocarcinoma, Mesonephric-Type; mesonephric duct adenocarcinoma
 
Monarch Initiative: MONDO:0003410

Definition

Cervical adenocarcinoma that derives from Wolffian duct remnants and shows mesonephric differentiation. It is not associated with human papillomavirus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWolffian duct adenocarcinoma

Recent clinical studies

Etiology

Mesonephric-like Differentiation of Ovarian Endometrioid and High-grade Serous Carcinomas: Clinicopathological and Molecular Characteristics Distinct from Those of Mesonephric-like Adenocarcinoma.
Choi KH, Kim H, Bae GE, Lee SH, Woo HY, Kim HS
Anticancer Res 2021 Sep;41(9):4587-4601. doi: 10.21873/anticanres.15272. PMID: 34475087
Clinicopathologic Characteristics of Mesonephric Adenocarcinomas and Mesonephric-like Adenocarcinomas in the Gynecologic Tract: A Multi-institutional Study.
Pors J, Segura S, Chiu DS, Almadani N, Ren H, Fix DJ, Howitt BE, Kolin D, McCluggage WG, Mirkovic J, Gilks B, Park KJ, Hoang L
Am J Surg Pathol 2021 Apr 1;45(4):498-506. doi: 10.1097/PAS.0000000000001612. PMID: 33165093Free PMC Article
Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report.
Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M
Diagn Pathol 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566Free PMC Article
Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.
Chen YB, Fine SW, Epstein JI
Am J Surg Pathol 2011 Jul;35(7):1054-61. doi: 10.1097/PAS.0b013e318218df97. PMID: 21606823
Renal collecting (Bellini) duct carcinoma displays similar characteristics to upper tract urothelial cell carcinoma.
Orsola A, Trias I, Raventós CX, Español I, Cecchini L, Orsola I
Urology 2005 Jan;65(1):49-54. doi: 10.1016/j.urology.2004.08.012. PMID: 15667862

Diagnosis

Mesonephric adenocarcinoma in the uterine corpus: A case report and review of the literature.
Tang X, Li L, He Y
Indian J Pathol Microbiol 2021 Oct-Dec;64(4):806-809. doi: 10.4103/IJPM.IJPM_298_20. PMID: 34673610
Mesonephric-like adenocarcinoma of the ovary: A case report and a review of the literature.
Chen Q, Shen Y, Xie C
Medicine (Baltimore) 2020 Nov 25;99(48):e23450. doi: 10.1097/MD.0000000000023450. PMID: 33235131Free PMC Article
Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report.
Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M
Diagn Pathol 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566Free PMC Article
Mesonephric proliferations of the female genital tract.
Howitt BE, Nucci MR
Pathology 2018 Feb;50(2):141-150. Epub 2017 Dec 19 doi: 10.1016/j.pathol.2017.11.084. PMID: 29269124
Mesonephric adenocarcinoma of the vagina : Diagnosis and multimodal treatment of a rare tumor and analysis of worldwide experience.
Mueller I, Kametriser G, Jacobs VR, Bogner G, Staudach A, Koch H, Wolfrum-Ristau P, Schausberger C, Fischer T, Sedlmayer F
Strahlenther Onkol 2016 Sep;192(9):668-71. Epub 2016 Jun 27 doi: 10.1007/s00066-016-1004-x. PMID: 27349710Free PMC Article

Therapy

Mesonephric adenocarcinoma in the uterine corpus: A case report and review of the literature.
Tang X, Li L, He Y
Indian J Pathol Microbiol 2021 Oct-Dec;64(4):806-809. doi: 10.4103/IJPM.IJPM_298_20. PMID: 34673610
Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report.
Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M
Diagn Pathol 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566Free PMC Article
The embryologic development of the human vagina.
Ulfelder H, Robboy SJ
Am J Obstet Gynecol 1976 Dec 1;126(7):769-76. doi: 10.1016/0002-9378(76)90666-9. PMID: 1033667

Prognosis

Mesonephric-like adenocarcinoma of the ovary: A case report and a review of the literature.
Chen Q, Shen Y, Xie C
Medicine (Baltimore) 2020 Nov 25;99(48):e23450. doi: 10.1097/MD.0000000000023450. PMID: 33235131Free PMC Article
Targeted Genomic Profiling Reveals Recurrent KRAS Mutations in Mesonephric-like Adenocarcinomas of the Female Genital Tract.
Mirkovic J, McFarland M, Garcia E, Sholl LM, Lindeman N, MacConaill L, Dong F, Hirsch M, Nucci MR, Quick CM, Crum CP, McCluggage WG, Howitt BE
Am J Surg Pathol 2018 Feb;42(2):227-233. doi: 10.1097/PAS.0000000000000958. PMID: 28984674
Mesonephric adenocarcinoma of the vagina : Diagnosis and multimodal treatment of a rare tumor and analysis of worldwide experience.
Mueller I, Kametriser G, Jacobs VR, Bogner G, Staudach A, Koch H, Wolfrum-Ristau P, Schausberger C, Fischer T, Sedlmayer F
Strahlenther Onkol 2016 Sep;192(9):668-71. Epub 2016 Jun 27 doi: 10.1007/s00066-016-1004-x. PMID: 27349710Free PMC Article
Is female adnexal tumour of probable wolffian origin a benign lesion? A systematic review of the English literature.
Heatley MK
Pathology 2009;41(7):645-8. doi: 10.3109/00313020903273084. PMID: 20001344
Renal collecting (Bellini) duct carcinoma displays similar characteristics to upper tract urothelial cell carcinoma.
Orsola A, Trias I, Raventós CX, Español I, Cecchini L, Orsola I
Urology 2005 Jan;65(1):49-54. doi: 10.1016/j.urology.2004.08.012. PMID: 15667862

Clinical prediction guides

Mesonephric adenocarcinoma in the uterine corpus: A case report and review of the literature.
Tang X, Li L, He Y
Indian J Pathol Microbiol 2021 Oct-Dec;64(4):806-809. doi: 10.4103/IJPM.IJPM_298_20. PMID: 34673610
Dedifferentiated Mesonephric-like Adenocarcinoma of the Uterine Corpus.
Choi S, Na K, Kim SW, Kim HS
Anticancer Res 2021 May;41(5):2719-2726. doi: 10.21873/anticanres.15053. PMID: 33952503
Targeted Genomic Profiling Reveals Recurrent KRAS Mutations in Mesonephric-like Adenocarcinomas of the Female Genital Tract.
Mirkovic J, McFarland M, Garcia E, Sholl LM, Lindeman N, MacConaill L, Dong F, Hirsch M, Nucci MR, Quick CM, Crum CP, McCluggage WG, Howitt BE
Am J Surg Pathol 2018 Feb;42(2):227-233. doi: 10.1097/PAS.0000000000000958. PMID: 28984674
Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.
Chen YB, Fine SW, Epstein JI
Am J Surg Pathol 2011 Jul;35(7):1054-61. doi: 10.1097/PAS.0b013e318218df97. PMID: 21606823
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ
Am J Surg Pathol 2010 Feb;34(2):137-46. doi: 10.1097/PAS.0b013e3181c89c98. PMID: 20061933

Recent systematic reviews

Is female adnexal tumour of probable wolffian origin a benign lesion? A systematic review of the English literature.
Heatley MK
Pathology 2009;41(7):645-8. doi: 10.3109/00313020903273084. PMID: 20001344

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