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Uterine corpus cellular leiomyoma

MedGen UID:
276938
•Concept ID:
C1519845
•
Neoplastic Process
Synonyms: body of uterus cellular leiomyoma; cellular leiomyoma of body of uterus; Uterine Corpus Cellular Leiomyoma; uterine corpus cellular leiomyoma
 
Monarch Initiative: MONDO:0004162

Definition

A morphologic variant of leiomyoma arising from the uterine corpus. It is characterized by a dense cellular infiltrate composed of spindle or round cells with scant cytoplasm and a less obvious interlacing fascicle pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUterine corpus cellular leiomyoma

Professional guidelines

PubMed

Uterine Morcellation for Presumed Leiomyomas: ACOG Committee Opinion, Number 822.
Obstet Gynecol 2021 Mar 1;137(3):e63-e74. doi: 10.1097/AOG.0000000000004291. PMID: 33595252
ACOG Committee Opinion No. 770: Uterine Morcellation for Presumed Leiomyomas.
Obstet Gynecol 2019 Mar;133(3):e238-e248. doi: 10.1097/AOG.0000000000003126. PMID: 30801477

Recent clinical studies

Etiology

Fumarate Hydratase-Deficient Leiomyoma of the Uterine Corpus: Comparative Morphologic Analysis of Protein-Deficient Tumors With and Without Pathogenic Germline Fumarate Hydratase Gene Mutations.
Shi W, Liu Y, Aisagbonhi O, Roma AA, Hasteh F, Zare SY, Fadare O
Int J Surg Pathol 2024 Apr;32(2):340-355. Epub 2023 Jun 13 doi: 10.1177/10668969231180285. PMID: 37312573
Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri.
Dvorská D, Škovierová H, Braný D, Halašová E, Danková Z
Int J Mol Sci 2019 Aug 5;20(15) doi: 10.3390/ijms20153825. PMID: 31387281Free PMC Article
Molecular and clinical attributes of uterine leiomyomas.
Dvorská D, Braný D, Danková Z, Halašová E, Višňovský J
Tumour Biol 2017 Jun;39(6):1010428317710226. doi: 10.1177/1010428317710226. PMID: 28653894
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D
Eur J Gynaecol Oncol 2006;27(1):73-7. PMID: 16550975
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
El-Fiky SM, Taha YM
Acta Histochem 1976;56(1):1-17. doi: 10.1016/S0065-1281(76)80022-0. PMID: 184637

Diagnosis

Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri.
Dvorská D, Škovierová H, Braný D, Halašová E, Danková Z
Int J Mol Sci 2019 Aug 5;20(15) doi: 10.3390/ijms20153825. PMID: 31387281Free PMC Article
Molecular and clinical attributes of uterine leiomyomas.
Dvorská D, Braný D, Danková Z, Halašová E, Višňovský J
Tumour Biol 2017 Jun;39(6):1010428317710226. doi: 10.1177/1010428317710226. PMID: 28653894
Epithelioid vascular leiomyoma of the uterus mimicking glomangiomyoma.
Sakai Y
Arch Gynecol Obstet 2007 Jan;275(1):59-61. Epub 2006 May 5 doi: 10.1007/s00404-006-0167-6. PMID: 16676196
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D
Eur J Gynaecol Oncol 2006;27(1):73-7. PMID: 16550975
Micronuclei level in exfoliated buccal mucosa cells of patients with benign and malignant tumors of female reproductive organs and breast.
Nersesyan AK, Adamyan RT
Tsitol Genet 2004 May-Jun;38(3):72-5. PMID: 15619992

Therapy

Fumarate Hydratase-Deficient Leiomyoma of the Uterine Corpus: Comparative Morphologic Analysis of Protein-Deficient Tumors With and Without Pathogenic Germline Fumarate Hydratase Gene Mutations.
Shi W, Liu Y, Aisagbonhi O, Roma AA, Hasteh F, Zare SY, Fadare O
Int J Surg Pathol 2024 Apr;32(2):340-355. Epub 2023 Jun 13 doi: 10.1177/10668969231180285. PMID: 37312573
Uterine Morcellation for Presumed Leiomyomas: ACOG Committee Opinion, Number 822.
Obstet Gynecol 2021 Mar 1;137(3):e63-e74. doi: 10.1097/AOG.0000000000004291. PMID: 33595252
ACOG Committee Opinion No. 770: Uterine Morcellation for Presumed Leiomyomas.
Obstet Gynecol 2019 Mar;133(3):e238-e248. doi: 10.1097/AOG.0000000000003126. PMID: 30801477
The opioid neuropeptides in uterine fibroid pseudocapsules: a putative association with cervical integrity in human reproduction.
Malvasi A, Cavallotti C, Nicolardi G, Pellegrino M, Vergara D, Greco M, Kosmas I, Mynbaev OA, Kumakiri J, Tinelli A
Gynecol Endocrinol 2013 Nov;29(11):982-8. Epub 2013 Aug 12 doi: 10.3109/09513590.2013.824958. PMID: 23937196
Cervical choriocarcinoma associated with an intrauterine contraceptive device: a case report.
Martin BR 3rd, Orr JW Jr, Austin JM Jr
Am J Obstet Gynecol 1983 Oct 1;147(3):343-4. doi: 10.1016/0002-9378(83)91127-4. PMID: 6684883

Prognosis

The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
Rubisz P, Hirnle L, Kobierzycki C
Curr Issues Mol Biol 2021 Jul 25;43(2):802-817. doi: 10.3390/cimb43020058. PMID: 34449552Free PMC Article
Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri.
Dvorská D, Škovierová H, Braný D, Halašová E, Danková Z
Int J Mol Sci 2019 Aug 5;20(15) doi: 10.3390/ijms20153825. PMID: 31387281Free PMC Article
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D
Eur J Gynaecol Oncol 2006;27(1):73-7. PMID: 16550975
Micronuclei level in exfoliated buccal mucosa cells of patients with benign and malignant tumors of female reproductive organs and breast.
Nersesyan AK, Adamyan RT
Tsitol Genet 2004 May-Jun;38(3):72-5. PMID: 15619992
Cervical choriocarcinoma associated with an intrauterine contraceptive device: a case report.
Martin BR 3rd, Orr JW Jr, Austin JM Jr
Am J Obstet Gynecol 1983 Oct 1;147(3):343-4. doi: 10.1016/0002-9378(83)91127-4. PMID: 6684883

Clinical prediction guides

The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
Rubisz P, Hirnle L, Kobierzycki C
Curr Issues Mol Biol 2021 Jul 25;43(2):802-817. doi: 10.3390/cimb43020058. PMID: 34449552Free PMC Article
Dissecting leiomyoma of the uterus with unusual clinical and pathological features.
Lenz J, Chvátal R, Konečná P
Ceska Gynekol 2020 Winter;85(3):197-200. PMID: 33562973
Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri.
Dvorská D, Škovierová H, Braný D, Halašová E, Danková Z
Int J Mol Sci 2019 Aug 5;20(15) doi: 10.3390/ijms20153825. PMID: 31387281Free PMC Article
Micronuclei level in exfoliated buccal mucosa cells of patients with benign and malignant tumors of female reproductive organs and breast.
Nersesyan AK, Adamyan RT
Tsitol Genet 2004 May-Jun;38(3):72-5. PMID: 15619992
Cytoenzymology of benign and malignant tumours of the corpus uteri. I. Respiratory enzymes.
El-Fiky SM, Taha YM
Acta Histochem 1976;56(1):1-17. doi: 10.1016/S0065-1281(76)80022-0. PMID: 184637

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