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Uterine corpus cellular leiomyoma

MedGen UID:
276938
•Concept ID:
C1519845
•
Neoplastic Process
Synonyms: body of uterus cellular leiomyoma; cellular leiomyoma of body of uterus; Uterine Corpus Cellular Leiomyoma; uterine corpus cellular leiomyoma
 
Monarch Initiative: MONDO:0004162

Definition

A morphologic variant of leiomyoma arising from the uterine corpus. It is characterized by a dense cellular infiltrate composed of spindle or round cells with scant cytoplasm and a less obvious interlacing fascicle pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUterine corpus cellular leiomyoma

Professional guidelines

PubMed

Uterine Morcellation for Presumed Leiomyomas: ACOG Committee Opinion, Number 822.
Obstet Gynecol 2021 Mar 1;137(3):e63-e74. doi: 10.1097/AOG.0000000000004291. PMID: 33595252
ACOG Committee Opinion No. 770: Uterine Morcellation for Presumed Leiomyomas.
Obstet Gynecol 2019 Mar;133(3):e238-e248. doi: 10.1097/AOG.0000000000003126. PMID: 30801477

Recent clinical studies

Etiology

Fumarate Hydratase-Deficient Leiomyoma of the Uterine Corpus: Comparative Morphologic Analysis of Protein-Deficient Tumors With and Without Pathogenic Germline Fumarate Hydratase Gene Mutations.
Shi W, Liu Y, Aisagbonhi O, Roma AA, Hasteh F, Zare SY, Fadare O
Int J Surg Pathol 2024 Apr;32(2):340-355. Epub 2023 Jun 13 doi: 10.1177/10668969231180285. PMID: 37312573
The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
Rubisz P, Hirnle L, Kobierzycki C
Curr Issues Mol Biol 2021 Jul 25;43(2):802-817. doi: 10.3390/cimb43020058. PMID: 34449552Free PMC Article
Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri.
Dvorská D, Škovierová H, Braný D, Halašová E, Danková Z
Int J Mol Sci 2019 Aug 5;20(15) doi: 10.3390/ijms20153825. PMID: 31387281Free PMC Article
Molecular and clinical attributes of uterine leiomyomas.
Dvorská D, Braný D, Danková Z, Halašová E, Višňovský J
Tumour Biol 2017 Jun;39(6):1010428317710226. doi: 10.1177/1010428317710226. PMID: 28653894
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D
Eur J Gynaecol Oncol 2006;27(1):73-7. PMID: 16550975

Diagnosis

Fumarate Hydratase-Deficient Leiomyoma of the Uterine Corpus: Comparative Morphologic Analysis of Protein-Deficient Tumors With and Without Pathogenic Germline Fumarate Hydratase Gene Mutations.
Shi W, Liu Y, Aisagbonhi O, Roma AA, Hasteh F, Zare SY, Fadare O
Int J Surg Pathol 2024 Apr;32(2):340-355. Epub 2023 Jun 13 doi: 10.1177/10668969231180285. PMID: 37312573
The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
Rubisz P, Hirnle L, Kobierzycki C
Curr Issues Mol Biol 2021 Jul 25;43(2):802-817. doi: 10.3390/cimb43020058. PMID: 34449552Free PMC Article
Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri.
Dvorská D, Škovierová H, Braný D, Halašová E, Danková Z
Int J Mol Sci 2019 Aug 5;20(15) doi: 10.3390/ijms20153825. PMID: 31387281Free PMC Article
Molecular and clinical attributes of uterine leiomyomas.
Dvorská D, Braný D, Danková Z, Halašová E, Višňovský J
Tumour Biol 2017 Jun;39(6):1010428317710226. doi: 10.1177/1010428317710226. PMID: 28653894
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D
Eur J Gynaecol Oncol 2006;27(1):73-7. PMID: 16550975

Therapy

Fumarate Hydratase-Deficient Leiomyoma of the Uterine Corpus: Comparative Morphologic Analysis of Protein-Deficient Tumors With and Without Pathogenic Germline Fumarate Hydratase Gene Mutations.
Shi W, Liu Y, Aisagbonhi O, Roma AA, Hasteh F, Zare SY, Fadare O
Int J Surg Pathol 2024 Apr;32(2):340-355. Epub 2023 Jun 13 doi: 10.1177/10668969231180285. PMID: 37312573
Uterine Morcellation for Presumed Leiomyomas: ACOG Committee Opinion, Number 822.
Obstet Gynecol 2021 Mar 1;137(3):e63-e74. doi: 10.1097/AOG.0000000000004291. PMID: 33595252
ACOG Committee Opinion No. 770: Uterine Morcellation for Presumed Leiomyomas.
Obstet Gynecol 2019 Mar;133(3):e238-e248. doi: 10.1097/AOG.0000000000003126. PMID: 30801477
The opioid neuropeptides in uterine fibroid pseudocapsules: a putative association with cervical integrity in human reproduction.
Malvasi A, Cavallotti C, Nicolardi G, Pellegrino M, Vergara D, Greco M, Kosmas I, Mynbaev OA, Kumakiri J, Tinelli A
Gynecol Endocrinol 2013 Nov;29(11):982-8. Epub 2013 Aug 12 doi: 10.3109/09513590.2013.824958. PMID: 23937196
Cervical choriocarcinoma associated with an intrauterine contraceptive device: a case report.
Martin BR 3rd, Orr JW Jr, Austin JM Jr
Am J Obstet Gynecol 1983 Oct 1;147(3):343-4. doi: 10.1016/0002-9378(83)91127-4. PMID: 6684883

Prognosis

The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
Rubisz P, Hirnle L, Kobierzycki C
Curr Issues Mol Biol 2021 Jul 25;43(2):802-817. doi: 10.3390/cimb43020058. PMID: 34449552Free PMC Article
Uterine Morcellation for Presumed Leiomyomas: ACOG Committee Opinion, Number 822.
Obstet Gynecol 2021 Mar 1;137(3):e63-e74. doi: 10.1097/AOG.0000000000004291. PMID: 33595252
Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri.
Dvorská D, Škovierová H, Braný D, Halašová E, Danková Z
Int J Mol Sci 2019 Aug 5;20(15) doi: 10.3390/ijms20153825. PMID: 31387281Free PMC Article
Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus.
Zhao L, Ma Q, Wang Q, Zeng Y, Luo Q, Xiao H
Diagn Pathol 2016 Jan 20;11:9. doi: 10.1186/s13000-016-0464-8. PMID: 26791260Free PMC Article
Mesenchymal tumors of the uterine corpus with heterologous and hematopoietic components: a study of ten cases and review of the literature.
Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Kontogianni-Katsarou K, Koliopoulos C, Botsis D
Eur J Gynaecol Oncol 2006;27(1):73-7. PMID: 16550975

Clinical prediction guides

The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
Rubisz P, Hirnle L, Kobierzycki C
Curr Issues Mol Biol 2021 Jul 25;43(2):802-817. doi: 10.3390/cimb43020058. PMID: 34449552Free PMC Article
Dissecting leiomyoma of the uterus with unusual clinical and pathological features.
Lenz J, Chvátal R, Konečná P
Ceska Gynekol 2020 Winter;85(3):197-200. PMID: 33562973
Liquid Biopsy as a Tool for Differentiation of Leiomyomas and Sarcomas of Corpus Uteri.
Dvorská D, Škovierová H, Braný D, Halašová E, Danková Z
Int J Mol Sci 2019 Aug 5;20(15) doi: 10.3390/ijms20153825. PMID: 31387281Free PMC Article
Primary diffuse large B cell lymphoma arising from a leiomyoma of the uterine corpus.
Zhao L, Ma Q, Wang Q, Zeng Y, Luo Q, Xiao H
Diagn Pathol 2016 Jan 20;11:9. doi: 10.1186/s13000-016-0464-8. PMID: 26791260Free PMC Article
p53 expression in neoplasms of the uterine corpus.
Bur ME, Perlman C, Edelmann L, Fey E, Rose PG
Am J Clin Pathol 1992 Jul;98(1):81-7. doi: 10.1093/ajcp/98.1.81. PMID: 1615931

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