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Cellular leiomyoma

MedGen UID:
83155
•Concept ID:
C0334477
•
Neoplastic Process
Synonyms: Cellular Leiomyoma; cellular leiomyoma; cellular leiomyoma (morphologic abnormality)
SNOMED CT: Cellular leiomyoma (90955001); Cellular leiomyoma (754555501000119102)
 
Monarch Initiative: MONDO:0003296

Definition

A morphologic variant of classic leiomyoma characterized by a dense cellular infiltrate composed of spindle or round cells with scant cytoplasm and a less obvious interlacing fascicle pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular leiomyoma

Professional guidelines

PubMed

The utility of MRI for the preoperative differential diagnosis of uterine sarcoma and leiomyoma: a single-center study.
Yazawa H, Yazawa R, Anjo K, Inazuki A, Kikuta M
Fukushima J Med Sci 2024 Oct 18;70(4):211-218. Epub 2024 Oct 4 doi: 10.5387/fms.23-00018. PMID: 39370272
IFITM1, CD10, SMA, and h-caldesmon as a helpful combination in differential diagnosis between endometrial stromal tumor and cellular leiomyoma.
Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086Free PMC Article
High expression of EZH2 as a marker for the differential diagnosis of malignant and benign myogenic tumors.
Zhang N, Zeng Z, Li S, Wang F, Huang P
Sci Rep 2018 Aug 17;8(1):12331. doi: 10.1038/s41598-018-30648-7. PMID: 30120321Free PMC Article

Recent clinical studies

Etiology

Low-Grade Endometrial Stromal Sarcoma Diagnosed 8 Years After Hysterectomy With Morcellation.
Sanneh A, Murdock T, Wethington SL, Fader AN, Xing D, Beavis AL
Obstet Gynecol 2020 Aug;136(2):365-368. doi: 10.1097/AOG.0000000000003908. PMID: 32649495
The diagnostic problem of endometrial stromal sarcoma: report on six cases.
Amant F, Moerman P, Cadron I, Neven P, Berteloot P, Vergote I
Gynecol Oncol 2003 Jul;90(1):37-43. doi: 10.1016/s0090-8258(03)00207-5. PMID: 12821339
Epstein-Barr virus-associated smooth muscle tumors in ataxia-telangiectasia: a case report and review.
Reyes C, Abuzaitoun O, De Jong A, Hanson C, Langston C
Hum Pathol 2002 Jan;33(1):133-6. doi: 10.1053/hupa.2002.30214. PMID: 11823985
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765
A 15-year-old girl with an expansively growing tumour.
de Rooy CG, Wiegerinck MA
Eur J Obstet Gynecol Reprod Biol 1986 Sep;22(5-6):373-7. doi: 10.1016/0028-2243(86)90128-0. PMID: 3770287

Diagnosis

Highly cellular leiomyoma - A great histopathological masquerader of endometrial stromal sarcoma.
Garikapati K, Sharmila V, Joshi P, Bharti JN
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S943-S945. Epub 2023 Apr 28 doi: 10.4103/jcrt.jcrt_1064_22. PMID: 38384086
Low-Grade Endometrial Stromal Sarcoma Diagnosed 8 Years After Hysterectomy With Morcellation.
Sanneh A, Murdock T, Wethington SL, Fader AN, Xing D, Beavis AL
Obstet Gynecol 2020 Aug;136(2):365-368. doi: 10.1097/AOG.0000000000003908. PMID: 32649495
Unusual types of smooth muscle tumors of uterine corpus: case reports and literature review.
Makharoblidze E, Goishvili N, Mchedlishvili M, Khakhutaishvili I, Jangavadze M
Georgian Med News 2013 Mar;(216):7-11. PMID: 23567300
Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques.
Baker P, Oliva E
J Clin Pathol 2007 Mar;60(3):235-43. doi: 10.1136/jcp.2005.031203. PMID: 17347285Free PMC Article
Immunohistochemical expression of CD10 antigen in uterine adenosarcoma.
Amant F, Steenkiste E, Schurmans K, Verbist L, Abeler VM, Tulunay G, de Jonge E, Massuger L, Moerman P, Vergote I
Int J Gynecol Cancer 2004 Nov-Dec;14(6):1118-21. doi: 10.1111/j.1048-891X.2004.14610.x. PMID: 15571618

Therapy

Low-Grade Endometrial Stromal Sarcoma Diagnosed 8 Years After Hysterectomy With Morcellation.
Sanneh A, Murdock T, Wethington SL, Fader AN, Xing D, Beavis AL
Obstet Gynecol 2020 Aug;136(2):365-368. doi: 10.1097/AOG.0000000000003908. PMID: 32649495
Submyometrial vasopressin injection before microwave ablation of vascular-rich submucosal myomas: a preliminary case study.
Tsuda A, Kanaoka Y
Int J Hyperthermia 2019;36(1):739-743. doi: 10.1080/02656736.2019.1612102. PMID: 31385549
Transcervical microwave myolysis for uterine myomas assisted by transvaginal ultrasonic guidance.
Kanaoka Y, Yoshida C, Fukuda T, Kajitani K, Ishiko O
J Obstet Gynaecol Res 2009 Feb;35(1):145-51. doi: 10.1111/j.1447-0756.2008.00872.x. PMID: 19215562

Prognosis

HISTOPATHOLOGICAL, PROLIFERATIVE, APOPTOTIC AND HORMONAL CHARACTERISTICS OF VARIOUS TYPES OF LEIOMYOMAS.
Kiknadze T, Tevdorashvili G, Muzashvili T, Gachechiladze M, Burkadze G
Georgian Med News 2021 Mar;(312):119-125. PMID: 33964839
Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques.
Baker P, Oliva E
J Clin Pathol 2007 Mar;60(3):235-43. doi: 10.1136/jcp.2005.031203. PMID: 17347285Free PMC Article
Immunohistochemical expression of CD10 antigen in uterine adenosarcoma.
Amant F, Steenkiste E, Schurmans K, Verbist L, Abeler VM, Tulunay G, de Jonge E, Massuger L, Moerman P, Vergote I
Int J Gynecol Cancer 2004 Nov-Dec;14(6):1118-21. doi: 10.1111/j.1048-891X.2004.14610.x. PMID: 15571618
A 15-year-old girl with an expansively growing tumour.
de Rooy CG, Wiegerinck MA
Eur J Obstet Gynecol Reprod Biol 1986 Sep;22(5-6):373-7. doi: 10.1016/0028-2243(86)90128-0. PMID: 3770287
Cellular leiomyomas of the stomach in 49 patients.
Appelman H, Helwig EB
Arch Pathol Lab Med 1977 Jul;101(7):373-7. PMID: 577393

Clinical prediction guides

Raf kinase inhibitor protein expression in smooth muscle tumours of the uterus: a diagnostic marker for leiomyosarcoma?
Greco S, Pinheiro J, Cardoso-Carneiro D, Giantomassi F, Pellegrino P, Scaglione G, Delli Carpini G, Ciavattini A, Zannoni GF, Goteri G, Martinho O, Ciarmela P
Reprod Biomed Online 2024 Jun;48(6):103816. Epub 2024 Jan 13 doi: 10.1016/j.rbmo.2024.103816. PMID: 38608337
IFITM1, CD10, SMA, and h-caldesmon as a helpful combination in differential diagnosis between endometrial stromal tumor and cellular leiomyoma.
Zhao W, Cui M, Zhang R, Shen X, Xiong X, Ji X, Tao L, Jia W, Pang L, Sun Z, Wang C, Zou H
BMC Cancer 2021 Sep 23;21(1):1047. doi: 10.1186/s12885-021-08781-w. PMID: 34556086Free PMC Article
Prevalence of cellular leiomyoma and partially cellular leiomyoma in postoperative samples - analysis of 384 cases.
Sikora-Szczęśniak DL
Ginekol Pol 2016;87(9):609-616. doi: 10.5603/GP.2016.0054. PMID: 27723066
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations.
Oliva E
Int J Gynecol Pathol 2014 Jul;33(4):374-84. doi: 10.1097/PGP.0000000000000141. PMID: 24901397
Immunohistochemical expression of CD10 antigen in uterine adenosarcoma.
Amant F, Steenkiste E, Schurmans K, Verbist L, Abeler VM, Tulunay G, de Jonge E, Massuger L, Moerman P, Vergote I
Int J Gynecol Cancer 2004 Nov-Dec;14(6):1118-21. doi: 10.1111/j.1048-891X.2004.14610.x. PMID: 15571618

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