U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gallbladder Papillary Biliary Intraepithelial Neoplasia

MedGen UID:
310796
•Concept ID:
C1708177
•
Neoplastic Process
Synonyms: Gallbladder Papillary BilIN; Gallbladder Papillary Intraepithelial Neoplasia

Definition

Biliary intraepithelial neoplasia that affects the gallbladder epithelium. It is characterized by the presence of intraluminal micropapillary projections. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Papillary Biliary Intraepithelial Neoplasia

Recent clinical studies

Etiology

Diagnostic usefulness of SpyGlass in intracholecystic papillary neoplasm with pancreaticobiliary maljunction: a case report and comparison with conventional gallbladder cancer with pancreaticobiliary maljunction.
Akita M, Yanagimoto H, Tsugawa D, Ajiki T, Masuda A, Komatsu M, Goto T, Kido M, Toyama H, Fukumoto T
Clin J Gastroenterol 2023 Jun;16(3):476-481. Epub 2023 Mar 3 doi: 10.1007/s12328-023-01778-x. PMID: 36867354
Gallbladder Cancer: A Single-Institution 10-Year Experience-Analysis of Adenocarcinoma Subtypes and Tumors Arising from Intracholecystic Papillary Neoplasms.
Berger Y, Sullivan BJ, Leigh NL, Bekhor EY, Dhorajiya P, Mani M, Magge DR, Cha DE, Sarpel U, Hiotis SP, Labow DM, Ward SC, Golas BJ, Cohen NA
Ann Surg Oncol 2022 Aug;29(8):5167-5175. Epub 2022 Apr 18 doi: 10.1245/s10434-022-11719-6. PMID: 35437668
Prognostic implications of the coexisting precursor lesion types in invasive gallbladder cancer.
Mochidome N, Koga Y, Ohishi Y, Miyazaki T, Matsuda R, Yamada Y, Aishima S, Nakamura M, Oda Y
Hum Pathol 2021 Aug;114:44-53. Epub 2021 May 11 doi: 10.1016/j.humpath.2021.05.001. PMID: 33989638
Complex APC germline mutation associated metaplasia and intraepithelial neoplasia (CAM-IEN) of the gallbladder.
Böger C, Haag J, Egberts JH, Röcken C
Pathol Res Pract 2016 Jan;212(1):54-8. Epub 2015 Nov 14 doi: 10.1016/j.prp.2015.11.010. PMID: 26643927
Gallbladder cancers: associated conditions, histological types, prognosis, and prevention.
Cariati A, Piromalli E, Cetta F
Eur J Gastroenterol Hepatol 2014 May;26(5):562-9. doi: 10.1097/MEG.0000000000000074. PMID: 24614695

Diagnosis

Gallbladder Cancer: A Single-Institution 10-Year Experience-Analysis of Adenocarcinoma Subtypes and Tumors Arising from Intracholecystic Papillary Neoplasms.
Berger Y, Sullivan BJ, Leigh NL, Bekhor EY, Dhorajiya P, Mani M, Magge DR, Cha DE, Sarpel U, Hiotis SP, Labow DM, Ward SC, Golas BJ, Cohen NA
Ann Surg Oncol 2022 Aug;29(8):5167-5175. Epub 2022 Apr 18 doi: 10.1245/s10434-022-11719-6. PMID: 35437668
Characterization of high-grade biliary intraepithelial neoplasm of the gallbladder in comparison with intracholecystic papillary neoplasm.
Nakanuma Y, Sugino T, Okamura Y, Nomura Y, Watanabe H, Terada T, Sato Y
Hum Pathol 2021 Oct;116:22-30. Epub 2021 Jul 12 doi: 10.1016/j.humpath.2021.06.007. PMID: 34265338
Unraveling Neuroendocrine Gallbladder Cancer: Comprehensive Clinicopathologic and Molecular Characterization.
de Bitter TJJ, Kroeze LI, de Reuver PR, van Vliet S, Vink-Börger E, von Rhein D, Jansen EAM, Nagtegaal ID, Ligtenberg MJL, van der Post RS
JCO Precis Oncol 2021;5 Epub 2021 Mar 8 doi: 10.1200/PO.20.00487. PMID: 34036234Free PMC Article
Tumoral Versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract, Gallbladder, and Ampulla of Vater.
Jang KT, Ahn S
Arch Pathol Lab Med 2016 May;140(5):429-36. doi: 10.5858/arpa.2015-0319-RA. PMID: 27128300
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Therapy

Gallbladder cancers: associated conditions, histological types, prognosis, and prevention.
Cariati A, Piromalli E, Cetta F
Eur J Gastroenterol Hepatol 2014 May;26(5):562-9. doi: 10.1097/MEG.0000000000000074. PMID: 24614695

Prognosis

Gallbladder Cancer: A Single-Institution 10-Year Experience-Analysis of Adenocarcinoma Subtypes and Tumors Arising from Intracholecystic Papillary Neoplasms.
Berger Y, Sullivan BJ, Leigh NL, Bekhor EY, Dhorajiya P, Mani M, Magge DR, Cha DE, Sarpel U, Hiotis SP, Labow DM, Ward SC, Golas BJ, Cohen NA
Ann Surg Oncol 2022 Aug;29(8):5167-5175. Epub 2022 Apr 18 doi: 10.1245/s10434-022-11719-6. PMID: 35437668
Low-Grade Dysplastic Intracholecystic Papillary Neoplasia: A Case Report.
Logrado A, Constantino J, Daniel C, Pereira J, Carvalho MT, Casimiro C
Am J Case Rep 2021 Mar 3;22:e929788. doi: 10.12659/AJCR.929788. PMID: 33654049Free PMC Article
Gallbladder cancers: associated conditions, histological types, prognosis, and prevention.
Cariati A, Piromalli E, Cetta F
Eur J Gastroenterol Hepatol 2014 May;26(5):562-9. doi: 10.1097/MEG.0000000000000074. PMID: 24614695
Precancerous lesions of the biliary tree.
Klöppel G, Adsay V, Konukiewitz B, Kleeff J, Schlitter AM, Esposito I
Best Pract Res Clin Gastroenterol 2013 Apr;27(2):285-97. doi: 10.1016/j.bpg.2013.04.002. PMID: 23809246
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Clinical prediction guides

Diagnostic usefulness of SpyGlass in intracholecystic papillary neoplasm with pancreaticobiliary maljunction: a case report and comparison with conventional gallbladder cancer with pancreaticobiliary maljunction.
Akita M, Yanagimoto H, Tsugawa D, Ajiki T, Masuda A, Komatsu M, Goto T, Kido M, Toyama H, Fukumoto T
Clin J Gastroenterol 2023 Jun;16(3):476-481. Epub 2023 Mar 3 doi: 10.1007/s12328-023-01778-x. PMID: 36867354
Neuroendocrine Carcinomas of the Gallbladder: A Clinicopathologic and Immunohistochemical Analysis of 34 Resected Cases.
Lee SM, Sung CO
Am J Surg Pathol 2020 Oct;44(10):1308-1321. doi: 10.1097/PAS.0000000000001536. PMID: 32739935

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...