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Gallbladder biliary intraepithelial neoplasia

MedGen UID:
317714
•Concept ID:
C1708174
•
Neoplastic Process
Synonyms: Gallbladder Biliary Intraepithelial Neoplasia; gallbladder biliary intraepithelial neoplasia; Gallbladder BilIN; gallbladder BilIN; Gallbladder Dysplasia; gallbladder dysplasia; Gallbladder Intraepithelial Neoplasia; gallbladder intraepithelial neoplasia; Intracystic Biliary Intraepithelial Neoplasia; intracystic biliary intraepithelial neoplasia; Intracystic BilIN; intracystic BilIN
 
Monarch Initiative: MONDO:0006218

Definition

A neoplastic, non-invasive lesion that affects the gallbladder epithelium. It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder biliary intraepithelial neoplasia

Professional guidelines

PubMed

Gallbladder cancer epidemiology, treatment and survival in Southern Finland - a population-based study.
Koppatz H, Takala S, Peltola K, But A, Mäkisalo H, Nordin A, Sallinen V
Scand J Gastroenterol 2021 Aug;56(8):929-939. Epub 2021 Jul 5 doi: 10.1080/00365521.2021.1915373. PMID: 34224306
AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With Primary Sclerosing Cholangitis: Expert Review.
Bowlus CL, Lim JK, Lindor KD
Clin Gastroenterol Hepatol 2019 Nov;17(12):2416-2422. Epub 2019 Jul 12 doi: 10.1016/j.cgh.2019.07.011. PMID: 31306801
Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article

Recent clinical studies

Etiology

EGFR, HER2, and MET gene amplification and protein expression profiles in biliary tract cancer and their prognostic significance.
Kim Y, Jee S, Kim H, Paik SS, Choi D, Yoo SH, Shin SJ
Oncologist 2024 Aug 5;29(8):e1051-e1060. doi: 10.1093/oncolo/oyae076. PMID: 38709907Free PMC Article
Clinical implications of pediatric biliary intraepithelial neoplasia diagnosed from a choledochal cyst specimen.
Gang S, Kwon H, Song IH, Namgoong JM
World J Surg Oncol 2024 Apr 20;22(1):105. doi: 10.1186/s12957-024-03384-8. PMID: 38643155Free PMC Article
Occult pancreaticobiliary reflux is a pathogenic factor of some benign biliary diseases and gallbladder cancer.
Wang L, Zhang ZW, Guo T, Xie P, Huang XR, Yu YH
Hepatobiliary Pancreat Dis Int 2023 Jun;22(3):288-293. Epub 2022 Aug 21 doi: 10.1016/j.hbpd.2022.08.010. PMID: 36041970
Long-term exposure to genistein inhibits the proliferation of gallbladder cancer by downregulating the MCM complex.
Geng Y, Chen S, Yang Y, Miao H, Li X, Li G, Ma J, Zhang T, Ren T, Li Y, Li L, Liu L, Yang J, Wang Z, Zou L, Liu K, Li Y, Yan S, Cui X, Sun X, Yang B, Zhang L, Han X, Wang C, Chen B, Yue X, Liang W, Ren J, Jia J, Gu J, Li Z, Zhao T, Wang P, Wei D, Qiu S, Xiang D, Xu X, Chen W, He M, Yang L, Wang H, Chen T, Hua R, Wang X, Wu X, Gong W, Wang G, Li M, Zhang W, Shao R, Wu W, Liu Y
Sci Bull (Beijing) 2022 Apr 30;67(8):813-824. Epub 2022 Jan 17 doi: 10.1016/j.scib.2022.01.011. PMID: 36546234
AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With Primary Sclerosing Cholangitis: Expert Review.
Bowlus CL, Lim JK, Lindor KD
Clin Gastroenterol Hepatol 2019 Nov;17(12):2416-2422. Epub 2019 Jul 12 doi: 10.1016/j.cgh.2019.07.011. PMID: 31306801

Diagnosis

Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells.
Wang Z, Li W, Wang X, Zhu Q, Liu L, Qiu S, Zou L, Liu K, Li G, Miao H, Yang Y, Jiang C, Liu Y, Shao R, Wang X, Liu Y
Chin Med J (Engl) 2023 Sep 20;136(18):2210-2220. Epub 2023 Jul 24 doi: 10.1097/CM9.0000000000002675. PMID: 37488674Free PMC Article
Intraductal Tubulopapillary Neoplasm of the Pancreas and Bile Duct: A Review.
Kuan LL, Dennison AR, Garcea G
Pancreas 2020 Apr;49(4):498-502. doi: 10.1097/MPA.0000000000001518. PMID: 32282762
Tumoral Versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract, Gallbladder, and Ampulla of Vater.
Jang KT, Ahn S
Arch Pathol Lab Med 2016 May;140(5):429-36. doi: 10.5858/arpa.2015-0319-RA. PMID: 27128300
Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Therapy

The significance of anatomic tumor location in gallbladder cancer.
Leigh N, Pletcher E, Solomon D, Sarpel U, Labow DM, Magge DR, Golas BJ
J Surg Oncol 2021 Mar;123(4):932-938. Epub 2020 Dec 23 doi: 10.1002/jso.26345. PMID: 33368336
Impaired gallbladder function in patients after total gastrectomy.
Tyrväinen T, Nordback I, Toikka J, Piiroinen A, Herzig KH, Mäkelä K, Sand J
Scand J Gastroenterol 2017 Mar;52(3):334-337. Epub 2016 Nov 24 doi: 10.1080/00365521.2016.1256422. PMID: 27881023
Gallbladder cancers: associated conditions, histological types, prognosis, and prevention.
Cariati A, Piromalli E, Cetta F
Eur J Gastroenterol Hepatol 2014 May;26(5):562-9. doi: 10.1097/MEG.0000000000000074. PMID: 24614695
Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article
Epidermal growth factor receptor immunoreactivity in gallbladder and extrahepatic biliary tract tumours.
Lee CS, Pirdas A
Pathol Res Pract 1995 Nov;191(11):1087-91. doi: 10.1016/S0344-0338(11)80652-7. PMID: 8822109

Prognosis

Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway.
He Z, Zhong Y, Regmi P, Lv T, Ma W, Wang J, Liu F, Yang S, Zhong Y, Zhou R, Jin Y, Cheng N, Shi Y, Hu H, Li F
Mol Cancer 2024 Mar 27;23(1):65. doi: 10.1186/s12943-024-01979-z. PMID: 38532427Free PMC Article
Dysplasia and Early Carcinoma of the Gallbladder and Bile Ducts: Terminology, Classification, and Significance.
Adsay NV, Basturk O
Gastroenterol Clin North Am 2024 Mar;53(1):85-108. Epub 2023 Nov 17 doi: 10.1016/j.gtc.2023.10.001. PMID: 38280752
Intraductal Tubulopapillary Neoplasm of the Pancreas and Bile Duct: A Review.
Kuan LL, Dennison AR, Garcea G
Pancreas 2020 Apr;49(4):498-502. doi: 10.1097/MPA.0000000000001518. PMID: 32282762
Precancerous lesions of the biliary tree.
Klöppel G, Adsay V, Konukiewitz B, Kleeff J, Schlitter AM, Esposito I
Best Pract Res Clin Gastroenterol 2013 Apr;27(2):285-97. doi: 10.1016/j.bpg.2013.04.002. PMID: 23809246
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Clinical prediction guides

Clinical implications of pediatric biliary intraepithelial neoplasia diagnosed from a choledochal cyst specimen.
Gang S, Kwon H, Song IH, Namgoong JM
World J Surg Oncol 2024 Apr 20;22(1):105. doi: 10.1186/s12957-024-03384-8. PMID: 38643155Free PMC Article
Simultaneous activation of Kras-Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway.
Namikawa M, Fukuda A, Mizukoshi K, Iwane K, Kawai M, Yamakawa G, Omatsu M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Tsuruyama T, Taura K, Hatano E, Seno H
J Pathol 2023 Aug;260(4):478-492. Epub 2023 Jun 13 doi: 10.1002/path.6139. PMID: 37310065
AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With Primary Sclerosing Cholangitis: Expert Review.
Bowlus CL, Lim JK, Lindor KD
Clin Gastroenterol Hepatol 2019 Nov;17(12):2416-2422. Epub 2019 Jul 12 doi: 10.1016/j.cgh.2019.07.011. PMID: 31306801
Impaired gallbladder function in patients after total gastrectomy.
Tyrväinen T, Nordback I, Toikka J, Piiroinen A, Herzig KH, Mäkelä K, Sand J
Scand J Gastroenterol 2017 Mar;52(3):334-337. Epub 2016 Nov 24 doi: 10.1080/00365521.2016.1256422. PMID: 27881023
KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas.
Hsu M, Sasaki M, Igarashi S, Sato Y, Nakanuma Y
Cancer 2013 May 1;119(9):1669-74. Epub 2013 Jan 18 doi: 10.1002/cncr.27955. PMID: 23335286

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