U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gallbladder biliary intraepithelial neoplasia

MedGen UID:
317714
Concept ID:
C1708174
Neoplastic Process
Synonyms: Gallbladder Biliary Intraepithelial Neoplasia; gallbladder biliary intraepithelial neoplasia; Gallbladder BilIN; gallbladder BilIN; Gallbladder Dysplasia; gallbladder dysplasia; Gallbladder Intraepithelial Neoplasia; gallbladder intraepithelial neoplasia; Intracystic Biliary Intraepithelial Neoplasia; intracystic biliary intraepithelial neoplasia; Intracystic BilIN; intracystic BilIN
 
Monarch Initiative: MONDO:0006218

Definition

A neoplastic, non-invasive lesion that affects the gallbladder epithelium. It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder biliary intraepithelial neoplasia

Professional guidelines

PubMed

Koppatz H, Takala S, Peltola K, But A, Mäkisalo H, Nordin A, Sallinen V
Scand J Gastroenterol 2021 Aug;56(8):929-939. Epub 2021 Jul 5 doi: 10.1080/00365521.2021.1915373. PMID: 34224306
Bowlus CL, Lim JK, Lindor KD
Clin Gastroenterol Hepatol 2019 Nov;17(12):2416-2422. Epub 2019 Jul 12 doi: 10.1016/j.cgh.2019.07.011. PMID: 31306801
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article

Recent clinical studies

Etiology

Pehlivanoglu B, Akkas G, Memis B, Basturk O, Reid MD, Saka B, Dursun N, Bagci P, Balci S, Sarmiento J, Maithel SK, Bandyopadhyay S, Escalona OT, Araya JC, Losada H, Goodman M, Knight JH, Roa JC, Adsay V
Virchows Arch 2023 Feb;482(2):311-323. Epub 2022 Dec 29 doi: 10.1007/s00428-022-03482-6. PMID: 36580138
Wang L, Zhang ZW, Guo T, Xie P, Huang XR, Yu YH
Hepatobiliary Pancreat Dis Int 2023 Jun;22(3):288-293. Epub 2022 Aug 21 doi: 10.1016/j.hbpd.2022.08.010. PMID: 36041970
Geng Y, Chen S, Yang Y, Miao H, Li X, Li G, Ma J, Zhang T, Ren T, Li Y, Li L, Liu L, Yang J, Wang Z, Zou L, Liu K, Li Y, Yan S, Cui X, Sun X, Yang B, Zhang L, Han X, Wang C, Chen B, Yue X, Liang W, Ren J, Jia J, Gu J, Li Z, Zhao T, Wang P, Wei D, Qiu S, Xiang D, Xu X, Chen W, He M, Yang L, Wang H, Chen T, Hua R, Wang X, Wu X, Gong W, Wang G, Li M, Zhang W, Shao R, Wu W, Liu Y
Sci Bull (Beijing) 2022 Apr 30;67(8):813-824. Epub 2022 Jan 17 doi: 10.1016/j.scib.2022.01.011. PMID: 36546234
Bowlus CL, Lim JK, Lindor KD
Clin Gastroenterol Hepatol 2019 Nov;17(12):2416-2422. Epub 2019 Jul 12 doi: 10.1016/j.cgh.2019.07.011. PMID: 31306801
Tyrväinen T, Nordback I, Toikka J, Piiroinen A, Herzig KH, Mäkelä K, Sand J
Scand J Gastroenterol 2017 Mar;52(3):334-337. Epub 2016 Nov 24 doi: 10.1080/00365521.2016.1256422. PMID: 27881023

Diagnosis

Wang Z, Li W, Wang X, Zhu Q, Liu L, Qiu S, Zou L, Liu K, Li G, Miao H, Yang Y, Jiang C, Liu Y, Shao R, Wang X, Liu Y
Chin Med J (Engl) 2023 Sep 20;136(18):2210-2220. Epub 2023 Jul 24 doi: 10.1097/CM9.0000000000002675. PMID: 37488674Free PMC Article
Nakanuma Y, Sugino T, Okamura Y, Nomura Y, Watanabe H, Terada T, Sato Y
Hum Pathol 2021 Oct;116:22-30. Epub 2021 Jul 12 doi: 10.1016/j.humpath.2021.06.007. PMID: 34265338
Kuan LL, Dennison AR, Garcea G
Pancreas 2020 Apr;49(4):498-502. doi: 10.1097/MPA.0000000000001518. PMID: 32282762
Jang KT, Ahn S
Arch Pathol Lab Med 2016 May;140(5):429-36. doi: 10.5858/arpa.2015-0319-RA. PMID: 27128300
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article

Therapy

Leigh N, Pletcher E, Solomon D, Sarpel U, Labow DM, Magge DR, Golas BJ
J Surg Oncol 2021 Mar;123(4):932-938. Epub 2020 Dec 23 doi: 10.1002/jso.26345. PMID: 33368336
Tyrväinen T, Nordback I, Toikka J, Piiroinen A, Herzig KH, Mäkelä K, Sand J
Scand J Gastroenterol 2017 Mar;52(3):334-337. Epub 2016 Nov 24 doi: 10.1080/00365521.2016.1256422. PMID: 27881023
Cariati A, Piromalli E, Cetta F
Eur J Gastroenterol Hepatol 2014 May;26(5):562-9. doi: 10.1097/MEG.0000000000000074. PMID: 24614695
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article
Lee CS, Pirdas A
Pathol Res Pract 1995 Nov;191(11):1087-91. doi: 10.1016/S0344-0338(11)80652-7. PMID: 8822109

Prognosis

Namikawa M, Fukuda A, Mizukoshi K, Iwane K, Kawai M, Yamakawa G, Omatsu M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Tsuruyama T, Taura K, Hatano E, Seno H
J Pathol 2023 Aug;260(4):478-492. Epub 2023 Jun 13 doi: 10.1002/path.6139. PMID: 37310065
Pehlivanoglu B, Akkas G, Memis B, Basturk O, Reid MD, Saka B, Dursun N, Bagci P, Balci S, Sarmiento J, Maithel SK, Bandyopadhyay S, Escalona OT, Araya JC, Losada H, Goodman M, Knight JH, Roa JC, Adsay V
Virchows Arch 2023 Feb;482(2):311-323. Epub 2022 Dec 29 doi: 10.1007/s00428-022-03482-6. PMID: 36580138
Kuan LL, Dennison AR, Garcea G
Pancreas 2020 Apr;49(4):498-502. doi: 10.1097/MPA.0000000000001518. PMID: 32282762
Hu YP, Jin YP, Wu XS, Yang Y, Li YS, Li HF, Xiang SS, Song XL, Jiang L, Zhang YJ, Huang W, Chen SL, Liu FT, Chen C, Zhu Q, Chen HZ, Shao R, Liu YB
Mol Cancer 2019 Nov 21;18(1):167. doi: 10.1186/s12943-019-1097-9. PMID: 31752906Free PMC Article
Klöppel G, Adsay V, Konukiewitz B, Kleeff J, Schlitter AM, Esposito I
Best Pract Res Clin Gastroenterol 2013 Apr;27(2):285-97. doi: 10.1016/j.bpg.2013.04.002. PMID: 23809246

Clinical prediction guides

Gang S, Kwon H, Song IH, Namgoong JM
World J Surg Oncol 2024 Apr 20;22(1):105. doi: 10.1186/s12957-024-03384-8. PMID: 38643155
Namikawa M, Fukuda A, Mizukoshi K, Iwane K, Kawai M, Yamakawa G, Omatsu M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Tsuruyama T, Taura K, Hatano E, Seno H
J Pathol 2023 Aug;260(4):478-492. Epub 2023 Jun 13 doi: 10.1002/path.6139. PMID: 37310065
Hu YP, Jin YP, Wu XS, Yang Y, Li YS, Li HF, Xiang SS, Song XL, Jiang L, Zhang YJ, Huang W, Chen SL, Liu FT, Chen C, Zhu Q, Chen HZ, Shao R, Liu YB
Mol Cancer 2019 Nov 21;18(1):167. doi: 10.1186/s12943-019-1097-9. PMID: 31752906Free PMC Article
Bowlus CL, Lim JK, Lindor KD
Clin Gastroenterol Hepatol 2019 Nov;17(12):2416-2422. Epub 2019 Jul 12 doi: 10.1016/j.cgh.2019.07.011. PMID: 31306801
Hsu M, Sasaki M, Igarashi S, Sato Y, Nakanuma Y
Cancer 2013 May 1;119(9):1669-74. Epub 2013 Jan 18 doi: 10.1002/cncr.27955. PMID: 23335286

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...