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Colon signet ring cell adenocarcinoma

MedGen UID:
313039
Concept ID:
C1707436
Neoplastic Process
Synonyms: colon signet ring adenocarcinoma; Colon Signet Ring Cell Adenocarcinoma; colon signet ring cell adenocarcinoma; colon signet Ring cell adenocarcinoma; Colon Signet-Ring Cell Adenocarcinoma; colonic signet Ring adenocarcinoma; Colonic Signet Ring Cell Adenocarcinoma; colonic signet Ring cell adenocarcinoma; Signet Ring Cell Adenocarcinoma of Colon; signet Ring cell adenocarcinoma of colon; Signet Ring Cell Adenocarcinoma of the Colon; signet Ring cell adenocarcinoma of the colon; Signet Ring Cell Colon Adenocarcinoma; signet Ring cell colon adenocarcinoma
 
Monarch Initiative: MONDO:0002495

Definition

An invasive adenocarcinoma of the colon characterized by the presence of malignant glandular epithelial cells which contain prominent intracytoplasmic mucin (signet ring cells). The signet ring cells constitute more than 50% of the malignant cells. [from NCI]

Professional guidelines

PubMed

Hyung J, Cho EJ, Kim J, Kim JH, Kim JE, Hong YS, Kim TW, Sung CO, Kim SY
Cancer Res Treat 2022 Oct;54(4):1175-1190. Epub 2022 Jan 12 doi: 10.4143/crt.2021.1133. PMID: 35038827Free PMC Article
Pour Farid P, Eckstein M, Merkel S, Grützmann R, Hartmann A, Bruns V, Benz M, Schneider-Stock R, Geppert CI
Int J Mol Sci 2021 Dec 3;22(23) doi: 10.3390/ijms222313108. PMID: 34884913Free PMC Article
Franko J, Le VH, Tee MC, Lin M, Sedinkin J, Raman S, Frankova D
Cancer Treat Res Commun 2021;29:100475. Epub 2021 Oct 11 doi: 10.1016/j.ctarc.2021.100475. PMID: 34655861

Recent clinical studies

Etiology

Weng MT, Chao KH, Tung CC, Chang HC, Shih IL, Lin BR, Shieh MJ, Shun CT, Wong JM, Wei SC
BMC Gastroenterol 2022 Apr 8;22(1):173. doi: 10.1186/s12876-022-02258-1. PMID: 35395754Free PMC Article
Franko J, Le VH, Tee MC, Lin M, Sedinkin J, Raman S, Frankova D
Cancer Treat Res Commun 2021;29:100475. Epub 2021 Oct 11 doi: 10.1016/j.ctarc.2021.100475. PMID: 34655861
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Wei Q, Wang X, Gao J, Li J, Li J, Qi C, Li Y, Li Z, Shen L
PLoS One 2016;11(6):e0156659. Epub 2016 Jun 14 doi: 10.1371/journal.pone.0156659. PMID: 27300552Free PMC Article
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Diagnosis

Weng MT, Chao KH, Tung CC, Chang HC, Shih IL, Lin BR, Shieh MJ, Shun CT, Wong JM, Wei SC
BMC Gastroenterol 2022 Apr 8;22(1):173. doi: 10.1186/s12876-022-02258-1. PMID: 35395754Free PMC Article
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Karaosmanoglu AD, Onur MR, Salman MC, Usubutun A, Karcaaltincaba M, Ozmen MN, Akata D
Abdom Radiol (NY) 2019 Apr;44(4):1493-1505. doi: 10.1007/s00261-018-1809-4. PMID: 30361868
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Mijinyawa MS, Sani MU, Yusuf SM, Mohammed AZ, Alhassan SU
Niger J Med 2009 Oct-Dec;18(4):416-9. doi: 10.4314/njm.v18i4.51255. PMID: 20120149

Therapy

Gao Q, Zhang C, Dong Z, Guo Y, Zhang L
Comput Intell Neurosci 2022;2022:6122261. Epub 2022 May 27 doi: 10.1155/2022/6122261. PMID: 35669650Free PMC Article
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Morales-Cruz M, Salgado-Nesme N, Trolle-Silva AM, Rodríguez-Quintero JH
BMJ Case Rep 2019 Apr 30;12(4) doi: 10.1136/bcr-2018-229135. PMID: 31040144Free PMC Article
Hugen N, Verhoeven RH, Lemmens VE, van Aart CJ, Elferink MA, Radema SA, Nagtegaal ID, de Wilt JH
Int J Cancer 2015 Jan 15;136(2):333-9. Epub 2014 May 28 doi: 10.1002/ijc.28981. PMID: 24841868
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Prognosis

An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Grotz TE, Fournier KF, Mansfield PF
Surg Oncol Clin N Am 2018 Jul;27(3):443-462. doi: 10.1016/j.soc.2018.02.012. PMID: 29935682
Arifi S, Elmesbahi O, Amarti Riffi A
Bull Cancer 2015 Oct;102(10):880-8. Epub 2015 Sep 26 doi: 10.1016/j.bulcan.2015.07.005. PMID: 26412710
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Clinical prediction guides

Güzel Y, Kaplan İ, Kepenek F, Söğütçü N, Kömek H
Clin Nucl Med 2022 Jul 1;47(7):e509-e512. Epub 2022 Apr 5 doi: 10.1097/RLU.0000000000004166. PMID: 35675142
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Song IH, Hong SM, Yu E, Yoon YS, Park IJ, Lim SB, Kim JC, Yu CS, Kim J
Pathology 2019 Jun;51(4):384-391. Epub 2019 Apr 24 doi: 10.1016/j.pathol.2019.03.001. PMID: 31029443
Grotz TE, Fournier KF, Mansfield PF
Surg Oncol Clin N Am 2018 Jul;27(3):443-462. doi: 10.1016/j.soc.2018.02.012. PMID: 29935682
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Recent systematic reviews

Shen C, Tannenbaum D, Horn R, Rogers J, Eng C, Zhou S, Johnson B, Kopetz S, Morris V, Overman M, Parseghian C, Chang GJ, Lopez-Olivo MA, Kanwal R, Ellis LM, Dasari A
JAMA Netw Open 2022 May 2;5(5):e2213588. doi: 10.1001/jamanetworkopen.2022.13588. PMID: 35608860Free PMC Article
Lionetti R, DE Luca M, Raffone A, Travaglino A, Coppellotti A, Peltrini R, Bracale U, D'Ambra M, Insabato L, Zullo F, D'Armiento M, Corcione F
Minerva Obstet Gynecol 2022 Aug;74(4):356-363. Epub 2021 May 4 doi: 10.23736/S2724-606X.21.04797-7. PMID: 33944524
Kodama M, Moeini A, Machida H, Blake EA, Grubbs BH, Matsuo K
Arch Gynecol Obstet 2016 Sep;294(3):589-98. Epub 2016 Feb 20 doi: 10.1007/s00404-016-4048-3. PMID: 26897498
Rotimi O, Abdulkareem FB
Niger Postgrad Med J 2014 Mar;21(1):68-73. PMID: 24956622

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