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Cutaneous Adult T-Cell Leukemia/Lymphoma

MedGen UID:
313067
•Concept ID:
C1707540
•
Neoplastic Process
Synonym: Cutaneous Adult T-Cell Lymphoma/Leukemia

Definition

Adult T-cell leukemia/lymphoma affecting the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Adult T-Cell Leukemia/Lymphoma

Professional guidelines

PubMed

New entity, definition and diagnostic criteria of cutaneous adult T-cell leukemia/lymphoma: human T-lymphotropic virus type 1 proviral DNA load can distinguish between cutaneous and smoldering types.
Amano M, Kurokawa M, Ogata K, Itoh H, Kataoka H, Setoyama M
J Dermatol 2008 May;35(5):270-5. doi: 10.1111/j.1346-8138.2008.00465.x. PMID: 18477226
The role of alemtuzumab in the management of T-cell malignancies.
Dearden C
Semin Oncol 2006 Apr;33(2 Suppl 5):S44-52. doi: 10.1053/j.seminoncol.2006.01.029. PMID: 16720203

Recent clinical studies

Etiology

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Aggressive Cutaneous Lymphomas and Their Mimics.
Moy AP, Pulitzer MP
Surg Pathol Clin 2023 Jun;16(2):361-383. Epub 2023 Mar 10 doi: 10.1016/j.path.2023.01.009. PMID: 37149363
UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial.
Benjamin R, Jain N, Maus MV, Boissel N, Graham C, Jozwik A, Yallop D, Konopleva M, Frigault MJ, Teshima T, Kato K, Boucaud F, Balandraud S, Gianella-Borradori A, Binlich F, Marchiq I, Dupouy S, Almena-Carrasco M, Pannaux M, Fouliard S, Brissot E, Mohty M; CALM Study Group
Lancet Haematol 2022 Nov;9(11):e833-e843. Epub 2022 Oct 10 doi: 10.1016/S2352-3026(22)00245-9. PMID: 36228643
Cutaneous manifestations of adult T-cell leukemia/lymphoma.
Miyashiro D, Sanches JA
Semin Diagn Pathol 2020 Mar;37(2):81-91. Epub 2019 Jul 30 doi: 10.1053/j.semdp.2019.07.010. PMID: 31387753
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article

Diagnosis

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Therapeutic approaches for HTLV-1-associated adult T-cell leukemia/lymphoma: a comprehensive review.
Letafati A, Soheili R, Norouzi M, Soleimani P, Mozhgani SH
Med Oncol 2023 Sep 9;40(10):295. doi: 10.1007/s12032-023-02166-8. PMID: 37689806
Aggressive Cutaneous Lymphomas and Their Mimics.
Moy AP, Pulitzer MP
Surg Pathol Clin 2023 Jun;16(2):361-383. Epub 2023 Mar 10 doi: 10.1016/j.path.2023.01.009. PMID: 37149363
Aggressive cutaneous T-cell lymphomas.
Junkins-Hopkins Md JM
Semin Diagn Pathol 2017 Jan;34(1):44-59. Epub 2016 Dec 24 doi: 10.1053/j.semdp.2016.11.004. PMID: 28187925
Adult T-cell leukemia/lymphoma.
Oliveira PD, Farre L, Bittencourt AL
Rev Assoc Med Bras (1992) 2016 Oct;62(7):691-700. doi: 10.1590/1806-9282.62.07.691. PMID: 27925051

Therapy

UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial.
Benjamin R, Jain N, Maus MV, Boissel N, Graham C, Jozwik A, Yallop D, Konopleva M, Frigault MJ, Teshima T, Kato K, Boucaud F, Balandraud S, Gianella-Borradori A, Binlich F, Marchiq I, Dupouy S, Almena-Carrasco M, Pannaux M, Fouliard S, Brissot E, Mohty M; CALM Study Group
Lancet Haematol 2022 Nov;9(11):e833-e843. Epub 2022 Oct 10 doi: 10.1016/S2352-3026(22)00245-9. PMID: 36228643
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
T-cell lymphomas, a challenging disease: types, treatments, and future.
Ma H, Abdul-Hay M
Int J Clin Oncol 2017 Feb;22(1):18-51. Epub 2016 Oct 14 doi: 10.1007/s10147-016-1045-2. PMID: 27743148Free PMC Article
CCR4 and its ligands: from bench to bedside.
Yoshie O, Matsushima K
Int Immunol 2015 Jan;27(1):11-20. Epub 2014 Aug 2 doi: 10.1093/intimm/dxu079. PMID: 25087232
Mogamulizumab and the treatment of CCR4-positive T-cell lymphomas.
Remer M, Al-Shamkhani A, Glennie M, Johnson P
Immunotherapy 2014;6(11):1187-206. doi: 10.2217/imt.14.94. PMID: 25496334

Prognosis

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Cutaneous manifestations of adult T-cell leukemia/lymphoma.
Miyashiro D, Sanches JA
Semin Diagn Pathol 2020 Mar;37(2):81-91. Epub 2019 Jul 30 doi: 10.1053/j.semdp.2019.07.010. PMID: 31387753
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
Aggressive cutaneous T-cell lymphomas.
Junkins-Hopkins Md JM
Semin Diagn Pathol 2017 Jan;34(1):44-59. Epub 2016 Dec 24 doi: 10.1053/j.semdp.2016.11.004. PMID: 28187925
Adult T-cell leukemia/lymphoma.
Oliveira PD, Farre L, Bittencourt AL
Rev Assoc Med Bras (1992) 2016 Oct;62(7):691-700. doi: 10.1590/1806-9282.62.07.691. PMID: 27925051

Clinical prediction guides

The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis.
Oliveira PD, Ribeiro GS, Anjos RO, Dias MA, Farre L, Araújo I, Bittencourt AL
PLoS Negl Trop Dis 2022 Oct;16(10):e0010807. Epub 2022 Oct 19 doi: 10.1371/journal.pntd.0010807. PMID: 36260617Free PMC Article
HTLV, a multi organ oncovirus.
Ramezani S, Rezaee SA, Farjami Z, Ebrahimi N, Abdullabass HK, Ibrahim Jebur MI, Rafatpanah H, Akbarin MM
Microb Pathog 2022 Aug;169:105622. Epub 2022 Jun 7 doi: 10.1016/j.micpath.2022.105622. PMID: 35688412
Cutaneous manifestations of adult T-cell leukemia/lymphoma.
Miyashiro D, Sanches JA
Semin Diagn Pathol 2020 Mar;37(2):81-91. Epub 2019 Jul 30 doi: 10.1053/j.semdp.2019.07.010. PMID: 31387753
Aggressive cutaneous T-cell lymphomas.
Junkins-Hopkins Md JM
Semin Diagn Pathol 2017 Jan;34(1):44-59. Epub 2016 Dec 24 doi: 10.1053/j.semdp.2016.11.004. PMID: 28187925
Tumor necrosis factor-alpha and interferon-gamma, but not HTLV-I tax, are likely factors in the epidermotropism of cutaneous T-cell lymphoma via induction of interferon-inducible protein-10.
Daliani D, Ulmer RA, Jackow C, Pugh W, Gansbacher B, Cabanillas F, Duvic M, Sarris AH
Leuk Lymphoma 1998 Apr;29(3-4):315-28. doi: 10.3109/10428199809068568. PMID: 9684929

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