U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant Mediastinal Germ Cell Tumor with Associated Hematologic Malignancy

MedGen UID:
313417
Concept ID:
C1708955
Neoplastic Process
Synonym: Malignant Mediastinal Germ Cell Tumor with Associated Hematological Malignancy

Definition

An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum and is associated with a hematologic malignancy. The hematologic malignancies are clonally related to the malignant germ cell tumor and include acute leukemias, myelodysplastic syndromes, myeloproliferative neoplasms, and mastocytosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Mediastinal Germ Cell Tumor with Associated Hematologic Malignancy

Recent clinical studies

Etiology

Aguiar-Bujanda D, Croissier-Sánchez L, Pérez-Cabrera D, Galván-Ruiz S
Am J Clin Oncol 2024 Feb 1;47(2):58-63. Epub 2023 Oct 19 doi: 10.1097/COC.0000000000001061. PMID: 37853566
Taza F, Abonour R, Zaid MA, Althouse SK, Anouti B, Akel R, Hanna NH, Adra N, Einhorn LH
Clin Genitourin Cancer 2023 Apr;21(2):213-220. Epub 2023 Jan 18 doi: 10.1016/j.clgc.2023.01.004. PMID: 36737276
Sowithayasakul P, Sinlapamongkolkul P, Treetipsatit J, Vathana N, Narkbunnam N, Sanpakit K, Buaboonnam J
J Pediatr Hematol Oncol 2018 Aug;40(6):450-455. doi: 10.1097/MPH.0000000000001233. PMID: 29864110
Chen K, Cai Y, Zhang M, Wu Z, Wu Y
Pediatr Blood Cancer 2018 Sep;65(9):e27229. Epub 2018 May 24 doi: 10.1002/pbc.27229. PMID: 29797641
Hartmann JT, Nichols CR, Droz JP, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Fizazi K, Einhorn L, Kanz L, Bokemeyer C
J Natl Cancer Inst 2000 Jan 5;92(1):54-61. doi: 10.1093/jnci/92.1.54. PMID: 10620634

Diagnosis

Aguiar-Bujanda D, Croissier-Sánchez L, Pérez-Cabrera D, Galván-Ruiz S
Am J Clin Oncol 2024 Feb 1;47(2):58-63. Epub 2023 Oct 19 doi: 10.1097/COC.0000000000001061. PMID: 37853566
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
Sowithayasakul P, Sinlapamongkolkul P, Treetipsatit J, Vathana N, Narkbunnam N, Sanpakit K, Buaboonnam J
J Pediatr Hematol Oncol 2018 Aug;40(6):450-455. doi: 10.1097/MPH.0000000000001233. PMID: 29864110
Chen K, Cai Y, Zhang M, Wu Z, Wu Y
Pediatr Blood Cancer 2018 Sep;65(9):e27229. Epub 2018 May 24 doi: 10.1002/pbc.27229. PMID: 29797641
Maese L, Li KD, Xu X, Afify Z, Paxton CN, Putnam A
Fetal Pediatr Pathol 2017 Apr;36(2):168-176. Epub 2017 Jan 19 doi: 10.1080/15513815.2016.1273983. PMID: 28103116

Therapy

Taza F, Abonour R, Zaid MA, Althouse SK, Anouti B, Akel R, Hanna NH, Adra N, Einhorn LH
Clin Genitourin Cancer 2023 Apr;21(2):213-220. Epub 2023 Jan 18 doi: 10.1016/j.clgc.2023.01.004. PMID: 36737276
Chen K, Cai Y, Zhang M, Wu Z, Wu Y
Pediatr Blood Cancer 2018 Sep;65(9):e27229. Epub 2018 May 24 doi: 10.1002/pbc.27229. PMID: 29797641
Zhao GQ, Dowell JE
Expert Rev Hematol 2012 Aug;5(4):427-37. doi: 10.1586/ehm.12.24. PMID: 22992236
Hirai Y, Yoshimasu T, Oura S, Okamura Y
Interact Cardiovasc Thorac Surg 2011 Jan;12(1):96-7. Epub 2010 Oct 12 doi: 10.1510/icvts.2010.242867. PMID: 20940164
Fizazi K, Culine S, Droz JP, Kramar A, Théodore C, Ruffié P, Le Chevalier T
J Clin Oncol 1998 Feb;16(2):725-32. doi: 10.1200/JCO.1998.16.2.725. PMID: 9469363

Prognosis

Egan C, Lack J, Skarshaug S, Pham TA, Abdullaev Z, Xi L, Pack S, Pittaluga S, Jaffe ES, Raffeld M
Mod Pathol 2021 Feb;34(2):336-347. Epub 2020 Sep 14 doi: 10.1038/s41379-020-00673-x. PMID: 32929178Free PMC Article
Chen K, Cai Y, Zhang M, Wu Z, Wu Y
Pediatr Blood Cancer 2018 Sep;65(9):e27229. Epub 2018 May 24 doi: 10.1002/pbc.27229. PMID: 29797641
Maese L, Li KD, Xu X, Afify Z, Paxton CN, Putnam A
Fetal Pediatr Pathol 2017 Apr;36(2):168-176. Epub 2017 Jan 19 doi: 10.1080/15513815.2016.1273983. PMID: 28103116
Zhao GQ, Dowell JE
Expert Rev Hematol 2012 Aug;5(4):427-37. doi: 10.1586/ehm.12.24. PMID: 22992236
Thomas CR Jr, Bonomi PD
Curr Opin Oncol 1991 Apr;3(2):335-43. doi: 10.1097/00001622-199104000-00015. PMID: 1648973

Clinical prediction guides

Leng C, Cui Y, Mai Z, Chen R, Yuan J, Wang K, Wen J, Fu J, Liu Q
Int J Surg 2023 Sep 1;109(9):2574-2584. doi: 10.1097/JS9.0000000000000507. PMID: 37222675Free PMC Article
Chen K, Cai Y, Zhang M, Wu Z, Wu Y
Pediatr Blood Cancer 2018 Sep;65(9):e27229. Epub 2018 May 24 doi: 10.1002/pbc.27229. PMID: 29797641
Hartmann JT, Nichols CR, Droz JP, Horwich A, Gerl A, Fossa SD, Beyer J, Pont J, Fizazi K, Einhorn L, Kanz L, Bokemeyer C
J Natl Cancer Inst 2000 Jan 5;92(1):54-61. doi: 10.1093/jnci/92.1.54. PMID: 10620634
Thomas CR Jr, Bonomi PD
Curr Opin Oncol 1991 Apr;3(2):335-43. doi: 10.1097/00001622-199104000-00015. PMID: 1648973
Nichols CR, Roth BJ, Heerema N, Griep J, Tricot G
N Engl J Med 1990 May 17;322(20):1425-9. doi: 10.1056/NEJM199005173222004. PMID: 2158625

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...