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Extragonadal nonseminomatous germ cell tumor

MedGen UID:
233662
•Concept ID:
C1334582
•
Neoplastic Process
Synonyms: Cancer of Extragonadal Non-Seminomatous Germ Cell; cancer of extragonadal non-seminomatous germ cell; Cancer of the Extragonadal Non-Seminomatous Germ Cell; cancer of the extragonadal non-seminomatous germ cell; Extragonadal Non-Seminomatous Germ Cell Cancer; extragonadal non-seminomatous germ cell cancer; extragonadal nonseminomatous germ cell tumor; Extragonadal Primary Nonseminoma; extragonadal primary Nonseminoma; Malignant Extragonadal Non-Seminomatous Germ Cell Neoplasm; malignant extragonadal non-seminomatous germ cell neoplasm; Malignant Extragonadal Non-Seminomatous Germ Cell Tumor; malignant extragonadal non-seminomatous germ cell tumor; malignant extragonadal non-seminomatous germ cell tumour; Malignant Extragonadal Nongerminomatous Germ Cell Tumor; Malignant Extragonadal Nonseminoma; malignant extragonadal Nonseminoma; Malignant Neoplasm of Extragonadal Non-Seminomatous Germ Cell; malignant neoplasm of extragonadal non-seminomatous germ cell; Malignant Neoplasm of the Extragonadal Non-Seminomatous Germ Cell; malignant neoplasm of the extragonadal non-seminomatous germ cell; Malignant Tumor of Extragonadal Non-Seminomatous Germ Cell; malignant tumor of extragonadal non-seminomatous germ cell; Malignant Tumor of the Extragonadal Non-Seminomatous Germ Cell; malignant tumor of the extragonadal non-seminomatous germ cell; malignant tumour of extragonadal non-seminomatous germ cell; malignant tumour of the extragonadal non-seminomatous germ cell; Primary Malignant Extragonadal Nonseminoma; primary malignant extragonadal Nonseminoma
 
Monarch Initiative: MONDO:0003578

Definition

A malignant nongerminomatous germ cell tumor that develops as a primary tumor in an anatomic site other than the testis or ovary. [from NCI]

Professional guidelines

PubMed

How to classify, diagnose, treat and follow-up extragonadal germ cell tumors? A systematic review of available evidence.
Winter C, Zengerling F, Busch J, Heinzelbecker J, Pfister D, Ruf C, Lackner J, Albers P, Kliesch S, Schmidt S, Bokemeyer C
World J Urol 2022 Dec;40(12):2863-2878. Epub 2022 May 12 doi: 10.1007/s00345-022-04009-z. PMID: 35554637Free PMC Article
Clinical Features and Treatment Outcomes in Patients with Extragonadal Germ Cell Tumors: A Single-center Experience.
Makino T, Konaka H, Namiki M
Anticancer Res 2016 Jan;36(1):313-7. PMID: 26722059
Treatment outcome of patients with extragonadal nonseminomatous germ cell tumors: the Saitama Cancer Center experience.
Fukui N, Kohno Y, Ishioka J, Fukuda H, Kageyama Y, Higashi Y
Int J Clin Oncol 2013 Aug;18(4):731-4. Epub 2012 Jul 5 doi: 10.1007/s10147-012-0436-2. PMID: 22763659

Recent clinical studies

Etiology

First-line high-dose chemotherapy for patients with poor prognosis extragonadal germ cell tumors: the experience of the European Bone Marrow Transplantation (EBMT) Solid Tumors Working Party.
Rosti G, De Giorgi U, Wandt H, Lioure B, Leyvraz S, Kolbe K, Papiani G, Ballardini M, Kulekci A, Demirer T; Solid Tumours Working Party
Bone Marrow Transplant 2004 Dec;34(12):1033-7. doi: 10.1038/sj.bmt.1704704. PMID: 15516940

Diagnosis

NUT midline carcinoma mimicking a germ cell tumor: a case report.
Harada Y, Koyama T, Takeuchi K, Shoji K, Hoshi K, Oyama Y
BMC Cancer 2016 Nov 17;16(1):895. doi: 10.1186/s12885-016-2944-3. PMID: 27855672Free PMC Article

Therapy

First-line high-dose chemotherapy for patients with poor prognosis extragonadal germ cell tumors: the experience of the European Bone Marrow Transplantation (EBMT) Solid Tumors Working Party.
Rosti G, De Giorgi U, Wandt H, Lioure B, Leyvraz S, Kolbe K, Papiani G, Ballardini M, Kulekci A, Demirer T; Solid Tumours Working Party
Bone Marrow Transplant 2004 Dec;34(12):1033-7. doi: 10.1038/sj.bmt.1704704. PMID: 15516940

Prognosis

NUT midline carcinoma mimicking a germ cell tumor: a case report.
Harada Y, Koyama T, Takeuchi K, Shoji K, Hoshi K, Oyama Y
BMC Cancer 2016 Nov 17;16(1):895. doi: 10.1186/s12885-016-2944-3. PMID: 27855672Free PMC Article
First-line high-dose chemotherapy for patients with poor prognosis extragonadal germ cell tumors: the experience of the European Bone Marrow Transplantation (EBMT) Solid Tumors Working Party.
Rosti G, De Giorgi U, Wandt H, Lioure B, Leyvraz S, Kolbe K, Papiani G, Ballardini M, Kulekci A, Demirer T; Solid Tumours Working Party
Bone Marrow Transplant 2004 Dec;34(12):1033-7. doi: 10.1038/sj.bmt.1704704. PMID: 15516940

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