U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant Mediastinal Nongerminomatous Germ Cell Tumor

MedGen UID:
277351
•Concept ID:
C1334666
•
Neoplastic Process
Synonyms: Malignant Mediastinal Non-Seminomatous Germ Cell Tumor; Mediastinal Malignant Non-Seminomatous Germ Cell Neoplasm; Mediastinal Malignant Non-Seminomatous Germ Cell Tumor; Non-Seminomatous Malignant Germ Cell Neoplasm of Mediastinum; Non-Seminomatous Malignant Germ Cell Neoplasm of the Mediastinum; Non-Seminomatous Malignant Germ Cell Tumor of Mediastinum; Non-Seminomatous Malignant Germ Cell Tumor of the Mediastinum

Definition

An extragonadal nongerminomatous malignant germ cell tumor that arises from the mediastinum. This category includes embryonal carcinoma, yolk sac tumor, choriocarcinoma, and mixed germ cell tumors. [from NCI]

Recent clinical studies

Etiology

Salvage high-dose chemotherapy for children with extragonadal germ-cell tumours.
De Giorgi U, Rosti G, Slavin S, Yaniv I, Harousseau JL, Ladenstein R, Demirer T, Dini G; European Group for Blood and Marrow Transplantation Solid Tumours and Paediatric Disease Working Parties
Br J Cancer 2005 Aug 22;93(4):412-7. doi: 10.1038/sj.bjc.6602724. PMID: 16106248Free PMC Article
Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols.
Schneider DT, Calaminus G, Koch S, Teske C, Schmidt P, Haas RJ, Harms D, Göbel U
Pediatr Blood Cancer 2004 Feb;42(2):169-75. doi: 10.1002/pbc.10321. PMID: 14752882
Nongerminomatous malignant germ cell tumors in children. A review of 89 cases from the Pediatric Oncology Group, 1971-1984.
Hawkins EP, Finegold MJ, Hawkins HK, Krischer JP, Starling KA, Weinberg A
Cancer 1986 Dec 15;58(12):2579-84. doi: 10.1002/1097-0142(19861215)58:12<2579::aid-cncr2820581204>3.0.co;2-v. PMID: 3022907

Diagnosis

Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols.
Schneider DT, Calaminus G, Koch S, Teske C, Schmidt P, Haas RJ, Harms D, Göbel U
Pediatr Blood Cancer 2004 Feb;42(2):169-75. doi: 10.1002/pbc.10321. PMID: 14752882

Therapy

Salvage high-dose chemotherapy for children with extragonadal germ-cell tumours.
De Giorgi U, Rosti G, Slavin S, Yaniv I, Harousseau JL, Ladenstein R, Demirer T, Dini G; European Group for Blood and Marrow Transplantation Solid Tumours and Paediatric Disease Working Parties
Br J Cancer 2005 Aug 22;93(4):412-7. doi: 10.1038/sj.bjc.6602724. PMID: 16106248Free PMC Article

Prognosis

Nongerminomatous malignant germ cell tumors in children. A review of 89 cases from the Pediatric Oncology Group, 1971-1984.
Hawkins EP, Finegold MJ, Hawkins HK, Krischer JP, Starling KA, Weinberg A
Cancer 1986 Dec 15;58(12):2579-84. doi: 10.1002/1097-0142(19861215)58:12<2579::aid-cncr2820581204>3.0.co;2-v. PMID: 3022907

Clinical prediction guides

Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols.
Schneider DT, Calaminus G, Koch S, Teske C, Schmidt P, Haas RJ, Harms D, Göbel U
Pediatr Blood Cancer 2004 Feb;42(2):169-75. doi: 10.1002/pbc.10321. PMID: 14752882

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...