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Dermatitis, atopic, 5(ATOD5)

MedGen UID:
381292
•Concept ID:
C1853900
•
Disease or Syndrome
Synonym: Dermatitis, Atopic, 5
 
Monarch Initiative: MONDO:0011608
OMIM®: 605844

Definition

An inherited susceptibility or predisposition to developing atopic dermatitis that is associated with variation in the region 13q12-q14. [from MONDO]

Professional guidelines

PubMed

International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.
Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
Guidelines for diagnosis, prevention, and treatment of hand eczema.
Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, Bauer A, Brans R, Cannavo A, Christoffers WA, Crépy MN, Elsner P, Fartasch M, Filon FL, Giménez-Arnau AM, Gonçalo M, Guzmán-Perera MG, Hamann CR, Hoetzenecker W, Johansen JD, John SM, Kunkeler ACM, Hadzavdic SL, Molin S, Nixon R, Oosterhaven JAF, Rustemeyer T, Serra-Baldrich E, Shah M, Simon D, Skudlik C, Spiewak R, Valiukevičienė S, Voorberg AN, Weisshaar E, Agner T
Contact Dermatitis 2022 May;86(5):357-378. Epub 2022 Mar 3 doi: 10.1111/cod.14035. PMID: 34971008
Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I.
Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, Gieler U, Girolomoni G, Lau S, Muraro A, Czarnecka-Operacz M, Schäfer T, Schmid-Grendelmeier P, Simon D, Szalai Z, Szepietowski JC, Taïeb A, Torrelo A, Werfel T, Ring J; European Dermatology Forum (EDF), the European Academy of Dermatology and Venereology (EADV), the European Academy of Allergy and Clinical Immunology (EAACI), the European Task Force on Atopic Dermatitis (ETFAD), European Federation of Allergy and Airways Diseases Patients’ Associations (EFA), the European Society for Dermatology and Psychiatry (ESDaP), the European Society of Pediatric Dermatology (ESPD), Global Allergy and Asthma European Network (GA2LEN) and the European Union of Medical Specialists (UEMS)
J Eur Acad Dermatol Venereol 2018 May;32(5):657-682. doi: 10.1111/jdv.14891. PMID: 29676534

Recent clinical studies

Etiology

Comorbidities of atopic dermatitis-what does the evidence say?
Thyssen JP, Halling AS, Schmid-Grendelmeier P, Guttman-Yassky E, Silverberg JI
J Allergy Clin Immunol 2023 May;151(5):1155-1162. Epub 2023 Jan 6 doi: 10.1016/j.jaci.2022.12.002. PMID: 36621338
Early initiation of short-term emollient use for the prevention of atopic dermatitis in high-risk infants-The STOP-AD randomised controlled trial.
Ní Chaoimh C, Lad D, Nico C, Puppels GJ, Wong XFCC, Common JE, Murray DM, Irvine AD, Hourihane JO
Allergy 2023 Apr;78(4):984-994. Epub 2022 Sep 8 doi: 10.1111/all.15491. PMID: 35997592Free PMC Article
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial.
Reich K, Thyssen JP, Blauvelt A, Eyerich K, Soong W, Rice ZP, Hong HC, Katoh N, Valenzuela F, DiBonaventura M, Bratt TA, Zhang F, Clibborn C, Rojo R, Valdez H, Kerkmann U
Lancet 2022 Jul 23;400(10348):273-282. doi: 10.1016/S0140-6736(22)01199-0. PMID: 35871814
Phototherapy for atopic dermatitis.
Rodenbeck DL, Silverberg JI, Silverberg NB
Clin Dermatol 2016 Sep-Oct;34(5):607-13. Epub 2016 May 20 doi: 10.1016/j.clindermatol.2016.05.011. PMID: 27638440

Diagnosis

Challenging Best Practice of Atopic Dermatitis.
Arkwright PD, Koplin JJ
J Allergy Clin Immunol Pract 2023 May;11(5):1391-1393. Epub 2023 Mar 23 doi: 10.1016/j.jaip.2023.03.023. PMID: 36963616
Novel insights into atopic dermatitis.
Schuler CF 4th, Billi AC, Maverakis E, Tsoi LC, Gudjonsson JE
J Allergy Clin Immunol 2023 May;151(5):1145-1154. Epub 2022 Nov 22 doi: 10.1016/j.jaci.2022.10.023. PMID: 36428114Free PMC Article
Early initiation of short-term emollient use for the prevention of atopic dermatitis in high-risk infants-The STOP-AD randomised controlled trial.
Ní Chaoimh C, Lad D, Nico C, Puppels GJ, Wong XFCC, Common JE, Murray DM, Irvine AD, Hourihane JO
Allergy 2023 Apr;78(4):984-994. Epub 2022 Sep 8 doi: 10.1111/all.15491. PMID: 35997592Free PMC Article
Everything is connected in atopic dermatitis.
Buhl T
J Dtsch Dermatol Ges 2022 May;20(5):565-566. doi: 10.1111/ddg.14815. PMID: 35578414
Atopic dermatitis.
Heath CR, Usatine RP
J Fam Pract 2021 Jun;70(5):252. doi: 10.12788/jfp.0211. PMID: 34410918

Therapy

Systemic treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu AWL, Wong MM, Rayner DG, Guyatt GH, Díaz Martinez JP, Ceccacci R, Zhao IX, McMullen E, Srivastava A, Wang J, Wen A, Wang FC, Brignardello-Petersen R, Izcovich A, Oykhman P, Wheeler KE, Wang J, Spergel JM, Singh JA, Silverberg JI, Ong PY, O'Brien M, Martin SA, Lio PA, Lind ML, LeBovidge J, Kim E, Huynh J, Greenhawt M, Gardner DD, Frazier WT, Ellison K, Chen L, Capozza K, De Benedetto A, Boguniewicz M, Smith Begolka W, Asiniwasis RN, Schneider LC, Chu DK
J Allergy Clin Immunol 2023 Dec;152(6):1470-1492. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.029. PMID: 37678577
Early initiation of short-term emollient use for the prevention of atopic dermatitis in high-risk infants-The STOP-AD randomised controlled trial.
Ní Chaoimh C, Lad D, Nico C, Puppels GJ, Wong XFCC, Common JE, Murray DM, Irvine AD, Hourihane JO
Allergy 2023 Apr;78(4):984-994. Epub 2022 Sep 8 doi: 10.1111/all.15491. PMID: 35997592Free PMC Article
Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial.
Reich K, Thyssen JP, Blauvelt A, Eyerich K, Soong W, Rice ZP, Hong HC, Katoh N, Valenzuela F, DiBonaventura M, Bratt TA, Zhang F, Clibborn C, Rojo R, Valdez H, Kerkmann U
Lancet 2022 Jul 23;400(10348):273-282. doi: 10.1016/S0140-6736(22)01199-0. PMID: 35871814
Tralokinumab for the Treatment of Atopic Dermatitis.
Freitas E, Guttman-Yassky E, Torres T
Am J Clin Dermatol 2021 Sep;22(5):625-638. Epub 2021 Jun 21 doi: 10.1007/s40257-021-00613-8. PMID: 34155602
Phototherapy for atopic dermatitis.
Rodenbeck DL, Silverberg JI, Silverberg NB
Clin Dermatol 2016 Sep-Oct;34(5):607-13. Epub 2016 May 20 doi: 10.1016/j.clindermatol.2016.05.011. PMID: 27638440

Prognosis

Preclinical Atopic Dermatitis Skin in Infants: An Emerging Research Area.
Paller AS, Scharschmidt TC, Kezic S, Irvine AD
J Invest Dermatol 2024 May;144(5):1001-1009. Epub 2024 Apr 3 doi: 10.1016/j.jid.2024.02.021. PMID: 38573278
Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Biomarkers in atopic dermatitis.
Bakker D, de Bruin-Weller M, Drylewicz J, van Wijk F, Thijs J
J Allergy Clin Immunol 2023 May;151(5):1163-1168. Epub 2023 Feb 14 doi: 10.1016/j.jaci.2023.01.019. PMID: 36792449
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Atopic dermatitis in Indian children: The influence of lower socioeconomic status.
Sarkar R, Narang I
Clin Dermatol 2018 Sep-Oct;36(5):585-594. Epub 2018 Jun 2 doi: 10.1016/j.clindermatol.2018.05.009. PMID: 30217271

Clinical prediction guides

Preclinical Atopic Dermatitis Skin in Infants: An Emerging Research Area.
Paller AS, Scharschmidt TC, Kezic S, Irvine AD
J Invest Dermatol 2024 May;144(5):1001-1009. Epub 2024 Apr 3 doi: 10.1016/j.jid.2024.02.021. PMID: 38573278
Staphylococcus aureus: The Bug Behind the Itch in Atopic Dermatitis.
Gallo RL, Horswill AR
J Invest Dermatol 2024 May;144(5):950-953. Epub 2024 Feb 29 doi: 10.1016/j.jid.2024.01.001. PMID: 38430083
Biomarkers in atopic dermatitis.
Bakker D, de Bruin-Weller M, Drylewicz J, van Wijk F, Thijs J
J Allergy Clin Immunol 2023 May;151(5):1163-1168. Epub 2023 Feb 14 doi: 10.1016/j.jaci.2023.01.019. PMID: 36792449
Epidemiology of adult atopic dermatitis.
Sacotte R, Silverberg JI
Clin Dermatol 2018 Sep-Oct;36(5):595-605. Epub 2018 May 31 doi: 10.1016/j.clindermatol.2018.05.007. PMID: 30217272
Are baths desirable in atopic dermatitis?
Sarre ME, Martin L, Moote W, Mazza JA, Annweiler C
J Eur Acad Dermatol Venereol 2015 Jul;29(7):1265-74. Epub 2015 Jan 27 doi: 10.1111/jdv.12946. PMID: 25627035

Recent systematic reviews

Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Systemic treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu AWL, Wong MM, Rayner DG, Guyatt GH, Díaz Martinez JP, Ceccacci R, Zhao IX, McMullen E, Srivastava A, Wang J, Wen A, Wang FC, Brignardello-Petersen R, Izcovich A, Oykhman P, Wheeler KE, Wang J, Spergel JM, Singh JA, Silverberg JI, Ong PY, O'Brien M, Martin SA, Lio PA, Lind ML, LeBovidge J, Kim E, Huynh J, Greenhawt M, Gardner DD, Frazier WT, Ellison K, Chen L, Capozza K, De Benedetto A, Boguniewicz M, Smith Begolka W, Asiniwasis RN, Schneider LC, Chu DK
J Allergy Clin Immunol 2023 Dec;152(6):1470-1492. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.029. PMID: 37678577
Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu DK, Chu AWL, Rayner DG, Guyatt GH, Yepes-Nuñez JJ, Gomez-Escobar L, Pérez-Herrera LC, Díaz Martinez JP, Brignardello-Petersen R, Sadeghirad B, Wong MM, Ceccacci R, Zhao IX, Basmaji J, MacDonald M, Chu X, Islam N, Gao Y, Izcovich A, Asiniwasis RN, Boguniewicz M, De Benedetto A, Capozza K, Chen L, Ellison K, Frazier WT, Greenhawt M, Huynh J, LeBovidge J, Lio PA, Martin SA, O'Brien M, Ong PY, Silverberg JI, Spergel JM, Smith Begolka W, Wang J, Wheeler KE, Gardner DD, Schneider L
J Allergy Clin Immunol 2023 Dec;152(6):1493-1519. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.030. PMID: 37678572
Diagnosis of mycosis fungoides or Sézary syndrome after dupilumab use: A systematic review.
Jfri A, Smith JS, Larocca C
J Am Acad Dermatol 2023 May;88(5):1164-1166. Epub 2022 Dec 5 doi: 10.1016/j.jaad.2022.12.001. PMID: 36481378
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article

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