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Dermatitis, atopic, 5(ATOD5)

MedGen UID:
381292
•Concept ID:
C1853900
•
Disease or Syndrome
Synonym: Dermatitis, Atopic, 5
 
Monarch Initiative: MONDO:0011608
OMIM®: 605844

Definition

An inherited susceptibility or predisposition to developing atopic dermatitis that is associated with variation in the region 13q12-q14. [from MONDO]

Professional guidelines

PubMed

International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.
Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
Guidelines for diagnosis, prevention, and treatment of hand eczema.
Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, Bauer A, Brans R, Cannavo A, Christoffers WA, Crépy MN, Elsner P, Fartasch M, Filon FL, Giménez-Arnau AM, Gonçalo M, Guzmán-Perera MG, Hamann CR, Hoetzenecker W, Johansen JD, John SM, Kunkeler ACM, Hadzavdic SL, Molin S, Nixon R, Oosterhaven JAF, Rustemeyer T, Serra-Baldrich E, Shah M, Simon D, Skudlik C, Spiewak R, Valiukevičienė S, Voorberg AN, Weisshaar E, Agner T
Contact Dermatitis 2022 May;86(5):357-378. Epub 2022 Mar 3 doi: 10.1111/cod.14035. PMID: 34971008
Dupilumab for treatment of atopic dermatitis.
Seegräber M, Srour J, Walter A, Knop M, Wollenberg A
Expert Rev Clin Pharmacol 2018 May;11(5):467-474. Epub 2018 Mar 20 doi: 10.1080/17512433.2018.1449642. PMID: 29557246

Recent clinical studies

Etiology

Comorbidities of atopic dermatitis-what does the evidence say?
Thyssen JP, Halling AS, Schmid-Grendelmeier P, Guttman-Yassky E, Silverberg JI
J Allergy Clin Immunol 2023 May;151(5):1155-1162. Epub 2023 Jan 6 doi: 10.1016/j.jaci.2022.12.002. PMID: 36621338
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial.
Reich K, Thyssen JP, Blauvelt A, Eyerich K, Soong W, Rice ZP, Hong HC, Katoh N, Valenzuela F, DiBonaventura M, Bratt TA, Zhang F, Clibborn C, Rojo R, Valdez H, Kerkmann U
Lancet 2022 Jul 23;400(10348):273-282. doi: 10.1016/S0140-6736(22)01199-0. PMID: 35871814
Epidemiology of adult atopic dermatitis.
Sacotte R, Silverberg JI
Clin Dermatol 2018 Sep-Oct;36(5):595-605. Epub 2018 May 31 doi: 10.1016/j.clindermatol.2018.05.007. PMID: 30217272
Eczema.
Sohn A, Frankel A, Patel RV, Goldenberg G
Mt Sinai J Med 2011 Sep-Oct;78(5):730-9. doi: 10.1002/msj.20289. PMID: 21913202

Diagnosis

Biomarkers in atopic dermatitis.
Bakker D, de Bruin-Weller M, Drylewicz J, van Wijk F, Thijs J
J Allergy Clin Immunol 2023 May;151(5):1163-1168. Epub 2023 Feb 14 doi: 10.1016/j.jaci.2023.01.019. PMID: 36792449
Novel insights into atopic dermatitis.
Schuler CF 4th, Billi AC, Maverakis E, Tsoi LC, Gudjonsson JE
J Allergy Clin Immunol 2023 May;151(5):1145-1154. Epub 2022 Nov 22 doi: 10.1016/j.jaci.2022.10.023. PMID: 36428114Free PMC Article
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Atopic dermatitis in children.
Strathie Page S, Weston S, Loh R
Aust Fam Physician 2016 May;45(5):293-6. PMID: 27166464
Eczema.
Sohn A, Frankel A, Patel RV, Goldenberg G
Mt Sinai J Med 2011 Sep-Oct;78(5):730-9. doi: 10.1002/msj.20289. PMID: 21913202

Therapy

Systemic treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu AWL, Wong MM, Rayner DG, Guyatt GH, Díaz Martinez JP, Ceccacci R, Zhao IX, McMullen E, Srivastava A, Wang J, Wen A, Wang FC, Brignardello-Petersen R, Izcovich A, Oykhman P, Wheeler KE, Wang J, Spergel JM, Singh JA, Silverberg JI, Ong PY, O'Brien M, Martin SA, Lio PA, Lind ML, LeBovidge J, Kim E, Huynh J, Greenhawt M, Gardner DD, Frazier WT, Ellison K, Chen L, Capozza K, De Benedetto A, Boguniewicz M, Smith Begolka W, Asiniwasis RN, Schneider LC, Chu DK
J Allergy Clin Immunol 2023 Dec;152(6):1470-1492. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.029. PMID: 37678577
Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial.
Reich K, Thyssen JP, Blauvelt A, Eyerich K, Soong W, Rice ZP, Hong HC, Katoh N, Valenzuela F, DiBonaventura M, Bratt TA, Zhang F, Clibborn C, Rojo R, Valdez H, Kerkmann U
Lancet 2022 Jul 23;400(10348):273-282. doi: 10.1016/S0140-6736(22)01199-0. PMID: 35871814
Atopic dermatitis: new insight into the etiology, pathogenesis, diagnosis and novel treatment strategies.
Mandlik DS, Mandlik SK
Immunopharmacol Immunotoxicol 2021 Apr;43(2):105-125. Epub 2021 Feb 28 doi: 10.1080/08923973.2021.1889583. PMID: 33645388
Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis.
Guttman-Yassky E, Bissonnette R, Ungar B, Suárez-Fariñas M, Ardeleanu M, Esaki H, Suprun M, Estrada Y, Xu H, Peng X, Silverberg JI, Menter A, Krueger JG, Zhang R, Chaudhry U, Swanson B, Graham NMH, Pirozzi G, Yancopoulos GD, D Hamilton JD
J Allergy Clin Immunol 2019 Jan;143(1):155-172. Epub 2018 Sep 5 doi: 10.1016/j.jaci.2018.08.022. PMID: 30194992
Atopic dermatitis in children.
Strathie Page S, Weston S, Loh R
Aust Fam Physician 2016 May;45(5):293-6. PMID: 27166464

Prognosis

Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Atopic dermatitis and risk of 14 site-specific cancers: A Mendelian randomization study.
Liu Q, Chen L, Wang Y, Wang X, Lewis SJ, Wang J
J Eur Acad Dermatol Venereol 2023 Dec;37(12):2490-2497. Epub 2023 Aug 9 doi: 10.1111/jdv.19380. PMID: 37478287
Biomarkers in atopic dermatitis.
Bakker D, de Bruin-Weller M, Drylewicz J, van Wijk F, Thijs J
J Allergy Clin Immunol 2023 May;151(5):1163-1168. Epub 2023 Feb 14 doi: 10.1016/j.jaci.2023.01.019. PMID: 36792449
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Phase 2a randomized clinical trial of dupilumab (anti-IL-4Rα) for alopecia areata patients.
Guttman-Yassky E, Renert-Yuval Y, Bares J, Chima M, Hawkes JE, Gilleaudeau P, Sullivan-Whalen M, Singer GK, Garcet S, Pavel AB, Lebwohl MG, Krueger JG
Allergy 2022 Mar;77(3):897-906. Epub 2021 Sep 6 doi: 10.1111/all.15071. PMID: 34460948Free PMC Article

Clinical prediction guides

Biomarkers in atopic dermatitis.
Bakker D, de Bruin-Weller M, Drylewicz J, van Wijk F, Thijs J
J Allergy Clin Immunol 2023 May;151(5):1163-1168. Epub 2023 Feb 14 doi: 10.1016/j.jaci.2023.01.019. PMID: 36792449
Phase 2a randomized clinical trial of dupilumab (anti-IL-4Rα) for alopecia areata patients.
Guttman-Yassky E, Renert-Yuval Y, Bares J, Chima M, Hawkes JE, Gilleaudeau P, Sullivan-Whalen M, Singer GK, Garcet S, Pavel AB, Lebwohl MG, Krueger JG
Allergy 2022 Mar;77(3):897-906. Epub 2021 Sep 6 doi: 10.1111/all.15071. PMID: 34460948Free PMC Article
Epidemiology of adult atopic dermatitis.
Sacotte R, Silverberg JI
Clin Dermatol 2018 Sep-Oct;36(5):595-605. Epub 2018 May 31 doi: 10.1016/j.clindermatol.2018.05.007. PMID: 30217272
Epidemiology of atopic dermatitis in adults: Results from an international survey.
Barbarot S, Auziere S, Gadkari A, Girolomoni G, Puig L, Simpson EL, Margolis DJ, de Bruin-Weller M, Eckert L
Allergy 2018 Jun;73(6):1284-1293. Epub 2018 Feb 13 doi: 10.1111/all.13401. PMID: 29319189
Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis.
Dermatology 1993;186(1):23-31. doi: 10.1159/000247298. PMID: 8435513

Recent systematic reviews

Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Systemic treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu AWL, Wong MM, Rayner DG, Guyatt GH, Díaz Martinez JP, Ceccacci R, Zhao IX, McMullen E, Srivastava A, Wang J, Wen A, Wang FC, Brignardello-Petersen R, Izcovich A, Oykhman P, Wheeler KE, Wang J, Spergel JM, Singh JA, Silverberg JI, Ong PY, O'Brien M, Martin SA, Lio PA, Lind ML, LeBovidge J, Kim E, Huynh J, Greenhawt M, Gardner DD, Frazier WT, Ellison K, Chen L, Capozza K, De Benedetto A, Boguniewicz M, Smith Begolka W, Asiniwasis RN, Schneider LC, Chu DK
J Allergy Clin Immunol 2023 Dec;152(6):1470-1492. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.029. PMID: 37678577
Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials.
Chu DK, Chu AWL, Rayner DG, Guyatt GH, Yepes-Nuñez JJ, Gomez-Escobar L, Pérez-Herrera LC, Díaz Martinez JP, Brignardello-Petersen R, Sadeghirad B, Wong MM, Ceccacci R, Zhao IX, Basmaji J, MacDonald M, Chu X, Islam N, Gao Y, Izcovich A, Asiniwasis RN, Boguniewicz M, De Benedetto A, Capozza K, Chen L, Ellison K, Frazier WT, Greenhawt M, Huynh J, LeBovidge J, Lio PA, Martin SA, O'Brien M, Ong PY, Silverberg JI, Spergel JM, Smith Begolka W, Wang J, Wheeler KE, Gardner DD, Schneider L
J Allergy Clin Immunol 2023 Dec;152(6):1493-1519. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.030. PMID: 37678572
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Comparative efficacy and safety of systemic therapies used in moderate-to-severe atopic dermatitis: a systematic literature review and network meta-analysis.
Silverberg JI, Thyssen JP, Fahrbach K, Mickle K, Cappelleri JC, Romero W, Cameron MC, Myers DE, Clibborn C, DiBonaventura M
J Eur Acad Dermatol Venereol 2021 Sep;35(9):1797-1810. Epub 2021 Jun 12 doi: 10.1111/jdv.17351. PMID: 33991374Free PMC Article

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