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Dermatitis, atopic, 8(ATOD8)

MedGen UID:
462113
•Concept ID:
C3150763
•
Disease or Syndrome
Synonym: DERMATITIS, ATOPIC, SEVERITY OF
 
Monarch Initiative: MONDO:0013294
OMIM®: 613518

Definition

An inherited susceptibility or predisposition to developing atopic dermatitis that is associated with variation in the region 4q22.1. [from MONDO]

Professional guidelines

PubMed

Review of an established UK home phototherapy service 1998-2011: improving access to a cost-effective treatment for chronic skin disease.
Cameron H, Yule S, Dawe RS, Ibbotson SH, Moseley H, Ferguson J
Public Health 2014 Apr;128(4):317-24. Epub 2014 Apr 13 doi: 10.1016/j.puhe.2014.01.011. PMID: 24726005
Food anaphylaxis in schools: evaluation of the management plan and the efficiency of the emergency kit.
Moneret-Vautrin DA, Kanny G, Morisset M, Flabbee J, Guénard L, Beaudouin E, Parisot L
Allergy 2001 Nov;56(11):1071-6. doi: 10.1034/j.1398-9995.2001.00047.x. PMID: 11703221

Recent clinical studies

Etiology

Early initiation of short-term emollient use for the prevention of atopic dermatitis in high-risk infants-The STOP-AD randomised controlled trial.
Ní Chaoimh C, Lad D, Nico C, Puppels GJ, Wong XFCC, Common JE, Murray DM, Irvine AD, Hourihane JO
Allergy 2023 Apr;78(4):984-994. Epub 2022 Sep 8 doi: 10.1111/all.15491. PMID: 35997592Free PMC Article
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial.
Reich K, Thyssen JP, Blauvelt A, Eyerich K, Soong W, Rice ZP, Hong HC, Katoh N, Valenzuela F, DiBonaventura M, Bratt TA, Zhang F, Clibborn C, Rojo R, Valdez H, Kerkmann U
Lancet 2022 Jul 23;400(10348):273-282. doi: 10.1016/S0140-6736(22)01199-0. PMID: 35871814
Atopic dermatitis: global epidemiology and risk factors.
Nutten S
Ann Nutr Metab 2015;66 Suppl 1:8-16. Epub 2015 Apr 24 doi: 10.1159/000370220. PMID: 25925336
Atopic dermatitis in the elderly.
Tanei R
Inflamm Allergy Drug Targets 2009 Dec;8(5):398-404. doi: 10.2174/1871528110908050398. PMID: 20025588

Diagnosis

Early initiation of short-term emollient use for the prevention of atopic dermatitis in high-risk infants-The STOP-AD randomised controlled trial.
Ní Chaoimh C, Lad D, Nico C, Puppels GJ, Wong XFCC, Common JE, Murray DM, Irvine AD, Hourihane JO
Allergy 2023 Apr;78(4):984-994. Epub 2022 Sep 8 doi: 10.1111/all.15491. PMID: 35997592Free PMC Article
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Update on Atopic Dermatitis: Diagnosis, Severity Assessment, and Treatment Selection.
Fishbein AB, Silverberg JI, Wilson EJ, Ong PY
J Allergy Clin Immunol Pract 2020 Jan;8(1):91-101. Epub 2019 Aug 29 doi: 10.1016/j.jaip.2019.06.044. PMID: 31474543Free PMC Article
Phototherapy in Atopic Dermatitis.
Ortiz-Salvador JM, Pérez-Ferriols A
Adv Exp Med Biol 2017;996:279-286. doi: 10.1007/978-3-319-56017-5_23. PMID: 29124708

Therapy

Early initiation of short-term emollient use for the prevention of atopic dermatitis in high-risk infants-The STOP-AD randomised controlled trial.
Ní Chaoimh C, Lad D, Nico C, Puppels GJ, Wong XFCC, Common JE, Murray DM, Irvine AD, Hourihane JO
Allergy 2023 Apr;78(4):984-994. Epub 2022 Sep 8 doi: 10.1111/all.15491. PMID: 35997592Free PMC Article
Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial.
Reich K, Thyssen JP, Blauvelt A, Eyerich K, Soong W, Rice ZP, Hong HC, Katoh N, Valenzuela F, DiBonaventura M, Bratt TA, Zhang F, Clibborn C, Rojo R, Valdez H, Kerkmann U
Lancet 2022 Jul 23;400(10348):273-282. doi: 10.1016/S0140-6736(22)01199-0. PMID: 35871814
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis.
Hou DD, Zhang W, Gao YL, Sun YZ, Wang HX, Qi RQ, Chen HD, Gao XH
Int Immunopharmacol 2019 Sep;74:105676. Epub 2019 Jun 7 doi: 10.1016/j.intimp.2019.105676. PMID: 31181406
Phototherapy in Atopic Dermatitis.
Ortiz-Salvador JM, Pérez-Ferriols A
Adv Exp Med Biol 2017;996:279-286. doi: 10.1007/978-3-319-56017-5_23. PMID: 29124708

Prognosis

Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication.
Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Molecular Mechanisms of Atopic Dermatitis Pathogenesis.
Sroka-Tomaszewska J, Trzeciak M
Int J Mol Sci 2021 Apr 16;22(8) doi: 10.3390/ijms22084130. PMID: 33923629Free PMC Article
Atopic Dermatitis: Identification and Management of Complicating Factors.
Tamagawa-Mineoka R, Katoh N
Int J Mol Sci 2020 Apr 11;21(8) doi: 10.3390/ijms21082671. PMID: 32290423Free PMC Article
SnapshotDx Quiz: August 2018.
McBride JD, Gonzalez A, Miteva M
J Invest Dermatol 2018 Aug;138(8):e51. doi: 10.1016/j.jid.2018.05.022. PMID: 30032789

Clinical prediction guides

Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Efficacy and safety of ruxolitinib cream for the treatment of atopic dermatitis: Results from 2 phase 3, randomized, double-blind studies.
Papp K, Szepietowski JC, Kircik L, Toth D, Eichenfield LF, Leung DYM, Forman SB, Venturanza ME, Sun K, Kuligowski ME, Simpson EL
J Am Acad Dermatol 2021 Oct;85(4):863-872. Epub 2021 May 4 doi: 10.1016/j.jaad.2021.04.085. PMID: 33957195
Artificial Intelligence in Multiphoton Tomography: Atopic Dermatitis Diagnosis.
Guimarães P, Batista A, Zieger M, Kaatz M, Koenig K
Sci Rep 2020 May 14;10(1):7968. doi: 10.1038/s41598-020-64937-x. PMID: 32409755Free PMC Article
Atopic Dermatitis: Identification and Management of Complicating Factors.
Tamagawa-Mineoka R, Katoh N
Int J Mol Sci 2020 Apr 11;21(8) doi: 10.3390/ijms21082671. PMID: 32290423Free PMC Article
Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis.
Hou DD, Zhang W, Gao YL, Sun YZ, Wang HX, Qi RQ, Chen HD, Gao XH
Int Immunopharmacol 2019 Sep;74:105676. Epub 2019 Jun 7 doi: 10.1016/j.intimp.2019.105676. PMID: 31181406

Recent systematic reviews

Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study.
Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Oral Collagen Supplementation: A Systematic Review of Dermatological Applications.
Choi FD, Sung CT, Juhasz ML, Mesinkovsk NA
J Drugs Dermatol 2019 Jan 1;18(1):9-16. PMID: 30681787
Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence.
Vaughn AR, Branum A, Sivamani RK
Phytother Res 2016 Aug;30(8):1243-64. Epub 2016 May 23 doi: 10.1002/ptr.5640. PMID: 27213821
Does atopic dermatitis cause food allergy? A systematic review.
Tsakok T, Marrs T, Mohsin M, Baron S, du Toit G, Till S, Flohr C
J Allergy Clin Immunol 2016 Apr;137(4):1071-1078. Epub 2016 Feb 18 doi: 10.1016/j.jaci.2015.10.049. PMID: 26897122

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