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Leishmaniasis, diffuse cutaneous

MedGen UID:
39020
Concept ID:
C0085311
Disease or Syndrome
Synonyms: Cutaneous Leishmaniases, Diffuse; Cutaneous Leishmaniasis, Diffuse; Diffuse Cutaneous Leishmaniases; Diffuse Cutaneous Leishmaniasis; Leishmaniases, Diffuse Cutaneous; Leishmaniasis, Diffuse Cutaneous
SNOMED CT: DCL - Diffuse cutaneous leishmaniasis (38573008); Diffuse cutaneous leishmaniasis (38573008)
 
Monarch Initiative: MONDO:0043904

Definition

A form of LEISHMANIASIS, CUTANEOUS caused by Leishmania aethiopica in Ethiopia and Kenya, L. pifanoi in Venezuela, L. braziliensis in South America, and L. mexicana in Central America. This disease is characterized by massive dissemination of skin lesions without visceral involvement. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeishmaniasis, diffuse cutaneous

Professional guidelines

PubMed

Fikre H, Mohammed R, Atinafu S, van Griensven J, Diro E
Trop Med Int Health 2017 Oct;22(10):1293-1301. Epub 2017 Aug 13 doi: 10.1111/tmi.12928. PMID: 28712122
Handler MZ, Patel PA, Kapila R, Al-Qubati Y, Schwartz RA
J Am Acad Dermatol 2015 Dec;73(6):911-26; 927-8. doi: 10.1016/j.jaad.2014.09.014. PMID: 26568336
Soto J, Soto P
Expert Rev Anti Infect Ther 2006 Apr;4(2):177-85. doi: 10.1586/14787210.4.2.177. PMID: 16597200

Recent clinical studies

Etiology

Salaiza-Suazo N, Porcel-Aranibar R, Cañeda-Guzmán IC, Ruiz-Remigio A, Zamora-Chimal J, Delgado-Domínguez J, Cervantes-Sarabia R, Carrada-Figueroa G, Sánchez-Barragán B, Leal-Ascencio VJ, Pérez-Torres A, Rodríguez-Martínez HA, Becker I
PLoS One 2024;19(2):e0296887. Epub 2024 Feb 15 doi: 10.1371/journal.pone.0296887. PMID: 38359037Free PMC Article
Rabito MF, Britta EA, Pelegrini BL, Scariot DB, Almeida MB, Nixdorf SL, Nakamura CV, Ferreira IC
Exp Parasitol 2014 Aug;143:18-23. Epub 2014 May 5 doi: 10.1016/j.exppara.2014.04.014. PMID: 24810433
Carrada G, Cañeda C, Salaiza N, Delgado J, Ruiz A, Sanchez B, Gutiérrez-Kobeh L, Aguirre M, Becker I
Parasite Immunol 2007 Mar;29(3):117-26. doi: 10.1111/j.1365-3024.2006.00924.x. PMID: 17266739
Sosa-Estani S, Segura EL, Salomón OD, Gómez A, Peralta M, Coutada V, Ruiz LM
Rev Soc Bras Med Trop 2000 Nov-Dec;33(6):573-82. doi: 10.1590/s0037-86822000000600009. PMID: 11175588
Schönian G, Akuffo H, Lewin S, Maasho K, Nylén S, Pratlong F, Eisenberger CL, Schnur LF, Presber W
Mol Biochem Parasitol 2000 Mar 5;106(2):239-48. doi: 10.1016/s0166-6851(99)00216-9. PMID: 10699253

Diagnosis

Kevric I, Cappel MA, Keeling JH
Dermatol Clin 2015 Jul;33(3):579-93. doi: 10.1016/j.det.2015.03.018. PMID: 26143433
Schriefer A, Guimarães LH, Machado PR, Lessa M, Lessa HA, Lago E, Ritt G, Góes-Neto A, Schriefer AL, Riley LW, Carvalho EM
Emerg Infect Dis 2009 Jun;15(6):871-6. doi: 10.3201/eid1506.080406. PMID: 19523284Free PMC Article
Pereira Ede F, Thomaz-Soccol V, Lima HC, Thomaz-Soccol A, de Castro EA, Mulinari-Brenner F, Queiroz-Telles F, Luz E
Exp Dermatol 2008 Dec;17(12):1024-30. Epub 2008 Jul 7 doi: 10.1111/j.1600-0625.2008.00744.x. PMID: 18637136
Sharquie KE, Najim RA
Saudi Med J 2004 Jul;25(7):951-4. PMID: 15235707
Grevelink SA, Lerner EA
J Am Acad Dermatol 1996 Feb;34(2 Pt 1):257-72. doi: 10.1016/s0190-9622(96)80121-6. PMID: 8642091

Therapy

Kevric I, Cappel MA, Keeling JH
Dermatol Clin 2015 Jul;33(3):579-93. doi: 10.1016/j.det.2015.03.018. PMID: 26143433
Pereira LI, Dorta ML, Pereira AJ, Bastos RP, Oliveira MA, Pinto SA, Galdino H Jr, Mayrink W, Barcelos W, Toledo VP, Lima GM, Ribeiro-Dias F
Am J Trop Med Hyg 2009 Sep;81(3):378-83. PMID: 19706899
Carrada G, Cañeda C, Salaiza N, Delgado J, Ruiz A, Sanchez B, Gutiérrez-Kobeh L, Aguirre M, Becker I
Parasite Immunol 2007 Mar;29(3):117-26. doi: 10.1111/j.1365-3024.2006.00924.x. PMID: 17266739
Sharquie KE, Najim RA
Saudi Med J 2004 Jul;25(7):951-4. PMID: 15235707
Convit J, Ulrich M, Polegre MA, Avila A, Rodríguez N, Mazzedo MI, Blanco B
Mem Inst Oswaldo Cruz 2004 Feb;99(1):57-62. Epub 2004 Mar 31 doi: 10.1590/s0074-02762004000100010. PMID: 15057348

Prognosis

Yadav N, Madke B
Am J Trop Med Hyg 2023 Aug 2;109(2):315-318. Epub 2023 Jul 10 doi: 10.4269/ajtmh.23-0170. PMID: 37429574Free PMC Article
Kevric I, Cappel MA, Keeling JH
Dermatol Clin 2015 Jul;33(3):579-93. doi: 10.1016/j.det.2015.03.018. PMID: 26143433
Schriefer A, Guimarães LH, Machado PR, Lessa M, Lessa HA, Lago E, Ritt G, Góes-Neto A, Schriefer AL, Riley LW, Carvalho EM
Emerg Infect Dis 2009 Jun;15(6):871-6. doi: 10.3201/eid1506.080406. PMID: 19523284Free PMC Article
Sharquie KE, Najim RA
Saudi Med J 2004 Jul;25(7):951-4. PMID: 15235707
Sosa-Estani S, Segura EL, Salomón OD, Gómez A, Peralta M, Coutada V, Ruiz LM
Rev Soc Bras Med Trop 2000 Nov-Dec;33(6):573-82. doi: 10.1590/s0037-86822000000600009. PMID: 11175588

Clinical prediction guides

de Macedo-Silva ST, Visbal G, Urbina JA, de Souza W, Rodrigues JC
Antimicrob Agents Chemother 2015 Oct;59(10):6402-18. Epub 2015 Aug 3 doi: 10.1128/AAC.01150-15. PMID: 26239973Free PMC Article
Campanelli AP, Brodskyn CI, Boaventura V, Silva C, Roselino AM, Costa J, Saldanha AC, de Freitas LA, de Oliveira CI, Barral-Netto M, Silva JS, Barral A
Hum Immunol 2010 Dec;71(12):1220-7. Epub 2010 Sep 18 doi: 10.1016/j.humimm.2010.09.002. PMID: 20854864
Novais FO, Santiago RC, Báfica A, Khouri R, Afonso L, Borges VM, Brodskyn C, Barral-Netto M, Barral A, de Oliveira CI
J Immunol 2009 Dec 15;183(12):8088-98. doi: 10.4049/jimmunol.0803720. PMID: 19923470
Schriefer A, Guimarães LH, Machado PR, Lessa M, Lessa HA, Lago E, Ritt G, Góes-Neto A, Schriefer AL, Riley LW, Carvalho EM
Emerg Infect Dis 2009 Jun;15(6):871-6. doi: 10.3201/eid1506.080406. PMID: 19523284Free PMC Article
Carrada G, Cañeda C, Salaiza N, Delgado J, Ruiz A, Sanchez B, Gutiérrez-Kobeh L, Aguirre M, Becker I
Parasite Immunol 2007 Mar;29(3):117-26. doi: 10.1111/j.1365-3024.2006.00924.x. PMID: 17266739

Recent systematic reviews

Freire ML, Rêgo FD, Cota G, Pascoal-Xavier MA, Oliveira E
PLoS One 2021;16(5):e0251956. Epub 2021 May 27 doi: 10.1371/journal.pone.0251956. PMID: 34043671Free PMC Article
Murase LS, de Souza JVP, de Lima Neto QA, de Mello TFP, Cardoso BM, Lera-Nonose DSSL, Teixeira JJV, Lonardoni MVC, Demarchi IG
Parasitology 2018 Oct;145(12):1499-1509. Epub 2018 Mar 13 doi: 10.1017/S0031182018000367. PMID: 29530102

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