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Cutaneous leishmaniasis

MedGen UID:
9715
•Concept ID:
C0023283
•
Disease or Syndrome
Synonyms: Cutaneous Leishmaniases; Cutaneous Leishmaniasis; Leishmaniases, Cutaneous; Leishmaniasis, Cutaneous
SNOMED CT: Cutaneous leishmaniasis (240637006)
 
Monarch Initiative: MONDO:0005446

Definition

Leishmaniasis affecting the skin. It is the most common form of leishmaniasis. It presents with erythematous macules and papules, and nodules which may eventually ulcerate. The lesions appear in the bite site in the exposed skin areas. [from NCI]

Professional guidelines

PubMed

Cutaneous Leishmaniasis: A 2022 Updated Narrative Review into Diagnosis and Management Developments.
de Vries HJC, Schallig HD
Am J Clin Dermatol 2022 Nov;23(6):823-840. Epub 2022 Sep 14 doi: 10.1007/s40257-022-00726-8. PMID: 36103050Free PMC Article
Cutaneous Leishmaniasis: Updates in Diagnosis and Management.
Aronson NE, Joya CA
Infect Dis Clin North Am 2019 Mar;33(1):101-117. doi: 10.1016/j.idc.2018.10.004. PMID: 30712756
Honey as a topical treatment for wounds.
Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N
Cochrane Database Syst Rev 2015 Mar 6;2015(3):CD005083. doi: 10.1002/14651858.CD005083.pub4. PMID: 25742878Free PMC Article

Recent clinical studies

Etiology

Cutaneous Leishmaniasis: A 2022 Updated Narrative Review into Diagnosis and Management Developments.
de Vries HJC, Schallig HD
Am J Clin Dermatol 2022 Nov;23(6):823-840. Epub 2022 Sep 14 doi: 10.1007/s40257-022-00726-8. PMID: 36103050Free PMC Article
Host-Directed Therapies for Cutaneous Leishmaniasis.
Novais FO, Amorim CF, Scott P
Front Immunol 2021;12:660183. Epub 2021 Mar 26 doi: 10.3389/fimmu.2021.660183. PMID: 33841444Free PMC Article
Cutaneous Leishmaniasis: Updates in Diagnosis and Management.
Aronson NE, Joya CA
Infect Dis Clin North Am 2019 Mar;33(1):101-117. doi: 10.1016/j.idc.2018.10.004. PMID: 30712756
Leishmaniasis.
Neuber H
J Dtsch Dermatol Ges 2008 Sep;6(9):754-65. doi: 10.1111/j.1610-0387.2008.06809.x. PMID: 19000063
Cutaneous leishmaniasis.
Reithinger R, Dujardin JC, Louzir H, Pirmez C, Alexander B, Brooker S
Lancet Infect Dis 2007 Sep;7(9):581-96. doi: 10.1016/S1473-3099(07)70209-8. PMID: 17714672

Diagnosis

Cutaneous Leishmaniasis.
Crecelius EM, Burnett MW
J Spec Oper Med 2021 Spring;21(1):113-114. doi: 10.55460/IMV2-JGWD. PMID: 33721318
Cutaneous leishmaniasis: A great imitator.
Gurel MS, Tekin B, Uzun S
Clin Dermatol 2020 Mar-Apr;38(2):140-151. Epub 2019 Oct 24 doi: 10.1016/j.clindermatol.2019.10.008. PMID: 32513395
Cutaneous Leishmaniasis: Updates in Diagnosis and Management.
Aronson NE, Joya CA
Infect Dis Clin North Am 2019 Mar;33(1):101-117. doi: 10.1016/j.idc.2018.10.004. PMID: 30712756
Biomarkers of Cutaneous Leishmaniasis.
Bahrami F, Harandi AM, Rafati S
Front Cell Infect Microbiol 2018;8:222. Epub 2018 Jun 26 doi: 10.3389/fcimb.2018.00222. PMID: 29998089Free PMC Article
Leishmaniasis.
Neuber H
J Dtsch Dermatol Ges 2008 Sep;6(9):754-65. doi: 10.1111/j.1610-0387.2008.06809.x. PMID: 19000063

Therapy

Cutaneous Leishmaniasis: Updates in Diagnosis and Management.
Aronson NE, Joya CA
Infect Dis Clin North Am 2019 Mar;33(1):101-117. doi: 10.1016/j.idc.2018.10.004. PMID: 30712756
Chemotherapy of leishmaniasis: present challenges.
Uliana SRB, Trinconi CT, Coelho AC
Parasitology 2018 Apr;145(4):464-480. Epub 2017 Jan 20 doi: 10.1017/S0031182016002523. PMID: 28103966
Honey as a topical treatment for wounds.
Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N
Cochrane Database Syst Rev 2015 Mar 6;2015(3):CD005083. doi: 10.1002/14651858.CD005083.pub4. PMID: 25742878Free PMC Article
Miltefosine and cutaneous leishmaniasis.
Machado PR, Penna G
Curr Opin Infect Dis 2012 Apr;25(2):141-4. doi: 10.1097/QCO.0b013e3283509cac. PMID: 22248979
Cutaneous and mucocutaneous leishmaniasis: emerging therapies and progress in disease management.
Ameen M
Expert Opin Pharmacother 2010 Mar;11(4):557-69. doi: 10.1517/14656560903555219. PMID: 20163267

Prognosis

Cutaneous leishmaniasis: A great imitator.
Gurel MS, Tekin B, Uzun S
Clin Dermatol 2020 Mar-Apr;38(2):140-151. Epub 2019 Oct 24 doi: 10.1016/j.clindermatol.2019.10.008. PMID: 32513395
Rarely seen infections.
Amer M, Amer A
Clin Dermatol 2014 Nov-Dec;32(6):744-51. Epub 2014 Mar 2 doi: 10.1016/j.clindermatol.2014.02.013. PMID: 25441467
Leishmaniasis.
Neuber H
J Dtsch Dermatol Ges 2008 Sep;6(9):754-65. doi: 10.1111/j.1610-0387.2008.06809.x. PMID: 19000063
Cutaneous leishmaniasis.
Reithinger R, Dujardin JC, Louzir H, Pirmez C, Alexander B, Brooker S
Lancet Infect Dis 2007 Sep;7(9):581-96. doi: 10.1016/S1473-3099(07)70209-8. PMID: 17714672
Cutaneous leishmaniasis treatment.
Minodier P, Parola P
Travel Med Infect Dis 2007 May;5(3):150-8. Epub 2006 Oct 31 doi: 10.1016/j.tmaid.2006.09.004. PMID: 17448941

Clinical prediction guides

Mechanisms of Immunopathogenesis in Cutaneous Leishmaniasis And Post Kala-azar Dermal Leishmaniasis (PKDL).
Volpedo G, Pacheco-Fernandez T, Holcomb EA, Cipriano N, Cox B, Satoskar AR
Front Cell Infect Microbiol 2021;11:685296. Epub 2021 Jun 8 doi: 10.3389/fcimb.2021.685296. PMID: 34169006Free PMC Article
American cutaneous leishmaniasis in infancy and childhood.
Paniz-Mondolfi AE, Talhari C, García Bustos MF, Rosales T, Villamil-Gomez WE, Marquez M, Pérez Alvarez AM, Tálamo Sánchez AI, Rodriguez-Morales AJ
Int J Dermatol 2017 Dec;56(12):1328-1341. Epub 2017 Jul 25 doi: 10.1111/ijd.13664. PMID: 28741648
Cutaneous Manifestations of Human and Murine Leishmaniasis.
Scorza BM, Carvalho EM, Wilson ME
Int J Mol Sci 2017 Jun 18;18(6) doi: 10.3390/ijms18061296. PMID: 28629171Free PMC Article
Leishmaniasis.
Von Stebut E
J Dtsch Dermatol Ges 2015 Mar;13(3):191-200; quiz 201. doi: 10.1111/ddg.12595. PMID: 25721626
Miltefosine for visceral and cutaneous leishmaniasis: drug characteristics and evidence-based treatment recommendations.
Monge-Maillo B, López-Vélez R
Clin Infect Dis 2015 May 1;60(9):1398-404. Epub 2015 Jan 18 doi: 10.1093/cid/civ004. PMID: 25601455

Recent systematic reviews

Cutaneous leishmaniasis in Iran: A systematic review and meta-analysis.
Sabzevari S, Teshnizi SH, Shokri A, Bahrami F, Kouhestani F
Microb Pathog 2021 Mar;152:104721. Epub 2021 Feb 1 doi: 10.1016/j.micpath.2020.104721. PMID: 33539962
Leishmaniasis and Trace Element Alterations: a Systematic Review.
Taghipour A, Abdoli A, Ramezani A, Abolghazi A, Mofazzal Jahromi MA, Maani S, Heidar Nejadi SM, Rasti S, Shams M, Ghasemi E
Biol Trace Elem Res 2021 Oct;199(10):3918-3938. Epub 2021 Jan 6 doi: 10.1007/s12011-020-02505-0. PMID: 33405078
Atypical presentations of cutaneous leishmaniasis: A systematic review.
Meireles CB, Maia LC, Soares GC, Teodoro IPP, Gadelha MDSV, da Silva CGL, de Lima MAP
Acta Trop 2017 Aug;172:240-254. Epub 2017 May 17 doi: 10.1016/j.actatropica.2017.05.022. PMID: 28526427
Honey as a topical treatment for wounds.
Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N
Cochrane Database Syst Rev 2015 Mar 6;2015(3):CD005083. doi: 10.1002/14651858.CD005083.pub4. PMID: 25742878Free PMC Article
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update.
Reveiz L, Maia-Elkhoury AN, Nicholls RS, Romero GA, Yadon ZE
PLoS One 2013;8(4):e61843. Epub 2013 Apr 29 doi: 10.1371/journal.pone.0061843. PMID: 23637917Free PMC Article

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