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Therapy-Related Myelodysplastic/Myeloproliferative Neoplasm

MedGen UID:
417377
Concept ID:
C2826148
Neoplastic Process
Synonym: Therapy-Related Myelodysplastic/Myeloproliferative Disease

Definition

A myelodysplastic/myeloproliferative neoplasm arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTherapy-Related Myelodysplastic/Myeloproliferative Neoplasm

Professional guidelines

PubMed

Kantarjian HM, Kadia TM, DiNardo CD, Welch MA, Ravandi F
Cancer 2021 Apr 15;127(8):1186-1207. Epub 2021 Mar 18 doi: 10.1002/cncr.33477. PMID: 33734442
Guru Murthy GS, Abedin S
Best Pract Res Clin Haematol 2019 Mar;32(1):40-46. Epub 2019 Feb 26 doi: 10.1016/j.beha.2019.02.012. PMID: 30927974
Bertoli S, Sterin A, Tavitian S, Oberic L, Ysebaert L, Bouabdallah R, Vergez F, Sarry A, Bérard E, Huguet F, Laurent G, Prébet T, Vey N, Récher C
Oncotarget 2016 Dec 27;7(52):85937-85947. doi: 10.18632/oncotarget.13262. PMID: 27852053Free PMC Article

Recent clinical studies

Etiology

Bataller A, Gener-Ricos G, Almanza-Huante E, Chien KS, Urrutia S, Bazinet A, Rodriguez-Sevilla JJ, Hammond D, Sasaki K, Takahashi K, DiNardo CD, Ravandi F, Borthakur G, Kadia TM, Kanagal-Shamanna R, Kantarjian HM, Garcia-Manero G, Montalban-Bravo G
Blood Adv 2024 Jun 11;8(11):2695-2706. doi: 10.1182/bloodadvances.2024012565. PMID: 38513082Free PMC Article
Jelloul FZ, Quesada AE, Yang RK, Li S, Wang W, Xu J, Tang G, Yin CC, Fang H, El Hussein S, Khoury J, Bassett RL, Garcia-Manero G, Manasanch EE, Orlowski RZ, Qazilbash MH, Patel KP, Medeiros LJ, Lin P
Mod Pathol 2023 Jun;36(6):100166. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100166. PMID: 36990279
Guru Murthy GS, Abedin S
Best Pract Res Clin Haematol 2019 Mar;32(1):40-46. Epub 2019 Feb 26 doi: 10.1016/j.beha.2019.02.012. PMID: 30927974
Björkholm M, Hultcrantz M, Derolf ÅR
Best Pract Res Clin Haematol 2014 Jun;27(2):141-53. Epub 2014 Jul 19 doi: 10.1016/j.beha.2014.07.003. PMID: 25189725
Wang SA, Hasserjian RP
Hum Pathol 2012 Feb;43(2):153-64. Epub 2011 Dec 9 doi: 10.1016/j.humpath.2011.08.008. PMID: 22154053

Diagnosis

Wintering A, Smith S, Fuh B, Rangaswami A, Dahl G, Chien M, Gruber TA, Dang J, Li LS, Lenzen A, Savelli S, Dvorak CC, Agrawal AK, Stieglitz E
Pediatr Blood Cancer 2022 May;69(5):e29499. Epub 2021 Dec 22 doi: 10.1002/pbc.29499. PMID: 34939322Free PMC Article
Guru Murthy GS, Abedin S
Best Pract Res Clin Haematol 2019 Mar;32(1):40-46. Epub 2019 Feb 26 doi: 10.1016/j.beha.2019.02.012. PMID: 30927974
Wall M
Methods Mol Biol 2017;1541:209-222. doi: 10.1007/978-1-4939-6703-2_18. PMID: 27910026
Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA
Am J Clin Pathol 2015 Aug;144(2):207-18. doi: 10.1309/AJCPU1JO2LYTWUAV. PMID: 26185306
Wang SA, Hasserjian RP
Hum Pathol 2012 Feb;43(2):153-64. Epub 2011 Dec 9 doi: 10.1016/j.humpath.2011.08.008. PMID: 22154053

Therapy

Jelloul FZ, Quesada AE, Yang RK, Li S, Wang W, Xu J, Tang G, Yin CC, Fang H, El Hussein S, Khoury J, Bassett RL, Garcia-Manero G, Manasanch EE, Orlowski RZ, Qazilbash MH, Patel KP, Medeiros LJ, Lin P
Mod Pathol 2023 Jun;36(6):100166. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100166. PMID: 36990279
Kantarjian HM, Kadia TM, DiNardo CD, Welch MA, Ravandi F
Cancer 2021 Apr 15;127(8):1186-1207. Epub 2021 Mar 18 doi: 10.1002/cncr.33477. PMID: 33734442
Guru Murthy GS, Abedin S
Best Pract Res Clin Haematol 2019 Mar;32(1):40-46. Epub 2019 Feb 26 doi: 10.1016/j.beha.2019.02.012. PMID: 30927974
Nishiyama T, Ishikawa Y, Kawashima N, Akashi A, Adachi Y, Hattori H, Ushijima Y, Kiyoi H
Cancer Genet 2018 Apr;222-223:38-45. Epub 2018 Mar 8 doi: 10.1016/j.cancergen.2018.02.006. PMID: 29666007
Björkholm M, Hultcrantz M, Derolf ÅR
Best Pract Res Clin Haematol 2014 Jun;27(2):141-53. Epub 2014 Jul 19 doi: 10.1016/j.beha.2014.07.003. PMID: 25189725

Prognosis

Sasaki K, Ravandi F, Kadia TM, Borthakur G, Short NJ, Jain N, Daver NG, Jabbour EJ, Garcia-Manero G, Loghavi S, Patel KP, Montalban-Bravo G, Masarova L, DiNardo CD, Kantarjian HM
Cancer 2023 Apr 1;129(7):1017-1029. Epub 2023 Jan 30 doi: 10.1002/cncr.34609. PMID: 36715486
Jahn J, Diamond B, Hsu J, Montoya S, Totiger TM, Landgren O, Maura F, Taylor J
Leuk Res 2023 Mar;126:107020. Epub 2023 Jan 20 doi: 10.1016/j.leukres.2023.107020. PMID: 36696829
Wintering A, Smith S, Fuh B, Rangaswami A, Dahl G, Chien M, Gruber TA, Dang J, Li LS, Lenzen A, Savelli S, Dvorak CC, Agrawal AK, Stieglitz E
Pediatr Blood Cancer 2022 May;69(5):e29499. Epub 2021 Dec 22 doi: 10.1002/pbc.29499. PMID: 34939322Free PMC Article
Kantarjian HM, Kadia TM, DiNardo CD, Welch MA, Ravandi F
Cancer 2021 Apr 15;127(8):1186-1207. Epub 2021 Mar 18 doi: 10.1002/cncr.33477. PMID: 33734442
Wall M
Methods Mol Biol 2017;1541:209-222. doi: 10.1007/978-1-4939-6703-2_18. PMID: 27910026

Clinical prediction guides

Bataller A, Gener-Ricos G, Almanza-Huante E, Chien KS, Urrutia S, Bazinet A, Rodriguez-Sevilla JJ, Hammond D, Sasaki K, Takahashi K, DiNardo CD, Ravandi F, Borthakur G, Kadia TM, Kanagal-Shamanna R, Kantarjian HM, Garcia-Manero G, Montalban-Bravo G
Blood Adv 2024 Jun 11;8(11):2695-2706. doi: 10.1182/bloodadvances.2024012565. PMID: 38513082Free PMC Article
Sasaki K, Ravandi F, Kadia TM, Borthakur G, Short NJ, Jain N, Daver NG, Jabbour EJ, Garcia-Manero G, Loghavi S, Patel KP, Montalban-Bravo G, Masarova L, DiNardo CD, Kantarjian HM
Cancer 2023 Apr 1;129(7):1017-1029. Epub 2023 Jan 30 doi: 10.1002/cncr.34609. PMID: 36715486
Kuendgen A, Nomdedeu M, Tuechler H, Garcia-Manero G, Komrokji RS, Sekeres MA, Della Porta MG, Cazzola M, DeZern AE, Roboz GJ, Steensma DP, Van de Loosdrecht AA, Schlenk RF, Grau J, Calvo X, Blum S, Pereira A, Valent P, Costa D, Giagounidis A, Xicoy B, Döhner H, Platzbecker U, Pedro C, Lübbert M, Oiartzabal I, Díez-Campelo M, Cedena MT, Machherndl-Spandl S, López-Pavía M, Baldus CD, Martinez-de-Sola M, Stauder R, Merchan B, List A, Ganster C, Schroeder T, Voso MT, Pfeilstöcker M, Sill H, Hildebrandt B, Esteve J, Nomdedeu B, Cobo F, Haas R, Sole F, Germing U, Greenberg PL, Haase D, Sanz G
Leukemia 2021 Mar;35(3):835-849. Epub 2020 Jun 29 doi: 10.1038/s41375-020-0917-7. PMID: 32595214Free PMC Article
Wall M
Methods Mol Biol 2017;1541:209-222. doi: 10.1007/978-1-4939-6703-2_18. PMID: 27910026
Orazi A
Pathobiology 2007;74(2):97-114. doi: 10.1159/000101709. PMID: 17587881

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