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Therapy-Related Myelodysplastic/Myeloproliferative Neoplasm

MedGen UID:
417377
•Concept ID:
C2826148
•
Neoplastic Process
Synonym: Therapy-Related Myelodysplastic/Myeloproliferative Disease

Definition

A myelodysplastic/myeloproliferative neoplasm arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTherapy-Related Myelodysplastic/Myeloproliferative Neoplasm

Professional guidelines

PubMed

Acute myeloid leukemia: Treatment and research outlook for 2021 and the MD Anderson approach.
Kantarjian HM, Kadia TM, DiNardo CD, Welch MA, Ravandi F
Cancer 2021 Apr 15;127(8):1186-1207. Epub 2021 Mar 18 doi: 10.1002/cncr.33477. PMID: 33734442
Myeloid malignancies after treatment for solid tumours.
Guru Murthy GS, Abedin S
Best Pract Res Clin Haematol 2019 Mar;32(1):40-46. Epub 2019 Feb 26 doi: 10.1016/j.beha.2019.02.012. PMID: 30927974
Therapy-related acute myeloid leukemia following treatment of lymphoid malignancies.
Bertoli S, Sterin A, Tavitian S, Oberic L, Ysebaert L, Bouabdallah R, Vergez F, Sarry A, Bérard E, Huguet F, Laurent G, Prébet T, Vey N, Récher C
Oncotarget 2016 Dec 27;7(52):85937-85947. doi: 10.18632/oncotarget.13262. PMID: 27852053Free PMC Article

Recent clinical studies

Etiology

Clinicopathologic Features of Therapy-Related Myeloid Neoplasms in Patients with Myeloma in the Era of Novel Therapies.
Jelloul FZ, Quesada AE, Yang RK, Li S, Wang W, Xu J, Tang G, Yin CC, Fang H, El Hussein S, Khoury J, Bassett RL, Garcia-Manero G, Manasanch EE, Orlowski RZ, Qazilbash MH, Patel KP, Medeiros LJ, Lin P
Mod Pathol 2023 Jun;36(6):100166. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100166. PMID: 36990279
Therapy-selected clonal hematopoiesis and its role in myeloid neoplasms.
Jahn J, Diamond B, Hsu J, Montoya S, Totiger TM, Landgren O, Maura F, Taylor J
Leuk Res 2023 Mar;126:107020. Epub 2023 Jan 20 doi: 10.1016/j.leukres.2023.107020. PMID: 36696829
Myeloid malignancies after treatment for solid tumours.
Guru Murthy GS, Abedin S
Best Pract Res Clin Haematol 2019 Mar;32(1):40-46. Epub 2019 Feb 26 doi: 10.1016/j.beha.2019.02.012. PMID: 30927974
Leukemic transformation in myeloproliferative neoplasms: therapy-related or unrelated?
Björkholm M, Hultcrantz M, Derolf ÅR
Best Pract Res Clin Haematol 2014 Jun;27(2):141-53. Epub 2014 Jul 19 doi: 10.1016/j.beha.2014.07.003. PMID: 25189725
Erythroid proliferations in myeloid neoplasms.
Wang SA, Hasserjian RP
Hum Pathol 2012 Feb;43(2):153-64. Epub 2011 Dec 9 doi: 10.1016/j.humpath.2011.08.008. PMID: 22154053

Diagnosis

Clinicopathologic Features of Therapy-Related Myeloid Neoplasms in Patients with Myeloma in the Era of Novel Therapies.
Jelloul FZ, Quesada AE, Yang RK, Li S, Wang W, Xu J, Tang G, Yin CC, Fang H, El Hussein S, Khoury J, Bassett RL, Garcia-Manero G, Manasanch EE, Orlowski RZ, Qazilbash MH, Patel KP, Medeiros LJ, Lin P
Mod Pathol 2023 Jun;36(6):100166. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100166. PMID: 36990279
Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature.
Wintering A, Smith S, Fuh B, Rangaswami A, Dahl G, Chien M, Gruber TA, Dang J, Li LS, Lenzen A, Savelli S, Dvorak CC, Agrawal AK, Stieglitz E
Pediatr Blood Cancer 2022 May;69(5):e29499. Epub 2021 Dec 22 doi: 10.1002/pbc.29499. PMID: 34939322Free PMC Article
Myeloid malignancies after treatment for solid tumours.
Guru Murthy GS, Abedin S
Best Pract Res Clin Haematol 2019 Mar;32(1):40-46. Epub 2019 Feb 26 doi: 10.1016/j.beha.2019.02.012. PMID: 30927974
Recurrent Cytogenetic Abnormalities in Myelodysplastic Syndromes.
Wall M
Methods Mol Biol 2017;1541:209-222. doi: 10.1007/978-1-4939-6703-2_18. PMID: 27910026
Therapy-Related Myeloid Neoplasms.
Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA
Am J Clin Pathol 2015 Aug;144(2):207-18. doi: 10.1309/AJCPU1JO2LYTWUAV. PMID: 26185306

Therapy

Clinicopathologic Features of Therapy-Related Myeloid Neoplasms in Patients with Myeloma in the Era of Novel Therapies.
Jelloul FZ, Quesada AE, Yang RK, Li S, Wang W, Xu J, Tang G, Yin CC, Fang H, El Hussein S, Khoury J, Bassett RL, Garcia-Manero G, Manasanch EE, Orlowski RZ, Qazilbash MH, Patel KP, Medeiros LJ, Lin P
Mod Pathol 2023 Jun;36(6):100166. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100166. PMID: 36990279
Acute myeloid leukemia: Treatment and research outlook for 2021 and the MD Anderson approach.
Kantarjian HM, Kadia TM, DiNardo CD, Welch MA, Ravandi F
Cancer 2021 Apr 15;127(8):1186-1207. Epub 2021 Mar 18 doi: 10.1002/cncr.33477. PMID: 33734442
Myeloid malignancies after treatment for solid tumours.
Guru Murthy GS, Abedin S
Best Pract Res Clin Haematol 2019 Mar;32(1):40-46. Epub 2019 Feb 26 doi: 10.1016/j.beha.2019.02.012. PMID: 30927974
Mutation analysis of therapy-related myeloid neoplasms.
Nishiyama T, Ishikawa Y, Kawashima N, Akashi A, Adachi Y, Hattori H, Ushijima Y, Kiyoi H
Cancer Genet 2018 Apr;222-223:38-45. Epub 2018 Mar 8 doi: 10.1016/j.cancergen.2018.02.006. PMID: 29666007
Leukemic transformation in myeloproliferative neoplasms: therapy-related or unrelated?
Björkholm M, Hultcrantz M, Derolf ÅR
Best Pract Res Clin Haematol 2014 Jun;27(2):141-53. Epub 2014 Jul 19 doi: 10.1016/j.beha.2014.07.003. PMID: 25189725

Prognosis

Therapy-selected clonal hematopoiesis and its role in myeloid neoplasms.
Jahn J, Diamond B, Hsu J, Montoya S, Totiger TM, Landgren O, Maura F, Taylor J
Leuk Res 2023 Mar;126:107020. Epub 2023 Jan 20 doi: 10.1016/j.leukres.2023.107020. PMID: 36696829
Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature.
Wintering A, Smith S, Fuh B, Rangaswami A, Dahl G, Chien M, Gruber TA, Dang J, Li LS, Lenzen A, Savelli S, Dvorak CC, Agrawal AK, Stieglitz E
Pediatr Blood Cancer 2022 May;69(5):e29499. Epub 2021 Dec 22 doi: 10.1002/pbc.29499. PMID: 34939322Free PMC Article
The utility of a myeloid mutation panel for the diagnosis of myelodysplastic syndrome and myelodysplastic/myeloproliferative neoplasm.
Ibrar W, Zhang W, Cox JL, Cushman-Vokoun A, Fu K, Greiner TC, Yuan J
Int J Lab Hematol 2021 Dec;43(6):1501-1509. Epub 2021 Jul 16 doi: 10.1111/ijlh.13659. PMID: 34270867
Acute myeloid leukemia: Treatment and research outlook for 2021 and the MD Anderson approach.
Kantarjian HM, Kadia TM, DiNardo CD, Welch MA, Ravandi F
Cancer 2021 Apr 15;127(8):1186-1207. Epub 2021 Mar 18 doi: 10.1002/cncr.33477. PMID: 33734442
Recurrent Cytogenetic Abnormalities in Myelodysplastic Syndromes.
Wall M
Methods Mol Biol 2017;1541:209-222. doi: 10.1007/978-1-4939-6703-2_18. PMID: 27910026

Clinical prediction guides

Prediction of survival with lower intensity therapy among older patients with acute myeloid leukemia.
Sasaki K, Ravandi F, Kadia TM, Borthakur G, Short NJ, Jain N, Daver NG, Jabbour EJ, Garcia-Manero G, Loghavi S, Patel KP, Montalban-Bravo G, Masarova L, DiNardo CD, Kantarjian HM
Cancer 2023 Apr 1;129(7):1017-1029. Epub 2023 Jan 30 doi: 10.1002/cncr.34609. PMID: 36715486
The utility of a myeloid mutation panel for the diagnosis of myelodysplastic syndrome and myelodysplastic/myeloproliferative neoplasm.
Ibrar W, Zhang W, Cox JL, Cushman-Vokoun A, Fu K, Greiner TC, Yuan J
Int J Lab Hematol 2021 Dec;43(6):1501-1509. Epub 2021 Jul 16 doi: 10.1111/ijlh.13659. PMID: 34270867
Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification-an approach to classification of patients with t-MDS.
Kuendgen A, Nomdedeu M, Tuechler H, Garcia-Manero G, Komrokji RS, Sekeres MA, Della Porta MG, Cazzola M, DeZern AE, Roboz GJ, Steensma DP, Van de Loosdrecht AA, Schlenk RF, Grau J, Calvo X, Blum S, Pereira A, Valent P, Costa D, Giagounidis A, Xicoy B, Döhner H, Platzbecker U, Pedro C, Lübbert M, Oiartzabal I, Díez-Campelo M, Cedena MT, Machherndl-Spandl S, López-Pavía M, Baldus CD, Martinez-de-Sola M, Stauder R, Merchan B, List A, Ganster C, Schroeder T, Voso MT, Pfeilstöcker M, Sill H, Hildebrandt B, Esteve J, Nomdedeu B, Cobo F, Haas R, Sole F, Germing U, Greenberg PL, Haase D, Sanz G
Leukemia 2021 Mar;35(3):835-849. Epub 2020 Jun 29 doi: 10.1038/s41375-020-0917-7. PMID: 32595214Free PMC Article
Recurrent Cytogenetic Abnormalities in Myelodysplastic Syndromes.
Wall M
Methods Mol Biol 2017;1541:209-222. doi: 10.1007/978-1-4939-6703-2_18. PMID: 27910026
Histopathology in the diagnosis and classification of acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic/myeloproliferative diseases.
Orazi A
Pathobiology 2007;74(2):97-114. doi: 10.1159/000101709. PMID: 17587881

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