U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neovascularization

MedGen UID:
45041
Concept ID:
C0027686
Pathologic Function
Synonyms: Angiogenesis, Pathologic; Angiogenesis, Pathological; Neovascularization, Pathologic; Neovascularization, Pathological; Pathologic Angiogenesis; Pathologic Neovascularization; Pathological Angiogenesis; Pathological Neovascularization
SNOMED CT: Neovascularization (13018008); Neovascularity (13018008); Vascularization (13018008)

Definition

The formation of new or recent blood vessels. The vasculature network is critical to the development of neoplasms. As the tumor burden grows, vascular endothelial cells are recruited to form new blood vessels as an increased demand for blood and nourishment is required. [from NCI]

Professional guidelines

PubMed

Moncla LM, Briend M, Bossé Y, Mathieu P
Nat Rev Cardiol 2023 Aug;20(8):546-559. Epub 2023 Feb 24 doi: 10.1038/s41569-023-00845-7. PMID: 36829083
Flores R, Carneiro Â, Vieira M, Tenreiro S, Seabra MC
Ophthalmologica 2021;244(6):495-511. Epub 2021 Jun 15 doi: 10.1159/000517520. PMID: 34130290
Knapik JJ, Pope R
J Spec Oper Med 2020 Spring;20(1):125-140. doi: 10.55460/QXTX-A72P. PMID: 32203618

Recent clinical studies

Etiology

Yokoi T, Ohno-Matsui K
Asia Pac J Ophthalmol (Phila) 2018 Nov-Dec;7(6):415-421. Epub 2018 Sep 26 doi: 10.22608/APO.2018290. PMID: 30255668
Thuruthumaly C, Yee DC, Rao PK
Curr Opin Ophthalmol 2014 Nov;25(6):508-12. doi: 10.1097/ICU.0000000000000100. PMID: 25237930
Bhadada SV, Goyal BR, Patel MM
Fundam Clin Pharmacol 2011 Feb;25(1):29-47. doi: 10.1111/j.1472-8206.2010.00814.x. PMID: 20199582
Henry TD
BMJ 1999 Jun 5;318(7197):1536-9. doi: 10.1136/bmj.318.7197.1536. PMID: 10356013Free PMC Article
Caffery BE, Josephson JE
Optom Clin 1995;4(3):19-29. PMID: 7767016

Diagnosis

Deindl E, Quax PHA
Int J Mol Sci 2021 Dec 9;22(24) doi: 10.3390/ijms222413244. PMID: 34948041Free PMC Article
Nicholas MP, Mysore N
Exp Eye Res 2021 Jan;202:108363. Epub 2020 Nov 19 doi: 10.1016/j.exer.2020.108363. PMID: 33221371
James JJ, Tennant SL
Clin Radiol 2018 Aug;73(8):715-723. Epub 2018 Jun 21 doi: 10.1016/j.crad.2018.05.005. PMID: 29937340
Spaide RF
Retina 2017 Apr;37(4):609-610. doi: 10.1097/IAE.0000000000001575. PMID: 28207610
Kamaya A, Maturen KE, Tye GA, Liu YI, Parti NN, Desser TS
Semin Ultrasound CT MR 2009 Oct;30(5):387-407. doi: 10.1053/j.sult.2009.06.001. PMID: 19842564

Therapy

Rajasekar J, Perumal MK, Vallikannan B
J Nutr Biochem 2019 Sep;71:1-15. Epub 2019 May 3 doi: 10.1016/j.jnutbio.2019.04.006. PMID: 31174052
Zhang Z, Ji S, Zhang B, Liu J, Qin Y, Xu J, Yu X
Biomed Pharmacother 2018 Dec;108:1135-1140. Epub 2018 Oct 1 doi: 10.1016/j.biopha.2018.09.136. PMID: 30372814
Petty AJ, Yang Y
Immunotherapy 2017 Mar;9(3):289-302. doi: 10.2217/imt-2016-0135. PMID: 28231720Free PMC Article
Ratajska A, Jankowska-Steifer E, Czarnowska E, Olkowski R, Gula G, Niderla-Bielińska J, Flaht-Zabost A, Jasińska A
Cells Tissues Organs 2017;203(3):141-152. Epub 2016 Sep 22 doi: 10.1159/000448551. PMID: 27654624
Batchelor TT, Reardon DA, de Groot JF, Wick W, Weller M
Clin Cancer Res 2014 Nov 15;20(22):5612-9. doi: 10.1158/1078-0432.CCR-14-0834. PMID: 25398844Free PMC Article

Prognosis

Marquezan MC, Nascimento H, Dalbem D, Muccioli C, Belfort R
Ocul Immunol Inflamm 2020 Apr 2;28(3):402-408. Epub 2019 May 23 doi: 10.1080/09273948.2019.1588982. PMID: 31120768
Ikuno Y
Retina 2017 Dec;37(12):2347-2351. doi: 10.1097/IAE.0000000000001489. PMID: 28590964
Kaszubski P, Ben Ami T, Saade C, Smith RT
Ophthalmic Res 2016;55(4):185-93. Epub 2016 Feb 13 doi: 10.1159/000443209. PMID: 26871899Free PMC Article
Foster PJ, Jiang Y
Eye (Lond) 2014 Feb;28(2):202-8. Epub 2014 Jan 10 doi: 10.1038/eye.2013.280. PMID: 24406412Free PMC Article
Bossi E, Koerner F
Intensive Care Med 1995 Mar;21(3):241-6. doi: 10.1007/BF01701481. PMID: 7790613

Clinical prediction guides

Tang L, He G, Liu X, Xu W
Reproduction 2017 Jun;153(6):R227-R240. doi: 10.1530/REP-16-0287. PMID: 28476912
Tsitsia V, Svolou P, Kapsalaki E, Theodorou K, Vassiou K, Valotassiou V, Georgoulias P, Fezoulidis I, Tsougos I
Hell J Nucl Med 2017 Jan-Apr;20(1):57-61. PMID: 28426840
McDermott S, Kilcoyne A
QJM 2016 May;109(5):295-9. Epub 2015 Aug 7 doi: 10.1093/qjmed/hcv141. PMID: 26253299Free PMC Article
Inaba Y, Lindner JR
Transl Res 2012 Mar;159(3):140-8. Epub 2012 Jan 4 doi: 10.1016/j.trsl.2011.12.001. PMID: 22340763Free PMC Article
Wykrzykowska JJ, Henry TD, Lesser JR, Schwartz RS
Nat Rev Cardiol 2009 Oct;6(10):648-58. Epub 2009 Sep 8 doi: 10.1038/nrcardio.2009.157. PMID: 19736553

Recent systematic reviews

Zhang L, Ran QB, Lei CY, Zhang MX
Surv Ophthalmol 2023 Nov-Dec;68(6):1084-1092. Epub 2023 Jun 14 doi: 10.1016/j.survophthal.2023.06.002. PMID: 37321477
Cui E, Kersche G, Grubic N, Hétu MF, Pang SC, Sillesen H, Johri AM
J Clin Lipidol 2023 May-Jun;17(3):315-326. Epub 2023 Apr 26 doi: 10.1016/j.jacl.2023.04.009. PMID: 37173161
Kirnaz S, Capadona C, Wong T, Goldberg JL, Medary B, Sommer F, McGrath LB Jr, Härtl R
World Neurosurg 2022 Jan;157:264-273. doi: 10.1016/j.wneu.2021.09.066. PMID: 34929784
Gheorghe A, Mahdi L, Musat O
Rom J Ophthalmol 2015 Apr-Jun;59(2):74-7. PMID: 26978865Free PMC Article
Chen YB, LaCasce AS
Expert Opin Investig Drugs 2008 Jun;17(6):939-44. doi: 10.1517/13543784.17.6.939. PMID: 18491994

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...