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Paraplegia

MedGen UID:
45323
Concept ID:
C0030486
Disease or Syndrome
Synonym: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk
SNOMED CT: Paraplegia (60389000); Paralysis of both lower limbs (60389000); Lower paraplegia (60389000); Paraplegia (complete or partial paralysis of legs) (60389000)
 
HPO: HP:0010550
Monarch Initiative: MONDO:0003757

Definition

Severe or complete weakness of both lower extremities with sparing of the upper extremities. [from HPO]

Conditions with this feature

Professional guidelines

PubMed

Upchurch GR Jr, Escobar GA, Azizzadeh A, Beck AW, Conrad MF, Matsumura JS, Murad MH, Perry RJ, Singh MJ, Veeraswamy RK, Wang GJ
J Vasc Surg 2021 Jan;73(1S):55S-83S. Epub 2020 Jul 3 doi: 10.1016/j.jvs.2020.05.076. PMID: 32628988
Wang B, Gao W, Hao D
Curr Drug Targets 2020;21(4):320-327. doi: 10.2174/1389450120666191002151637. PMID: 31577205
Tweedy SM, Beckman EM, Geraghty TJ, Theisen D, Perret C, Harvey LA, Vanlandewijck YC
J Sci Med Sport 2017 Feb;20(2):108-115. Epub 2016 Mar 9 doi: 10.1016/j.jsams.2016.02.001. PMID: 27185457

Recent clinical studies

Etiology

Fink JK
Handb Clin Neurol 2023;196:59-88. doi: 10.1016/B978-0-323-98817-9.00022-3. PMID: 37620092
Ho NJ, Chen X, Lei Y, Gu S
Zool Res 2023 May 18;44(3):650-662. doi: 10.24272/j.issn.2095-8137.2022.281. PMID: 37161652Free PMC Article
Murala S, Nagarajan E, Bollu PC
Neurol Sci 2021 Mar;42(3):883-894. Epub 2021 Jan 13 doi: 10.1007/s10072-020-04981-7. PMID: 33439395
Shribman S, Reid E, Crosby AH, Houlden H, Warner TT
Lancet Neurol 2019 Dec;18(12):1136-1146. Epub 2019 Jul 31 doi: 10.1016/S1474-4422(19)30235-2. PMID: 31377012
Blackstone C
Handb Clin Neurol 2018;148:633-652. doi: 10.1016/B978-0-444-64076-5.00041-7. PMID: 29478605

Diagnosis

Fink JK
Handb Clin Neurol 2023;196:59-88. doi: 10.1016/B978-0-323-98817-9.00022-3. PMID: 37620092
Meyyazhagan A, Orlacchio A
Int J Mol Sci 2022 Feb 1;23(3) doi: 10.3390/ijms23031697. PMID: 35163618Free PMC Article
Murala S, Nagarajan E, Bollu PC
Neurol Sci 2021 Mar;42(3):883-894. Epub 2021 Jan 13 doi: 10.1007/s10072-020-04981-7. PMID: 33439395
Fink JK
Curr Neurol Neurosci Rep 2006 Jan;6(1):65-76. doi: 10.1007/s11910-996-0011-1. PMID: 16469273
Baker JH, Silver JR
J Neurol Neurosurg Psychiatry 1987 Apr;50(4):375-82. doi: 10.1136/jnnp.50.4.375. PMID: 3585346Free PMC Article

Therapy

Chen X, Dong T, Hu Y, De Pace R, Mattera R, Eberhardt K, Ziegler M, Pirovolakis T, Sahin M, Bonifacino JS, Ebrahimi-Fakhari D, Gray SJ
J Clin Invest 2023 May 15;133(10) doi: 10.1172/JCI164575. PMID: 36951961Free PMC Article
Goel T, Sharma N, Gehlot A, Srivastav AK
J Spinal Cord Med 2023 Nov;46(6):964-974. Epub 2021 Dec 22 doi: 10.1080/10790268.2021.2012053. PMID: 34935603Free PMC Article
Haubert LL, Mulroy SJ, Eberly VJ, Gronley JK, Hatchett PE, Conners SG
Top Spinal Cord Inj Rehabil 2021 Fall;27(4):40-52. Epub 2021 Jun 30 doi: 10.46292/sci20-00013. PMID: 34866887Free PMC Article
Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J
JAMA 2015 Jun 23-30;313(24):2456-73. doi: 10.1001/jama.2015.6358. PMID: 26103030
Mulroy SJ, Thompson L, Kemp B, Hatchett PP, Newsam CJ, Lupold DG, Haubert LL, Eberly V, Ge TT, Azen SP, Winstein CJ, Gordon J; Physical Therapy Clinical Research Network (PTClinResNet)
Phys Ther 2011 Mar;91(3):305-24. Epub 2011 Feb 3 doi: 10.2522/ptj.20100182. PMID: 21292803

Prognosis

Kawashima A, Kodama K, Okubo Y, Endo W, Inui T, Ikeda M, Katata Y, Togashi N, Ohba C, Imagawa E, Iwama K, Mizuguchi T, Kitami M, Aihara Y, Takayama J, Tamiya G, Kikuchi A, Kure S, Saitsu H, Matsumoto N, Haginoya K
Am J Med Genet A 2024 Oct;194(10):e63656. Epub 2024 May 17 doi: 10.1002/ajmg.a.63656. PMID: 38760879
Wei J, Hu Z, Wang W, Ding R, Chen Z, Yuan X, Xu F
Ann Thorac Surg 2024 Jun;117(6):1136-1143. Epub 2024 Feb 6 doi: 10.1016/j.athoracsur.2024.01.026. PMID: 38331207
Cheng Z, Xu J, Guo Y
Heart Surg Forum 2021 May 25;24(3):E487-E492. doi: 10.1532/hsf.3731. PMID: 34173757
Nienaber CA, Rousseau H, Eggebrecht H, Kische S, Fattori R, Rehders TC, Kundt G, Scheinert D, Czerny M, Kleinfeldt T, Zipfel B, Labrousse L, Ince H; INSTEAD Trial
Circulation 2009 Dec 22;120(25):2519-28. Epub 2009 Dec 7 doi: 10.1161/CIRCULATIONAHA.109.886408. PMID: 19996018
Moon MS
Spine (Phila Pa 1976) 1997 Aug 1;22(15):1791-7. doi: 10.1097/00007632-199708010-00022. PMID: 9259793

Clinical prediction guides

Ibrahim AA, Ollenschläger M, Klebe S, Schüle R, Jeschonneck N, Kellner M, Loris E, Greinwalder T, Eskofier BM, Winkler J, Gaßner H, Regensburger M
Eur J Neurol 2024 Aug;31(8):e16367. Epub 2024 Jun 10 doi: 10.1111/ene.16367. PMID: 38859620Free PMC Article
Obiegbu HO, Ndukwu C
Niger J Clin Pract 2024 May 1;27(5):565-569. Epub 2024 May 29 doi: 10.4103/njcp.njcp_390_23. PMID: 38842704
Saffari A, Kellner M, Jordan C, Rosengarten H, Mo A, Zhang B, Strelko O, Neuser S, Davis MY, Yoshikura N, Futamura N, Takeuchi T, Nabatame S, Ishiura H, Tsuji S, Aldeen HS, Cali E, Rocca C, Houlden H, Efthymiou S, Assmann B, Yoon G, Trombetta BA, Kivisäkk P, Eichler F, Nan H, Takiyama Y, Tessa A, Santorelli FM, Sahin M, Blackstone C, Yang E, Schüle R, Ebrahimi-Fakhari D
Brain 2023 May 2;146(5):2003-2015. doi: 10.1093/brain/awac391. PMID: 36315648Free PMC Article
Hsu SL, Hsueh HW, Chen SY, Chang YY, Tan S, Hong CT, Tsai YS, Yu KW, Wu HM, Liao YC, Soong BW, Hu CJ, Lan MY, Lee YC
Parkinsonism Relat Disord 2021 Jun;87:87-91. Epub 2021 May 11 doi: 10.1016/j.parkreldis.2021.05.004. PMID: 34015694
Donovan WH, Brown DJ, Ditunno JF Jr, Dollfus P, Frankel HL
Spinal Cord 1997 May;35(5):275-81. doi: 10.1038/sj.sc.3100449. PMID: 9160450

Recent systematic reviews

Pozza DH, Tavares I, Cruz CD, Fonseca S
Int J Mol Sci 2023 Feb 28;24(5) doi: 10.3390/ijms24054665. PMID: 36902095Free PMC Article
Santos LV, Pereira ET, Reguera-García MM, Oliveira CEP, Moreira OC
J Bodyw Mov Ther 2022 Jan;29:154-160. Epub 2021 Oct 12 doi: 10.1016/j.jbmt.2021.09.031. PMID: 35248264
Crowley E, Harrison AJ, Lyons M
Sports Med 2017 Nov;47(11):2285-2307. doi: 10.1007/s40279-017-0730-2. PMID: 28497283
Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J
JAMA 2015 Jun 23-30;313(24):2456-73. doi: 10.1001/jama.2015.6358. PMID: 26103030
Ruano L, Melo C, Silva MC, Coutinho P
Neuroepidemiology 2014;42(3):174-83. Epub 2014 Mar 5 doi: 10.1159/000358801. PMID: 24603320

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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