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High Grade Pancreatic Intraepithelial Neoplasia

MedGen UID:
459371
Concept ID:
C2987145
Neoplastic Process
Synonyms: Grade 3 Pancreatic Intraepithelial Neoplasia; Grade III Pancreatic Intraepithelial Neoplasia; High Grade PanIN; High-Grade Pancreatic Intraepithelial Neoplasia; High-Grade PanIN; Pancreatic Intraepithelial Neoplasia-3

Definition

A pancreatic epithelial neoplasia characterized by the presence of papillary and rarely flat architectural patterns with formation of cribriform patterns and luminal necrosis. Severe dysplasia is present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Pancreatic Intraepithelial Neoplasia

Professional guidelines

PubMed

Corral JE, Mareth KF, Riegert-Johnson DL, Das A, Wallace MB
Clin Gastroenterol Hepatol 2019 Jan;17(1):41-53. Epub 2018 Jun 30 doi: 10.1016/j.cgh.2018.04.065. PMID: 29775792

Recent clinical studies

Etiology

Das KK, Brown JW, Fernandez Del-Castillo C, Huynh T, Mills JC, Matsuda Y, Das KM, Mino-Kenudson M
Hum Pathol 2021 May;111:36-44. Epub 2021 Jan 30 doi: 10.1016/j.humpath.2021.01.003. PMID: 33524436Free PMC Article
Miyasaka Y, Ohtsuka T, Matsuda R, Mori Y, Nakata K, Ohuchida K, Nakamura M
Surg Today 2020 Aug;50(8):832-840. Epub 2019 Jul 25 doi: 10.1007/s00595-019-01852-3. PMID: 31346809
Lindquist CM, Miller FH, Hammond NA, Nikolaidis P
Abdom Radiol (NY) 2018 Feb;43(2):264-272. doi: 10.1007/s00261-017-1308-z. PMID: 28840303
Park JR, Li F, Oza VM, Sklaw BC, Cronley KM, Wellner M, Swanson B, Krishna SG
Hepatobiliary Pancreat Dis Int 2017 Apr;16(2):202-208. doi: 10.1016/s1499-3872(16)60186-8. PMID: 28381386
Petrone MC, Arcidiacono PG
Expert Rev Gastroenterol Hepatol 2016;10(2):157-9. Epub 2015 Dec 14 doi: 10.1586/17474124.2016.1122521. PMID: 26582179

Diagnosis

Hanada K, Shimizu A, Kurihara K, Ikeda M, Yamamoto T, Okuda Y, Tazuma S
Dig Endosc 2022 Jul;34(5):927-937. Epub 2022 Feb 14 doi: 10.1111/den.14240. PMID: 35165942
Shintakuya R, Kohashi T, Honmyo N, Hihara J, Kaneko M, Yukutake M, Sekito T, Mukaida H
Clin J Gastroenterol 2022 Jun;15(3):662-667. Epub 2022 Jan 7 doi: 10.1007/s12328-021-01587-0. PMID: 34994960
Das KK, Brown JW, Fernandez Del-Castillo C, Huynh T, Mills JC, Matsuda Y, Das KM, Mino-Kenudson M
Hum Pathol 2021 May;111:36-44. Epub 2021 Jan 30 doi: 10.1016/j.humpath.2021.01.003. PMID: 33524436Free PMC Article
Miyasaka Y, Ohtsuka T, Matsuda R, Mori Y, Nakata K, Ohuchida K, Nakamura M
Surg Today 2020 Aug;50(8):832-840. Epub 2019 Jul 25 doi: 10.1007/s00595-019-01852-3. PMID: 31346809
Petrone MC, Arcidiacono PG
Expert Rev Gastroenterol Hepatol 2016;10(2):157-9. Epub 2015 Dec 14 doi: 10.1586/17474124.2016.1122521. PMID: 26582179

Therapy

Sagami R, Yamao K, Minami R, Nakahodo J, Akiyama H, Nishikiori H, Mizukami K, Yamao K, Bhatia V, Amano Y, Murakami K
Gut Liver 2024 Mar 15;18(2):338-347. Epub 2023 May 11 doi: 10.5009/gnl220521. PMID: 37165770Free PMC Article
Hanada K, Shimizu A, Kurihara K, Ikeda M, Yamamoto T, Okuda Y, Tazuma S
Dig Endosc 2022 Jul;34(5):927-937. Epub 2022 Feb 14 doi: 10.1111/den.14240. PMID: 35165942
Ta N, Huang X, Zheng K, Zhang Y, Gao Y, Deng L, Zhang B, Jiang H, Zheng J
Cell Physiol Biochem 2018;51(2):711-728. Epub 2018 Nov 21 doi: 10.1159/000495328. PMID: 30463064

Prognosis

Nakahodo J, Kikuyama M, Fukumura Y, Horiguchi SI, Chiba K, Tabata H, Suzuki M, Kamisawa T
Pancreatology 2022 Dec;22(8):1148-1158. Epub 2022 Oct 17 doi: 10.1016/j.pan.2022.10.003. PMID: 36273992
Hanada K, Shimizu A, Kurihara K, Ikeda M, Yamamoto T, Okuda Y, Tazuma S
Dig Endosc 2022 Jul;34(5):927-937. Epub 2022 Feb 14 doi: 10.1111/den.14240. PMID: 35165942
Miyasaka Y, Ohtsuka T, Matsuda R, Mori Y, Nakata K, Ohuchida K, Nakamura M
Surg Today 2020 Aug;50(8):832-840. Epub 2019 Jul 25 doi: 10.1007/s00595-019-01852-3. PMID: 31346809
Park JR, Li F, Oza VM, Sklaw BC, Cronley KM, Wellner M, Swanson B, Krishna SG
Hepatobiliary Pancreat Dis Int 2017 Apr;16(2):202-208. doi: 10.1016/s1499-3872(16)60186-8. PMID: 28381386
Petrone MC, Arcidiacono PG
Expert Rev Gastroenterol Hepatol 2016;10(2):157-9. Epub 2015 Dec 14 doi: 10.1586/17474124.2016.1122521. PMID: 26582179

Clinical prediction guides

Nakahodo J, Kikuyama M, Fukumura Y, Horiguchi SI, Chiba K, Tabata H, Suzuki M, Kamisawa T
Pancreatology 2022 Dec;22(8):1148-1158. Epub 2022 Oct 17 doi: 10.1016/j.pan.2022.10.003. PMID: 36273992
Das KK, Brown JW, Fernandez Del-Castillo C, Huynh T, Mills JC, Matsuda Y, Das KM, Mino-Kenudson M
Hum Pathol 2021 May;111:36-44. Epub 2021 Jan 30 doi: 10.1016/j.humpath.2021.01.003. PMID: 33524436Free PMC Article
Miyasaka Y, Ohtsuka T, Matsuda R, Mori Y, Nakata K, Ohuchida K, Nakamura M
Surg Today 2020 Aug;50(8):832-840. Epub 2019 Jul 25 doi: 10.1007/s00595-019-01852-3. PMID: 31346809
Park JR, Li F, Oza VM, Sklaw BC, Cronley KM, Wellner M, Swanson B, Krishna SG
Hepatobiliary Pancreat Dis Int 2017 Apr;16(2):202-208. doi: 10.1016/s1499-3872(16)60186-8. PMID: 28381386
Petrone MC, Arcidiacono PG
Expert Rev Gastroenterol Hepatol 2016;10(2):157-9. Epub 2015 Dec 14 doi: 10.1586/17474124.2016.1122521. PMID: 26582179

Recent systematic reviews

Corral JE, Mareth KF, Riegert-Johnson DL, Das A, Wallace MB
Clin Gastroenterol Hepatol 2019 Jan;17(1):41-53. Epub 2018 Jun 30 doi: 10.1016/j.cgh.2018.04.065. PMID: 29775792

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