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High Grade Pancreatic Intraepithelial Neoplasia

MedGen UID:
459371
•Concept ID:
C2987145
•
Neoplastic Process
Synonyms: Grade 3 Pancreatic Intraepithelial Neoplasia; Grade III Pancreatic Intraepithelial Neoplasia; High Grade PanIN; High-Grade Pancreatic Intraepithelial Neoplasia; High-Grade PanIN; Pancreatic Intraepithelial Neoplasia-3

Definition

A pancreatic epithelial neoplasia characterized by the presence of papillary and rarely flat architectural patterns with formation of cribriform patterns and luminal necrosis. Severe dysplasia is present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Pancreatic Intraepithelial Neoplasia

Professional guidelines

PubMed

Diagnostic Yield From Screening Asymptomatic Individuals at High Risk for Pancreatic Cancer: A Meta-analysis of Cohort Studies.
Corral JE, Mareth KF, Riegert-Johnson DL, Das A, Wallace MB
Clin Gastroenterol Hepatol 2019 Jan;17(1):41-53. Epub 2018 Jun 30 doi: 10.1016/j.cgh.2018.04.065. PMID: 29775792

Recent clinical studies

Etiology

Focal pancreatic parenchyma atrophy is a harbinger of pancreatic cancer and a clue to the intraductal spreading subtype.
Nakahodo J, Kikuyama M, Fukumura Y, Horiguchi SI, Chiba K, Tabata H, Suzuki M, Kamisawa T
Pancreatology 2022 Dec;22(8):1148-1158. Epub 2022 Oct 17 doi: 10.1016/j.pan.2022.10.003. PMID: 36273992
mAb Das-1 identifies pancreatic ductal adenocarcinoma and high-grade pancreatic intraepithelial neoplasia with high accuracy.
Das KK, Brown JW, Fernandez Del-Castillo C, Huynh T, Mills JC, Matsuda Y, Das KM, Mino-Kenudson M
Hum Pathol 2021 May;111:36-44. Epub 2021 Jan 30 doi: 10.1016/j.humpath.2021.01.003. PMID: 33524436Free PMC Article
Pancreatic cancer screening.
Lindquist CM, Miller FH, Hammond NA, Nikolaidis P
Abdom Radiol (NY) 2018 Feb;43(2):264-272. doi: 10.1007/s00261-017-1308-z. PMID: 28840303
High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia.
Park JR, Li F, Oza VM, Sklaw BC, Cronley KM, Wellner M, Swanson B, Krishna SG
Hepatobiliary Pancreat Dis Int 2017 Apr;16(2):202-208. doi: 10.1016/s1499-3872(16)60186-8. PMID: 28381386
New strategies for the early detection of pancreatic cancer.
Petrone MC, Arcidiacono PG
Expert Rev Gastroenterol Hepatol 2016;10(2):157-9. Epub 2015 Dec 14 doi: 10.1586/17474124.2016.1122521. PMID: 26582179

Diagnosis

Focal pancreatic parenchyma atrophy is a harbinger of pancreatic cancer and a clue to the intraductal spreading subtype.
Nakahodo J, Kikuyama M, Fukumura Y, Horiguchi SI, Chiba K, Tabata H, Suzuki M, Kamisawa T
Pancreatology 2022 Dec;22(8):1148-1158. Epub 2022 Oct 17 doi: 10.1016/j.pan.2022.10.003. PMID: 36273992
Endoscopic approach in the diagnosis of high-grade pancreatic intraepithelial neoplasia.
Hanada K, Shimizu A, Kurihara K, Ikeda M, Yamamoto T, Okuda Y, Tazuma S
Dig Endosc 2022 Jul;34(5):927-937. Epub 2022 Feb 14 doi: 10.1111/den.14240. PMID: 35165942
mAb Das-1 identifies pancreatic ductal adenocarcinoma and high-grade pancreatic intraepithelial neoplasia with high accuracy.
Das KK, Brown JW, Fernandez Del-Castillo C, Huynh T, Mills JC, Matsuda Y, Das KM, Mino-Kenudson M
Hum Pathol 2021 May;111:36-44. Epub 2021 Jan 30 doi: 10.1016/j.humpath.2021.01.003. PMID: 33524436Free PMC Article
A case of concurrent pancreatic intraepithelial neoplasia and type 1 autoimmune pancreatitis with marked pancreatic duct dilatation.
Takano Y, Nagahama M, Yamamura E, Maruoka N, Yokomizo K, Mizukami H, Tanaka J, Ohike N
Clin J Gastroenterol 2016 Aug;9(4):266-71. Epub 2016 Jun 28 doi: 10.1007/s12328-016-0666-3. PMID: 27351197
New strategies for the early detection of pancreatic cancer.
Petrone MC, Arcidiacono PG
Expert Rev Gastroenterol Hepatol 2016;10(2):157-9. Epub 2015 Dec 14 doi: 10.1586/17474124.2016.1122521. PMID: 26582179

Therapy

Endoscopic approach in the diagnosis of high-grade pancreatic intraepithelial neoplasia.
Hanada K, Shimizu A, Kurihara K, Ikeda M, Yamamoto T, Okuda Y, Tazuma S
Dig Endosc 2022 Jul;34(5):927-937. Epub 2022 Feb 14 doi: 10.1111/den.14240. PMID: 35165942
miRNA-1290 Promotes Aggressiveness in Pancreatic Ductal Adenocarcinoma by Targeting IKK1.
Ta N, Huang X, Zheng K, Zhang Y, Gao Y, Deng L, Zhang B, Jiang H, Zheng J
Cell Physiol Biochem 2018;51(2):711-728. Epub 2018 Nov 21 doi: 10.1159/000495328. PMID: 30463064

Prognosis

Focal pancreatic parenchyma atrophy is a harbinger of pancreatic cancer and a clue to the intraductal spreading subtype.
Nakahodo J, Kikuyama M, Fukumura Y, Horiguchi SI, Chiba K, Tabata H, Suzuki M, Kamisawa T
Pancreatology 2022 Dec;22(8):1148-1158. Epub 2022 Oct 17 doi: 10.1016/j.pan.2022.10.003. PMID: 36273992
Endoscopic approach in the diagnosis of high-grade pancreatic intraepithelial neoplasia.
Hanada K, Shimizu A, Kurihara K, Ikeda M, Yamamoto T, Okuda Y, Tazuma S
Dig Endosc 2022 Jul;34(5):927-937. Epub 2022 Feb 14 doi: 10.1111/den.14240. PMID: 35165942
High-risk lesions in the remnant pancreas: fate of the remnant pancreas after pancreatic resection for pancreatic cancer and intraductal papillary mucinous neoplasms.
Miyasaka Y, Ohtsuka T, Matsuda R, Mori Y, Nakata K, Ohuchida K, Nakamura M
Surg Today 2020 Aug;50(8):832-840. Epub 2019 Jul 25 doi: 10.1007/s00595-019-01852-3. PMID: 31346809
High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia.
Park JR, Li F, Oza VM, Sklaw BC, Cronley KM, Wellner M, Swanson B, Krishna SG
Hepatobiliary Pancreat Dis Int 2017 Apr;16(2):202-208. doi: 10.1016/s1499-3872(16)60186-8. PMID: 28381386
New strategies for the early detection of pancreatic cancer.
Petrone MC, Arcidiacono PG
Expert Rev Gastroenterol Hepatol 2016;10(2):157-9. Epub 2015 Dec 14 doi: 10.1586/17474124.2016.1122521. PMID: 26582179

Clinical prediction guides

Focal pancreatic parenchyma atrophy is a harbinger of pancreatic cancer and a clue to the intraductal spreading subtype.
Nakahodo J, Kikuyama M, Fukumura Y, Horiguchi SI, Chiba K, Tabata H, Suzuki M, Kamisawa T
Pancreatology 2022 Dec;22(8):1148-1158. Epub 2022 Oct 17 doi: 10.1016/j.pan.2022.10.003. PMID: 36273992
mAb Das-1 identifies pancreatic ductal adenocarcinoma and high-grade pancreatic intraepithelial neoplasia with high accuracy.
Das KK, Brown JW, Fernandez Del-Castillo C, Huynh T, Mills JC, Matsuda Y, Das KM, Mino-Kenudson M
Hum Pathol 2021 May;111:36-44. Epub 2021 Jan 30 doi: 10.1016/j.humpath.2021.01.003. PMID: 33524436Free PMC Article
High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia.
Park JR, Li F, Oza VM, Sklaw BC, Cronley KM, Wellner M, Swanson B, Krishna SG
Hepatobiliary Pancreat Dis Int 2017 Apr;16(2):202-208. doi: 10.1016/s1499-3872(16)60186-8. PMID: 28381386
A case of concurrent pancreatic intraepithelial neoplasia and type 1 autoimmune pancreatitis with marked pancreatic duct dilatation.
Takano Y, Nagahama M, Yamamura E, Maruoka N, Yokomizo K, Mizukami H, Tanaka J, Ohike N
Clin J Gastroenterol 2016 Aug;9(4):266-71. Epub 2016 Jun 28 doi: 10.1007/s12328-016-0666-3. PMID: 27351197
New strategies for the early detection of pancreatic cancer.
Petrone MC, Arcidiacono PG
Expert Rev Gastroenterol Hepatol 2016;10(2):157-9. Epub 2015 Dec 14 doi: 10.1586/17474124.2016.1122521. PMID: 26582179

Recent systematic reviews

Diagnostic Yield From Screening Asymptomatic Individuals at High Risk for Pancreatic Cancer: A Meta-analysis of Cohort Studies.
Corral JE, Mareth KF, Riegert-Johnson DL, Das A, Wallace MB
Clin Gastroenterol Hepatol 2019 Jan;17(1):41-53. Epub 2018 Jun 30 doi: 10.1016/j.cgh.2018.04.065. PMID: 29775792

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