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Gastric Carcinoma with Lymphoid Stroma

MedGen UID:
459623
•Concept ID:
C2987397
•
Neoplastic Process
Synonyms: Gastric Lymphoepithelioma-Like Carcinoma; Gastric Medullary Carcinoma

Definition

A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of prominent lymphocytic stromal infiltration and poorly formed tubular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Carcinoma with Lymphoid Stroma

Recent clinical studies

Etiology

Clinicopathological Characteristics of Advanced Epstein-Barr Virus-associated Gastric Cancer Highlighting Aberrant p53 Expression.
Jang H, Seo AN, Kim M
Anticancer Res 2022 Oct;42(10):4955-4962. doi: 10.21873/anticanres.16002. PMID: 36191967
Gastric Carcinoma with Lymphoid Stroma: A Combination of Mismatch Repair Deficient Medullary Type and Epstein-Barr Virus-associated Gastric Carcinomas.
Uner M, Isık A, Oztop S, Karabulut E, Demirkol-Canlı S, Akyol A
Int J Surg Pathol 2022 Sep;30(6):623-633. Epub 2022 Feb 21 doi: 10.1177/10668969221080062. PMID: 35188817
Postoperative outcomes of gastric carcinoma with lymphoid stroma.
Iwasaki K, Suda T, Takano Y, Ohno Y, Yamada E, Okazaki N, Takahashi K, Watanabe T, Makuuchi Y, Ota Y, Osaka Y, Seshimo A, Katsumata K, Tsuchida A
World J Surg Oncol 2020 May 21;18(1):102. doi: 10.1186/s12957-020-01878-9. PMID: 32438924Free PMC Article
Gastric Carcinomas With Lymphoid Stroma: An Evaluation of the Histopathologic and Molecular Features.
Hissong E, Ramrattan G, Zhang P, Zhou XK, Young G, Klimstra DS, Shia J, Fernandes H, Yantiss RK
Am J Surg Pathol 2018 Apr;42(4):453-462. doi: 10.1097/PAS.0000000000001018. PMID: 29438172
Clinicopathologic features of early gastric carcinoma with lymphoid stroma and feasibility of endoscopic submucosal dissection.
Shin DH, Kim GH, Lee BE, Lee JW, Ha DW, Jeon HK, Baek DH, Song GA, Ahn SJ, Park DY
Surg Endosc 2017 Oct;31(10):4156-4164. Epub 2017 Apr 13 doi: 10.1007/s00464-017-5470-8. PMID: 28409376

Diagnosis

Epstein-Barr virus-associated gastric adenosquamous carcinoma with concurrent gastric carcinoma with lymphoid stroma: a case report and review of the literature.
Cao F, Yan Y, Niu D, Huang X, Jia L, Diao X, Li Z
BMC Gastroenterol 2022 Jul 16;22(1):346. doi: 10.1186/s12876-022-02417-4. PMID: 35842595Free PMC Article
Gastric Carcinoma with Lymphoid Stroma: A Combination of Mismatch Repair Deficient Medullary Type and Epstein-Barr Virus-associated Gastric Carcinomas.
Uner M, Isık A, Oztop S, Karabulut E, Demirkol-Canlı S, Akyol A
Int J Surg Pathol 2022 Sep;30(6):623-633. Epub 2022 Feb 21 doi: 10.1177/10668969221080062. PMID: 35188817
Postoperative outcomes of gastric carcinoma with lymphoid stroma.
Iwasaki K, Suda T, Takano Y, Ohno Y, Yamada E, Okazaki N, Takahashi K, Watanabe T, Makuuchi Y, Ota Y, Osaka Y, Seshimo A, Katsumata K, Tsuchida A
World J Surg Oncol 2020 May 21;18(1):102. doi: 10.1186/s12957-020-01878-9. PMID: 32438924Free PMC Article
Gastric Carcinomas With Lymphoid Stroma: An Evaluation of the Histopathologic and Molecular Features.
Hissong E, Ramrattan G, Zhang P, Zhou XK, Young G, Klimstra DS, Shia J, Fernandes H, Yantiss RK
Am J Surg Pathol 2018 Apr;42(4):453-462. doi: 10.1097/PAS.0000000000001018. PMID: 29438172
Features of Gastric Carcinoma With Lymphoid Stroma Associated With Epstein-Barr Virus.
Lim H, Park YS, Lee JH, Son DH, Ahn JY, Choi KS, Kim DH, Choi KD, Song HJ, Lee GH, Jung HY, Kim JH, Yook JH, Kim BS
Clin Gastroenterol Hepatol 2015 Oct;13(10):1738-1744.e2. Epub 2015 Apr 23 doi: 10.1016/j.cgh.2015.04.015. PMID: 25912839

Therapy

Infrequent overexpression of p53 protein in Epstein-Barr virus-associated gastric carcinomas.
Ojima H, Fukuda T, Nakajima T, Nagamachi Y
Jpn J Cancer Res 1997 Mar;88(3):262-6. doi: 10.1111/j.1349-7006.1997.tb00376.x. PMID: 9140110Free PMC Article

Prognosis

Very low risk of lymph node metastasis in Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma.
Cheng Y, Zhou X, Xu K, Huang J, Huang Q
BMC Gastroenterol 2020 Aug 17;20(1):273. doi: 10.1186/s12876-020-01422-9. PMID: 32807085Free PMC Article
Postoperative outcomes of gastric carcinoma with lymphoid stroma.
Iwasaki K, Suda T, Takano Y, Ohno Y, Yamada E, Okazaki N, Takahashi K, Watanabe T, Makuuchi Y, Ota Y, Osaka Y, Seshimo A, Katsumata K, Tsuchida A
World J Surg Oncol 2020 May 21;18(1):102. doi: 10.1186/s12957-020-01878-9. PMID: 32438924Free PMC Article
Clinicopathologic features of early gastric carcinoma with lymphoid stroma and feasibility of endoscopic submucosal dissection.
Shin DH, Kim GH, Lee BE, Lee JW, Ha DW, Jeon HK, Baek DH, Song GA, Ahn SJ, Park DY
Surg Endosc 2017 Oct;31(10):4156-4164. Epub 2017 Apr 13 doi: 10.1007/s00464-017-5470-8. PMID: 28409376
Clinical application of early gastric carcinoma with lymphoid stroma based on lymph node metastasis status.
Lim H, Lee IS, Lee JH, Park YS, Kang HJ, Na HK, Ahn JY, Kim DH, Choi KD, Song HJ, Lee GH, Jung HY, Kim JH, Kim BS, Yook JH, Kim BS
Gastric Cancer 2017 Sep;20(5):793-801. Epub 2017 Feb 15 doi: 10.1007/s10120-017-0703-z. PMID: 28205059
Features of Gastric Carcinoma With Lymphoid Stroma Associated With Epstein-Barr Virus.
Lim H, Park YS, Lee JH, Son DH, Ahn JY, Choi KS, Kim DH, Choi KD, Song HJ, Lee GH, Jung HY, Kim JH, Yook JH, Kim BS
Clin Gastroenterol Hepatol 2015 Oct;13(10):1738-1744.e2. Epub 2015 Apr 23 doi: 10.1016/j.cgh.2015.04.015. PMID: 25912839

Clinical prediction guides

Genetic landscape and PD-L1 expression in Epstein-Barr virus-associated gastric cancer according to the histological pattern.
Park JH, Cho HJ, Seo J, Park KB, Kwon YH, Bae HI, Seo AN, Kim M
Sci Rep 2023 Nov 9;13(1):19487. doi: 10.1038/s41598-023-45930-6. PMID: 37945587Free PMC Article
Epstein-Barr Virus Positive Gastric Cancer: A Distinct Subtype Candidate for Immunotherapy.
Pereira MA, Batista DAM, Ramos MFKP, Cardili L, Ribeiro RRE, Dias AR, Zilberstein B, Ribeiro U Jr, Cecconello I, Alves VAF, Mello ES
J Surg Res 2021 May;261:130-138. Epub 2021 Jan 8 doi: 10.1016/j.jss.2020.12.029. PMID: 33429221
Postoperative outcomes of gastric carcinoma with lymphoid stroma.
Iwasaki K, Suda T, Takano Y, Ohno Y, Yamada E, Okazaki N, Takahashi K, Watanabe T, Makuuchi Y, Ota Y, Osaka Y, Seshimo A, Katsumata K, Tsuchida A
World J Surg Oncol 2020 May 21;18(1):102. doi: 10.1186/s12957-020-01878-9. PMID: 32438924Free PMC Article
Clinicopathologic features of early gastric carcinoma with lymphoid stroma and feasibility of endoscopic submucosal dissection.
Shin DH, Kim GH, Lee BE, Lee JW, Ha DW, Jeon HK, Baek DH, Song GA, Ahn SJ, Park DY
Surg Endosc 2017 Oct;31(10):4156-4164. Epub 2017 Apr 13 doi: 10.1007/s00464-017-5470-8. PMID: 28409376
Epstein-Barr virus in gastric carcinomas with lymphoid stroma.
Chang MS, Kim WH, Kim CW, Kim YI
Histopathology 2000 Oct;37(4):309-15. doi: 10.1046/j.1365-2559.2000.01014.x. PMID: 11012737

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