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Gastric Carcinoma with Lymphoid Stroma

MedGen UID:
459623
•Concept ID:
C2987397
•
Neoplastic Process
Synonyms: Gastric Lymphoepithelioma-Like Carcinoma; Gastric Medullary Carcinoma

Definition

A rare adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of prominent lymphocytic stromal infiltration and poorly formed tubular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Carcinoma with Lymphoid Stroma

Recent clinical studies

Therapy

Infrequent overexpression of p53 protein in Epstein-Barr virus-associated gastric carcinomas.
Ojima H, Fukuda T, Nakajima T, Nagamachi Y
Jpn J Cancer Res 1997 Mar;88(3):262-6. doi: 10.1111/j.1349-7006.1997.tb00376.x. PMID: 9140110Free PMC Article

Prognosis

Clinical Significance of Epstein-Barr Virus and Helicobacter pylori Infection in Gastric Carcinoma.
Noh JH, Shin JY, Lee JH, Park YS, Lee IS, Kim GH, Na HK, Ahn JY, Jung KW, Kim DH, Choi KD, Song HJ, Lee GH, Jung HY
Gut Liver 2023 Jan 15;17(1):69-77. Epub 2022 May 25 doi: 10.5009/gnl210593. PMID: 35611669Free PMC Article
Postoperative outcomes of gastric carcinoma with lymphoid stroma.
Iwasaki K, Suda T, Takano Y, Ohno Y, Yamada E, Okazaki N, Takahashi K, Watanabe T, Makuuchi Y, Ota Y, Osaka Y, Seshimo A, Katsumata K, Tsuchida A
World J Surg Oncol 2020 May 21;18(1):102. doi: 10.1186/s12957-020-01878-9. PMID: 32438924Free PMC Article
Clinicopathologic features of early gastric carcinoma with lymphoid stroma and feasibility of endoscopic submucosal dissection.
Shin DH, Kim GH, Lee BE, Lee JW, Ha DW, Jeon HK, Baek DH, Song GA, Ahn SJ, Park DY
Surg Endosc 2017 Oct;31(10):4156-4164. Epub 2017 Apr 13 doi: 10.1007/s00464-017-5470-8. PMID: 28409376
Clinical application of early gastric carcinoma with lymphoid stroma based on lymph node metastasis status.
Lim H, Lee IS, Lee JH, Park YS, Kang HJ, Na HK, Ahn JY, Kim DH, Choi KD, Song HJ, Lee GH, Jung HY, Kim JH, Kim BS, Yook JH, Kim BS
Gastric Cancer 2017 Sep;20(5):793-801. Epub 2017 Feb 15 doi: 10.1007/s10120-017-0703-z. PMID: 28205059
Features of Gastric Carcinoma With Lymphoid Stroma Associated With Epstein-Barr Virus.
Lim H, Park YS, Lee JH, Son DH, Ahn JY, Choi KS, Kim DH, Choi KD, Song HJ, Lee GH, Jung HY, Kim JH, Yook JH, Kim BS
Clin Gastroenterol Hepatol 2015 Oct;13(10):1738-1744.e2. Epub 2015 Apr 23 doi: 10.1016/j.cgh.2015.04.015. PMID: 25912839

Clinical prediction guides

Genetic landscape and PD-L1 expression in Epstein-Barr virus-associated gastric cancer according to the histological pattern.
Park JH, Cho HJ, Seo J, Park KB, Kwon YH, Bae HI, Seo AN, Kim M
Sci Rep 2023 Nov 9;13(1):19487. doi: 10.1038/s41598-023-45930-6. PMID: 37945587Free PMC Article
Epstein-Barr Virus Positive Gastric Cancer: A Distinct Subtype Candidate for Immunotherapy.
Pereira MA, Batista DAM, Ramos MFKP, Cardili L, Ribeiro RRE, Dias AR, Zilberstein B, Ribeiro U Jr, Cecconello I, Alves VAF, Mello ES
J Surg Res 2021 May;261:130-138. Epub 2021 Jan 8 doi: 10.1016/j.jss.2020.12.029. PMID: 33429221
Postoperative outcomes of gastric carcinoma with lymphoid stroma.
Iwasaki K, Suda T, Takano Y, Ohno Y, Yamada E, Okazaki N, Takahashi K, Watanabe T, Makuuchi Y, Ota Y, Osaka Y, Seshimo A, Katsumata K, Tsuchida A
World J Surg Oncol 2020 May 21;18(1):102. doi: 10.1186/s12957-020-01878-9. PMID: 32438924Free PMC Article
Clinicopathologic features of early gastric carcinoma with lymphoid stroma and feasibility of endoscopic submucosal dissection.
Shin DH, Kim GH, Lee BE, Lee JW, Ha DW, Jeon HK, Baek DH, Song GA, Ahn SJ, Park DY
Surg Endosc 2017 Oct;31(10):4156-4164. Epub 2017 Apr 13 doi: 10.1007/s00464-017-5470-8. PMID: 28409376
Gastric carcinoma with lymphoid stroma. Analysis using mucin histochemistry and immunohistochemistry.
Lertprasertsuke N, Tsutsumi Y
Virchows Arch A Pathol Anat Histopathol 1989;414(3):231-41. doi: 10.1007/BF00822027. PMID: 2494803

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