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Increased serum prostaglandin E2

MedGen UID:
461708
Concept ID:
C3150358
Finding
Synonym: Elevated prostaglandin E2
 
HPO: HP:0003566

Definition

An increased concentration of prostaglandin E2 in the blood. [from HPO]

Conditions with this feature

Familial hypokalemic alkalosis, Gullner type
MedGen UID:
78677
Concept ID:
C0268444
Disease or Syndrome
Bartter disease type 2
MedGen UID:
343428
Concept ID:
C1855849
Disease or Syndrome
Bartter syndrome refers to a group of disorders that are unified by autosomal recessive transmission of impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and hypercalciuria. Clinical disease results from defective renal reabsorption of sodium chloride in the thick ascending limb (TAL) of the Henle loop, where 30% of filtered salt is normally reabsorbed (Simon et al., 1997). Patients with antenatal forms of Bartter syndrome typically present with premature birth associated with polyhydramnios and low birth weight and may develop life-threatening dehydration in the neonatal period. Patients with classic Bartter syndrome (see BARTS3, 607364) present later in life and may be sporadically asymptomatic or mildly symptomatic (summary by Simon et al., 1996 and Fremont and Chan, 2012). For a discussion of genetic heterogeneity of Bartter syndrome, see 607364.
Bartter disease type 1
MedGen UID:
355727
Concept ID:
C1866495
Disease or Syndrome
Bartter syndrome refers to a group of disorders that are unified by autosomal recessive transmission of impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and hypercalciuria. Clinical disease results from defective renal reabsorption of sodium chloride in the thick ascending limb (TAL) of the Henle loop, where 30% of filtered salt is normally reabsorbed (Simon et al., 1997). Patients with antenatal forms of Bartter syndrome typically present with premature birth associated with polyhydramnios and low birth weight and may develop life-threatening dehydration in the neonatal period. Patients with classic Bartter syndrome (see BARTS3, 607364) present later in life and may be sporadically asymptomatic or mildly symptomatic (summary by Simon et al., 1996 and Fremont and Chan, 2012). For a discussion of genetic heterogeneity of Bartter syndrome, see 607364.

Professional guidelines

PubMed

Lev-Ari S, Lichtenberg D, Arber N
Recent Pat Anticancer Drug Discov 2008 Jan;3(1):55-62. doi: 10.2174/157489208783478720. PMID: 18289124
Lindheimer MD, Katz AI
Annu Rev Med 1989;40:233-50. doi: 10.1146/annurev.me.40.020189.001313. PMID: 2658750
Goa KL, Monk JP
Drugs 1987 Nov;34(5):539-59. doi: 10.2165/00003495-198734050-00003. PMID: 3121276

Recent clinical studies

Etiology

Badrani JH, Cavagnero K, Eastman JJ, Kim AS, Strohm A, Yan C, Deconde A, Zuraw BL, White AA, Christiansen SC, Doherty TA
J Allergy Clin Immunol 2023 Nov;152(5):1330-1335.e1. Epub 2023 Aug 3 doi: 10.1016/j.jaci.2023.06.028. PMID: 37543185Free PMC Article
Irún P, Gracia R, Piazuelo E, Pardo J, Morte E, Paño JR, Boza J, Carrera-Lasfuentes P, Higuera GA, Lanas A
Sci Rep 2023 Apr 20;13(1):6497. doi: 10.1038/s41598-023-33682-2. PMID: 37081104Free PMC Article
Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, Keyes GS, Yuan ZX, Miller V, Lynch C, Honvoh G, Park J, Levy R, Domenichiello AF, Johnston A, Majchrzak-Hong S, Hibbeln JR, Barrow DA, Loewke J, Davis JM, Mannes A, Palsson OS, Suchindran CM, Gaylord SA, Mann JD
BMJ 2021 Jun 30;374:n1448. doi: 10.1136/bmj.n1448. PMID: 34526307Free PMC Article
Kazancioglu S, Yilmaz FM, Bastug A, Ozbay BO, Aydos O, Yücel Ç, Bodur H, Yilmaz G
Jpn J Infect Dis 2021 Nov 22;74(6):530-536. Epub 2021 Mar 31 doi: 10.7883/yoken.JJID.2021.020. PMID: 33790073
Wu Y, Zhao Y, Yang HZ, Wang YJ, Chen Y
Biosci Rep 2021 Feb 26;41(2) doi: 10.1042/BSR20202924. PMID: 33565572Free PMC Article

Diagnosis

Buchheit KM, Sohail A, Hacker J, Maurer R, Gakpo D, Bensko JC, Taliaferro F, Ordovas-Montanes J, Laidlaw TM
J Allergy Clin Immunol 2022 Aug;150(2):415-424. Epub 2022 Apr 20 doi: 10.1016/j.jaci.2022.04.007. PMID: 35460728Free PMC Article
Losso JN, Finley JW, Karki N, Liu AG, Prudente A, Tipton R, Yu Y, Greenway FL
Am J Ther 2018 Mar/Apr;25(2):e194-e201. doi: 10.1097/MJT.0000000000000584. PMID: 28901958Free PMC Article
Choi JH, Kim JH, Park HS
Curr Opin Allergy Clin Immunol 2015 Feb;15(1):21-6. doi: 10.1097/ACI.0000000000000122. PMID: 25546326
Tisdale MJ
Curr Opin Clin Nutr Metab Care 1998 May;1(3):253-6. doi: 10.1097/00075197-199805000-00003. PMID: 10565357
Lindheimer MD, Katz AI
Annu Rev Med 1989;40:233-50. doi: 10.1146/annurev.me.40.020189.001313. PMID: 2658750

Therapy

Badrani JH, Cavagnero K, Eastman JJ, Kim AS, Strohm A, Yan C, Deconde A, Zuraw BL, White AA, Christiansen SC, Doherty TA
J Allergy Clin Immunol 2023 Nov;152(5):1330-1335.e1. Epub 2023 Aug 3 doi: 10.1016/j.jaci.2023.06.028. PMID: 37543185Free PMC Article
Sun Q, Zhang Y, Ding Y, Xie W, Li H, Li S, Li Y, Cai M
Cells 2022 Sep 5;11(17) doi: 10.3390/cells11172760. PMID: 36078169Free PMC Article
Buchheit KM, Sohail A, Hacker J, Maurer R, Gakpo D, Bensko JC, Taliaferro F, Ordovas-Montanes J, Laidlaw TM
J Allergy Clin Immunol 2022 Aug;150(2):415-424. Epub 2022 Apr 20 doi: 10.1016/j.jaci.2022.04.007. PMID: 35460728Free PMC Article
Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, Keyes GS, Yuan ZX, Miller V, Lynch C, Honvoh G, Park J, Levy R, Domenichiello AF, Johnston A, Majchrzak-Hong S, Hibbeln JR, Barrow DA, Loewke J, Davis JM, Mannes A, Palsson OS, Suchindran CM, Gaylord SA, Mann JD
BMJ 2021 Jun 30;374:n1448. doi: 10.1136/bmj.n1448. PMID: 34526307Free PMC Article
Losso JN, Finley JW, Karki N, Liu AG, Prudente A, Tipton R, Yu Y, Greenway FL
Am J Ther 2018 Mar/Apr;25(2):e194-e201. doi: 10.1097/MJT.0000000000000584. PMID: 28901958Free PMC Article

Prognosis

Badrani JH, Cavagnero K, Eastman JJ, Kim AS, Strohm A, Yan C, Deconde A, Zuraw BL, White AA, Christiansen SC, Doherty TA
J Allergy Clin Immunol 2023 Nov;152(5):1330-1335.e1. Epub 2023 Aug 3 doi: 10.1016/j.jaci.2023.06.028. PMID: 37543185Free PMC Article
Mauro D, Srinath A, Guggino G, Nicolaidou V, Raimondo S, Ellis JJ, Whyte J, Nicoletti MM, Romano M, Kenna TJ, Cañete JD, Alessandro R, Rizzo A, Brown MA, Horwood NJ, Haroon N, Ciccia F
Clin Immunol 2023 Jun;251:109332. Epub 2023 Apr 17 doi: 10.1016/j.clim.2023.109332. PMID: 37075950
Wang IC, Sugai JV, Majzoub J, Johnston J, Giannobile WV, Wang HL
J Periodontol 2022 Jun;93(6):824-836. Epub 2022 Jan 19 doi: 10.1002/JPER.21-0419. PMID: 34807456
Kazancioglu S, Yilmaz FM, Bastug A, Ozbay BO, Aydos O, Yücel Ç, Bodur H, Yilmaz G
Jpn J Infect Dis 2021 Nov 22;74(6):530-536. Epub 2021 Mar 31 doi: 10.7883/yoken.JJID.2021.020. PMID: 33790073
Choi JH, Kim JH, Park HS
Curr Opin Allergy Clin Immunol 2015 Feb;15(1):21-6. doi: 10.1097/ACI.0000000000000122. PMID: 25546326

Clinical prediction guides

Badrani JH, Cavagnero K, Eastman JJ, Kim AS, Strohm A, Yan C, Deconde A, Zuraw BL, White AA, Christiansen SC, Doherty TA
J Allergy Clin Immunol 2023 Nov;152(5):1330-1335.e1. Epub 2023 Aug 3 doi: 10.1016/j.jaci.2023.06.028. PMID: 37543185Free PMC Article
Mauro D, Srinath A, Guggino G, Nicolaidou V, Raimondo S, Ellis JJ, Whyte J, Nicoletti MM, Romano M, Kenna TJ, Cañete JD, Alessandro R, Rizzo A, Brown MA, Horwood NJ, Haroon N, Ciccia F
Clin Immunol 2023 Jun;251:109332. Epub 2023 Apr 17 doi: 10.1016/j.clim.2023.109332. PMID: 37075950
Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, Keyes GS, Yuan ZX, Miller V, Lynch C, Honvoh G, Park J, Levy R, Domenichiello AF, Johnston A, Majchrzak-Hong S, Hibbeln JR, Barrow DA, Loewke J, Davis JM, Mannes A, Palsson OS, Suchindran CM, Gaylord SA, Mann JD
BMJ 2021 Jun 30;374:n1448. doi: 10.1136/bmj.n1448. PMID: 34526307Free PMC Article
Kazancioglu S, Yilmaz FM, Bastug A, Ozbay BO, Aydos O, Yücel Ç, Bodur H, Yilmaz G
Jpn J Infect Dis 2021 Nov 22;74(6):530-536. Epub 2021 Mar 31 doi: 10.7883/yoken.JJID.2021.020. PMID: 33790073
Wang D, Huang S, Yuan X, Liang J, Xu R, Yao G, Feng X, Sun L
Cell Mol Immunol 2017 May;14(5):423-431. Epub 2015 Oct 5 doi: 10.1038/cmi.2015.89. PMID: 26435067Free PMC Article

Recent systematic reviews

de Mello-Neto JM, Nunes JGR, Tadakamadla SK, da Silva Figueredo CM
Int J Environ Res Public Health 2021 Aug 25;18(17) doi: 10.3390/ijerph18178958. PMID: 34501547Free PMC Article

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