Gastric mucosal hypertrophy

MedGen UID:: 4844
•Concept ID:: C0017155
•: Disease or Syndrome

Synonyms:	GASTRITIS, FAMILIAL GIANT HYPERTROPHIC; Gastritis, Hypertrophic; Gastroenteropathy, protein losing; Giant hypertrophic gastritis; Giant hypertrophic gastropathy; Giant hypertrophy of the gastric mucosa; Hypertrophic gastropathy; Menetrier disease
SNOMED CT:	Hypertrophic gastropathy (413219009); Gastric hyperplasia (60002000); Gastric mucosal hyperplasia (60002000); Giant rugal hypertrophy of stomach (60002000); Hyperplastic gastropathy (60002000); Hyperplastic gastropathy of mucous cell type (60002000); Hypertrophic bulbous gastritis (60002000); Menetrier disease (60002000); Proliferative chronic hypertrophic gastritis (60002000); Polypoid swelling of gastric mucous membrane (60002000); Massive hypertrophic gastritis (60002000); Hypertrophic proliferative gastritis (60002000); Adenopapillomatosis gastrica (60002000); Giant hypertrophic gastritis (60002000); Gastritis hypertrophica gigantica (60002000); Gastritis hypertrophica gigantea (60002000); Hypertrophic gastritis (60002000); Ménétrier's disease (60002000); Gastric mucosal hypertrophy (60002000); Gastritis hypertrophic gigantica (60002000); Giant rugal gastritis (60002000); Chronic hypertrophic gastritis (60002000); Giant rugal hypertrophy (60002000)
Modes of inheritance:	Autosomal dominant inheritance MedGen UID: 141047 •Concept ID: C0443147 • Intellectual Product Source: Orphanet A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. Unknown inheritance MedGen UID: 989040 •Concept ID: CN307042 • Finding Source: Orphanet Hereditary clinical entity whose mode of inheritance is unknown. See: This record Not genetically inherited MedGen UID: 988794 •Concept ID: CN307044 • Finding Source: Orphanet clinical entity without genetic inheritance. See: This record Autosomal dominant inheritance (Orphanet) Unknown inheritance (Orphanet) Not genetically inherited (Orphanet)

HPO:	HP:0005246
Monarch Initiative:	MONDO:0007652
OMIM®:	137280
Orphanet:	ORPHA2494

Definition

A type of gastritis characterized by excessive proliferation of the gastric mucosa and diffuse thickening of the gastric mucosal folds. [from HPO]

Clinical features

From HPO

Vascular dilatation

MedGen UID:: 8076
•Concept ID:: C0002940
•: Pathologic Function

Abnormal outpouching or sac-like dilatation in the wall of an atery, vein or the heart.

See: Feature record | Search on this feature

Gastric mucosal hypertrophy

MedGen UID:: 4844
•Concept ID:: C0017155
•: Disease or Syndrome

A type of gastritis characterized by excessive proliferation of the gastric mucosa and diffuse thickening of the gastric mucosal folds.

See: Feature record | Search on this feature

Hypoproteinemia

MedGen UID:: 581229
•Concept ID:: C0392692
•: Finding

A decreased concentration of protein in the blood.

See: Feature record | Search on this feature

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Abnormality of metabolism/homeostasis
- Hypoproteinemia
Abnormality of the cardiovascular system
- Vascular dilatation
Abnormality of the digestive system
- Gastric mucosal hypertrophy

Term Hierarchy

GTR
MeSH
Orphanet

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGastric mucosal hypertrophy

Abnormality of the digestive system
- Abnormal digestive system morphology
  - Abnormal gastrointestinal tract morphology
    - Abnormal stomach morphology
      - Abnormal gastric mucosa morphology
        Gastritis
        Gastric mucosal hypertrophy

Follow this link to review classifications for Gastric mucosal hypertrophy in Orphanet.

Conditions with this feature

Gastric mucosal hypertrophy

MedGen UID:: 4844
•Concept ID:: C0017155
•: Disease or Syndrome

A type of gastritis characterized by excessive proliferation of the gastric mucosa and diffuse thickening of the gastric mucosal folds.

See: Condition Record

Gastric mucosal hypertrophy

Professional guidelines

PubMed

Evolving molecular targets in the treatment of nonmalignant gastrointestinal diseases.

Katzka DA, Loftus EV Jr, Camilleri M
Clin Pharmacol Ther 2012 Sep;92(3):306-20. Epub 2012 Jul 25 doi: 10.1038/clpt.2012.77. PMID: 22828717

Premalignant lesions and conditions for gastric adenocarcinoma: diagnosis, management and surveillance guidelines.

Kyrlagkitsis I, Karamanolis DG
Hepatogastroenterology 2003 Mar-Apr;50(50):592-600. PMID: 12749280

Giant gastric folds: differential diagnosis at US.

Okanobu H, Hata J, Haruma K, Hara M, Nakamura K, Tanaka S, Chayama K
Radiology 2003 Mar;226(3):686-90. Epub 2003 Jan 24 doi: 10.1148/radiol.2263012080. PMID: 12601220

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