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Abnormal platelet morphology

MedGen UID:
488945
•Concept ID:
C0855742
•
Finding
Synonym: Abnormal shape of platelets
 
HPO: HP:0011875

Definition

An anomaly in platelet form, ultrastructure, or intracellular organelles. [from HPO]

Professional guidelines

PubMed

Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management.
Tefferi A, Vannucchi AM, Barbui T
Am J Hematol 2024 Apr;99(4):697-718. Epub 2024 Jan 25 doi: 10.1002/ajh.27216. PMID: 38269572
Myelodysplastic syndromes with ring sideroblasts (MDS-RS) and MDS/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T) - "2021 update on diagnosis, risk-stratification, and management".
Patnaik MM, Tefferi A
Am J Hematol 2021 Mar 1;96(3):379-394. Epub 2021 Jan 28 doi: 10.1002/ajh.26090. PMID: 33428785
2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society.
January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, Conti JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT, Sacco RL, Stevenson WG, Tchou PJ, Tracy CM, Yancy CW; American College of Cardiology/American Heart Association Task Force on Practice Guidelines
J Am Coll Cardiol 2014 Dec 2;64(21):e1-76. Epub 2014 Mar 28 doi: 10.1016/j.jacc.2014.03.022. PMID: 24685669

Recent clinical studies

Etiology

Clinical Course and Outcome of Childhood Acquired Platelet Dysfunction with Eosinophilia.
Chotsampancharoen T, Sripornsawan P, Duangchu S, McNeil E
Acta Haematol 2018;139(1):28-32. Epub 2018 Jan 11 doi: 10.1159/000485790. PMID: 29393084
Platelet function in adolescent idiopathic scoliosis.
Kahmann RD, Donohue JM, Bradford DS, White JG, Rao GH
Spine (Phila Pa 1976) 1992 Feb;17(2):145-8. doi: 10.1097/00007632-199202000-00005. PMID: 1553584
Polycythaemia and thrombocythaemia in the elderly.
Pearson TC, Messinezy M
Baillieres Clin Haematol 1987 Jun;1(2):355-87. doi: 10.1016/s0950-3536(87)80006-9. PMID: 3322442
Bleeding and thrombosis in the myeloproliferative disorders.
Schafer AI
Blood 1984 Jul;64(1):1-12. PMID: 6375757
Microscopic platelet size and morphology in various hematologic disorders.
Zeigler Z, Murphy S, Gardner FH
Blood 1978 Mar;51(3):479-86. PMID: 414804

Diagnosis

Clinical Course and Outcome of Childhood Acquired Platelet Dysfunction with Eosinophilia.
Chotsampancharoen T, Sripornsawan P, Duangchu S, McNeil E
Acta Haematol 2018;139(1):28-32. Epub 2018 Jan 11 doi: 10.1159/000485790. PMID: 29393084
Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome.
Nurden P, Debili N, Coupry I, Bryckaert M, Youlyouz-Marfak I, Solé G, Pons AC, Berrou E, Adam F, Kauskot A, Lamazière JM, Rameau P, Fergelot P, Rooryck C, Cailley D, Arveiler B, Lacombe D, Vainchenker W, Nurden A, Goizet C
Blood 2011 Nov 24;118(22):5928-37. Epub 2011 Sep 29 doi: 10.1182/blood-2011-07-365601. PMID: 21960593
Agranular platelets as a cardinal feature of ARC syndrome.
Kim SM, Chang HK, Song JW, Koh H, Han SJ; Severance Pediatric Liver Disease Research Group
J Pediatr Hematol Oncol 2010 May;32(4):253-8. doi: 10.1097/MPH.0b013e3181c3a8d0. PMID: 20224444
Essential thrombocythemia in a dog: case report and literature review.
Bass MC, Schultze AE
J Am Anim Hosp Assoc 1998 May-Jun;34(3):197-203. doi: 10.5326/15473317-34-3-197. PMID: 9590446
Polycythaemia and thrombocythaemia in the elderly.
Pearson TC, Messinezy M
Baillieres Clin Haematol 1987 Jun;1(2):355-87. doi: 10.1016/s0950-3536(87)80006-9. PMID: 3322442

Therapy

Segmented neutrophil size and platelet morphology in HIV/AIDS patients.
Bamberg R, Johnson J
Clin Lab Sci 2002 Winter;15(1):18-22. PMID: 12778952
Essential thrombocythemia in a dog: case report and literature review.
Bass MC, Schultze AE
J Am Anim Hosp Assoc 1998 May-Jun;34(3):197-203. doi: 10.5326/15473317-34-3-197. PMID: 9590446
Balloon-like platelets in myelodysplastic syndromes--a feature of dysmegakaryopoiesis?
Widell S, Hast R
Leuk Res 1987;11(8):747-52. doi: 10.1016/0145-2126(87)90012-9. PMID: 3306168
Bleeding and thrombosis in the myeloproliferative disorders.
Schafer AI
Blood 1984 Jul;64(1):1-12. PMID: 6375757
Pseudothrombocytopenia due to platelet aggregation and degranulation in blood collected in EDTA.
Mant MJ, Doery JC, Gauldie J, Sims H
Scand J Haematol 1975 Oct;15(3):161-70. doi: 10.1111/j.1600-0609.1975.tb01070.x. PMID: 812172

Prognosis

Clinical Course and Outcome of Childhood Acquired Platelet Dysfunction with Eosinophilia.
Chotsampancharoen T, Sripornsawan P, Duangchu S, McNeil E
Acta Haematol 2018;139(1):28-32. Epub 2018 Jan 11 doi: 10.1159/000485790. PMID: 29393084
Biochemistry of adolescent idiopathic scoliosis.
Lombardi G, Akoume MY, Colombini A, Moreau A, Banfi G
Adv Clin Chem 2011;54:165-82. doi: 10.1016/b978-0-12-387025-4.00007-8. PMID: 21874761

Clinical prediction guides

Agranular platelets as a cardinal feature of ARC syndrome.
Kim SM, Chang HK, Song JW, Koh H, Han SJ; Severance Pediatric Liver Disease Research Group
J Pediatr Hematol Oncol 2010 May;32(4):253-8. doi: 10.1097/MPH.0b013e3181c3a8d0. PMID: 20224444
Platelet pathology in sex-linked GATA-1 dyserythropoietic macrothrombocytopenia I ultrastructure.
White JG, Nichols WL, Steensma DP
Platelets 2007 Jun;18(4):273-83. doi: 10.1080/09537100601065825. PMID: 17538848
Segmented neutrophil size and platelet morphology in HIV/AIDS patients.
Bamberg R, Johnson J
Clin Lab Sci 2002 Winter;15(1):18-22. PMID: 12778952
Microscopic platelet size and morphology in various hematologic disorders.
Zeigler Z, Murphy S, Gardner FH
Blood 1978 Mar;51(3):479-86. PMID: 414804
Pseudothrombocytopenia due to platelet aggregation and degranulation in blood collected in EDTA.
Mant MJ, Doery JC, Gauldie J, Sims H
Scand J Haematol 1975 Oct;15(3):161-70. doi: 10.1111/j.1600-0609.1975.tb01070.x. PMID: 812172

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