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Soft palate cancer

MedGen UID:
57552
•Concept ID:
C0153376
•
Neoplastic Process
Synonyms: cancer of soft palate; Malignant Neoplasm of Soft Palate; malignant neoplasm of soft palate; Malignant Neoplasm of the Soft Palate; malignant neoplasm of the soft palate; Malignant Soft Palate Neoplasm; malignant soft palate neoplasm; Malignant Soft Palate Tumor; malignant soft palate tumor; malignant soft palate tumour; Malignant tumor of soft palate; Malignant Tumor of Soft Palate; malignant tumor of soft palate; Malignant Tumor of the Soft Palate; malignant tumor of the soft palate; malignant tumour of soft palate; malignant tumour of the soft palate; soft palate cancer
SNOMED CT: Malignant tumor of soft palate (363388009)
 
Monarch Initiative: MONDO:0004611

Definition

A primary or metastatic malignant neoplasm that affects the soft palate. [from NCI]

Professional guidelines

PubMed

A review of the evaluation and management of velopharyngeal insufficiency in children.
Ruda JM, Krakovitz P, Rose AS
Otolaryngol Clin North Am 2012 Jun;45(3):653-69, viii. doi: 10.1016/j.otc.2012.03.005. PMID: 22588042
Oropharyngeal cancer: current understanding and management.
Cohan DM, Popat S, Kaplan SE, Rigual N, Loree T, Hicks WL Jr
Curr Opin Otolaryngol Head Neck Surg 2009 Apr;17(2):88-94. doi: 10.1097/moo.0b013e32832984c0. PMID: 19373958
Early detection, diagnosis, and management of oral and oropharyngeal cancer.
Mashberg A, Samit AM
CA Cancer J Clin 1989 Mar-Apr;39(2):67-88. doi: 10.3322/canjclin.39.2.67. PMID: 2495159

Curated

NCCN, Head and Neck, 2.2022

Recent clinical studies

Etiology

Application of prolonged submental perforator flap to repair the postoperative defect of upper airway malignancy.
Ma H, Zhong Q, Hou L, Feng L, He S, Lian M, Zhao Y, Wang R, Fang J
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5507-5518. Epub 2023 Aug 2 doi: 10.1007/s00405-023-08131-5. PMID: 37530858Free PMC Article
Functional outcomes of soft palate free flap reconstruction following oropharyngeal cancer surgery.
Melan JB, Philouze P, Pradat P, Benzerdjeb N, Blanc J, Ceruse P, Fuchsmann C
Eur J Surg Oncol 2021 Sep;47(9):2265-2271. Epub 2021 May 7 doi: 10.1016/j.ejso.2021.04.044. PMID: 33994058
Techniques and outcomes in microsurgical soft palate reconstruction.
Fries CA, Al Deek N, Wei FC
Head Neck 2019 Jul;41(7):2085-2092. Epub 2019 Jan 28 doi: 10.1002/hed.25662. PMID: 30693590
Advanced soft palate cancer: the clinical importance of the parapharyngeal space.
Douglas WG, Rigual NR, Giese W, Bauer J, Wiseman SM, Loree TR, Schwarz J, Alrawi S, Hicks WL Jr
Otolaryngol Head Neck Surg 2005 Jul;133(1):66-9. doi: 10.1016/j.otohns.2005.03.007. PMID: 16025055

Diagnosis

Cardiac metastasis of head and neck squamous cell carcinoma.
Nagata S, Ota K, Nagata M, Shinohara M
Int J Oral Maxillofac Surg 2012 Dec;41(12):1458-62. Epub 2012 Aug 24 doi: 10.1016/j.ijom.2012.07.017. PMID: 22921451

Therapy

Interstitial and external radiotherapy in carcinoma of the soft palate and uvula.
Esche BA, Haie CM, Gerbaulet AP, Eschwege F, Richard JM, Chassagne D
Int J Radiat Oncol Biol Phys 1988 Sep;15(3):619-25. doi: 10.1016/0360-3016(88)90303-3. PMID: 3138213

Prognosis

Functional outcomes of soft palate free flap reconstruction following oropharyngeal cancer surgery.
Melan JB, Philouze P, Pradat P, Benzerdjeb N, Blanc J, Ceruse P, Fuchsmann C
Eur J Surg Oncol 2021 Sep;47(9):2265-2271. Epub 2021 May 7 doi: 10.1016/j.ejso.2021.04.044. PMID: 33994058
Cardiac metastasis of head and neck squamous cell carcinoma.
Nagata S, Ota K, Nagata M, Shinohara M
Int J Oral Maxillofac Surg 2012 Dec;41(12):1458-62. Epub 2012 Aug 24 doi: 10.1016/j.ijom.2012.07.017. PMID: 22921451
Advanced soft palate cancer: the clinical importance of the parapharyngeal space.
Douglas WG, Rigual NR, Giese W, Bauer J, Wiseman SM, Loree TR, Schwarz J, Alrawi S, Hicks WL Jr
Otolaryngol Head Neck Surg 2005 Jul;133(1):66-9. doi: 10.1016/j.otohns.2005.03.007. PMID: 16025055

Clinical prediction guides

Application of prolonged submental perforator flap to repair the postoperative defect of upper airway malignancy.
Ma H, Zhong Q, Hou L, Feng L, He S, Lian M, Zhao Y, Wang R, Fang J
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5507-5518. Epub 2023 Aug 2 doi: 10.1007/s00405-023-08131-5. PMID: 37530858Free PMC Article
Functional outcomes of soft palate free flap reconstruction following oropharyngeal cancer surgery.
Melan JB, Philouze P, Pradat P, Benzerdjeb N, Blanc J, Ceruse P, Fuchsmann C
Eur J Surg Oncol 2021 Sep;47(9):2265-2271. Epub 2021 May 7 doi: 10.1016/j.ejso.2021.04.044. PMID: 33994058
Techniques and outcomes in microsurgical soft palate reconstruction.
Fries CA, Al Deek N, Wei FC
Head Neck 2019 Jul;41(7):2085-2092. Epub 2019 Jan 28 doi: 10.1002/hed.25662. PMID: 30693590
Gene mutations in the D-loop region of mitochondrial DNA in oral squamous cell carcinoma.
Yuan RT, Sun Y, Bu LX, Jia MY
Mol Med Rep 2015 Jun;11(6):4496-500. Epub 2015 Jan 22 doi: 10.3892/mmr.2015.3240. PMID: 25625701
Modified folding radial forearm flap in soft palate and tonsillar fossa reconstruction.
Kang HG, Park MC, Lim H, Kim JH, Lee IJ
J Craniofac Surg 2013 Mar;24(2):458-60. doi: 10.1097/SCS.0b013e31826cfecf. PMID: 23524714

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