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Benign neoplasm of prostate

MedGen UID:
57577
•Concept ID:
C0154009
•
Neoplastic Process
Synonyms: Benign Neoplasm of Prostate; benign neoplasm of prostate; Benign Neoplasm of the Prostate; benign neoplasm of the prostate; Benign Prostate Neoplasm; benign prostate neoplasm; Benign Prostate Tumor; benign prostate tumor; benign prostate tumour; Benign Prostatic Neoplasm; benign prostatic neoplasm; Benign prostatic tumor; Benign tumor of prostate; Benign Tumor of Prostate; benign tumor of prostate; Benign Tumor of the Prostate; benign tumor of the prostate; benign tumour of prostate; benign tumour of the prostate; prostate gland benign neoplasm
SNOMED CT: Benign prostatic tumor (92308005); Benign tumor of prostate (92308005); Benign neoplasm of prostate (92308005)
 
Monarch Initiative: MONDO:0021510

Definition

A neoplasm that arises from the prostate and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include benign phyllodes tumor, leiomyoma, and fibroma. [from NCI]

Professional guidelines

PubMed

EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.
Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724
Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Parker C, Castro E, Fizazi K, Heidenreich A, Ost P, Procopio G, Tombal B, Gillessen S; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2020 Sep;31(9):1119-1134. Epub 2020 Jun 25 doi: 10.1016/j.annonc.2020.06.011. PMID: 32593798
The Diagnosis and Treatment of Prostate Cancer: A Review.
Litwin MS, Tan HJ
JAMA 2017 Jun 27;317(24):2532-2542. doi: 10.1001/jama.2017.7248. PMID: 28655021

Recent clinical studies

Etiology

Menin in Cancer.
Majer AD, Hua X, Katona BW
Genes (Basel) 2024 Sep 21;15(9) doi: 10.3390/genes15091231. PMID: 39336822Free PMC Article
Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality: A Secondary Analysis of the CAP Randomized Clinical Trial.
Martin RM, Turner EL, Young GJ, Metcalfe C, Walsh EI, Lane JA, Sterne JAC, Noble S, Holding P, Ben-Shlomo Y, Williams NJ, Pashayan N, Bui MN, Albertsen PC, Seibert TM, Zietman AL, Oxley J, Adolfsson J, Mason MD, Davey Smith G, Neal DE, Hamdy FC, Donovan JL; CAP Trial Group
JAMA 2024 May 7;331(17):1460-1470. doi: 10.1001/jama.2024.4011. PMID: 38581198Free PMC Article
Functional Outcomes After Localized Prostate Cancer Treatment.
Al Hussein Al Awamlh B, Wallis CJD, Penson DF, Huang LC, Zhao Z, Conwill R, Talwar R, Morgans AK, Goodman M, Hamilton AS, Wu XC, Paddock LE, Stroup A, O'Neil BB, Koyama T, Hoffman KE, Barocas DA
JAMA 2024 Jan 23;331(4):302-317. doi: 10.1001/jama.2023.26491. PMID: 38261043Free PMC Article
Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis.
van Tuijl LA, Basten M, Pan KY, Vermeulen R, Portengen L, de Graeff A, Dekker J, Geerlings MI, Hoogendoorn A, Lamers F, Voogd AC, Abell J, Awadalla P, Beekman ATF, Bjerkeset O, Boyd A, Cui Y, Frank P, Galenkamp H, Garssen B, Hellingman S, Huisman M, Huss A, de Jong TR, Keats MR, Kok AAL, Krokstad S, van Leeuwen FE, Luik AI, Noisel N, Onland-Moret NC, Payette Y, Penninx BWJH, Rissanen I, Roest AM, Ruiter R, Schoevers RA, Soave D, Spaan M, Steptoe A, Stronks K, Sund ER, Sweeney E, Twait EL, Teyhan A, Verschuren WMM, van der Willik KD, Rosmalen JGM, Ranchor AV
Cancer 2023 Oct 15;129(20):3287-3299. Epub 2023 Aug 7 doi: 10.1002/cncr.34853. PMID: 37545248
Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).
Hanson H, Astiazaran-Symonds E, Amendola LM, Balmaña J, Foulkes WD, James P, Klugman S, Ngeow J, Schmutzler R, Voian N, Wick MJ, Pal T, Tischkowitz M, Stewart DR; ACMG Professional Practices and Guidelines Committee. Electronic address: documents@acmg.net
Genet Med 2023 Oct;25(10):100870. Epub 2023 Jul 25 doi: 10.1016/j.gim.2023.100870. PMID: 37490054Free PMC Article

Diagnosis

Prostate cancer microenvironment: multidimensional regulation of immune cells, vascular system, stromal cells, and microbiota.
Chen L, Xu YX, Wang YS, Ren YY, Dong XM, Wu P, Xie T, Zhang Q, Zhou JL
Mol Cancer 2024 Oct 12;23(1):229. doi: 10.1186/s12943-024-02137-1. PMID: 39395984Free PMC Article
Global burden of benign prostatic hyperplasia, urinary tract infections, urolithiasis, bladder cancer, kidney cancer, and prostate cancer from 1990 to 2021.
Zi H, Liu MY, Luo LS, Huang Q, Luo PC, Luan HH, Huang J, Wang DQ, Wang YB, Zhang YY, Yu RP, Li YT, Zheng H, Liu TZ, Fan Y, Zeng XT
Mil Med Res 2024 Sep 18;11(1):64. doi: 10.1186/s40779-024-00569-w. PMID: 39294748Free PMC Article
Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality: A Secondary Analysis of the CAP Randomized Clinical Trial.
Martin RM, Turner EL, Young GJ, Metcalfe C, Walsh EI, Lane JA, Sterne JAC, Noble S, Holding P, Ben-Shlomo Y, Williams NJ, Pashayan N, Bui MN, Albertsen PC, Seibert TM, Zietman AL, Oxley J, Adolfsson J, Mason MD, Davey Smith G, Neal DE, Hamdy FC, Donovan JL; CAP Trial Group
JAMA 2024 May 7;331(17):1460-1470. doi: 10.1001/jama.2024.4011. PMID: 38581198Free PMC Article
Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis.
van Tuijl LA, Basten M, Pan KY, Vermeulen R, Portengen L, de Graeff A, Dekker J, Geerlings MI, Hoogendoorn A, Lamers F, Voogd AC, Abell J, Awadalla P, Beekman ATF, Bjerkeset O, Boyd A, Cui Y, Frank P, Galenkamp H, Garssen B, Hellingman S, Huisman M, Huss A, de Jong TR, Keats MR, Kok AAL, Krokstad S, van Leeuwen FE, Luik AI, Noisel N, Onland-Moret NC, Payette Y, Penninx BWJH, Rissanen I, Roest AM, Ruiter R, Schoevers RA, Soave D, Spaan M, Steptoe A, Stronks K, Sund ER, Sweeney E, Twait EL, Teyhan A, Verschuren WMM, van der Willik KD, Rosmalen JGM, Ranchor AV
Cancer 2023 Oct 15;129(20):3287-3299. Epub 2023 Aug 7 doi: 10.1002/cncr.34853. PMID: 37545248
Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).
Hanson H, Astiazaran-Symonds E, Amendola LM, Balmaña J, Foulkes WD, James P, Klugman S, Ngeow J, Schmutzler R, Voian N, Wick MJ, Pal T, Tischkowitz M, Stewart DR; ACMG Professional Practices and Guidelines Committee. Electronic address: documents@acmg.net
Genet Med 2023 Oct;25(10):100870. Epub 2023 Jul 25 doi: 10.1016/j.gim.2023.100870. PMID: 37490054Free PMC Article

Therapy

Serum PSA-based early detection of prostate cancer in Europe and globally: past, present and future.
Van Poppel H, Albreht T, Basu P, Hogenhout R, Collen S, Roobol M
Nat Rev Urol 2022 Sep;19(9):562-572. Epub 2022 Aug 16 doi: 10.1038/s41585-022-00638-6. PMID: 35974245
An Updated Systematic Review on Focal Therapy in Localized Prostate Cancer: What Has Changed over the Past 5 Years?
Hopstaken JS, Bomers JGR, Sedelaar MJP, Valerio M, Fütterer JJ, Rovers MM
Eur Urol 2022 Jan;81(1):5-33. Epub 2021 Sep 4 doi: 10.1016/j.eururo.2021.08.005. PMID: 34489140
MRI-Targeted or Standard Biopsy in Prostate Cancer Screening.
Eklund M, Jäderling F, Discacciati A, Bergman M, Annerstedt M, Aly M, Glaessgen A, Carlsson S, Grönberg H, Nordström T; STHLM3 consortium
N Engl J Med 2021 Sep 2;385(10):908-920. Epub 2021 Jul 9 doi: 10.1056/NEJMoa2100852. PMID: 34237810
Advanced Prostate Cancer: Treatment Advances and Future Directions.
Swami U, McFarland TR, Nussenzveig R, Agarwal N
Trends Cancer 2020 Aug;6(8):702-715. Epub 2020 Jun 10 doi: 10.1016/j.trecan.2020.04.010. PMID: 32534790
MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis.
Kasivisvanathan V, Rannikko AS, Borghi M, Panebianco V, Mynderse LA, Vaarala MH, Briganti A, Budäus L, Hellawell G, Hindley RG, Roobol MJ, Eggener S, Ghei M, Villers A, Bladou F, Villeirs GM, Virdi J, Boxler S, Robert G, Singh PB, Venderink W, Hadaschik BA, Ruffion A, Hu JC, Margolis D, Crouzet S, Klotz L, Taneja SS, Pinto P, Gill I, Allen C, Giganti F, Freeman A, Morris S, Punwani S, Williams NR, Brew-Graves C, Deeks J, Takwoingi Y, Emberton M, Moore CM; PRECISION Study Group Collaborators
N Engl J Med 2018 May 10;378(19):1767-1777. Epub 2018 Mar 18 doi: 10.1056/NEJMoa1801993. PMID: 29552975Free PMC Article

Prognosis

Causal relationship between prostatic diseases and prostate cancer: a mendelian randomization study.
Huang J, Sun J, Wang K, Zheng L, Fan Y, Qian B
BMC Cancer 2024 Jun 27;24(1):774. doi: 10.1186/s12885-024-12551-9. PMID: 38937672Free PMC Article
The Prostate Stromal Transcriptome in Aggressive and Lethal Prostate Cancer.
Ma C, Zhou Y, Fanelli GN, Stopsack KH, Fiorentino M, Zadra G, Mucci LA, Loda M, Tyekucheva S, Penney KL
Mol Cancer Res 2023 Mar 1;21(3):253-260. doi: 10.1158/1541-7786.MCR-22-0627. PMID: 36511902Free PMC Article
The role of novel imaging in prostate cancer focal therapy: treatment and follow-up.
Rothberg MB, Enders JJ, Kozel Z, Gopal N, Turkbey B, Pinto PA
Curr Opin Urol 2022 May 1;32(3):231-238. Epub 2022 Mar 11 doi: 10.1097/MOU.0000000000000986. PMID: 35275101
Focal therapy of prostate and kidney cancer.
Aminsharifi A, de la Rosette J, Polascik TJ
Curr Opin Urol 2018 Nov;28(6):491-492. doi: 10.1097/MOU.0000000000000552. PMID: 30239417
Inflammation and prostate carcinogenesis.
Nakai Y, Nonomura N
Int J Urol 2013 Feb;20(2):150-60. Epub 2012 Jul 31 doi: 10.1111/j.1442-2042.2012.03101.x. PMID: 22852773

Clinical prediction guides

Causal relationship between prostatic diseases and prostate cancer: a mendelian randomization study.
Huang J, Sun J, Wang K, Zheng L, Fan Y, Qian B
BMC Cancer 2024 Jun 27;24(1):774. doi: 10.1186/s12885-024-12551-9. PMID: 38937672Free PMC Article
Association between cathepsins and benign prostate diseases: a bidirectional two-sample Mendelian randomization study.
Cao H, Liu B, Gong K, Wu H, Wang Y, Zhang H, Shi C, Wang P, Du H, Zhou H, Wang S
Front Endocrinol (Lausanne) 2024;15:1348310. Epub 2024 Jun 5 doi: 10.3389/fendo.2024.1348310. PMID: 38904040Free PMC Article
Interobserver Agreement and Accuracy in Interpreting mpMRI of the Prostate: a Systematic Review.
Annamalai A, Fustok JN, Beltran-Perez J, Rashad AT, Krane LS, Triche BL
Curr Urol Rep 2022 Jan;23(1):1-10. Epub 2022 Feb 28 doi: 10.1007/s11934-022-01084-y. PMID: 35226257
Clinical Impact of Circulating Tumor Cells in Patients with Localized Prostate Cancer.
Broncy L, Paterlini-Bréchot P
Cells 2019 Jul 3;8(7) doi: 10.3390/cells8070676. PMID: 31277346Free PMC Article
Cholesterol and benign prostate disease.
Freeman MR, Solomon KR
Differentiation 2011 Nov-Dec;82(4-5):244-52. Epub 2011 Aug 20 doi: 10.1016/j.diff.2011.04.005. PMID: 21862201Free PMC Article

Recent systematic reviews

2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review.
Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV
Eur Urol 2023 Aug;84(2):191-206. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.04.021. PMID: 37202314Free PMC Article
Head-to-head Comparison of the Diagnostic Accuracy of Prostate-specific Membrane Antigen Positron Emission Tomography and Conventional Imaging Modalities for Initial Staging of Intermediate- to High-risk Prostate Cancer: A Systematic Review and Meta-analysis.
Chow KM, So WZ, Lee HJ, Lee A, Yap DWT, Takwoingi Y, Tay KJ, Tuan J, Thang SP, Lam W, Yuen J, Lawrentschuk N, Hofman MS, Murphy DG, Chen K
Eur Urol 2023 Jul;84(1):36-48. Epub 2023 Apr 7 doi: 10.1016/j.eururo.2023.03.001. PMID: 37032189
Radiotherapy of oligometastatic prostate cancer: a systematic review.
Rogowski P, Roach M 3rd, Schmidt-Hegemann NS, Trapp C, von Bestenbostel R, Shi R, Buchner A, Stief C, Belka C, Li M
Radiat Oncol 2021 Mar 9;16(1):50. doi: 10.1186/s13014-021-01776-8. PMID: 33750437Free PMC Article
EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II-2020 Update: Treatment of Relapsing and Metastatic Prostate Cancer.
Cornford P, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, der Kwast THV, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, der Poel HGV, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Mottet N
Eur Urol 2021 Feb;79(2):263-282. Epub 2020 Oct 7 doi: 10.1016/j.eururo.2020.09.046. PMID: 33039206
Surgery Versus Radiotherapy for Clinically-localized Prostate Cancer: A Systematic Review and Meta-analysis.
Wallis CJD, Saskin R, Choo R, Herschorn S, Kodama RT, Satkunasivam R, Shah PS, Danjoux C, Nam RK
Eur Urol 2016 Jul;70(1):21-30. Epub 2015 Dec 15 doi: 10.1016/j.eururo.2015.11.010. PMID: 26700655

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