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Desmoplastic Fibroma

MedGen UID:
60200
•Concept ID:
C0206645
•
Neoplastic Process
Synonyms: Collagenous Fibroma; Collagenous Fibromas; Desmoplastic Fibroblastoma; Desmoplastic Fibroblastomas; Desmoplastic Fibromas; Fibroblastoma, Desmoplastic; Fibroma, Collagenous; Fibroma, Desmoplastic
SNOMED CT: Desmoplastic fibroma (6842002)

Definition

A rare, benign, locally aggressive osteolytic neoplasm. It is characterized by the presence of a rich collagenous stroma and spindle cells with minimal cellular atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDesmoplastic Fibroma

Professional guidelines

PubMed

Management of fibro-osseous lesions of the craniofacial area. Presentation of 19 cases and review of the literature.
Suarez-Soto A, Baquero-Ruiz de la Hermosa MC, Minguez-Martínez I, Floría-García LM, Barea-Gámiz J, Delhom-Valero J, Risueño-Mata P
Med Oral Patol Oral Cir Bucal 2013 May 1;18(3):e479-85. doi: 10.4317/medoral.18289. PMID: 23524411Free PMC Article
Desmoplastic fibroma vs. desmoid tumor of bone. Two cases illustrating a problem in differential diagnosis and classification.
Hardy R, Lehrer H
Radiology 1967 May;88(5):899-901. doi: 10.1148/88.5.899. PMID: 6025046

Recent clinical studies

Etiology

Benign Bone Conditions That May Be FDG-avid and Mimic Malignancy.
Kwee TC, de Klerk JMH, Nix M, Heggelman BGF, Dubois SV, Adams HJA
Semin Nucl Med 2017 Jul;47(4):322-351. Epub 2017 Apr 12 doi: 10.1053/j.semnuclmed.2017.02.004. PMID: 28583274
Desmoplastic fibroma of the mandible: report of a misdiagnosed case.
Guerrero JS, Ruiz CA, Al-Jandan BA, Bustillo JA
J Mich Dent Assoc 2014 Mar;96(3):30-3. PMID: 24961082
Desmoplastic fibroma of the spine: a series of 12 cases and outcomes.
Yin H, Zhang D, Wu Z, Yang X, Jiao J, Wan W, Huang Q, Zhou W, Wang T, Jianru X
Spine J 2014 Aug 1;14(8):1622-8. Epub 2013 Oct 23 doi: 10.1016/j.spinee.2013.09.042. PMID: 24345470
Desmoplastic fibroma of the pediatric cranium: case report and review of the literature.
Cho BH, Tye GW, Fuller CE, Rhodes JL
Childs Nerv Syst 2013 Dec;29(12):2311-5. Epub 2013 Jun 28 doi: 10.1007/s00381-013-2210-9. PMID: 23812628
Desmoplastic fibroma of bone.
Inwards CY, Unni KK, Beabout JW, Sim FH
Cancer 1991 Nov 1;68(9):1978-83. doi: 10.1002/1097-0142(19911101)68:9<1978::aid-cncr2820680922>3.0.co;2-h. PMID: 1913545

Diagnosis

Recurrent FOSL1 rearrangements in desmoplastic fibroblastoma.
De Noon S, Piggott R, Trotman J, Tadross JA, Fittall M, Hughes D, Ye H, Munasinghe E, Murray M, Tirabosco R, Amary F, Coleman N, Watkins J, Hubank M, Tarpey P, Behjati S, Flanagan AM
J Pathol 2023 Feb;259(2):119-124. Epub 2023 Jan 3 doi: 10.1002/path.6038. PMID: 36426824Free PMC Article
Clinical and Imaging Features of Desmoplastic Fibroma of Bone for Correct Diagnosis and Differentiation.
Zhang ZZ, Cao L, Zhong ZW, Guo Z, Wu HZ, Wu WJ, Gao BL
Curr Med Imaging 2022;18(10):1093-1098. doi: 10.2174/1573405618666220411125408. PMID: 35410618
Fibrous and Fibro-Osseous Lesions of Bone.
Chebib I, Chang CY, Lozano-Calderon S
Surg Pathol Clin 2021 Dec;14(4):707-721. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.011. PMID: 34742489
Benign Bone Conditions That May Be FDG-avid and Mimic Malignancy.
Kwee TC, de Klerk JMH, Nix M, Heggelman BGF, Dubois SV, Adams HJA
Semin Nucl Med 2017 Jul;47(4):322-351. Epub 2017 Apr 12 doi: 10.1053/j.semnuclmed.2017.02.004. PMID: 28583274
Odontogenic fibroma.
Dunlap CL
Semin Diagn Pathol 1999 Nov;16(4):293-6. PMID: 10587271

Therapy

A study of 77 cases of surgically excised scalp and skull masses in pediatric patients.
Yoon SH, Park SH
Childs Nerv Syst 2008 Apr;24(4):459-65. Epub 2007 Nov 7 doi: 10.1007/s00381-007-0523-2. PMID: 17987301
Intermittent leg pain and swelling in a 30-year-old man.
Alemdaroğlu KB, Iltar S, Pulat H, Atlihan D
Clin Orthop Relat Res 2007 Sep;462:248-54. doi: 10.1097/BLO.0b013e31803bbae7. PMID: 17308475
Autologous stem cell transplantation for high-risk Ewing's sarcoma and other pediatric solid tumors.
Fraser CJ, Weigel BJ, Perentesis JP, Dusenbery KE, DeFor TE, Baker KS, Verneris MR
Bone Marrow Transplant 2006 Jan;37(2):175-81. doi: 10.1038/sj.bmt.1705224. PMID: 16273111
Desmoplastic fibroma with perineural extension.
Moorjani V, Stockton V
AJR Am J Roentgenol 2005 Dec;185(6):1498-9. doi: 10.2214/AJR.04.1526. PMID: 16304003
Osteosarcoma arising from desmoplastic fibroma treated 16 years earlier: a case report.
Takazawa K, Tsuchiya H, Yamamoto N, Nonomura A, Suzuki M, Taki J, Tomita K
J Orthop Sci 2003;8(6):864-8. doi: 10.1007/s00776-003-0725-8. PMID: 14648278

Prognosis

Diagnosis and Differential Diagnosis of Desmoplastic Fibroblastoma by Clinical, Radiological, and Histopathological Analyses.
Gong LH, Liu WF, Ding Y, Geng YH, Sun XQ, Huang XY
Chin Med J (Engl) 2018 Jan 5;131(1):32-36. doi: 10.4103/0366-6999.221274. PMID: 29271377Free PMC Article
Abdominal and pelvic tumors with musculoskeletal histology.
Dyrstad SW, Fowler AM, Jokerst CE, Baker JC, Hillen TJ, Menias C
Curr Probl Diagn Radiol 2014 Mar-Apr;43(2):68-79. doi: 10.1067/j.cpradiol.2013.11.001. PMID: 24629660
Primary musculoskeletal tumors of fibrous origin.
Smith SE, Kransdorf MJ
Semin Musculoskelet Radiol 2000;4(1):73-88. doi: 10.1055/s-2000-6856. PMID: 11061693
Odontogenic fibroma.
Dunlap CL
Semin Diagn Pathol 1999 Nov;16(4):293-6. PMID: 10587271
Desmoplastic fibroma of bone.
Inwards CY, Unni KK, Beabout JW, Sim FH
Cancer 1991 Nov 1;68(9):1978-83. doi: 10.1002/1097-0142(19911101)68:9<1978::aid-cncr2820680922>3.0.co;2-h. PMID: 1913545

Clinical prediction guides

Recurrent FOSL1 rearrangements in desmoplastic fibroblastoma.
De Noon S, Piggott R, Trotman J, Tadross JA, Fittall M, Hughes D, Ye H, Munasinghe E, Murray M, Tirabosco R, Amary F, Coleman N, Watkins J, Hubank M, Tarpey P, Behjati S, Flanagan AM
J Pathol 2023 Feb;259(2):119-124. Epub 2023 Jan 3 doi: 10.1002/path.6038. PMID: 36426824Free PMC Article
A desmoplastic fibroblastoma that developed in the anterior mediastinum: a case report.
Hato T, Kashimada H, Yamaguchi M, Sugiyama A, Inoue Y, Aoki K, Fukuda H, Gika M, Kikuchi J, Fujino T, Yamaguchi T, Tamaru JI, Kohno M, Nakayama M
J Med Case Rep 2021 Oct 18;15(1):525. doi: 10.1186/s13256-021-03014-x. PMID: 34663426Free PMC Article
Diagnosis and Differential Diagnosis of Desmoplastic Fibroblastoma by Clinical, Radiological, and Histopathological Analyses.
Gong LH, Liu WF, Ding Y, Geng YH, Sun XQ, Huang XY
Chin Med J (Engl) 2018 Jan 5;131(1):32-36. doi: 10.4103/0366-6999.221274. PMID: 29271377Free PMC Article
Desmoplastic fibroma of the spine: a series of 12 cases and outcomes.
Yin H, Zhang D, Wu Z, Yang X, Jiao J, Wan W, Huang Q, Zhou W, Wang T, Jianru X
Spine J 2014 Aug 1;14(8):1622-8. Epub 2013 Oct 23 doi: 10.1016/j.spinee.2013.09.042. PMID: 24345470
Desmoplastic fibroma of the rib with cystic change: a case report and literature review.
Okubo T, Saito T, Takagi T, Suehara Y, Kaneko K
Skeletal Radiol 2014 May;43(5):703-8. Epub 2013 Dec 3 doi: 10.1007/s00256-013-1772-7. PMID: 24292164

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