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Leprosy

MedGen UID:
6049
Concept ID:
C0023343
Disease or Syndrome
Synonym: Hansen's disease
SNOMED CT: Leprosy (81004002); Hansen's disease (81004002); Infection due to Mycobacterium leprae (81004002); Mycobacterium leprae infection (81004002)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
 
Monarch Initiative: MONDO:0005124
Orphanet: ORPHA548

Definition

A chronic infectious disease affecting primarily the skin and peripheral nervous system. [from ORDO]

Professional guidelines

PubMed

Mungroo MR, Khan NA, Siddiqui R
Microb Pathog 2020 Dec;149:104475. Epub 2020 Sep 12 doi: 10.1016/j.micpath.2020.104475. PMID: 32931893
Maymone MBC, Venkatesh S, Laughter M, Abdat R, Hugh J, Dacso MM, Rao PN, Stryjewska BM, Dunnick CA, Dellavalle RP
J Am Acad Dermatol 2020 Jul;83(1):17-30. Epub 2020 Mar 31 doi: 10.1016/j.jaad.2019.10.138. PMID: 32244016
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Recent clinical studies

Etiology

Froes LAR Junior, Sotto MN, Trindade MAB
An Bras Dermatol 2022 May-Jun;97(3):338-347. Epub 2022 Apr 2 doi: 10.1016/j.abd.2021.08.006. PMID: 35379512Free PMC Article
Tomaselli PJ, Dos Santos DF, Dos Santos ACJ, Antunes DE, Marques VD, Foss NT, Moreira CL, Nogueira PTB, Nascimento OJM, Neder L, Barreira AA, Frade MA, Goulart IMB, Marques W
Brain 2022 May 24;145(4):1499-1506. doi: 10.1093/brain/awab396. PMID: 34664630
Froes LAR Jr, Trindade MAB, Sotto MN
Int Rev Immunol 2022;41(2):72-83. Epub 2020 Nov 26 doi: 10.1080/08830185.2020.1851370. PMID: 33241709
Fava VM, Dallmann-Sauer M, Schurr E
Hum Genet 2020 Jun;139(6-7):835-846. Epub 2019 Nov 11 doi: 10.1007/s00439-019-02087-5. PMID: 31713021
Oliveira IVPM, Deps PD, Antunes JMAP
Rev Inst Med Trop Sao Paulo 2019 Sep 12;61:e44. doi: 10.1590/S1678-9946201961044. PMID: 31531622Free PMC Article

Diagnosis

Makhakhe L
S Afr Fam Pract (2004) 2021 Oct 29;63(1):e1-e6. doi: 10.4102/safp.v63i1.5311. PMID: 34797098Free PMC Article
Khadilkar SV, Patil SB, Shetty VP
J Neurol Sci 2021 Jan 15;420:117288. Epub 2020 Dec 25 doi: 10.1016/j.jns.2020.117288. PMID: 33360424
Aamir M, Sadaf A, Khan S, Perveen S, Khan A
Curr Top Med Chem 2018;18(18):1550-1558. doi: 10.2174/1568026618666181025100434. PMID: 30360715
Walker SL, Lockwood DN
Clin Dermatol 2007 Mar-Apr;25(2):165-72. doi: 10.1016/j.clindermatol.2006.05.012. PMID: 17350495
Haimanot RT, Melaku Z
Curr Opin Neurol 2000 Jun;13(3):317-22. doi: 10.1097/00019052-200006000-00015. PMID: 10871258

Therapy

Sardana K, Sachdeva S
J Cosmet Dermatol 2022 Jan;21(1):85-98. Epub 2021 Sep 26 doi: 10.1111/jocd.14436. PMID: 34564936
Van Der Werf TS, Barogui YT, Converse PJ, Phillips RO, Stienstra Y
Expert Rev Clin Pharmacol 2020 Apr;13(4):391-401. Epub 2020 Apr 20 doi: 10.1080/17512433.2020.1752663. PMID: 32310683Free PMC Article
Palit A, Kar HK
Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):115-123. doi: 10.4103/ijdvl.IJDVL_326_19. PMID: 31975697
Duthie MS, Gillis TP, Reed SG
Hum Vaccin 2011 Nov;7(11):1172-83. Epub 2011 Nov 1 doi: 10.4161/hv.7.11.16848. PMID: 22048122Free PMC Article
Ramos-e-Silva M, Rebello PF
Am J Clin Dermatol 2001;2(4):203-11. doi: 10.2165/00128071-200102040-00001. PMID: 11705247

Prognosis

Chakaya J, Petersen E, Nantanda R, Mungai BN, Migliori GB, Amanullah F, Lungu P, Ntoumi F, Kumarasamy N, Maeurer M, Zumla A
Int J Infect Dis 2022 Nov;124 Suppl 1:S26-S29. Epub 2022 Mar 20 doi: 10.1016/j.ijid.2022.03.011. PMID: 35321845Free PMC Article
Ploemacher T, Faber WR, Menke H, Rutten V, Pieters T
PLoS Negl Trop Dis 2020 Apr;14(4):e0008276. Epub 2020 Apr 27 doi: 10.1371/journal.pntd.0008276. PMID: 32339201Free PMC Article
Maymone MBC, Laughter M, Venkatesh S, Dacso MM, Rao PN, Stryjewska BM, Hugh J, Dellavalle RP, Dunnick CA
J Am Acad Dermatol 2020 Jul;83(1):1-14. Epub 2020 Mar 27 doi: 10.1016/j.jaad.2019.12.080. PMID: 32229279
Burstein R, Henry NJ, Collison ML, Marczak LB, Sligar A, Watson S, Marquez N, Abbasalizad-Farhangi M, Abbasi M, Abd-Allah F, Abdoli A, Abdollahi M, Abdollahpour I, Abdulkader RS, Abrigo MRM, Acharya D, Adebayo OM, Adekanmbi V, Adham D, Afshari M, Aghaali M, Ahmadi K, Ahmadi M, Ahmadpour E, Ahmed R, Akal CG, Akinyemi JO, Alahdab F, Alam N, Alamene GM, Alene KA, Alijanzadeh M, Alinia C, Alipour V, Aljunid SM, Almalki MJ, Al-Mekhlafi HM, Altirkawi K, Alvis-Guzman N, Amegah AK, Amini S, Amit AML, Anbari Z, Androudi S, Anjomshoa M, Ansari F, Antonio CAT, Arabloo J, Arefi Z, Aremu O, Armoon B, Arora A, Artaman A, Asadi A, Asadi-Aliabadi M, Ashraf-Ganjouei A, Assadi R, Ataeinia B, Atre SR, Quintanilla BPA, Ayanore MA, Azari S, Babaee E, Babazadeh A, Badawi A, Bagheri S, Bagherzadeh M, Baheiraei N, Balouchi A, Barac A, Bassat Q, Baune BT, Bayati M, Bedi N, Beghi E, Behzadifar M, Behzadifar M, Belay YB, Bell B, Bell ML, Berbada DA, Bernstein RS, Bhattacharjee NV, Bhattarai S, Bhutta ZA, Bijani A, Bohlouli S, Breitborde NJK, Britton G, Browne AJ, Nagaraja SB, Busse R, Butt ZA, Car J, Cárdenas R, Castañeda-Orjuela CA, Cerin E, Chanie WF, Chatterjee P, Chu DT, Cooper C, Costa VM, Dalal K, Dandona L, Dandona R, Daoud F, Daryani A, Das Gupta R, Davis I, Davis Weaver N, Davitoiu DV, De Neve JW, Demeke FM, Demoz GT, Deribe K, Desai R, Deshpande A, Desyibelew HD, Dey S, Dharmaratne SD, Dhimal M, Diaz D, Doshmangir L, Duraes AR, Dwyer-Lindgren L, Earl L, Ebrahimi R, Ebrahimpour S, Effiong A, Eftekhari A, Ehsani-Chimeh E, El Sayed I, El Sayed Zaki M, El Tantawi M, El-Khatib Z, Emamian MH, Enany S, Eskandarieh S, Eyawo O, Ezalarab M, Faramarzi M, Fareed M, Faridnia R, Faro A, Fazaeli AA, Fazlzadeh M, Fentahun N, Fereshtehnejad SM, Fernandes JC, Filip I, Fischer F, Foigt NA, Foroutan M, Francis JM, Fukumoto T, Fullman N, Gallus S, Gebre DG, Gebrehiwot TT, Gebremeskel GG, Gessner BD, Geta B, Gething PW, Ghadimi R, Ghadiri K, Ghajarzadeh M, Ghashghaee A, Gill PS, Gill TK, Golding N, Gomes NGM, Gona PN, Gopalani SV, Gorini G, Goulart BNG, Graetz N, Greaves F, Green MS, Guo Y, Haj-Mirzaian A, Haj-Mirzaian A, Hall BJ, Hamidi S, Haririan H, Haro JM, Hasankhani M, Hasanpoor E, Hasanzadeh A, Hassankhani H, Hassen HY, Hegazy MI, Hendrie D, Heydarpour F, Hird TR, Hoang CL, Hollerich G, Rad EH, Hoseini-Ghahfarokhi M, Hossain N, Hosseini M, Hosseinzadeh M, Hostiuc M, Hostiuc S, Househ M, Hsairi M, Ilesanmi OS, Imani-Nasab MH, Iqbal U, Irvani SSN, Islam N, Islam SMS, Jürisson M, Balalami NJ, Jalali A, Javidnia J, Jayatilleke AU, Jenabi E, Ji JS, Jobanputra YB, Johnson K, Jonas JB, Shushtari ZJ, Jozwiak JJ, Kabir A, Kahsay A, Kalani H, Kalhor R, Karami M, Karki S, Kasaeian A, Kassebaum NJ, Keiyoro PN, Kemp GR, Khabiri R, Khader YS, Khafaie MA, Khan EA, Khan J, Khan MS, Khang YH, Khatab K, Khater A, Khater MM, Khatony A, Khazaei M, Khazaei S, Khazaei-Pool M, Khubchandani J, Kianipour N, Kim YJ, Kimokoti RW, Kinyoki DK, Kisa A, Kisa S, Kolola T, Kosen S, Koul PA, Koyanagi A, Kraemer MUG, Krishan K, Krohn KJ, Kugbey N, Kumar GA, Kumar M, Kumar P, Kuupiel D, Lacey B, Lad SD, Lami FH, Larsson AO, Lee PH, Leili M, Levine AJ, Li S, Lim LL, Listl S, Longbottom J, Lopez JCF, Lorkowski S, Magdeldin S, Abd El Razek HM, Abd El Razek MM, Majeed A, Maleki A, Malekzadeh R, Malta DC, Mamun AA, Manafi N, Manda AL, Mansourian M, Martins-Melo FR, Masaka A, Massenburg BB, Maulik PK, Mayala BK, Mazidi M, McKee M, Mehrotra R, Mehta KM, Meles GG, Mendoza W, Menezes RG, Meretoja A, Meretoja TJ, Mestrovic T, Miller TR, Miller-Petrie MK, Mills EJ, Milne GJ, Mini GK, Mir SM, Mirjalali H, Mirrakhimov EM, Mohamadi E, Mohammad DK, Darwesh AM, Mezerji NMG, Mohammed AS, Mohammed S, Mokdad AH, Molokhia M, Monasta L, Moodley Y, Moosazadeh M, Moradi G, Moradi M, Moradi Y, Moradi-Lakeh M, Moradinazar M, Moraga P, Morawska L, Mosapour A, Mousavi SM, Mueller UO, Muluneh AG, Mustafa G, Nabavizadeh B, Naderi M, Nagarajan AJ, Nahvijou A, Najafi F, Nangia V, Ndwandwe DE, Neamati N, Negoi I, Negoi RI, Ngunjiri JW, Thi Nguyen HL, Nguyen LH, Nguyen SH, Nielsen KR, Ningrum DNA, Nirayo YL, Nixon MR, Nnaji CA, Nojomi M, Noroozi M, Nosratnejad S, Noubiap JJ, Motlagh SN, Ofori-Asenso R, Ogbo FA, Oladimeji KE, Olagunju AT, Olfatifar M, Olum S, Olusanya BO, Oluwasanu MM, Onwujekwe OE, Oren E, Ortega-Altamirano DDV, Ortiz A, Osarenotor O, Osei FB, Osgood-Zimmerman AE, Otstavnov SS, Owolabi MO, P A M, Pagheh AS, Pakhale S, Panda-Jonas S, Pandey A, Park EK, Parsian H, Pashaei T, Patel SK, Pepito VCF, Pereira A, Perkins S, Pickering BV, Pilgrim T, Pirestani M, Piroozi B, Pirsaheb M, Plana-Ripoll O, Pourjafar H, Puri P, Qorbani M, Quintana H, Rabiee M, Rabiee N, Radfar A, Rafiei A, Rahim F, Rahimi Z, Rahimi-Movaghar V, Rahimzadeh S, Rajati F, Raju SB, Ramezankhani A, Ranabhat CL, Rasella D, Rashedi V, Rawal L, Reiner RC Jr, Renzaho AMN, Rezaei S, Rezapour A, Riahi SM, Ribeiro AI, Roever L, Roro EM, Roser M, Roshandel G, Roshani D, Rostami A, Rubagotti E, Rubino S, Sabour S, Sadat N, Sadeghi E, Saeedi R, Safari Y, Safari-Faramani R, Safdarian M, Sahebkar A, Salahshoor MR, Salam N, Salamati P, Salehi F, Zahabi SS, Salimi Y, Salimzadeh H, Salomon JA, Sambala EZ, Samy AM, Santric Milicevic MM, Jose BPS, Saraswathy SYI, Sarmiento-Suárez R, Sartorius B, Sathian B, Saxena S, Sbarra AN, Schaeffer LE, Schwebel DC, Sepanlou SG, Seyedmousavi S, Shaahmadi F, Shaikh MA, Shams-Beyranvand M, Shamshirian A, Shamsizadeh M, Sharafi K, Sharif M, Sharif-Alhoseini M, Sharifi H, Sharma J, Sharma R, Sheikh A, Shields C, Shigematsu M, Shiri R, Shiue I, Shuval K, Siddiqi TJ, Silva JP, Singh JA, Sinha DN, Sisay MM, Sisay S, Sliwa K, Smith DL, Somayaji R, Soofi M, Soriano JB, Sreeramareddy CT, Sudaryanto A, Sufiyan MB, Sykes BL, Sylaja PN, Tabarés-Seisdedos R, Tabb KM, Tabuchi T, Taveira N, Temsah MH, Terkawi AS, Tessema ZT, Thankappan KR, Thirunavukkarasu S, To QG, Tovani-Palone MR, Tran BX, Tran KB, Ullah I, Usman MS, Uthman OA, Vahedian-Azimi A, Valdez PR, van Boven JFM, Vasankari TJ, Vasseghian Y, Veisani Y, Venketasubramanian N, Violante FS, Vladimirov SK, Vlassov V, Vos T, Vu GT, Vujcic IS, Waheed Y, Wakefield J, Wang H, Wang Y, Wang YP, Ward JL, Weintraub RG, Weldegwergs KG, Weldesamuel GT, Westerman R, Wiysonge CS, Wondafrash DZ, Woyczynski L, Wu AM, Xu G, Yadegar A, Yamada T, Yazdi-Feyzabadi V, Yilgwan CS, Yip P, Yonemoto N, Lebni JY, Younis MZ, Yousefifard M, Yousof HSA, Yu C, Yusefzadeh H, Zabeh E, Moghadam TZ, Bin Zaman S, Zamani M, Zandian H, Zangeneh A, Zerfu TA, Zhang Y, Ziapour A, Zodpey S, Murray CJL, Hay SI
Nature 2019 Oct;574(7778):353-358. Epub 2019 Oct 16 doi: 10.1038/s41586-019-1545-0. PMID: 31619795Free PMC Article
White C, Franco-Paredes C
Clin Microbiol Rev 2015 Jan;28(1):80-94. doi: 10.1128/CMR.00079-13. PMID: 25567223Free PMC Article

Clinical prediction guides

Malhotra KP, Husain N
Indian J Pathol Microbiol 2022 May;65(Supplement):S300-S309. doi: 10.4103/ijpm.ijpm_1083_21. PMID: 35562162
Makhakhe L
S Afr Fam Pract (2004) 2021 Oct 29;63(1):e1-e6. doi: 10.4102/safp.v63i1.5311. PMID: 34797098Free PMC Article
Ayatollahi A, Gholami J, Saberi M, Hosseini H, Firooz A
Lasers Med Sci 2020 Jul;35(5):1007-1024. Epub 2020 Feb 5 doi: 10.1007/s10103-020-02957-9. PMID: 32026164
Robertson J
Bull Hist Med 2018;92(2):261-286. doi: 10.1353/bhm.2018.0027. PMID: 29961715
Lockwood DNj
BMJ Clin Evid 2007 Apr 1;2007 PMID: 19454067Free PMC Article

Recent systematic reviews

Li X, Li G, Yang J, Jin G, Shao Y, Li Y, Wei P, Zhang L
Int J Mol Sci 2022 Oct 18;23(20) doi: 10.3390/ijms232012443. PMID: 36293307Free PMC Article
Ploemacher T, Faber WR, Menke H, Rutten V, Pieters T
PLoS Negl Trop Dis 2020 Apr;14(4):e0008276. Epub 2020 Apr 27 doi: 10.1371/journal.pntd.0008276. PMID: 32339201Free PMC Article
Ayatollahi A, Gholami J, Saberi M, Hosseini H, Firooz A
Lasers Med Sci 2020 Jul;35(5):1007-1024. Epub 2020 Feb 5 doi: 10.1007/s10103-020-02957-9. PMID: 32026164
Hesseler MJ, Shyam N
J Am Acad Dermatol 2019 Sep;81(3):834-846. Epub 2019 Apr 19 doi: 10.1016/j.jaad.2019.04.037. PMID: 31009668
Lockwood DNj
BMJ Clin Evid 2007 Apr 1;2007 PMID: 19454067Free PMC Article

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