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Leprosy

MedGen UID:
6049
Concept ID:
C0023343
Disease or Syndrome
Synonym: Hansen's disease
SNOMED CT: Leprosy (81004002); Hansen's disease (81004002); Infection due to Mycobacterium leprae (81004002); Mycobacterium leprae infection (81004002)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
 
Monarch Initiative: MONDO:0005124
Orphanet: ORPHA548

Definition

A chronic infectious disease affecting primarily the skin and peripheral nervous system. [from ORDO]

Professional guidelines

PubMed

Maymone MBC, Venkatesh S, Laughter M, Abdat R, Hugh J, Dacso MM, Rao PN, Stryjewska BM, Dunnick CA, Dellavalle RP
J Am Acad Dermatol 2020 Jul;83(1):17-30. Epub 2020 Mar 31 doi: 10.1016/j.jaad.2019.10.138. PMID: 32244016
Alemu Belachew W, Naafs B
J Eur Acad Dermatol Venereol 2019 Jul;33(7):1205-1213. Epub 2019 Apr 3 doi: 10.1111/jdv.15569. PMID: 30945360
Saleem MD, Oussedik E, Picardo M, Schoch JJ
J Am Acad Dermatol 2019 May;80(5):1233-1250.e10. Epub 2018 Sep 17 doi: 10.1016/j.jaad.2018.07.070. PMID: 30236514

Recent clinical studies

Etiology

Froes LAR Junior, Sotto MN, Trindade MAB
An Bras Dermatol 2022 May-Jun;97(3):338-347. Epub 2022 Apr 2 doi: 10.1016/j.abd.2021.08.006. PMID: 35379512Free PMC Article
Tomaselli PJ, Dos Santos DF, Dos Santos ACJ, Antunes DE, Marques VD, Foss NT, Moreira CL, Nogueira PTB, Nascimento OJM, Neder L, Barreira AA, Frade MA, Goulart IMB, Marques W
Brain 2022 May 24;145(4):1499-1506. doi: 10.1093/brain/awab396. PMID: 34664630
Froes LAR Jr, Trindade MAB, Sotto MN
Int Rev Immunol 2022;41(2):72-83. Epub 2020 Nov 26 doi: 10.1080/08830185.2020.1851370. PMID: 33241709
Beldarraín-Chaple E
MEDICC Rev 2017 Jan;19(1):23-30. doi: 10.37757/MR2017.V19.N1.5. PMID: 28225542
Virmond M, Grzybowski A
Clin Dermatol 2015 Jan-Feb;33(1):1-2. doi: 10.1016/j.clindermatol.2014.10.002. PMID: 25432804

Diagnosis

Neema S, Battula S
N Engl J Med 2022 Sep 29;387(13):1217. doi: 10.1056/NEJMicm2202533. PMID: 36170503
Gómez-Cerquera JM, Herrera-Darias S, Domingo-Amela A, Graells-Estrada J
Med Clin (Barc) 2022 Dec 9;159(11):556. Epub 2022 Sep 16 doi: 10.1016/j.medcli.2022.07.015. PMID: 36116975
Makhakhe L
S Afr Fam Pract (2004) 2021 Oct 29;63(1):e1-e6. doi: 10.4102/safp.v63i1.5311. PMID: 34797098Free PMC Article
Khadilkar SV, Patil SB, Shetty VP
J Neurol Sci 2021 Jan 15;420:117288. Epub 2020 Dec 25 doi: 10.1016/j.jns.2020.117288. PMID: 33360424
Grzybowski A, Nita M
Clin Dermatol 2016 Jan-Feb;34(1):3-7. Epub 2015 Nov 17 doi: 10.1016/j.clindermatol.2015.10.003. PMID: 26773616

Therapy

Sardana K, Sachdeva S
J Cosmet Dermatol 2022 Jan;21(1):85-98. Epub 2021 Sep 26 doi: 10.1111/jocd.14436. PMID: 34564936
Van Der Werf TS, Barogui YT, Converse PJ, Phillips RO, Stienstra Y
Expert Rev Clin Pharmacol 2020 Apr;13(4):391-401. Epub 2020 Apr 20 doi: 10.1080/17512433.2020.1752663. PMID: 32310683Free PMC Article
Palit A, Kar HK
Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):115-123. doi: 10.4103/ijdvl.IJDVL_326_19. PMID: 31975697
O'Donnell MR, Padayatchi N, Metcalfe JZ
Int J Tuberc Lung Dis 2016 Dec 1;20(12):52-57. doi: 10.5588/ijtld.16.0073. PMID: 28240574
Gurfinkel P, Pina JC, Ramos-e-Silva M
J Drugs Dermatol 2009 Sep;8(9):846-51. PMID: 19746677

Prognosis

Chakaya J, Petersen E, Nantanda R, Mungai BN, Migliori GB, Amanullah F, Lungu P, Ntoumi F, Kumarasamy N, Maeurer M, Zumla A
Int J Infect Dis 2022 Nov;124 Suppl 1:S26-S29. Epub 2022 Mar 20 doi: 10.1016/j.ijid.2022.03.011. PMID: 35321845Free PMC Article
Maymone MBC, Laughter M, Venkatesh S, Dacso MM, Rao PN, Stryjewska BM, Hugh J, Dellavalle RP, Dunnick CA
J Am Acad Dermatol 2020 Jul;83(1):1-14. Epub 2020 Mar 27 doi: 10.1016/j.jaad.2019.12.080. PMID: 32229279
Mushtaq S
G Ital Dermatol Venereol 2020 Jun;155(3):269-279. Epub 2019 Apr 23 doi: 10.23736/S0392-0488.19.06249-7. PMID: 31042852
Burstein R, Henry NJ, Collison ML, Marczak LB, Sligar A, Watson S, Marquez N, Abbasalizad-Farhangi M, Abbasi M, Abd-Allah F, Abdoli A, Abdollahi M, Abdollahpour I, Abdulkader RS, Abrigo MRM, Acharya D, Adebayo OM, Adekanmbi V, Adham D, Afshari M, Aghaali M, Ahmadi K, Ahmadi M, Ahmadpour E, Ahmed R, Akal CG, Akinyemi JO, Alahdab F, Alam N, Alamene GM, Alene KA, Alijanzadeh M, Alinia C, Alipour V, Aljunid SM, Almalki MJ, Al-Mekhlafi HM, Altirkawi K, Alvis-Guzman N, Amegah AK, Amini S, Amit AML, Anbari Z, Androudi S, Anjomshoa M, Ansari F, Antonio CAT, Arabloo J, Arefi Z, Aremu O, Armoon B, Arora A, Artaman A, Asadi A, Asadi-Aliabadi M, Ashraf-Ganjouei A, Assadi R, Ataeinia B, Atre SR, Quintanilla BPA, Ayanore MA, Azari S, Babaee E, Babazadeh A, Badawi A, Bagheri S, Bagherzadeh M, Baheiraei N, Balouchi A, Barac A, Bassat Q, Baune BT, Bayati M, Bedi N, Beghi E, Behzadifar M, Behzadifar M, Belay YB, Bell B, Bell ML, Berbada DA, Bernstein RS, Bhattacharjee NV, Bhattarai S, Bhutta ZA, Bijani A, Bohlouli S, Breitborde NJK, Britton G, Browne AJ, Nagaraja SB, Busse R, Butt ZA, Car J, Cárdenas R, Castañeda-Orjuela CA, Cerin E, Chanie WF, Chatterjee P, Chu DT, Cooper C, Costa VM, Dalal K, Dandona L, Dandona R, Daoud F, Daryani A, Das Gupta R, Davis I, Davis Weaver N, Davitoiu DV, De Neve JW, Demeke FM, Demoz GT, Deribe K, Desai R, Deshpande A, Desyibelew HD, Dey S, Dharmaratne SD, Dhimal M, Diaz D, Doshmangir L, Duraes AR, Dwyer-Lindgren L, Earl L, Ebrahimi R, Ebrahimpour S, Effiong A, Eftekhari A, Ehsani-Chimeh E, El Sayed I, El Sayed Zaki M, El Tantawi M, El-Khatib Z, Emamian MH, Enany S, Eskandarieh S, Eyawo O, Ezalarab M, Faramarzi M, Fareed M, Faridnia R, Faro A, Fazaeli AA, Fazlzadeh M, Fentahun N, Fereshtehnejad SM, Fernandes JC, Filip I, Fischer F, Foigt NA, Foroutan M, Francis JM, Fukumoto T, Fullman N, Gallus S, Gebre DG, Gebrehiwot TT, Gebremeskel GG, Gessner BD, Geta B, Gething PW, Ghadimi R, Ghadiri K, Ghajarzadeh M, Ghashghaee A, Gill PS, Gill TK, Golding N, Gomes NGM, Gona PN, Gopalani SV, Gorini G, Goulart BNG, Graetz N, Greaves F, Green MS, Guo Y, Haj-Mirzaian A, Haj-Mirzaian A, Hall BJ, Hamidi S, Haririan H, Haro JM, Hasankhani M, Hasanpoor E, Hasanzadeh A, Hassankhani H, Hassen HY, Hegazy MI, Hendrie D, Heydarpour F, Hird TR, Hoang CL, Hollerich G, Rad EH, Hoseini-Ghahfarokhi M, Hossain N, Hosseini M, Hosseinzadeh M, Hostiuc M, Hostiuc S, Househ M, Hsairi M, Ilesanmi OS, Imani-Nasab MH, Iqbal U, Irvani SSN, Islam N, Islam SMS, Jürisson M, Balalami NJ, Jalali A, Javidnia J, Jayatilleke AU, Jenabi E, Ji JS, Jobanputra YB, Johnson K, Jonas JB, Shushtari ZJ, Jozwiak JJ, Kabir A, Kahsay A, Kalani H, Kalhor R, Karami M, Karki S, Kasaeian A, Kassebaum NJ, Keiyoro PN, Kemp GR, Khabiri R, Khader YS, Khafaie MA, Khan EA, Khan J, Khan MS, Khang YH, Khatab K, Khater A, Khater MM, Khatony A, Khazaei M, Khazaei S, Khazaei-Pool M, Khubchandani J, Kianipour N, Kim YJ, Kimokoti RW, Kinyoki DK, Kisa A, Kisa S, Kolola T, Kosen S, Koul PA, Koyanagi A, Kraemer MUG, Krishan K, Krohn KJ, Kugbey N, Kumar GA, Kumar M, Kumar P, Kuupiel D, Lacey B, Lad SD, Lami FH, Larsson AO, Lee PH, Leili M, Levine AJ, Li S, Lim LL, Listl S, Longbottom J, Lopez JCF, Lorkowski S, Magdeldin S, Abd El Razek HM, Abd El Razek MM, Majeed A, Maleki A, Malekzadeh R, Malta DC, Mamun AA, Manafi N, Manda AL, Mansourian M, Martins-Melo FR, Masaka A, Massenburg BB, Maulik PK, Mayala BK, Mazidi M, McKee M, Mehrotra R, Mehta KM, Meles GG, Mendoza W, Menezes RG, Meretoja A, Meretoja TJ, Mestrovic T, Miller TR, Miller-Petrie MK, Mills EJ, Milne GJ, Mini GK, Mir SM, Mirjalali H, Mirrakhimov EM, Mohamadi E, Mohammad DK, Darwesh AM, Mezerji NMG, Mohammed AS, Mohammed S, Mokdad AH, Molokhia M, Monasta L, Moodley Y, Moosazadeh M, Moradi G, Moradi M, Moradi Y, Moradi-Lakeh M, Moradinazar M, Moraga P, Morawska L, Mosapour A, Mousavi SM, Mueller UO, Muluneh AG, Mustafa G, Nabavizadeh B, Naderi M, Nagarajan AJ, Nahvijou A, Najafi F, Nangia V, Ndwandwe DE, Neamati N, Negoi I, Negoi RI, Ngunjiri JW, Thi Nguyen HL, Nguyen LH, Nguyen SH, Nielsen KR, Ningrum DNA, Nirayo YL, Nixon MR, Nnaji CA, Nojomi M, Noroozi M, Nosratnejad S, Noubiap JJ, Motlagh SN, Ofori-Asenso R, Ogbo FA, Oladimeji KE, Olagunju AT, Olfatifar M, Olum S, Olusanya BO, Oluwasanu MM, Onwujekwe OE, Oren E, Ortega-Altamirano DDV, Ortiz A, Osarenotor O, Osei FB, Osgood-Zimmerman AE, Otstavnov SS, Owolabi MO, P A M, Pagheh AS, Pakhale S, Panda-Jonas S, Pandey A, Park EK, Parsian H, Pashaei T, Patel SK, Pepito VCF, Pereira A, Perkins S, Pickering BV, Pilgrim T, Pirestani M, Piroozi B, Pirsaheb M, Plana-Ripoll O, Pourjafar H, Puri P, Qorbani M, Quintana H, Rabiee M, Rabiee N, Radfar A, Rafiei A, Rahim F, Rahimi Z, Rahimi-Movaghar V, Rahimzadeh S, Rajati F, Raju SB, Ramezankhani A, Ranabhat CL, Rasella D, Rashedi V, Rawal L, Reiner RC Jr, Renzaho AMN, Rezaei S, Rezapour A, Riahi SM, Ribeiro AI, Roever L, Roro EM, Roser M, Roshandel G, Roshani D, Rostami A, Rubagotti E, Rubino S, Sabour S, Sadat N, Sadeghi E, Saeedi R, Safari Y, Safari-Faramani R, Safdarian M, Sahebkar A, Salahshoor MR, Salam N, Salamati P, Salehi F, Zahabi SS, Salimi Y, Salimzadeh H, Salomon JA, Sambala EZ, Samy AM, Santric Milicevic MM, Jose BPS, Saraswathy SYI, Sarmiento-Suárez R, Sartorius B, Sathian B, Saxena S, Sbarra AN, Schaeffer LE, Schwebel DC, Sepanlou SG, Seyedmousavi S, Shaahmadi F, Shaikh MA, Shams-Beyranvand M, Shamshirian A, Shamsizadeh M, Sharafi K, Sharif M, Sharif-Alhoseini M, Sharifi H, Sharma J, Sharma R, Sheikh A, Shields C, Shigematsu M, Shiri R, Shiue I, Shuval K, Siddiqi TJ, Silva JP, Singh JA, Sinha DN, Sisay MM, Sisay S, Sliwa K, Smith DL, Somayaji R, Soofi M, Soriano JB, Sreeramareddy CT, Sudaryanto A, Sufiyan MB, Sykes BL, Sylaja PN, Tabarés-Seisdedos R, Tabb KM, Tabuchi T, Taveira N, Temsah MH, Terkawi AS, Tessema ZT, Thankappan KR, Thirunavukkarasu S, To QG, Tovani-Palone MR, Tran BX, Tran KB, Ullah I, Usman MS, Uthman OA, Vahedian-Azimi A, Valdez PR, van Boven JFM, Vasankari TJ, Vasseghian Y, Veisani Y, Venketasubramanian N, Violante FS, Vladimirov SK, Vlassov V, Vos T, Vu GT, Vujcic IS, Waheed Y, Wakefield J, Wang H, Wang Y, Wang YP, Ward JL, Weintraub RG, Weldegwergs KG, Weldesamuel GT, Westerman R, Wiysonge CS, Wondafrash DZ, Woyczynski L, Wu AM, Xu G, Yadegar A, Yamada T, Yazdi-Feyzabadi V, Yilgwan CS, Yip P, Yonemoto N, Lebni JY, Younis MZ, Yousefifard M, Yousof HSA, Yu C, Yusefzadeh H, Zabeh E, Moghadam TZ, Bin Zaman S, Zamani M, Zandian H, Zangeneh A, Zerfu TA, Zhang Y, Ziapour A, Zodpey S, Murray CJL, Hay SI
Nature 2019 Oct;574(7778):353-358. Epub 2019 Oct 16 doi: 10.1038/s41586-019-1545-0. PMID: 31619795Free PMC Article
White C, Franco-Paredes C
Clin Microbiol Rev 2015 Jan;28(1):80-94. doi: 10.1128/CMR.00079-13. PMID: 25567223Free PMC Article

Clinical prediction guides

Malhotra KP, Husain N
Indian J Pathol Microbiol 2022 May;65(Supplement):S300-S309. doi: 10.4103/ijpm.ijpm_1083_21. PMID: 35562162
Makhakhe L
S Afr Fam Pract (2004) 2021 Oct 29;63(1):e1-e6. doi: 10.4102/safp.v63i1.5311. PMID: 34797098Free PMC Article
Barcelos RMFM, Sousa GS, Almeida MV, Palacio FGL, Gaíva MAM, Ferreira SMB
Rev Esc Enferm USP 2021;55:e20200357. Epub 2021 Sep 6 doi: 10.1590/1980-220X-REEUSP-2020-0357. PMID: 34495209
Ayatollahi A, Gholami J, Saberi M, Hosseini H, Firooz A
Lasers Med Sci 2020 Jul;35(5):1007-1024. Epub 2020 Feb 5 doi: 10.1007/s10103-020-02957-9. PMID: 32026164
Silva CAM, Belisle JT
Front Immunol 2018;9:134. Epub 2018 Feb 2 doi: 10.3389/fimmu.2018.00134. PMID: 29472920Free PMC Article

Recent systematic reviews

Govindasamy K, Darlong J, Watson SI, Gill P
J Foot Ankle Res 2023 Nov 13;16(1):77. doi: 10.1186/s13047-023-00674-4. PMID: 37953361Free PMC Article
Li X, Li G, Yang J, Jin G, Shao Y, Li Y, Wei P, Zhang L
Int J Mol Sci 2022 Oct 18;23(20) doi: 10.3390/ijms232012443. PMID: 36293307Free PMC Article
Ayatollahi A, Gholami J, Saberi M, Hosseini H, Firooz A
Lasers Med Sci 2020 Jul;35(5):1007-1024. Epub 2020 Feb 5 doi: 10.1007/s10103-020-02957-9. PMID: 32026164
Hesseler MJ, Shyam N
J Am Acad Dermatol 2019 Sep;81(3):834-846. Epub 2019 Apr 19 doi: 10.1016/j.jaad.2019.04.037. PMID: 31009668
Garbino JA, Marques W Jr, Barreto JA, Heise CO, Rodrigues MM, Antunes SL, Soares CT, Floriano MC, Nery JA, Trindade MA, Carvalho NB, Andrada NC, Barreira AA, Virmond Mda C
Arq Neuropsiquiatr 2013 Jun;71(6):397-404. doi: 10.1590/0004-282X20130046. PMID: 23828524

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