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Lymphomatoid papulosis

MedGen UID:
61534
•Concept ID:
C0206182
•
Neoplastic Process
Synonym: LyP
SNOMED CT: Lymphomatoid papulosis (397353001); Lymphomatoid papulosis (31047003)
 
Monarch Initiative: MONDO:0020326
Orphanet: ORPHA98842

Definition

Lymphomatoid papulosis (LyP) is a rare cutaneous condition characterized by chronic, recurrent, and self-regressing papulonodular skin eruptions. It belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders, along with primary cutaneous anaplastic large cell lymphoma (primary C-ALCL; see this term) with which it shares overlapping clinical and histopathologic features. [from ORDO]

Professional guidelines

PubMed

A Practical Guide to the Diagnosis, Evaluation, and Treatment of Cutaneous T-Cell Lymphoma.
Shimshak S, Sokumbi O, Isaq N, Goyal A, Comfere N
Dermatol Clin 2023 Jan;41(1):209-229. doi: 10.1016/j.det.2022.07.019. PMID: 36410979
Lymphomatoid papulosis during upadaci-tinib treatment for rheumatoid arthritis.
Iinuma S, Hayashi K, Noguchi A, Ishida-Yamamoto A
Eur J Dermatol 2022 Jan 1;32(1):142-143. doi: 10.1684/ejd.2022.4238. PMID: 35653095Free PMC Article
Diagnosis and Management of Cutaneous Lymphomas Including Cutaneous T-cell Lymphoma.
Zic JA
Med Clin North Am 2021 Jul;105(4):737-755. doi: 10.1016/j.mcna.2021.04.010. PMID: 34059248

Recent clinical studies

Etiology

Cutaneous T-cell Lymphoma.
Weiner DM, Rook AH
Hematol Oncol Clin North Am 2024 Oct;38(5):1087-1110. Epub 2024 Jul 29 doi: 10.1016/j.hoc.2024.05.012. PMID: 39079789
Primary cutaneous T-cell lymphoma: a review of the most common entities with focus on recent updates.
Saleh JS, Subtil A, Hristov AC
Hum Pathol 2023 Oct;140:75-100. Epub 2023 Oct 4 doi: 10.1016/j.humpath.2023.09.009. PMID: 37802757
Lymphomatoid papulosis: an update and review.
Martinez-Cabriales SA, Walsh S, Sade S, Shear NH
J Eur Acad Dermatol Venereol 2020 Jan;34(1):59-73. Epub 2019 Oct 14 doi: 10.1111/jdv.15931. PMID: 31494989
The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas.
Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH, Jaffe ES
Blood 2019 Apr 18;133(16):1703-1714. Epub 2019 Jan 11 doi: 10.1182/blood-2018-11-881268. PMID: 30635287Free PMC Article
Cutaneous T-cell Lymphoma.
Pulitzer M
Clin Lab Med 2017 Sep;37(3):527-546. doi: 10.1016/j.cll.2017.06.006. PMID: 28802499Free PMC Article

Diagnosis

Lymphomatoid Papulosis.
Killoran E, Mehta-Shah N, Musiek A
JAMA Dermatol 2020 Mar 1;156(3):360. doi: 10.1001/jamadermatol.2019.4513. PMID: 31995140
Lymphomatoid papulosis.
Sica A, Vitiello P, Sorriento A, Ronchi A, Calogero A, Sagnelli C, Troiani T, Fasano M, Dodaro CA, Franco R, Casale B, Santangelo M, Ciccozzi M, Ciardiello F, Argenziano G, Moscarella E
Minerva Med 2020 Apr;111(2):166-172. Epub 2020 Jan 20 doi: 10.23736/S0026-4806.19.06395-X. PMID: 31958921
Lymphomatoid papulosis: an update and review.
Martinez-Cabriales SA, Walsh S, Sade S, Shear NH
J Eur Acad Dermatol Venereol 2020 Jan;34(1):59-73. Epub 2019 Oct 14 doi: 10.1111/jdv.15931. PMID: 31494989
The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas.
Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH, Jaffe ES
Blood 2019 Apr 18;133(16):1703-1714. Epub 2019 Jan 11 doi: 10.1182/blood-2018-11-881268. PMID: 30635287Free PMC Article
Cutaneous T-cell Lymphoma.
Pulitzer M
Clin Lab Med 2017 Sep;37(3):527-546. doi: 10.1016/j.cll.2017.06.006. PMID: 28802499Free PMC Article

Therapy

Histopathological Markers for Target Therapies in Primary Cutaneous Lymphomas.
Sonego B, Ibatici A, Rivoli G, Angelucci E, Sola S, Massone C
Cells 2023 Nov 20;12(22) doi: 10.3390/cells12222656. PMID: 37998391Free PMC Article
Topical methotrexate in dermatology: a review of the literature.
Aickara D, Bashyam AM, Pichardo RO, Feldman SR
J Dermatolog Treat 2022 Feb;33(1):512-517. Epub 2020 May 25 doi: 10.1080/09546634.2020.1770170. PMID: 32412810
Lymphomatoid Papulosis and Other Lymphoma-Like Diseases.
Moy A, Sun J, Ma S, Seminario-Vidal L
Dermatol Clin 2019 Oct;37(4):471-482. Epub 2019 Aug 6 doi: 10.1016/j.det.2019.05.005. PMID: 31466587
Lymphomatoid papulosis.
Wiznia LE, Cohen JM, Beasley JM, Meehan SA, Latkowski JM
Dermatol Online J 2018 Dec 15;24(12) PMID: 30677799
Phototherapy of cutaneous T-cell lymphomas.
Trautinger F
Photochem Photobiol Sci 2018 Dec 5;17(12):1904-1912. doi: 10.1039/c8pp00170g. PMID: 30325389

Prognosis

Primary cutaneous T-cell lymphoma: a review of the most common entities with focus on recent updates.
Saleh JS, Subtil A, Hristov AC
Hum Pathol 2023 Oct;140:75-100. Epub 2023 Oct 4 doi: 10.1016/j.humpath.2023.09.009. PMID: 37802757
Lymphomatoid papulosis.
Wagner G, Rose C, Klapper W, Sachse MM
J Dtsch Dermatol Ges 2020 Mar;18(3):199-205. Epub 2020 Feb 26 doi: 10.1111/ddg.14041. PMID: 32100965
Lymphomatoid papulosis.
Sica A, Vitiello P, Sorriento A, Ronchi A, Calogero A, Sagnelli C, Troiani T, Fasano M, Dodaro CA, Franco R, Casale B, Santangelo M, Ciccozzi M, Ciardiello F, Argenziano G, Moscarella E
Minerva Med 2020 Apr;111(2):166-172. Epub 2020 Jan 20 doi: 10.23736/S0026-4806.19.06395-X. PMID: 31958921
Lymphomatoid papulosis: an update and review.
Martinez-Cabriales SA, Walsh S, Sade S, Shear NH
J Eur Acad Dermatol Venereol 2020 Jan;34(1):59-73. Epub 2019 Oct 14 doi: 10.1111/jdv.15931. PMID: 31494989
The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas.
Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH, Jaffe ES
Blood 2019 Apr 18;133(16):1703-1714. Epub 2019 Jan 11 doi: 10.1182/blood-2018-11-881268. PMID: 30635287Free PMC Article

Clinical prediction guides

Epstein-Barr Virus-Associated Lymphomatoid Papules: A Sign of Immunosuppression Resembling Lymphomatoid Papulosis.
Hooper MJ, Lee WJ, LeWitt TM, Nguyen C, Griffin T, Chung C, Zhou XA, Guitart J
Am J Dermatopathol 2023 Dec 1;45(12):789-800. doi: 10.1097/DAD.0000000000002479. PMID: 37982462Free PMC Article
Primary Cutaneous CD30+ Lymphoproliferative Disorders: a Comprehensive Review.
Di Raimondo C, Parekh V, Song JY, Rosen ST, Querfeld C, Zain J, Martinez XU, Abdulla FR
Curr Hematol Malig Rep 2020 Aug;15(4):333-342. doi: 10.1007/s11899-020-00583-4. PMID: 32435988
Lymphomatoid Papulosis and Other Lymphoma-Like Diseases.
Moy A, Sun J, Ma S, Seminario-Vidal L
Dermatol Clin 2019 Oct;37(4):471-482. Epub 2019 Aug 6 doi: 10.1016/j.det.2019.05.005. PMID: 31466587
CD30+ T-cell lymphoproliferative disorders.
Martin JM, Wu H, Barta SK
Chin Clin Oncol 2019 Feb;8(1):4. Epub 2018 Oct 11 doi: 10.21037/cco.2018.09.06. PMID: 30525751
Aggressive cutaneous T-cell lymphomas.
Junkins-Hopkins Md JM
Semin Diagn Pathol 2017 Jan;34(1):44-59. Epub 2016 Dec 24 doi: 10.1053/j.semdp.2016.11.004. PMID: 28187925

Recent systematic reviews

Pediatric cellular neurothekeoma: Seven cases and systematic review of the literature.
Murphrey M, Huy Nguyen A, White KP, Krol A, Bernert R, Yarbrough K
Pediatr Dermatol 2020 Mar;37(2):320-325. Epub 2020 Jan 12 doi: 10.1111/pde.14043. PMID: 31930561
Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review.
Wieser I, Wohlmuth C, Nunez CA, Duvic M
Am J Clin Dermatol 2016 Aug;17(4):319-27. doi: 10.1007/s40257-016-0192-6. PMID: 27138554
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma.
Kempf W, Pfaltz K, Vermeer MH, Cozzio A, Ortiz-Romero PL, Bagot M, Olsen E, Kim YH, Dummer R, Pimpinelli N, Whittaker S, Hodak E, Cerroni L, Berti E, Horwitz S, Prince HM, Guitart J, Estrach T, Sanches JA, Duvic M, Ranki A, Dreno B, Ostheeren-Michaelis S, Knobler R, Wood G, Willemze R
Blood 2011 Oct 13;118(15):4024-35. Epub 2011 Aug 12 doi: 10.1182/blood-2011-05-351346. PMID: 21841159Free PMC Article

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