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Cutaneous Mature T-Cell and NK-Cell Neoplasm

MedGen UID:
317556
•Concept ID:
C1707552
•
Neoplastic Process

Definition

A group of neoplasms composed of T-lymphocytes with a mature (peripheral/post-thymic) immunophenotypic profile and/or NK-cells affecting the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Mature T-Cell and NK-Cell Neoplasm

Professional guidelines

PubMed

Treatment algorithms for mature T-cell and natural killer-cell neoplasms.
Tse E, Kwong YL
Future Oncol 2011 Sep;7(9):1101-12. doi: 10.2217/fon.11.84. PMID: 21919697
Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma).
Dearden CE, Johnson R, Pettengell R, Devereux S, Cwynarski K, Whittaker S, McMillan A; British Committee for Standards in Haematology
Br J Haematol 2011 May;153(4):451-85. Epub 2011 Apr 11 doi: 10.1111/j.1365-2141.2011.08651.x. PMID: 21480860
Classification and treatment of rare and aggressive types of peripheral T-cell/natural killer-cell lymphomas of the skin.
Rezania D, Sokol L, Cualing HD
Cancer Control 2007 Apr;14(2):112-23. doi: 10.1177/107327480701400204. PMID: 17387296

Recent clinical studies

Etiology

Transplantation.
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223
Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.
Pillai V, Tallarico M, Bishop MR, Lim MS
Br J Haematol 2016 May;173(4):573-81. Epub 2016 Mar 15 doi: 10.1111/bjh.14044. PMID: 26992145
Allogeneic transplantation in T-cell lymphomas.
Schmitz N, Wu HS, Glass B
Semin Hematol 2014 Jan;51(1):67-72. Epub 2013 Nov 28 doi: 10.1053/j.seminhematol.2013.11.010. PMID: 24468318
Treatment algorithms for mature T-cell and natural killer-cell neoplasms.
Tse E, Kwong YL
Future Oncol 2011 Sep;7(9):1101-12. doi: 10.2217/fon.11.84. PMID: 21919697
Classification of T-cell and NK-cell neoplasms based on the REAL classification.
Jaffe ES, Krenacs L, Raffeld M
Ann Oncol 1997;8 Suppl 2:17-24. PMID: 9209634

Diagnosis

Mature (non-anaplastic, non-cutaneous) T-/NK-cell lymphomas in children, adolescents and young adults: state of the science.
Flower A, Xavier AC, Cairo MS
Br J Haematol 2019 May;185(3):418-435. Epub 2019 Feb 1 doi: 10.1111/bjh.15767. PMID: 30706450
Transplantation.
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223
Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.
Pillai V, Tallarico M, Bishop MR, Lim MS
Br J Haematol 2016 May;173(4):573-81. Epub 2016 Mar 15 doi: 10.1111/bjh.14044. PMID: 26992145
Treatment algorithms for mature T-cell and natural killer-cell neoplasms.
Tse E, Kwong YL
Future Oncol 2011 Sep;7(9):1101-12. doi: 10.2217/fon.11.84. PMID: 21919697
Pathology and biology of peripheral T-cell lymphomas.
de Leval L, Gaulard P
Histopathology 2011 Jan;58(1):49-68. doi: 10.1111/j.1365-2559.2010.03704.x. PMID: 21261683

Therapy

Mature (non-anaplastic, non-cutaneous) T-/NK-cell lymphomas in children, adolescents and young adults: state of the science.
Flower A, Xavier AC, Cairo MS
Br J Haematol 2019 May;185(3):418-435. Epub 2019 Feb 1 doi: 10.1111/bjh.15767. PMID: 30706450
Transplantation.
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223
Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.
Pillai V, Tallarico M, Bishop MR, Lim MS
Br J Haematol 2016 May;173(4):573-81. Epub 2016 Mar 15 doi: 10.1111/bjh.14044. PMID: 26992145
Treatment algorithms for mature T-cell and natural killer-cell neoplasms.
Tse E, Kwong YL
Future Oncol 2011 Sep;7(9):1101-12. doi: 10.2217/fon.11.84. PMID: 21919697
Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma).
Dearden CE, Johnson R, Pettengell R, Devereux S, Cwynarski K, Whittaker S, McMillan A; British Committee for Standards in Haematology
Br J Haematol 2011 May;153(4):451-85. Epub 2011 Apr 11 doi: 10.1111/j.1365-2141.2011.08651.x. PMID: 21480860

Prognosis

Mature (non-anaplastic, non-cutaneous) T-/NK-cell lymphomas in children, adolescents and young adults: state of the science.
Flower A, Xavier AC, Cairo MS
Br J Haematol 2019 May;185(3):418-435. Epub 2019 Feb 1 doi: 10.1111/bjh.15767. PMID: 30706450
The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms.
Matutes E
Int J Lab Hematol 2018 May;40 Suppl 1:97-103. doi: 10.1111/ijlh.12817. PMID: 29741263
Allogeneic transplantation in T-cell lymphomas.
Schmitz N, Wu HS, Glass B
Semin Hematol 2014 Jan;51(1):67-72. Epub 2013 Nov 28 doi: 10.1053/j.seminhematol.2013.11.010. PMID: 24468318
Treatment algorithms for mature T-cell and natural killer-cell neoplasms.
Tse E, Kwong YL
Future Oncol 2011 Sep;7(9):1101-12. doi: 10.2217/fon.11.84. PMID: 21919697
Classification of T-cell and NK-cell neoplasms based on the REAL classification.
Jaffe ES, Krenacs L, Raffeld M
Ann Oncol 1997;8 Suppl 2:17-24. PMID: 9209634

Clinical prediction guides

Treating relapsed/refractory mature T- and NK-cell neoplasms with tislelizumab: a multicenter open-label phase 2 study.
Bachy E, Savage KJ, Huang H, Kwong YL, Gritti G, Zhang Q, Liberati AM, Cao J, Yang H, Hao S, Hu J, Zhou K, Petrini M, Russo F, Zhang H, Sang W, Ji J, Ferreri AJM, Damaj GL, Liu H, Zhang W, Ke X, Ghiggi C, Huang S, Li X, Yao H, Paik J, Novotny W, Zhou W, Zhu H, Zinzani PL
Blood Adv 2023 Aug 22;7(16):4435-4447. doi: 10.1182/bloodadvances.2022009575. PMID: 37276067Free PMC Article
Cutaneous lymphoma in Japan, 2012-2017: A nationwide study.
Fujii K, Hamada T, Shimauchi T, Asai J, Fujisawa Y, Ihn H, Katoh N
J Dermatol Sci 2020 Mar;97(3):187-193. Epub 2020 Jan 25 doi: 10.1016/j.jdermsci.2020.01.010. PMID: 32033869
Nationwide Statistical Analysis of Lymphoid Malignancies in Korea.
Lee H, Park HJ, Park EH, Ju HY, Oh CM, Kong HJ, Jung KW, Park BK, Lee E, Eom HS, Won YJ
Cancer Res Treat 2018 Jan;50(1):222-238. Epub 2017 Mar 30 doi: 10.4143/crt.2017.093. PMID: 28361523Free PMC Article
Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma).
Dearden CE, Johnson R, Pettengell R, Devereux S, Cwynarski K, Whittaker S, McMillan A; British Committee for Standards in Haematology
Br J Haematol 2011 May;153(4):451-85. Epub 2011 Apr 11 doi: 10.1111/j.1365-2141.2011.08651.x. PMID: 21480860
Classification of T-cell and NK-cell neoplasms based on the REAL classification.
Jaffe ES, Krenacs L, Raffeld M
Ann Oncol 1997;8 Suppl 2:17-24. PMID: 9209634

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