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Gliosarcoma

MedGen UID:
64638
•Concept ID:
C0206726
•
Neoplastic Process
Synonym: Sarcomatous glioblastoma
SNOMED CT: Gliosarcoma (35262004); Glioblastoma with sarcomatous component (35262004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016681
Orphanet: ORPHA251576

Definition

A rare histological variant of glioblastoma (WHO grade IV) characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation (WHO). [from NCI]

Professional guidelines

PubMed

Primary gliosarcoma: epidemiology, clinical presentation, management, and survival.
Ma R, Alexe DM, Pereira EA
J Neurosurg Sci 2020 Aug;64(4):341-346. Epub 2017 Nov 20 doi: 10.23736/S0390-5616.17.04077-2. PMID: 29154508
Prognosis and management of gliosarcoma patients: A review of literature.
Saadeh F, El Iskandarani S, Najjar M, Assi HI
Clin Neurol Neurosurg 2019 Jul;182:98-103. Epub 2019 May 14 doi: 10.1016/j.clineuro.2019.05.008. PMID: 31112812
Therapeutic management of gliosarcoma in the temozolomide era.
McAleer MF, Brown PD
CNS Oncol 2015;4(3):171-8. Epub 2015 Apr 23 doi: 10.2217/cns.14.61. PMID: 25905568Free PMC Article

Recent clinical studies

Etiology

Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
Umemura Y, Orringer D, Junck L, Varela ML, West MEJ, Faisal SM, Comba A, Heth J, Sagher O, Leung D, Mammoser A, Hervey-Jumper S, Zamler D, Yadav VN, Dunn P, Al-Holou W, Hollon T, Kim MM, Wahl DR, Camelo-Piragua S, Lieberman AP, Venneti S, McKeever P, Lawrence T, Kurokawa R, Sagher K, Altshuler D, Zhao L, Muraszko K, Castro MG, Lowenstein PR
Lancet Oncol 2023 Sep;24(9):1042-1052. doi: 10.1016/S1470-2045(23)00347-9. PMID: 37657463
Estimated Prevalence, Tumor Spectrum, and Neurofibromatosis Type 1-Like Phenotype of CDKN2A-Related Melanoma-Astrocytoma Syndrome.
Sargen MR, Kim J, Potjer TP, Velthuizen ME, Martir-Negron AE, Odia Y, Helgadottir H, Hatton JN, Haley JS, Thone G, Widemann BC, Gross AM, Yohe ME, Kaplan RN, Shern JF, Sundby RT, Astiazaran-Symonds E, Yang XR, Carey DJ, Tucker MA, Stewart DR, Goldstein AM
JAMA Dermatol 2023 Oct 1;159(10):1112-1118. doi: 10.1001/jamadermatol.2023.2621. PMID: 37585199Free PMC Article
Clinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1.
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO
Neuro Oncol 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. PMID: 36840626Free PMC Article
Glioblastoma: Changing concepts in the WHO CNS5 classification.
Chen J, Han P, Dahiya S
Indian J Pathol Microbiol 2022 May;65(Supplement):S24-S32. doi: 10.4103/ijpm.ijpm_1109_21. PMID: 35562131
Prognosis and management of gliosarcoma patients: A review of literature.
Saadeh F, El Iskandarani S, Najjar M, Assi HI
Clin Neurol Neurosurg 2019 Jul;182:98-103. Epub 2019 May 14 doi: 10.1016/j.clineuro.2019.05.008. PMID: 31112812

Diagnosis

Clinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1.
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO
Neuro Oncol 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. PMID: 36840626Free PMC Article
Update on Circumscribed Gliomas and Glioneuronal Tumors.
Chen J, Dahiya SM
Surg Pathol Clin 2020 Jun;13(2):249-266. doi: 10.1016/j.path.2020.02.004. PMID: 32389265
Gliosarcomas: magnetic resonance imaging findings.
Fukuda A, Queiroz LS, Reis F
Arq Neuropsiquiatr 2020 Feb;78(2):112-120. doi: 10.1590/0004-282X20190158. PMID: 32022137
Biological characteristics and outcomes of Gliosarcoma.
Hashmi FA, Salim A, Shamim MS, Bari ME
J Pak Med Assoc 2018 Aug;68(8):1273-1275. PMID: 30108403
Glioblastoma.
Miller CR, Perry A
Arch Pathol Lab Med 2007 Mar;131(3):397-406. doi: 10.5858/2007-131-397-G. PMID: 17516742

Therapy

Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
Umemura Y, Orringer D, Junck L, Varela ML, West MEJ, Faisal SM, Comba A, Heth J, Sagher O, Leung D, Mammoser A, Hervey-Jumper S, Zamler D, Yadav VN, Dunn P, Al-Holou W, Hollon T, Kim MM, Wahl DR, Camelo-Piragua S, Lieberman AP, Venneti S, McKeever P, Lawrence T, Kurokawa R, Sagher K, Altshuler D, Zhao L, Muraszko K, Castro MG, Lowenstein PR
Lancet Oncol 2023 Sep;24(9):1042-1052. doi: 10.1016/S1470-2045(23)00347-9. PMID: 37657463
A Phase 3b Study for Management of Ocular Side Effects in Patients with Epidermal Growth Factor Receptor-Amplified Glioblastoma Receiving Depatuxizumab Mafodotin.
Vize CJ, Kim SK, Matthews T, Macsai M, Merrell R, Hsu S, Kundu MG, Yoon J, Kennedy E, Pai M, Bain E, Lassman AB, Moazami G
Ophthalmic Res 2023;66(1):1030-1043. Epub 2023 May 31 doi: 10.1159/000531142. PMID: 37257422Free PMC Article
Primary versus secondary gliosarcoma: a systematic review and meta-analysis.
Vuong HG, Dunn IF
J Neurooncol 2022 Aug;159(1):195-200. Epub 2022 Jun 29 doi: 10.1007/s11060-022-04057-w. PMID: 35768633
Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors.
Kim H, Lim KY, Park JW, Kang J, Won JK, Lee K, Shim Y, Park CK, Kim SK, Choi SH, Kim TM, Yun H, Park SH
Lab Invest 2022 Feb;102(2):160-171. Epub 2021 Nov 30 doi: 10.1038/s41374-021-00694-3. PMID: 34848827Free PMC Article
Therapeutic management of gliosarcoma in the temozolomide era.
McAleer MF, Brown PD
CNS Oncol 2015;4(3):171-8. Epub 2015 Apr 23 doi: 10.2217/cns.14.61. PMID: 25905568Free PMC Article

Prognosis

Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
Umemura Y, Orringer D, Junck L, Varela ML, West MEJ, Faisal SM, Comba A, Heth J, Sagher O, Leung D, Mammoser A, Hervey-Jumper S, Zamler D, Yadav VN, Dunn P, Al-Holou W, Hollon T, Kim MM, Wahl DR, Camelo-Piragua S, Lieberman AP, Venneti S, McKeever P, Lawrence T, Kurokawa R, Sagher K, Altshuler D, Zhao L, Muraszko K, Castro MG, Lowenstein PR
Lancet Oncol 2023 Sep;24(9):1042-1052. doi: 10.1016/S1470-2045(23)00347-9. PMID: 37657463
Clinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1.
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO
Neuro Oncol 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. PMID: 36840626Free PMC Article
Prognosis and management of gliosarcoma patients: A review of literature.
Saadeh F, El Iskandarani S, Najjar M, Assi HI
Clin Neurol Neurosurg 2019 Jul;182:98-103. Epub 2019 May 14 doi: 10.1016/j.clineuro.2019.05.008. PMID: 31112812
Biological characteristics and outcomes of Gliosarcoma.
Hashmi FA, Salim A, Shamim MS, Bari ME
J Pak Med Assoc 2018 Aug;68(8):1273-1275. PMID: 30108403
Glioblastoma.
Miller CR, Perry A
Arch Pathol Lab Med 2007 Mar;131(3):397-406. doi: 10.5858/2007-131-397-G. PMID: 17516742

Clinical prediction guides

TERTmonitor-qPCR Detection of TERTp Mutations in Glioma.
Brás JP, Jesus TT, Prazeres H, Lima J, Soares P, Vinagre J
Genes (Basel) 2023 Aug 25;14(9) doi: 10.3390/genes14091693. PMID: 37761833Free PMC Article
Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
Umemura Y, Orringer D, Junck L, Varela ML, West MEJ, Faisal SM, Comba A, Heth J, Sagher O, Leung D, Mammoser A, Hervey-Jumper S, Zamler D, Yadav VN, Dunn P, Al-Holou W, Hollon T, Kim MM, Wahl DR, Camelo-Piragua S, Lieberman AP, Venneti S, McKeever P, Lawrence T, Kurokawa R, Sagher K, Altshuler D, Zhao L, Muraszko K, Castro MG, Lowenstein PR
Lancet Oncol 2023 Sep;24(9):1042-1052. doi: 10.1016/S1470-2045(23)00347-9. PMID: 37657463
Demographic, radiographic, molecular and clinical characteristics of primary gliosarcoma and differences to glioblastoma.
Pierscianek D, Ahmadipour Y, Michel A, Rauschenbach L, Darkwah Oppong M, Deuschl C, Kebir S, Wrede KH, Glas M, Stuschke M, Sure U, Jabbarli R
Clin Neurol Neurosurg 2021 Jan;200:106348. Epub 2020 Nov 1 doi: 10.1016/j.clineuro.2020.106348. PMID: 33158630
Gliosarcoma: a clinical and radiological analysis of 48 cases.
Yi X, Cao H, Tang H, Gong G, Hu Z, Liao W, Sun L, Chen BT, Li X
Eur Radiol 2019 Jan;29(1):429-438. Epub 2018 Jun 12 doi: 10.1007/s00330-018-5398-y. PMID: 29948068
Clinical and molecular characteristics of gliosarcoma and modern prognostic significance relative to conventional glioblastoma.
Smith DR, Wu CC, Saadatmand HJ, Isaacson SR, Cheng SK, Sisti MB, Bruce JN, Sheth SA, Lassman AB, Iwamoto FM, Wang SH, Canoll P, McKhann GM 2nd, Wang TJC
J Neurooncol 2018 Apr;137(2):303-311. Epub 2017 Dec 20 doi: 10.1007/s11060-017-2718-z. PMID: 29264835Free PMC Article

Recent systematic reviews

Primary versus secondary gliosarcoma: a systematic review and meta-analysis.
Vuong HG, Dunn IF
J Neurooncol 2022 Aug;159(1):195-200. Epub 2022 Jun 29 doi: 10.1007/s11060-022-04057-w. PMID: 35768633
Treatments of gliosarcoma of the brain: a systematic review and meta-analysis.
Wang X, Jiang J, Liu M, You C
Acta Neurol Belg 2021 Dec;121(6):1789-1797. Epub 2020 Nov 6 doi: 10.1007/s13760-020-01533-w. PMID: 33156945
Comparative epidemiology of gliosarcoma and glioblastoma and the impact of Race on overall survival: A systematic literature review.
Gerges C, Elder T, Penuela M, Rossetti N, Maynard M, Jeong S, Wright CH, Wright J, Zhou X, Burant C, Sajatovic M, Hodges T
Clin Neurol Neurosurg 2020 Aug;195:106054. Epub 2020 Jun 29 doi: 10.1016/j.clineuro.2020.106054. PMID: 32650210
Atypical Teratoid/Rhabdoid Tumor After In Vitro Fertilization: Illustrative Case Report and Systematic Literature Review.
Bunevicius A, Matukevicius A, Deltuva V, Gudinaviciene I, Pranys D, Tamasauskas A
World Neurosurg 2018 May;113:129-134. Epub 2018 Feb 13 doi: 10.1016/j.wneu.2018.02.012. PMID: 29452330
A Systematic Review on the Characteristics, Treatments and Outcomes of the Patients with Primary Spinal Glioblastomas or Gliosarcomas Reported in Literature until March 2015.
Beyer S, von Bueren AO, Klautke G, Guckenberger M, Kortmann RD, Pietschmann S, Müller K
PLoS One 2016;11(2):e0148312. Epub 2016 Feb 9 doi: 10.1371/journal.pone.0148312. PMID: 26859136Free PMC Article

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