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Myositis ossificans

MedGen UID:
6503
•Concept ID:
C0027122
•
Disease or Syndrome
Synonym: Myositis Ossificans
SNOMED CT: Muscle calcification and ossification (44551007); Muscle ossification (44551007); Muscular ossification (44551007); Myositis ossificans (44551007)
 
Monarch Initiative: MONDO:0003964

Definition

A self-limited benign neoplasm characterized by a zonal architecture. It is composed of spindle cells oriented randomly or in short intersecting fascicles. Peripherally, the spindle cells merge with osteoblasts that rim and populate ill-defined trabeculae and sheets of unmineralized woven bone, which is surrounded by well-formed trabecular and cortical-type bone that remodels into lamellar bone. Treatment is usually simple excision. Prognosis is excellent; recurrence is uncommon. (WHO 2020) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyositis ossificans

Professional guidelines

PubMed

Fasciitis ossificans: imaging features, histology, and differential diagnosis.
Dhillon P, Jebastin Thangaiah J, Anderson TL, Tiegs-Heiden CA
Clin Radiol 2023 Sep;78(9):697-702. Epub 2023 Jun 2 doi: 10.1016/j.crad.2023.05.008. PMID: 37331849
Treatment of muscle haematomas in haemophiliacs with special emphasis on percutaneous drainage.
De la Corte-Rodriguez H, Rodriguez-Merchan EC
Blood Coagul Fibrinolysis 2014 Dec;25(8):787-94. doi: 10.1097/MBC.0000000000000159. PMID: 24914744
Muscle contusion injuries: current treatment options.
Beiner JM, Jokl P
J Am Acad Orthop Surg 2001 Jul-Aug;9(4):227-37. doi: 10.5435/00124635-200107000-00002. PMID: 11476532

Recent clinical studies

Etiology

Heterotopic Ossification after Trauma.
Lawand J, Loeffelholz Z, Khurshid B, Barcak E
Orthop Clin North Am 2023 Jan;54(1):37-46. doi: 10.1016/j.ocl.2022.08.007. PMID: 36402509
Contemporary perspectives on heterotopic ossification.
Hwang CD, Pagani CA, Nunez JH, Cherief M, Qin Q, Gomez-Salazar M, Kadaikal B, Kang H, Chowdary AR, Patel N, James AW, Levi B
JCI Insight 2022 Jul 22;7(14) doi: 10.1172/jci.insight.158996. PMID: 35866484Free PMC Article
Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial.
Pignolo RJ, Baujat G, Hsiao EC, Keen R, Wilson A, Packman J, Strahs AL, Grogan DR, Kaplan FS
J Bone Miner Res 2022 Oct;37(10):1891-1902. Epub 2022 Aug 17 doi: 10.1002/jbmr.4655. PMID: 35854638Free PMC Article
Myositis Ossificans in Sport: A Review.
Devilbiss Z, Hess M, Ho GWK
Curr Sports Med Rep 2018 Sep;17(9):290-295. doi: 10.1249/JSR.0000000000000515. PMID: 30204632
Heterotopic ossification.
Kaplan FS, Glaser DL, Hebela N, Shore EM
J Am Acad Orthop Surg 2004 Mar-Apr;12(2):116-25. doi: 10.5435/00124635-200403000-00007. PMID: 15089085

Diagnosis

Fasciitis ossificans: imaging features, histology, and differential diagnosis.
Dhillon P, Jebastin Thangaiah J, Anderson TL, Tiegs-Heiden CA
Clin Radiol 2023 Sep;78(9):697-702. Epub 2023 Jun 2 doi: 10.1016/j.crad.2023.05.008. PMID: 37331849
Extra-skeletal osteosarcoma: a review.
Hesni S, Lindsay D, O'Donnell P, Saifuddin A
Skeletal Radiol 2023 Apr;52(4):633-648. Epub 2022 Oct 4 doi: 10.1007/s00256-022-04193-4. PMID: 36194245
Circumscribed myositis ossificans.
Wendling D, Chouk M, Guillot X, Aubry S, Prati C
Joint Bone Spine 2021 Mar;88(2):105119. Epub 2020 Dec 17 doi: 10.1016/j.jbspin.2020.105119. PMID: 33346106
Myositis Ossificans.
Walczak BE, Johnson CN, Howe BM
J Am Acad Orthop Surg 2015 Oct;23(10):612-22. Epub 2015 Aug 28 doi: 10.5435/JAAOS-D-14-00269. PMID: 26320160
Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons.
Pignolo RJ, Shore EM, Kaplan FS
Pediatr Endocrinol Rev 2013 Jun;10 Suppl 2(0 2):437-48. PMID: 23858627Free PMC Article

Therapy

Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial.
Di Rocco M, Forleo-Neto E, Pignolo RJ, Keen R, Orcel P, Funck-Brentano T, Roux C, Kolta S, Madeo A, Bubbear JS, Tabarkiewicz J, Szczepanek M, Bachiller-Corral J, Cheung AM, Dahir KM, Botman E, Raijmakers PG, Al Mukaddam M, Tile L, Portal-Celhay C, Sarkar N, Hou P, Musser BJ, Boyapati A, Mohammadi K, Mellis SJ, Rankin AJ, Economides AN, Trotter DG, Herman GA, O'Meara SJ, DelGizzi R, Weinreich DM, Yancopoulos GD, Eekhoff EMW, Kaplan FS
Nat Med 2023 Oct;29(10):2615-2624. Epub 2023 Sep 28 doi: 10.1038/s41591-023-02561-8. PMID: 37770652Free PMC Article
Reduction of New Heterotopic Ossification (HO) in the Open-Label, Phase 3 MOVE Trial of Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP).
Pignolo RJ, Hsiao EC, Al Mukaddam M, Baujat G, Berglund SK, Brown MA, Cheung AM, De Cunto C, Delai P, Haga N, Kannu P, Keen R, Le Quan Sang KH, Mancilla EE, Marino R, Strahs A, Kaplan FS
J Bone Miner Res 2023 Mar;38(3):381-394. Epub 2023 Jan 25 doi: 10.1002/jbmr.4762. PMID: 36583535
Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial.
Pignolo RJ, Baujat G, Hsiao EC, Keen R, Wilson A, Packman J, Strahs AL, Grogan DR, Kaplan FS
J Bone Miner Res 2022 Oct;37(10):1891-1902. Epub 2022 Aug 17 doi: 10.1002/jbmr.4655. PMID: 35854638Free PMC Article
Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles.
Eekhoff EMW, de Ruiter RD, Smilde BJ, Schoenmaker T, de Vries TJ, Netelenbos C, Hsiao EC, Scott C, Haga N, Grunwald Z, De Cunto CL, di Rocco M, Delai PLR, Diecidue RJ, Madhuri V, Cho TJ, Morhart R, Friedman CS, Zasloff M, Pals G, Shim JH, Gao G, Kaplan F, Pignolo RJ, Micha D
Hum Gene Ther 2022 Aug;33(15-16):782-788. doi: 10.1089/hum.2022.023. PMID: 35502479Free PMC Article
Muscle injuries: optimising recovery.
Järvinen TA, Järvinen TL, Kääriäinen M, Aärimaa V, Vaittinen S, Kalimo H, Järvinen M
Best Pract Res Clin Rheumatol 2007 Apr;21(2):317-31. doi: 10.1016/j.berh.2006.12.004. PMID: 17512485

Prognosis

Multi-omics therapeutic perspective on ACVR1 gene: from genetic alterations to potential targeting.
Nagar G, Mittal P, Gupta SRR, Pahuja M, Sanger M, Mishra R, Singh A, Singh IK
Brief Funct Genomics 2023 Apr 13;22(2):123-142. doi: 10.1093/bfgp/elac026. PMID: 36003055
Chondro-Osseous Lesions of Soft Tissue.
Cho SJ, Horvai A
Surg Pathol Clin 2015 Sep;8(3):419-44. doi: 10.1016/j.path.2015.05.004. PMID: 26297064
The imaging of myositis ossificans.
Tyler P, Saifuddin A
Semin Musculoskelet Radiol 2010 Jun;14(2):201-16. Epub 2010 May 18 doi: 10.1055/s-0030-1253161. PMID: 20486028
Inherited ossifying diseases.
Job-Deslandre C
Joint Bone Spine 2004 Mar;71(2):98-101. doi: 10.1016/s1297-319x(03)00130-1. PMID: 15116703
Heterotopic ossification.
Kaplan FS, Glaser DL, Hebela N, Shore EM
J Am Acad Orthop Surg 2004 Mar-Apr;12(2):116-25. doi: 10.5435/00124635-200403000-00007. PMID: 15089085

Clinical prediction guides

The Fibrodysplasia Ossificans Progressiva Physical Function Questionnaire (FOP-PFQ): A patient-reported, disease-specific measure.
Pignolo RJ, Kimel M, Whalen J, Kawata AK, Artyomenko A, Kaplan FS
Bone 2023 Mar;168:116642. Epub 2022 Dec 13 doi: 10.1016/j.bone.2022.116642. PMID: 36526263
Multi-omics therapeutic perspective on ACVR1 gene: from genetic alterations to potential targeting.
Nagar G, Mittal P, Gupta SRR, Pahuja M, Sanger M, Mishra R, Singh A, Singh IK
Brief Funct Genomics 2023 Apr 13;22(2):123-142. doi: 10.1093/bfgp/elac026. PMID: 36003055
Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva.
Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao EC
Orphanet J Rare Dis 2022 Mar 4;17(1):107. doi: 10.1186/s13023-022-02246-4. PMID: 35246171Free PMC Article
Are open surgery and total resection good choices for traumatic myositis ossificans in children?
Pu C, Su Y
Int Orthop 2021 Dec;45(12):3147-3154. Epub 2021 Sep 24 doi: 10.1007/s00264-021-05225-9. PMID: 34559305
Analysis of clinical manifestations and treatment in 26 children with fibrodysplasia ossificans progressiva in China.
Zhang JM, Li CF, Ke SY, Piao YR, Han TX, Kuang WY, Wang J, Deng JH, Tan XH, Li C
World J Pediatr 2020 Feb;16(1):82-88. Epub 2019 Sep 16 doi: 10.1007/s12519-019-00302-x. PMID: 31529313

Recent systematic reviews

Pin-Related Complications in Computer Navigated and Robotic-Assisted Knee Arthroplasty: A Systematic Review.
Thomas TL, Goh GS, Nguyen MK, Lonner JH
J Arthroplasty 2022 Nov;37(11):2291-2307.e2. Epub 2022 May 7 doi: 10.1016/j.arth.2022.05.012. PMID: 35537611
A Clinical Perspective on Advanced Developments in Bone Biopsy Assessment in Rare Bone Disorders.
Treurniet S, Eekhoff EMW, Schmidt FN, Micha D, Busse B, Bravenboer N
Front Endocrinol (Lausanne) 2020;11:399. Epub 2020 Jun 23 doi: 10.3389/fendo.2020.00399. PMID: 32714279Free PMC Article
Radiotherapy in Fibrodysplasia Ossificans Progressiva: A Case Report and Systematic Review of the Literature.
Botman E, Netelenbos JC, Rustemeyer T, Schoonmade LJ, Nieuwenhuijzen JA, Teunissen BP, Visser M, Raijmakers P, Lammertsma AA, Dahele M, Eekhoff M
Front Endocrinol (Lausanne) 2020;11:6. Epub 2020 Feb 12 doi: 10.3389/fendo.2020.00006. PMID: 32117050Free PMC Article
Aspiration of the elbow joint for treating radial head fractures.
Foocharoen T, Foocharoen C, Laopaiboon M, Tiamklang T
Cochrane Database Syst Rev 2014 Nov 22;2014(11):CD009949. doi: 10.1002/14651858.CD009949.pub2. PMID: 25416525Free PMC Article
Interventions for treating acute elbow dislocations in adults.
Taylor F, Sims M, Theis JC, Herbison GP
Cochrane Database Syst Rev 2012 Apr 18;2012(4):CD007908. doi: 10.1002/14651858.CD007908.pub2. PMID: 22513954Free PMC Article

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