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Type III hypersensitivity disease

MedGen UID:
7021
•Concept ID:
C0020951
•
Disease or Syndrome
Synonyms: Disease, Immune Complex; Diseases, Immune Complex; Hypersensitivities, Type III; Hypersensitivity, Type III; Immune Complex Disease; Immune Complex Diseases; Type III Hypersensitivities; Type III Hypersensitivity
 
Monarch Initiative: MONDO:0007004

Definition

Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides serum sickness and the arthus reaction, evidence supports a pathogenic role for immune complexes in many other immune system diseases including glomerulonephritis, systemic lupus erythematosus (lupus erythematosus, systemic) and polyarteritis nodosa. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType III hypersensitivity disease

Professional guidelines

PubMed

Dilated cardiomyopathy: causes, mechanisms, and current and future treatment approaches.
Heymans S, Lakdawala NK, Tschöpe C, Klingel K
Lancet 2023 Sep 16;402(10406):998-1011. doi: 10.1016/S0140-6736(23)01241-2. PMID: 37716772
Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA).
Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107
Atopic Dermatitis: Diagnosis and Treatment.
Frazier W, Bhardwaj N
Am Fam Physician 2020 May 15;101(10):590-598. PMID: 32412211

Recent clinical studies

Etiology

IgA vasculitis nephritis: insights from kidney biopsies.
Haas M
Curr Opin Nephrol Hypertens 2024 May 1;33(3):298-303. Epub 2024 Feb 19 doi: 10.1097/MNH.0000000000000972. PMID: 38411035
IgA vasculitis nephritis.
Nüsken E, Weber LT
Curr Opin Pediatr 2022 Apr 1;34(2):209-216. doi: 10.1097/MOP.0000000000001120. PMID: 35125382
European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative.
Ozen S, Marks SD, Brogan P, Groot N, de Graeff N, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Pilkington C, Ravelli A, van Royen A, Uziel Y, Vastert B, Wulffraat N, Kamphuis S, Beresford MW
Rheumatology (Oxford) 2019 Sep 1;58(9):1607-1616. doi: 10.1093/rheumatology/kez041. PMID: 30879080
Henoch-Schönlein Purpura: A Literature Review.
Hetland LE, Susrud KS, Lindahl KH, Bygum A
Acta Derm Venereol 2017 Nov 15;97(10):1160-1166. doi: 10.2340/00015555-2733. PMID: 28654132
Henoch-Schönlein purpura.
Robson WL, Leung AK
Adv Pediatr 1994;41:163-94. PMID: 7992683

Diagnosis

Diagnosis and management of leukocytoclastic vasculitis.
Fraticelli P, Benfaremo D, Gabrielli A
Intern Emerg Med 2021 Jun;16(4):831-841. Epub 2021 Mar 13 doi: 10.1007/s11739-021-02688-x. PMID: 33713282Free PMC Article
Henoch-Schönlein purpura.
Reamy BV, Williams PM, Lindsay TJ
Am Fam Physician 2009 Oct 1;80(7):697-704. PMID: 19817340
Urticarial vasculitis.
Venzor J, Lee WL, Huston DP
Clin Rev Allergy Immunol 2002 Oct;23(2):201-16. doi: 10.1385/CRIAI:23:2:201. PMID: 12221865
Diagnostic significance of hypocomplementemia.
Hebert LA, Cosio FG, Neff JC
Kidney Int 1991 May;39(5):811-21. doi: 10.1038/ki.1991.102. PMID: 1829775
IgA-associated glomerulonephritis.
McPhaul JJ Jr
Annu Rev Med 1977;28:37-42. doi: 10.1146/annurev.me.28.020177.000345. PMID: 140622

Therapy

Henoch-Schonlein purpura.
Reid-Adam J
Pediatr Rev 2014 Oct;35(10):447-9; discussion 449. doi: 10.1542/pir.35-10-447. PMID: 25274973
Henoch-Schönlein purpura in children.
Trnka P
J Paediatr Child Health 2013 Dec;49(12):995-1003. Epub 2013 Oct 18 doi: 10.1111/jpc.12403. PMID: 24134307
Small vessel vasculitis.
Brogan P, Eleftheriou D, Dillon M
Pediatr Nephrol 2010 Jun;25(6):1025-35. Epub 2009 Nov 3 doi: 10.1007/s00467-009-1317-4. PMID: 19885685Free PMC Article
Urticarial vasculitis.
Chang S, Carr W
Allergy Asthma Proc 2007 Jan-Feb;28(1):97-100. doi: 10.2500/aap.2007.28.2972. PMID: 17390766
Henoch-Schönlein purpura.
Robson WL, Leung AK
Adv Pediatr 1994;41:163-94. PMID: 7992683

Prognosis

IgA vasculitis nephritis.
Nüsken E, Weber LT
Curr Opin Pediatr 2022 Apr 1;34(2):209-216. doi: 10.1097/MOP.0000000000001120. PMID: 35125382
Vasculitis-What Do We Have to Know? A Review of Literature.
Shavit E, Alavi A, Sibbald RG
Int J Low Extrem Wounds 2018 Dec;17(4):218-226. Epub 2018 Dec 3 doi: 10.1177/1534734618804982. PMID: 30501545
Henoch-Schönlein purpura in children.
Trnka P
J Paediatr Child Health 2013 Dec;49(12):995-1003. Epub 2013 Oct 18 doi: 10.1111/jpc.12403. PMID: 24134307
Henoch-Schonlein purpura.
Ballinger S
Curr Opin Rheumatol 2003 Sep;15(5):591-4. doi: 10.1097/00002281-200309000-00012. PMID: 12960486
Urticarial vasculitis.
Venzor J, Lee WL, Huston DP
Clin Rev Allergy Immunol 2002 Oct;23(2):201-16. doi: 10.1385/CRIAI:23:2:201. PMID: 12221865

Clinical prediction guides

IgA vasculitis nephritis: insights from kidney biopsies.
Haas M
Curr Opin Nephrol Hypertens 2024 May 1;33(3):298-303. Epub 2024 Feb 19 doi: 10.1097/MNH.0000000000000972. PMID: 38411035
Calprotectin: from biomarker to biological function.
Jukic A, Bakiri L, Wagner EF, Tilg H, Adolph TE
Gut 2021 Oct;70(10):1978-1988. Epub 2021 Jun 18 doi: 10.1136/gutjnl-2021-324855. PMID: 34145045Free PMC Article
Henoch-Schönlein Purpura in Children: An Updated Review.
Leung AKC, Barankin B, Leong KF
Curr Pediatr Rev 2020;16(4):265-276. doi: 10.2174/1573396316666200508104708. PMID: 32384035
Tears and ocular surface disorders: Usefulness of biomarkers.
Di Zazzo A, Micera A, De Piano M, Cortes M, Bonini S
J Cell Physiol 2019 Jul;234(7):9982-9993. Epub 2018 Dec 4 doi: 10.1002/jcp.27895. PMID: 30515814
Skeletal muscle immunopathology.
Oxenhandler R, Hart MN
Hum Pathol 1983 Apr;14(4):326-37. doi: 10.1016/s0046-8177(83)80118-x. PMID: 6219935

Recent systematic reviews

The efficacy of rituximab in the treatment of IgA vasculitis nephritis.
Xiong Y, Cuevas S, Xu G, Zou H
Clin Exp Med 2024 Sep 9;24(1):213. doi: 10.1007/s10238-024-01461-6. PMID: 39249581Free PMC Article
Advances in pathogenesis of preeclampsia.
Yang M, Wang M, Li N
Arch Gynecol Obstet 2024 May;309(5):1815-1823. Epub 2024 Feb 29 doi: 10.1007/s00404-024-07393-6. PMID: 38421424
Role of NLRP3 in the pathogenesis and treatment of gout arthritis.
Liu YR, Wang JQ, Li J
Front Immunol 2023;14:1137822. Epub 2023 Mar 27 doi: 10.3389/fimmu.2023.1137822. PMID: 37051231Free PMC Article
The Gut Microbiome, Aging, and Longevity: A Systematic Review.
Badal VD, Vaccariello ED, Murray ER, Yu KE, Knight R, Jeste DV, Nguyen TT
Nutrients 2020 Dec 7;12(12) doi: 10.3390/nu12123759. PMID: 33297486Free PMC Article
CD8 + T-lymphocyte Encephalitis: A Systematic Review.
Santana LM, Valadares EA, Ferreira-Júnior CU, Santos MF, Albergaria BH, Rosa-Júnior M
AIDS Rev 2020 Jul 8;22(2):112-122. doi: 10.24875/AIDSRev.20000132. PMID: 32180590

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