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Metastatic Osteosarcoma

MedGen UID:
75830
•Concept ID:
C0278512
•
Neoplastic Process
Synonyms: Metastatic Osteogenic Sarcoma; Metastatic osteosarcoma; Osteosarcoma, Metastatic
SNOMED CT: Metastatic osteosarcoma (705145009)

Definition

An osteosarcoma which has spread to another anatomical site. [from NCI]

Professional guidelines

PubMed

Osteosarcoma: A comprehensive review of management and treatment strategies.
Jafari F, Javdansirat S, Sanaie S, Naseri A, Shamekh A, Rostamzadeh D, Dolati S
Ann Diagn Pathol 2020 Dec;49:151654. Epub 2020 Oct 25 doi: 10.1016/j.anndiagpath.2020.151654. PMID: 33130384
Current Treatment Considerations for Osteosarcoma Metastatic at Presentation.
Tsukamoto S, Errani C, Angelini A, Mavrogenis AF
Orthopedics 2020 Sep 1;43(5):e345-e358. Epub 2020 Aug 6 doi: 10.3928/01477447-20200721-05. PMID: 32745218
Radiopharmaceuticals for Treatment of Osteosarcoma.
Anderson PM
Adv Exp Med Biol 2020;1257:45-53. doi: 10.1007/978-3-030-43032-0_4. PMID: 32483729

Recent clinical studies

Etiology

Predicting metastasis at initial diagnosis and radiotherapy effectiveness in patients with metastatic osteosarcoma.
Chen W, He X, Yan Z, Lin X, Bai G
J Cancer Res Clin Oncol 2023 Sep;149(12):9587-9595. Epub 2023 May 24 doi: 10.1007/s00432-023-04869-x. PMID: 37222812Free PMC Article
Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling.
Yu L, Zhu H, Wang Z, Huang J, Zhu Y, Fan G, Wang Y, Chen X, Zhou G
Mol Cancer 2022 Aug 19;21(1):167. doi: 10.1186/s12943-022-01624-7. PMID: 35986280Free PMC Article
Recent and Ongoing Research into Metastatic Osteosarcoma Treatments.
Harris MA, Hawkins CJ
Int J Mol Sci 2022 Mar 30;23(7) doi: 10.3390/ijms23073817. PMID: 35409176Free PMC Article
SHH Signaling Pathway Drives Pediatric Bone Sarcoma Progression.
Lézot F, Corre I, Morice S, Rédini F, Verrecchia F
Cells 2020 Feb 26;9(3) doi: 10.3390/cells9030536. PMID: 32110934Free PMC Article
Metastatic osteosarcoma.
Daw NC, Billups CA, Rodriguez-Galindo C, McCarville MB, Rao BN, Cain AM, Jenkins JJ, Neel MD, Meyer WH
Cancer 2006 Jan 15;106(2):403-12. doi: 10.1002/cncr.21626. PMID: 16353204

Diagnosis

Predicting metastasis at initial diagnosis and radiotherapy effectiveness in patients with metastatic osteosarcoma.
Chen W, He X, Yan Z, Lin X, Bai G
J Cancer Res Clin Oncol 2023 Sep;149(12):9587-9595. Epub 2023 May 24 doi: 10.1007/s00432-023-04869-x. PMID: 37222812Free PMC Article
Pharmacogenetics of the Primary and Metastatic Osteosarcoma: Gene Expression Profile Associated with Outcome.
Trujillo-Paolillo A, Tesser-Gamba F, Seixas Alves MT, Filho RJG, Oliveira R, Petrilli AS, Toledo SRC
Int J Mol Sci 2023 Mar 15;24(6) doi: 10.3390/ijms24065607. PMID: 36982681Free PMC Article
Osteosarcoma: A comprehensive review of management and treatment strategies.
Jafari F, Javdansirat S, Sanaie S, Naseri A, Shamekh A, Rostamzadeh D, Dolati S
Ann Diagn Pathol 2020 Dec;49:151654. Epub 2020 Oct 25 doi: 10.1016/j.anndiagpath.2020.151654. PMID: 33130384
SHH Signaling Pathway Drives Pediatric Bone Sarcoma Progression.
Lézot F, Corre I, Morice S, Rédini F, Verrecchia F
Cells 2020 Feb 26;9(3) doi: 10.3390/cells9030536. PMID: 32110934Free PMC Article
βhCG-secreting osteosarcoma.
Harrold E, McMahon E, McGing P, Higgins M
BMJ Case Rep 2017 Apr 28;2017 doi: 10.1136/bcr-2016-218438. PMID: 28455292Free PMC Article

Therapy

Curcumin and its Analogs and Carriers: Potential Therapeutic Strategies for Human Osteosarcoma.
Lu KH, Lu PW, Lu EW, Lin CW, Yang SF
Int J Biol Sci 2023;19(4):1241-1265. Epub 2023 Feb 13 doi: 10.7150/ijbs.80590. PMID: 36923933Free PMC Article
The role of toceranib phosphate in dogs with non-mast cell neoplasia: A systematic review.
Frezoulis P, Harper A
Vet Comp Oncol 2022 Jun;20(2):362-371. Epub 2022 Jan 17 doi: 10.1111/vco.12799. PMID: 34981886
Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.
Regan DP, Chow L, Das S, Haines L, Palmer E, Kurihara JN, Coy JW, Mathias A, Thamm DH, Gustafson DL, Dow SW
Clin Cancer Res 2022 Feb 15;28(4):662-676. doi: 10.1158/1078-0432.CCR-21-2105. PMID: 34580111Free PMC Article
Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma.
Davis LE, Bolejack V, Ryan CW, Ganjoo KN, Loggers ET, Chawla S, Agulnik M, Livingston MB, Reed D, Keedy V, Rushing D, Okuno S, Reinke DK, Riedel RF, Attia S, Mascarenhas L, Maki RG
J Clin Oncol 2019 Jun 1;37(16):1424-1431. Epub 2019 Apr 23 doi: 10.1200/JCO.18.02374. PMID: 31013172Free PMC Article
Translational biology of osteosarcoma.
Kansara M, Teng MW, Smyth MJ, Thomas DM
Nat Rev Cancer 2014 Nov;14(11):722-35. Epub 2014 Oct 16 doi: 10.1038/nrc3838. PMID: 25319867

Prognosis

CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment.
Fujiwara T, Yakoub MA, Chandler A, Christ AB, Yang G, Ouerfelli O, Rajasekhar VK, Yoshida A, Kondo H, Hata T, Tazawa H, Dogan Y, Moore MAS, Fujiwara T, Ozaki T, Purdue E, Healey JH
Mol Cancer Ther 2021 Aug;20(8):1388-1399. Epub 2021 Jun 4 doi: 10.1158/1535-7163.MCT-20-0591. PMID: 34088832Free PMC Article
KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma.
Jiang Y, Li F, Gao B, Ma M, Chen M, Wu Y, Zhang W, Sun Y, Liu S, Shen H
Theranostics 2021;11(8):3868-3881. Epub 2021 Feb 6 doi: 10.7150/thno.53347. PMID: 33664867Free PMC Article
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.
Zhou Y, Yang D, Yang Q, Lv X, Huang W, Zhou Z, Wang Y, Zhang Z, Yuan T, Ding X, Tang L, Zhang J, Yin J, Huang Y, Yu W, Wang Y, Zhou C, Su Y, He A, Sun Y, Shen Z, Qian B, Meng W, Fei J, Yao Y, Pan X, Chen P, Hu H
Nat Commun 2020 Dec 10;11(1):6322. doi: 10.1038/s41467-020-20059-6. PMID: 33303760Free PMC Article
βhCG-secreting osteosarcoma.
Harrold E, McMahon E, McGing P, Higgins M
BMJ Case Rep 2017 Apr 28;2017 doi: 10.1136/bcr-2016-218438. PMID: 28455292Free PMC Article
Metastatic osteosarcoma.
Daw NC, Billups CA, Rodriguez-Galindo C, McCarville MB, Rao BN, Cain AM, Jenkins JJ, Neel MD, Meyer WH
Cancer 2006 Jan 15;106(2):403-12. doi: 10.1002/cncr.21626. PMID: 16353204

Clinical prediction guides

FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression.
Huang YC, Chen WC, Yu CL, Chang TK, I-Chin Wei A, Chang TM, Liu JF, Wang SW
Biochem Pharmacol 2023 Dec;218:115853. Epub 2023 Oct 11 doi: 10.1016/j.bcp.2023.115853. PMID: 37832794
Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.
Regan DP, Chow L, Das S, Haines L, Palmer E, Kurihara JN, Coy JW, Mathias A, Thamm DH, Gustafson DL, Dow SW
Clin Cancer Res 2022 Feb 15;28(4):662-676. doi: 10.1158/1078-0432.CCR-21-2105. PMID: 34580111Free PMC Article
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.
Zhou Y, Yang D, Yang Q, Lv X, Huang W, Zhou Z, Wang Y, Zhang Z, Yuan T, Ding X, Tang L, Zhang J, Yin J, Huang Y, Yu W, Wang Y, Zhou C, Su Y, He A, Sun Y, Shen Z, Qian B, Meng W, Fei J, Yao Y, Pan X, Chen P, Hu H
Nat Commun 2020 Dec 10;11(1):6322. doi: 10.1038/s41467-020-20059-6. PMID: 33303760Free PMC Article
Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma.
Davis LE, Bolejack V, Ryan CW, Ganjoo KN, Loggers ET, Chawla S, Agulnik M, Livingston MB, Reed D, Keedy V, Rushing D, Okuno S, Reinke DK, Riedel RF, Attia S, Mascarenhas L, Maki RG
J Clin Oncol 2019 Jun 1;37(16):1424-1431. Epub 2019 Apr 23 doi: 10.1200/JCO.18.02374. PMID: 31013172Free PMC Article
Metastatic osteosarcoma: a challenging multidisciplinary treatment.
Meazza C, Scanagatta P
Expert Rev Anticancer Ther 2016 May;16(5):543-56. Epub 2016 Apr 6 doi: 10.1586/14737140.2016.1168697. PMID: 26999418

Recent systematic reviews

Metastatic osteosarcoma involving the skin: A systematic review of patient demographics, clinical characteristics, and treatment outcomes.
Fried S, Suhrawardy A, Rehman R, Al-Jamal M, Moore D, Mehregan D
J Am Acad Dermatol 2023 Feb;88(2):470-471. Epub 2022 Jun 16 doi: 10.1016/j.jaad.2022.06.017. PMID: 35718194
The role of toceranib phosphate in dogs with non-mast cell neoplasia: A systematic review.
Frezoulis P, Harper A
Vet Comp Oncol 2022 Jun;20(2):362-371. Epub 2022 Jan 17 doi: 10.1111/vco.12799. PMID: 34981886
Effectiveness of mifamurtide in addition to standard chemotherapy for high-grade osteosarcoma: a systematic review.
Jimmy R, Stern C, Lisy K, White S
JBI Database System Rev Implement Rep 2017 Aug;15(8):2113-2152. doi: 10.11124/JBISRIR-2016-003105. PMID: 28800058

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