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Metastatic Osteosarcoma

MedGen UID:
75830
•Concept ID:
C0278512
•
Neoplastic Process
Synonyms: Metastatic Osteogenic Sarcoma; Metastatic osteosarcoma; Osteosarcoma, Metastatic
SNOMED CT: Metastatic osteosarcoma (705145009)

Definition

An osteosarcoma which has spread to another anatomical site. [from NCI]

Professional guidelines

PubMed

Osteosarcoma: A comprehensive review of management and treatment strategies.
Jafari F, Javdansirat S, Sanaie S, Naseri A, Shamekh A, Rostamzadeh D, Dolati S
Ann Diagn Pathol 2020 Dec;49:151654. Epub 2020 Oct 25 doi: 10.1016/j.anndiagpath.2020.151654. PMID: 33130384
Radiopharmaceuticals for Treatment of Osteosarcoma.
Anderson PM
Adv Exp Med Biol 2020;1257:45-53. doi: 10.1007/978-3-030-43032-0_4. PMID: 32483729
Metastatic osteosarcoma: a challenging multidisciplinary treatment.
Meazza C, Scanagatta P
Expert Rev Anticancer Ther 2016 May;16(5):543-56. Epub 2016 Apr 6 doi: 10.1586/14737140.2016.1168697. PMID: 26999418

Recent clinical studies

Etiology

The OSR9 Regimen: A New Augmentation Strategy for Osteosarcoma Treatment Using Nine Older Drugs from General Medicine to Inhibit Growth Drive.
Kast RE
Int J Mol Sci 2023 Oct 23;24(20) doi: 10.3390/ijms242015474. PMID: 37895152Free PMC Article
Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration.
Nishimura E, Fukuda K, Matsuda S, Kobayashi R, Matsui K, Takeuchi M, Okubo K, Hirahashi J, Nakamura R, Kawakubo H, Kitagawa Y
Surg Today 2023 Aug;53(8):973-983. Epub 2023 Jan 2 doi: 10.1007/s00595-022-02637-x. PMID: 36592222
A novel TP53 tandem duplication in a child with Li-Fraumeni syndrome.
Xu F, Aref-Eshghi E, Wu J, Schubert J, Wertheim G, Bhatti T, Pogoriler J, Patel M, Cao K, Long A, Fan Z, Denenberg EH, Fanning EA, Wilmoth DM, Luo M, Conlin LK, Dain AS, Zelley K, Baldino S, Balamuth N, MacFarland S, Li MM, Zhong Y
Cold Spring Harb Mol Case Stud 2022 Apr;8(3) Epub 2022 Apr 28 doi: 10.1101/mcs.a006181. PMID: 35232817Free PMC Article
Epidural versus Patient-Controlled Analgesia after Pediatric Thoracotomy for Malignancy: A Preliminary Review.
Gonzalez KW, Dalton BG, Millspaugh DL, Thomas PG, St Peter SD
Eur J Pediatr Surg 2016 Aug;26(4):340-3. Epub 2015 May 27 doi: 10.1055/s-0035-1554805. PMID: 26018213
Transmedullary amputation and resection of metastases in combined therapy of osteosarcoma.
Kumar AP, Wrenn EL Jr, Fleming ID, Pratt CB
J Pediatr Surg 1977 Jun;12(3):427-35. doi: 10.1016/0022-3468(77)90021-5. PMID: 267197

Diagnosis

Osteosarcoma: A comprehensive review of management and treatment strategies.
Jafari F, Javdansirat S, Sanaie S, Naseri A, Shamekh A, Rostamzadeh D, Dolati S
Ann Diagn Pathol 2020 Dec;49:151654. Epub 2020 Oct 25 doi: 10.1016/j.anndiagpath.2020.151654. PMID: 33130384
Methioninase Cell-Cycle Trap Cancer Chemotherapy.
Hoffman RM, Yano S, Igarashi K
Methods Mol Biol 2019;1866:133-148. doi: 10.1007/978-1-4939-8796-2_11. PMID: 30725413
βhCG-secreting osteosarcoma.
Harrold E, McMahon E, McGing P, Higgins M
BMJ Case Rep 2017 Apr 28;2017 doi: 10.1136/bcr-2016-218438. PMID: 28455292Free PMC Article
Metastatic osteosarcoma: a challenging multidisciplinary treatment.
Meazza C, Scanagatta P
Expert Rev Anticancer Ther 2016 May;16(5):543-56. Epub 2016 Apr 6 doi: 10.1586/14737140.2016.1168697. PMID: 26999418
Osteosarcoma metastatic to the kidney.
Lockhart SK, Coan JD, Jaffe N, Eftekhari F, David C, Shirkhoda A
Clin Imaging 1989 Jun;13(2):154-6. doi: 10.1016/0899-7071(89)90099-5. PMID: 2670146

Therapy

The OSR9 Regimen: A New Augmentation Strategy for Osteosarcoma Treatment Using Nine Older Drugs from General Medicine to Inhibit Growth Drive.
Kast RE
Int J Mol Sci 2023 Oct 23;24(20) doi: 10.3390/ijms242015474. PMID: 37895152Free PMC Article
Ubiquitin-specific proteases as therapeutic targets in paediatric primary bone tumours?
Mullard M, Lavaud M, Regnier L, Tesfaye R, Ory B, Rédini F, Verrecchia F
Biochem Pharmacol 2021 Dec;194:114797. Epub 2021 Oct 19 doi: 10.1016/j.bcp.2021.114797. PMID: 34678225
Methioninase Cell-Cycle Trap Cancer Chemotherapy.
Hoffman RM, Yano S, Igarashi K
Methods Mol Biol 2019;1866:133-148. doi: 10.1007/978-1-4939-8796-2_11. PMID: 30725413
Translational biology of osteosarcoma.
Kansara M, Teng MW, Smyth MJ, Thomas DM
Nat Rev Cancer 2014 Nov;14(11):722-35. Epub 2014 Oct 16 doi: 10.1038/nrc3838. PMID: 25319867
Is there a role for immunotherapy in osteosarcoma?
Loeb DM
Cancer Treat Res 2009;152:447-57. doi: 10.1007/978-1-4419-0284-9_25. PMID: 20213407

Prognosis

Extracellular Vesicles from Highly Metastatic Osteosarcoma Cells Induce Pro-Tumorigenic Macrophage Phenotypes.
Griffin KH, Mizenko RR, Arun V, Carney RP, Leach JK
Adv Biol (Weinh) 2024 Jun;8(6):e2300577. Epub 2024 Apr 10 doi: 10.1002/adbi.202300577. PMID: 38596830Free PMC Article
The OSR9 Regimen: A New Augmentation Strategy for Osteosarcoma Treatment Using Nine Older Drugs from General Medicine to Inhibit Growth Drive.
Kast RE
Int J Mol Sci 2023 Oct 23;24(20) doi: 10.3390/ijms242015474. PMID: 37895152Free PMC Article
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.
Zhou Y, Yang D, Yang Q, Lv X, Huang W, Zhou Z, Wang Y, Zhang Z, Yuan T, Ding X, Tang L, Zhang J, Yin J, Huang Y, Yu W, Wang Y, Zhou C, Su Y, He A, Sun Y, Shen Z, Qian B, Meng W, Fei J, Yao Y, Pan X, Chen P, Hu H
Nat Commun 2020 Dec 10;11(1):6322. doi: 10.1038/s41467-020-20059-6. PMID: 33303760Free PMC Article
βhCG-secreting osteosarcoma.
Harrold E, McMahon E, McGing P, Higgins M
BMJ Case Rep 2017 Apr 28;2017 doi: 10.1136/bcr-2016-218438. PMID: 28455292Free PMC Article
Palliative treatment for advanced or metastatic osteosarcoma.
Merimsky O, Kollender Y, Inbar M, Meller I, Bickels J
Isr Med Assoc J 2004 Jan;6(1):34-8. PMID: 14740508

Clinical prediction guides

Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.
Regan DP, Chow L, Das S, Haines L, Palmer E, Kurihara JN, Coy JW, Mathias A, Thamm DH, Gustafson DL, Dow SW
Clin Cancer Res 2022 Feb 15;28(4):662-676. doi: 10.1158/1078-0432.CCR-21-2105. PMID: 34580111Free PMC Article
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.
Zhou Y, Yang D, Yang Q, Lv X, Huang W, Zhou Z, Wang Y, Zhang Z, Yuan T, Ding X, Tang L, Zhang J, Yin J, Huang Y, Yu W, Wang Y, Zhou C, Su Y, He A, Sun Y, Shen Z, Qian B, Meng W, Fei J, Yao Y, Pan X, Chen P, Hu H
Nat Commun 2020 Dec 10;11(1):6322. doi: 10.1038/s41467-020-20059-6. PMID: 33303760Free PMC Article
Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma.
Davis LE, Bolejack V, Ryan CW, Ganjoo KN, Loggers ET, Chawla S, Agulnik M, Livingston MB, Reed D, Keedy V, Rushing D, Okuno S, Reinke DK, Riedel RF, Attia S, Mascarenhas L, Maki RG
J Clin Oncol 2019 Jun 1;37(16):1424-1431. Epub 2019 Apr 23 doi: 10.1200/JCO.18.02374. PMID: 31013172Free PMC Article
Metastatic osteosarcoma: a challenging multidisciplinary treatment.
Meazza C, Scanagatta P
Expert Rev Anticancer Ther 2016 May;16(5):543-56. Epub 2016 Apr 6 doi: 10.1586/14737140.2016.1168697. PMID: 26999418
Epidural versus Patient-Controlled Analgesia after Pediatric Thoracotomy for Malignancy: A Preliminary Review.
Gonzalez KW, Dalton BG, Millspaugh DL, Thomas PG, St Peter SD
Eur J Pediatr Surg 2016 Aug;26(4):340-3. Epub 2015 May 27 doi: 10.1055/s-0035-1554805. PMID: 26018213

Recent systematic reviews

Metastatic osteosarcoma involving the skin: A systematic review of patient demographics, clinical characteristics, and treatment outcomes.
Fried S, Suhrawardy A, Rehman R, Al-Jamal M, Moore D, Mehregan D
J Am Acad Dermatol 2023 Feb;88(2):470-471. Epub 2022 Jun 16 doi: 10.1016/j.jaad.2022.06.017. PMID: 35718194
The role of toceranib phosphate in dogs with non-mast cell neoplasia: A systematic review.
Frezoulis P, Harper A
Vet Comp Oncol 2022 Jun;20(2):362-371. Epub 2022 Jan 17 doi: 10.1111/vco.12799. PMID: 34981886
Effectiveness of mifamurtide in addition to standard chemotherapy for high-grade osteosarcoma: a systematic review.
Jimmy R, Stern C, Lisy K, White S
JBI Database System Rev Implement Rep 2017 Aug;15(8):2113-2152. doi: 10.11124/JBISRIR-2016-003105. PMID: 28800058

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