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Ovarian Non-Dysgerminomatous Germ Cell Tumor

MedGen UID:
769623
•Concept ID:
C3640983
•
Neoplastic Process
Synonym: Ovarian Nondysgerminomatous Germ Cell Tumor

Definition

A malignant germ cell tumor other than dysgerminoma that arises from the ovary. [from NCI]

Professional guidelines

PubMed

Current approaches to diagnosis and treatment of ovarian germ cell malignancies.
Fishman DA, Schwartz PE
Curr Opin Obstet Gynecol 1994 Feb;6(1):98-104. PMID: 8180359
Chemotherapy of germ-cell ovarian tumours: first-line treatment with etoposide, bleomycin and cisplatin or carboplatin.
Smales E, Peckham MJ
Eur J Cancer Clin Oncol 1987 May;23(5):469-74. doi: 10.1016/0277-5379(87)90305-1. PMID: 2443358

Recent clinical studies

Etiology

Long-term oncological and reproductive outcomes of fertility-sparing cytoreductive surgery in females aged 25 years and younger with malignant ovarian germ cell tumors.
Ertas IE, Taskin S, Goklu R, Bilgin M, Goc G, Yildirim Y, Ortac F
J Obstet Gynaecol Res 2014 Mar;40(3):797-805. Epub 2013 Dec 10 doi: 10.1111/jog.12253. PMID: 24320102
Treatment of ovarian germ cell tumors with a 3-day bleomycin, etoposide, and cisplatin regimen: a prospective multicenter study.
Dimopoulos MA, Papadimitriou C, Hamilos G, Efstathiou E, Vlahos G, Rodolakis A, Aravantinos G, Kalofonos H, Kouroussis C, Gika D, Skarlos D, Bamias A
Gynecol Oncol 2004 Dec;95(3):695-700. doi: 10.1016/j.ygyno.2004.08.018. PMID: 15581984
Malignant germ cell tumors of the ovary. Pregnancy considerations.
Bakri YN, Ezzat A, Akhtar, Dohami, Zahrani
Eur J Obstet Gynecol Reprod Biol 2000 May;90(1):87-91. doi: 10.1016/s0301-2115(99)00213-4. PMID: 10767517
Transformation of ovarian dysgerminoma to yolk sac tumor: evidence for a histogenetic continuum.
Parkash V, Carcangiu ML
Mod Pathol 1995 Oct;8(8):881-7. PMID: 8552580

Diagnosis

Surgery of germ cell tumours of the ovary.
Schwartz PE
Forum (Genova) 2000 Oct-Dec;10(4):355-65. PMID: 11535985
Current approaches to diagnosis and treatment of ovarian germ cell malignancies.
Fishman DA, Schwartz PE
Curr Opin Obstet Gynecol 1994 Feb;6(1):98-104. PMID: 8180359
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Therapy

Treatment of ovarian germ cell tumors with a 3-day bleomycin, etoposide, and cisplatin regimen: a prospective multicenter study.
Dimopoulos MA, Papadimitriou C, Hamilos G, Efstathiou E, Vlahos G, Rodolakis A, Aravantinos G, Kalofonos H, Kouroussis C, Gika D, Skarlos D, Bamias A
Gynecol Oncol 2004 Dec;95(3):695-700. doi: 10.1016/j.ygyno.2004.08.018. PMID: 15581984
Surgery of germ cell tumours of the ovary.
Schwartz PE
Forum (Genova) 2000 Oct-Dec;10(4):355-65. PMID: 11535985
Current approaches to diagnosis and treatment of ovarian germ cell malignancies.
Fishman DA, Schwartz PE
Curr Opin Obstet Gynecol 1994 Feb;6(1):98-104. PMID: 8180359
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993
Chemotherapy of germ-cell ovarian tumours: first-line treatment with etoposide, bleomycin and cisplatin or carboplatin.
Smales E, Peckham MJ
Eur J Cancer Clin Oncol 1987 May;23(5):469-74. doi: 10.1016/0277-5379(87)90305-1. PMID: 2443358

Prognosis

Surgery of germ cell tumours of the ovary.
Schwartz PE
Forum (Genova) 2000 Oct-Dec;10(4):355-65. PMID: 11535985
Malignant germ cell tumors of the ovary. Pregnancy considerations.
Bakri YN, Ezzat A, Akhtar, Dohami, Zahrani
Eur J Obstet Gynecol Reprod Biol 2000 May;90(1):87-91. doi: 10.1016/s0301-2115(99)00213-4. PMID: 10767517
Current approaches to diagnosis and treatment of ovarian germ cell malignancies.
Fishman DA, Schwartz PE
Curr Opin Obstet Gynecol 1994 Feb;6(1):98-104. PMID: 8180359
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Clinical prediction guides

Long-term oncological and reproductive outcomes of fertility-sparing cytoreductive surgery in females aged 25 years and younger with malignant ovarian germ cell tumors.
Ertas IE, Taskin S, Goklu R, Bilgin M, Goc G, Yildirim Y, Ortac F
J Obstet Gynaecol Res 2014 Mar;40(3):797-805. Epub 2013 Dec 10 doi: 10.1111/jog.12253. PMID: 24320102
Long-term results of two VAB-like regimens (vinblastine + actinomycin-D + bleomycin + cyclophosphamide + cisplatin) in malignant germ cell tumours of the ovary.
Culine S, Lhomme C, Kattan J, Duvillard P, Michel G, Droz JP
Eur J Cancer 1994;30A(9):1239-44. doi: 10.1016/0959-8049(94)90165-1. PMID: 7528029
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993
Chemotherapy of germ-cell ovarian tumours: first-line treatment with etoposide, bleomycin and cisplatin or carboplatin.
Smales E, Peckham MJ
Eur J Cancer Clin Oncol 1987 May;23(5):469-74. doi: 10.1016/0277-5379(87)90305-1. PMID: 2443358

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