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Salivary gland adenoid cystic carcinoma

MedGen UID:
79034
Concept ID:
C0279751
Neoplastic Process
Synonyms: Adenoid cystic carcinoma of salivary gland; Adenoid Cystic Carcinoma of Salivary Gland; adenoid cystic carcinoma of salivary gland; Adenoid Cystic Carcinoma of the Salivary Gland; adenoid cystic carcinoma of the salivary gland; cylindroma (morphologic abnormality); saliva-secreting gland adenoid cystic carcinoma; salivary gland adenoid cystic cancer; Salivary Gland Adenoid Cystic Carcinoma; salivary gland adenoid cystic carcinoma
SNOMED CT: Adenoid cystic carcinoma of salivary gland (422833009)
 
Monarch Initiative: MONDO:0003175

Definition

An adenoid cystic carcinoma arising from the salivary gland. It is characterized by the presence of epithelial and myoepithelial cells forming tubular, cribriform, and solid patterns. It usually presents as a slow growing mass. Patients may experience pain because of the tumor propensity for perineural invasion. The tumor may follow an aggressive clinical course with recurrences and mestastases to distant sites including lungs, bones, brain, and liver. [from NCI]

Professional guidelines

PubMed

Matsuba HM, Spector GJ, Thawley SE, Simpson JR, Mauney M, Pikul FJ
Cancer 1986 Feb 1;57(3):519-24. doi: 10.1002/1097-0142(19860201)57:3<519::aid-cncr2820570319>3.0.co;2-v. PMID: 3002583
Simpson JR, Thawley SE, Matsuba HM
Radiology 1984 May;151(2):509-12. doi: 10.1148/radiology.151.2.6324280. PMID: 6324280

Recent clinical studies

Therapy

Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898Free PMC Article
Locati LD, Galbiati D, Calareso G, Alfieri S, Singer S, Cavalieri S, Bergamini C, Bossi P, Orlandi E, Resteghini C, Platini F, Granata R, Quattrone P, Mancinelli M, Mariani L, Lo Vullo S, Licitra LF
Cancer 2020 Jan 1;126(9):1888-1894. Epub 2020 Feb 7 doi: 10.1002/cncr.32754. PMID: 32031693
Hsieh CE, Lin CY, Lee LY, Yang LY, Wang CC, Wang HM, Chang JT, Fan KH, Liao CT, Yen TC, Fang KH, Tsang YM
Radiat Oncol 2016 Mar 22;11:47. doi: 10.1186/s13014-016-0617-7. PMID: 27000157Free PMC Article
Routila J, Mäkelä JA, Luukkaa H, Leivo I, Irjala H, Westermarck J, Mäkitie A, Ventelä S
Genes Chromosomes Cancer 2016 Jan;55(1):69-81. Epub 2015 Sep 23 doi: 10.1002/gcc.22312. PMID: 26395031
Dodd RL, Slevin NJ
Oral Oncol 2006 Sep;42(8):759-69. Epub 2006 Jun 6 doi: 10.1016/j.oraloncology.2006.01.001. PMID: 16757203

Prognosis

Hämetoja H, Andersson LC, Mäkitie A, Bäck L, Hagström J, Haglund C
APMIS 2021 Aug;129(8):503-511. Epub 2021 Jun 25 doi: 10.1111/apm.13158. PMID: 34046926
Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898Free PMC Article
Ouyang DQ, Liang LZ, Zheng GS, Ke ZF, Weng DS, Yang WF, Su YX, Liao GQ
Medicine (Baltimore) 2017 Feb;96(5):e5964. doi: 10.1097/MD.0000000000005964. PMID: 28151884Free PMC Article
Thompson LD
Ear Nose Throat J 2015 Jul;94(7):262-4. doi: 10.1177/014556131509400707. PMID: 26214665
Dodd RL, Slevin NJ
Oral Oncol 2006 Sep;42(8):759-69. Epub 2006 Jun 6 doi: 10.1016/j.oraloncology.2006.01.001. PMID: 16757203

Clinical prediction guides

Zhou MJ, Yang JJ, Ma TY, Feng GX, Wang XL, Wang LY, Ge YZ, Gao R, Liu HL, Shan L, Kong L, Chen XH
Exp Mol Med 2023 Mar;55(3):597-611. Epub 2023 Mar 6 doi: 10.1038/s12276-023-00957-7. PMID: 36879115Free PMC Article
Cai HS, Huang SJ, Liang JF, Zhu Y, Hou JS
Biomed Res Int 2022;2022:7894523. Epub 2022 Aug 29 doi: 10.1155/2022/7894523. PMID: 36072473Free PMC Article
Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898Free PMC Article
Hou X, Yu Y, Feng J, Wang J, Zheng C, Ling Z, Ge M, Zhu X
Exp Cell Res 2017 Mar 15;352(2):403-411. Epub 2017 Feb 20 doi: 10.1016/j.yexcr.2017.02.029. PMID: 28228352
Rettig EM, Talbot CC Jr, Sausen M, Jones S, Bishop JA, Wood LD, Tokheim C, Niknafs N, Karchin R, Fertig EJ, Wheelan SJ, Marchionni L, Considine M, Ling S, Fakhry C, Papadopoulos N, Kinzler KW, Vogelstein B, Ha PK, Agrawal N
Cancer Prev Res (Phila) 2016 Apr;9(4):265-74. Epub 2016 Feb 9 doi: 10.1158/1940-6207.CAPR-15-0316. PMID: 26862087Free PMC Article

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