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Somatotrophinoma

MedGen UID:
82999
•Concept ID:
C0278864
•
Neoplastic Process

Professional guidelines

PubMed

Acromegaly: pathogenesis, diagnosis, and management.
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Recent clinical studies

Etiology

Acromegaly: Medical and Surgical Considerations.
Giantini-Larsen AM, Uribe-Cardenas R, Juthani RG
Otolaryngol Clin North Am 2022 Apr;55(2):331-341. Epub 2022 Mar 4 doi: 10.1016/j.otc.2021.12.007. PMID: 35256175
Aggressive somatotrophinomas lacking clinical symptoms: neurosurgical management.
Giordano M, Samii A, Fahlbusch R
Neurosurg Rev 2018 Oct;41(4):999-1005. Epub 2017 Dec 30 doi: 10.1007/s10143-017-0940-y. PMID: 29290044
The higher incidence of autoimmune thyroid disease in prolactinomas than in somatotrophinomas.
Dogansen SC, Selcukbiricik OS, Bilir BE, Yarman S
Growth Horm IGF Res 2016 Aug;29:45-49. Epub 2016 Apr 11 doi: 10.1016/j.ghir.2016.04.004. PMID: 27105040
Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly.
Theodoropoulou M, Tichomirowa MA, Sievers C, Yassouridis A, Arzberger T, Hougrand O, Deprez M, Daly AF, Petrossians P, Pagotto U, Beckers A, Stalla GK
Int J Cancer 2009 Nov 1;125(9):2122-6. doi: 10.1002/ijc.24602. PMID: 19637311

Diagnosis

Acromegaly: Medical and Surgical Considerations.
Giantini-Larsen AM, Uribe-Cardenas R, Juthani RG
Otolaryngol Clin North Am 2022 Apr;55(2):331-341. Epub 2022 Mar 4 doi: 10.1016/j.otc.2021.12.007. PMID: 35256175
The higher incidence of autoimmune thyroid disease in prolactinomas than in somatotrophinomas.
Dogansen SC, Selcukbiricik OS, Bilir BE, Yarman S
Growth Horm IGF Res 2016 Aug;29:45-49. Epub 2016 Apr 11 doi: 10.1016/j.ghir.2016.04.004. PMID: 27105040
Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly.
Theodoropoulou M, Tichomirowa MA, Sievers C, Yassouridis A, Arzberger T, Hougrand O, Deprez M, Daly AF, Petrossians P, Pagotto U, Beckers A, Stalla GK
Int J Cancer 2009 Nov 1;125(9):2122-6. doi: 10.1002/ijc.24602. PMID: 19637311
Giant somatotrophinoma without acromegalic features: more "quiet" than "silent": case report.
Sidhaye A, Burger P, Rigamonti D, Salvatori R
Neurosurgery 2005 May;56(5):E1154; discussion E1154. PMID: 15854264

Therapy

Acromegaly: Medical and Surgical Considerations.
Giantini-Larsen AM, Uribe-Cardenas R, Juthani RG
Otolaryngol Clin North Am 2022 Apr;55(2):331-341. Epub 2022 Mar 4 doi: 10.1016/j.otc.2021.12.007. PMID: 35256175
Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly.
Theodoropoulou M, Tichomirowa MA, Sievers C, Yassouridis A, Arzberger T, Hougrand O, Deprez M, Daly AF, Petrossians P, Pagotto U, Beckers A, Stalla GK
Int J Cancer 2009 Nov 1;125(9):2122-6. doi: 10.1002/ijc.24602. PMID: 19637311

Prognosis

Aggressive somatotrophinomas lacking clinical symptoms: neurosurgical management.
Giordano M, Samii A, Fahlbusch R
Neurosurg Rev 2018 Oct;41(4):999-1005. Epub 2017 Dec 30 doi: 10.1007/s10143-017-0940-y. PMID: 29290044
The higher incidence of autoimmune thyroid disease in prolactinomas than in somatotrophinomas.
Dogansen SC, Selcukbiricik OS, Bilir BE, Yarman S
Growth Horm IGF Res 2016 Aug;29:45-49. Epub 2016 Apr 11 doi: 10.1016/j.ghir.2016.04.004. PMID: 27105040
Studying Cat (Felis catus) Diabetes: Beware of the Acromegalic Imposter.
Niessen SJ, Forcada Y, Mantis P, Lamb CR, Harrington N, Fowkes R, Korbonits M, Smith K, Church DB
PLoS One 2015;10(5):e0127794. Epub 2015 May 29 doi: 10.1371/journal.pone.0127794. PMID: 26023776Free PMC Article
Estrogen receptors in human pituitary tumors.
Burdman JA, Pauni M, Heredia Sereno GM, Bordón AE
Horm Metab Res 2008 Aug;40(8):524-7. Epub 2008 Apr 9 doi: 10.1055/s-2008-1065338. PMID: 18398784

Clinical prediction guides

Studying Cat (Felis catus) Diabetes: Beware of the Acromegalic Imposter.
Niessen SJ, Forcada Y, Mantis P, Lamb CR, Harrington N, Fowkes R, Korbonits M, Smith K, Church DB
PLoS One 2015;10(5):e0127794. Epub 2015 May 29 doi: 10.1371/journal.pone.0127794. PMID: 26023776Free PMC Article
Do the aryl hydrocarbon receptor interacting protein variants (Q228K and Q307R) play a role in patients with familial and sporadic hormone-secreting pituitary adenomas?
Yarman S, Ogret YD, Oguz FS
Genet Test Mol Biomarkers 2015 Jul;19(7):394-8. Epub 2015 May 4 doi: 10.1089/gtmb.2014.0333. PMID: 25938168Free PMC Article
Evidence that PKA activity is constitutively activated in human GH-secreting adenoma cells in a patient with Carney complex harbouring a PRKAR1A mutation.
Takano K, Yasufuku-Takano J, Morita K, Mori S, Takei M, Osamura RY, Teramoto A, Fujita T
Clin Endocrinol (Oxf) 2009 May;70(5):769-75. Epub 2008 Oct 21 doi: 10.1111/j.1365-2265.2008.03457.x. PMID: 19178533
Relationship between protein kinase C and adenylyl cyclase activity in the regulation of growth hormone secretion by human pituitary somatotrophinomas.
Lei T, Adams EF, Buchfelder M, Fahlbusch R
Neurosurgery 1996 Sep;39(3):569-75; discussion 575-6. doi: 10.1097/00006123-199609000-00027. PMID: 8875488
Effects of insulin-like growth factor-I on growth hormone and prolactin secretion and cell proliferation of human somatotrophinomas and prolactinomas in vitro.
Atkin SL, Landolt AM, Foy P, Jeffreys RV, Hipkin L, White MC
Clin Endocrinol (Oxf) 1994 Oct;41(4):503-9. doi: 10.1111/j.1365-2265.1994.tb02582.x. PMID: 7525124

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