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Growth hormone-producing pituitary gland adenoma

MedGen UID:
82999
•Concept ID:
C0278864
•
Neoplastic Process
Synonym: Somatotrophinoma
 
Monarch Initiative: MONDO:0006238
Orphanet: ORPHA96256

Definition

An adenoma of the anterior lobe of the pituitary gland that produces growth hormone. The vast majority of cases are hormonally functioning and are associated with either gigantism or acromegaly. [from MONDO]

Professional guidelines

PubMed

Acromegaly: pathogenesis, diagnosis, and management.
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Recent clinical studies

Etiology

Extraocular Muscle Enlargement in Growth Hormone-Secreting Pituitary Adenomas.
Coutu B, Alvarez DA, Ciurej A, Moneymaker K, White M, Zhang C, Drincic A
AJNR Am J Neuroradiol 2022 Apr;43(4):597-602. Epub 2022 Mar 17 doi: 10.3174/ajnr.A7453. PMID: 35301224Free PMC Article
Acromegaly: Medical and Surgical Considerations.
Giantini-Larsen AM, Uribe-Cardenas R, Juthani RG
Otolaryngol Clin North Am 2022 Apr;55(2):331-341. Epub 2022 Mar 4 doi: 10.1016/j.otc.2021.12.007. PMID: 35256175
Surgical treatment of aggressive pituitary adenomas and pituitary carcinomas.
Buchfelder M, Schlaffer SM
Rev Endocr Metab Disord 2020 Jun;21(2):253-261. doi: 10.1007/s11154-020-09563-8. PMID: 32500483Free PMC Article
Molecular Biology of Pituitary Adenomas.
Faltermeier CM, Magill ST, Blevins LS Jr, Aghi MK
Neurosurg Clin N Am 2019 Oct;30(4):391-400. Epub 2019 Jul 5 doi: 10.1016/j.nec.2019.05.001. PMID: 31471046
Acromegaly.
Scacchi M, Cavagnini F
Pituitary 2006;9(4):297-303. doi: 10.1007/s11102-006-0409-4. PMID: 17077948

Diagnosis

Acromegaly: pathogenesis, diagnosis, and management.
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Acromegaly pathogenesis and treatment.
Melmed S
J Clin Invest 2009 Nov;119(11):3189-202. Epub 2009 Nov 2 doi: 10.1172/JCI39375. PMID: 19884662Free PMC Article

Therapy

Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
The Future of Somatostatin Receptor Ligands in Acromegaly.
Gadelha MR, Wildemberg LE, Kasuki L
J Clin Endocrinol Metab 2022 Jan 18;107(2):297-308. doi: 10.1210/clinem/dgab726. PMID: 34618894Free PMC Article
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Acromegaly.
Chanson P, Salenave S, Kamenicky P
Handb Clin Neurol 2014;124:197-219. doi: 10.1016/B978-0-444-59602-4.00014-9. PMID: 25248589

Prognosis

Multidisciplinary management of difficult/aggressive growth-hormone pituitary neuro-endocrine tumors.
Bianchi A, Chiloiro S, Giampietro A, Gaudino S, Calandrelli R, Mazzarella C, Caldarella C, Rigante M, Gessi M, Lauretti L, De Marinis L, Olivi A, Pontecorvi A, Doglietto F
Front Endocrinol (Lausanne) 2023;14:1123267. Epub 2023 May 3 doi: 10.3389/fendo.2023.1123267. PMID: 37206441Free PMC Article
Modern approach to resistant acromegaly.
Giustina A, di Filippo L, Uygur MM, Frara S
Endocrine 2023 May;80(2):303-307. Epub 2023 Feb 15 doi: 10.1007/s12020-023-03317-7. PMID: 36790521
Molecular targets in acromegaly.
Labadzhyan A, Melmed S
Front Endocrinol (Lausanne) 2022;13:1068061. Epub 2022 Dec 5 doi: 10.3389/fendo.2022.1068061. PMID: 36545335Free PMC Article
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Acromegaly.
Chanson P, Salenave S, Kamenicky P
Handb Clin Neurol 2014;124:197-219. doi: 10.1016/B978-0-444-59602-4.00014-9. PMID: 25248589

Clinical prediction guides

Multidisciplinary management of difficult/aggressive growth-hormone pituitary neuro-endocrine tumors.
Bianchi A, Chiloiro S, Giampietro A, Gaudino S, Calandrelli R, Mazzarella C, Caldarella C, Rigante M, Gessi M, Lauretti L, De Marinis L, Olivi A, Pontecorvi A, Doglietto F
Front Endocrinol (Lausanne) 2023;14:1123267. Epub 2023 May 3 doi: 10.3389/fendo.2023.1123267. PMID: 37206441Free PMC Article
Modern approach to resistant acromegaly.
Giustina A, di Filippo L, Uygur MM, Frara S
Endocrine 2023 May;80(2):303-307. Epub 2023 Feb 15 doi: 10.1007/s12020-023-03317-7. PMID: 36790521
Molecular targets in acromegaly.
Labadzhyan A, Melmed S
Front Endocrinol (Lausanne) 2022;13:1068061. Epub 2022 Dec 5 doi: 10.3389/fendo.2022.1068061. PMID: 36545335Free PMC Article
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Recent systematic reviews

Metabolomics in acromegaly: a systematic review.
Pînzariu O, Georgescu CE
J Investig Med 2023 Aug;71(6):634-645. Epub 2023 May 4 doi: 10.1177/10815589231169452. PMID: 37139720
Reported outcomes in transsphenoidal surgery for pituitary adenomas: a systematic review.
Layard Horsfall H, Lawrence A, Venkatesh A, Loh RTS, Jayapalan R, Koulouri O, Sharma R, Santarius T, Gurnell M, Dorward N, Mannion R, Marcus HJ, Kolias AG
Pituitary 2023 Apr;26(2):171-181. Epub 2023 Mar 2 doi: 10.1007/s11102-023-01303-w. PMID: 36862265Free PMC Article
Double pituitary adenomas are most commonly associated with GH- and ACTH-secreting tumors: systematic review of the literature.
Ogando-Rivas E, Alalade AF, Boatey J, Schwartz TH
Pituitary 2017 Dec;20(6):702-708. doi: 10.1007/s11102-017-0826-6. PMID: 28766078
Efficacy of transsphenoidal surgery in achieving biochemical cure of growth hormone-secreting pituitary adenomas among patients with cavernous sinus invasion: a systematic review and meta-analysis.
Briceno V, Zaidi HA, Doucette JA, Onomichi KB, Alreshidi A, Mekary RA, Smith TR
Neurol Res 2017 May;39(5):387-398. Epub 2017 Mar 16 doi: 10.1080/01616412.2017.1296653. PMID: 28301972
Endoscopic Endonasal versus Microsurgical Transsphenoidal Approach for Growth Hormone-Secreting Pituitary Adenomas-Systematic Review and Meta-Analysis.
Phan K, Xu J, Reddy R, Kalakoti P, Nanda A, Fairhall J
World Neurosurg 2017 Jan;97:398-406. Epub 2016 Oct 15 doi: 10.1016/j.wneu.2016.10.029. PMID: 27756664

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