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Severe cytologic atypia

MedGen UID:
83090
•Concept ID:
C0333868
•
Cell or Molecular Dysfunction
Synonym: Severe Cytologic Atypia
SNOMED CT: Severe cytologic atypia (53381003)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSevere cytologic atypia

Professional guidelines

PubMed

Application of Current Pathologic Criteria for Atypical Placental Site Nodule Suggests That Refined Criteria Are Needed.
Perez CE, Chapel DB, Skala SL
Int J Gynecol Pathol 2023 Sep 1;42(5):482-490. Epub 2023 Jan 3 doi: 10.1097/PGP.0000000000000934. PMID: 36728542
Smooth muscle tumors of the ovary: a clinicopathologic study of 54 cases emphasizing prognostic criteria, histologic variants, and differential diagnosis.
Lerwill MF, Sung R, Oliva E, Prat J, Young RH
Am J Surg Pathol 2004 Nov;28(11):1436-51. doi: 10.1097/01.pas.0000141393.99300.d0. PMID: 15489647
Adenocarcinoma of the hepatic duct junction. A reappraisal of the histologic criteria of malignancy.
Qualman SJ, Haupt HM, Bauer TW, Taxy JB
Cancer 1984 Apr 1;53(7):1545-51. doi: 10.1002/1097-0142(19840401)53:7<1545::aid-cncr2820530721>3.0.co;2-n. PMID: 6365304

Recent clinical studies

Etiology

Uterine Inflammatory Myofibroblastic Tumors: p16 as a Surrogate for CDKN2A Deletion and Predictor of Aggressive Behavior.
Devins KM, Ordulu Z, Mendoza RP, Croce S, Haridas R, Wanjari P, Pinto A, Oliva E, Bennett JA
Am J Surg Pathol 2024 Jul 1;48(7):813-824. Epub 2024 Apr 17 doi: 10.1097/PAS.0000000000002220. PMID: 38630911
Malignant Proliferating Pilar Tumor: Clinicopathologic, Immunohistochemical, and Molecular Study of 17 Cases.
Moran JMT, DeSimone MS, Mariño-Enríquez A, Russell-Goldman EE, Fletcher CDM, Mochel MC, Hoang MP
Am J Surg Pathol 2023 Oct 1;47(10):1151-1159. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002105. PMID: 37515420
Genomic analysis of blue nevi and related dermal melanocytic proliferations.
Maize JC Jr, McCalmont TH, Carlson JA, Busam KJ, Kutzner H, Bastian BC
Am J Surg Pathol 2005 Sep;29(9):1214-20. doi: 10.1097/01.pas.0000165527.01816.d1. PMID: 16096412
Improved identification of potentially dangerous pigmented skin lesions by computerized image analysis.
Jamora MJ, Wainwright BD, Meehan SA, Bystryn JC
Arch Dermatol 2003 Feb;139(2):195-8. doi: 10.1001/archderm.139.2.195. PMID: 12588225
Smooth-muscle tumors of the vulva. A clinicopathological study of 25 cases and review of the literature.
Nielsen GP, Rosenberg AE, Koerner FC, Young RH, Scully RE
Am J Surg Pathol 1996 Jul;20(7):779-93. doi: 10.1097/00000478-199607000-00001. PMID: 8669526

Diagnosis

Uterine Inflammatory Myofibroblastic Tumors: p16 as a Surrogate for CDKN2A Deletion and Predictor of Aggressive Behavior.
Devins KM, Ordulu Z, Mendoza RP, Croce S, Haridas R, Wanjari P, Pinto A, Oliva E, Bennett JA
Am J Surg Pathol 2024 Jul 1;48(7):813-824. Epub 2024 Apr 17 doi: 10.1097/PAS.0000000000002220. PMID: 38630911
Adenoid cystic carcinoma with dedifferentiation/expansion of the luminal cell component and preserved biphasic morphology - Early high-grade transformation.
Chia N, Petersson F
Ann Diagn Pathol 2021 Feb;50:151650. Epub 2020 Oct 24 doi: 10.1016/j.anndiagpath.2020.151650. PMID: 33254086
Chemotherapy-Associated Endometrial Atypia: A Potential Diagnostic Pitfall.
Wales C, Fadare O
Int J Surg Pathol 2018 May;26(3):229-231. Epub 2018 Feb 27 doi: 10.1177/1066896917741552. PMID: 29482404
Improved identification of potentially dangerous pigmented skin lesions by computerized image analysis.
Jamora MJ, Wainwright BD, Meehan SA, Bystryn JC
Arch Dermatol 2003 Feb;139(2):195-8. doi: 10.1001/archderm.139.2.195. PMID: 12588225
Crystals occurring in pulmonary cytology specimens. Association with Aspergillus infection.
Farley ML, Mabry L, Muñoz LA, Diserens HW
Acta Cytol 1985 Sep-Oct;29(5):737-44. PMID: 3863422

Therapy

Chemotherapy-Associated Endometrial Atypia: A Potential Diagnostic Pitfall.
Wales C, Fadare O
Int J Surg Pathol 2018 May;26(3):229-231. Epub 2018 Feb 27 doi: 10.1177/1066896917741552. PMID: 29482404
Eruptive post-chemotherapy in situ melanomas and dysplastic nevi.
Reutter JC, Long EM, Morrell DS, Thomas NE, Groben PA
Pediatr Dermatol 2007 Mar-Apr;24(2):135-7. doi: 10.1111/j.1525-1470.2007.00359.x. PMID: 17461808
Gynecomastia with marked cellular atypia associated with chemotherapy.
Jun Yang Y
Arch Pathol Lab Med 2002 May;126(5):613-4. doi: 10.5858/2002-126-0613-GWMCAA. PMID: 11958672

Prognosis

Uterine Inflammatory Myofibroblastic Tumors: p16 as a Surrogate for CDKN2A Deletion and Predictor of Aggressive Behavior.
Devins KM, Ordulu Z, Mendoza RP, Croce S, Haridas R, Wanjari P, Pinto A, Oliva E, Bennett JA
Am J Surg Pathol 2024 Jul 1;48(7):813-824. Epub 2024 Apr 17 doi: 10.1097/PAS.0000000000002220. PMID: 38630911
Symplastic leiomyomas of the scrotum: a comparative study to usual leiomyomas and leiomyosarcomas.
Matoso A, Chen S, Plaza JA, Osunkoya AO, Epstein JI
Am J Surg Pathol 2014 Oct;38(10):1410-7. doi: 10.1097/PAS.0000000000000228. PMID: 24832157
Prognostic significance of grading in lung adenocarcinoma.
Barletta JA, Yeap BY, Chirieac LR
Cancer 2010 Feb 1;116(3):659-69. doi: 10.1002/cncr.24831. PMID: 20014400Free PMC Article
Smooth muscle tumors of the ovary: a clinicopathologic study of 54 cases emphasizing prognostic criteria, histologic variants, and differential diagnosis.
Lerwill MF, Sung R, Oliva E, Prat J, Young RH
Am J Surg Pathol 2004 Nov;28(11):1436-51. doi: 10.1097/01.pas.0000141393.99300.d0. PMID: 15489647
Smooth-muscle tumors of the vulva. A clinicopathological study of 25 cases and review of the literature.
Nielsen GP, Rosenberg AE, Koerner FC, Young RH, Scully RE
Am J Surg Pathol 1996 Jul;20(7):779-93. doi: 10.1097/00000478-199607000-00001. PMID: 8669526

Clinical prediction guides

Uterine Inflammatory Myofibroblastic Tumors: p16 as a Surrogate for CDKN2A Deletion and Predictor of Aggressive Behavior.
Devins KM, Ordulu Z, Mendoza RP, Croce S, Haridas R, Wanjari P, Pinto A, Oliva E, Bennett JA
Am J Surg Pathol 2024 Jul 1;48(7):813-824. Epub 2024 Apr 17 doi: 10.1097/PAS.0000000000002220. PMID: 38630911
Anaplasia in pilocytic astrocytoma predicts aggressive behavior.
Rodriguez FJ, Scheithauer BW, Burger PC, Jenkins S, Giannini C
Am J Surg Pathol 2010 Feb;34(2):147-60. doi: 10.1097/PAS.0b013e3181c75238. PMID: 20061938
Prognostic significance of grading in lung adenocarcinoma.
Barletta JA, Yeap BY, Chirieac LR
Cancer 2010 Feb 1;116(3):659-69. doi: 10.1002/cncr.24831. PMID: 20014400Free PMC Article
Improved identification of potentially dangerous pigmented skin lesions by computerized image analysis.
Jamora MJ, Wainwright BD, Meehan SA, Bystryn JC
Arch Dermatol 2003 Feb;139(2):195-8. doi: 10.1001/archderm.139.2.195. PMID: 12588225
Crystals occurring in pulmonary cytology specimens. Association with Aspergillus infection.
Farley ML, Mabry L, Muñoz LA, Diserens HW
Acta Cytol 1985 Sep-Oct;29(5):737-44. PMID: 3863422

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