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Benign Leydig cell tumor

MedGen UID:
83142
•Concept ID:
C0334409
•
Neoplastic Process
Synonyms: adenoma, interstitial; Benign Interstitial Cell Neoplasm; benign interstitial cell neoplasm; Benign interstitial cell tumor; Benign Interstitial Cell Tumor; benign interstitial cell tumor; benign interstitial cell tumour; Benign Leydig Cell Neoplasm; benign Leydig cell neoplasm; Benign Leydig Cell Tumor; benign Leydig cell tumor; Interstitial cell tumor, benign; Leydig cell tumor, benign
SNOMED CT: Benign interstitial cell tumor (5014008); Benign Leydig cell tumor (5014008); Leydig cell tumor, benign (5014008); Interstitial cell tumor, benign (5014008)
 
Monarch Initiative: MONDO:0036990

Definition

A Leydig cell tumor which does not recur or metastasize. Morphologically, there is no evidence of cellular atypia, increased mitotic activity, necrosis, or vascular invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Leydig cell tumor

Professional guidelines

PubMed

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Gynaecomastia--pathophysiology, diagnosis and treatment.
Narula HS, Carlson HE
Nat Rev Endocrinol 2014 Nov;10(11):684-98. Epub 2014 Aug 12 doi: 10.1038/nrendo.2014.139. PMID: 25112235

Recent clinical studies

Etiology

SRY-Positive 46, XX Testicular Disorder of Sexual Development With Leydig Cell Tumor.
Osaka A, Ide H, Matsuoka K, Iwahata T, Kobori Y, Ban S, Okada H, Saito K
Am J Mens Health 2020 Sep-Oct;14(5):1557988320970071. doi: 10.1177/1557988320970071. PMID: 33131361Free PMC Article
Long-term followup after elective testis sparing surgery for Leydig cell tumors: a single center experience.
Giannarini G, Mogorovich A, Menchini Fabris F, Morelli G, De Maria M, Manassero F, Loggini B, Pingitore R, Cavazzana A, Selli C
J Urol 2007 Sep;178(3 Pt 1):872-6; quiz 1129. Epub 2007 Jul 16 doi: 10.1016/j.juro.2007.05.077. PMID: 17631320
Conservative surgical therapy for leydig cell tumor.
Carmignani L, Colombo R, Gadda F, Galasso G, Lania A, Palou J, Algaba F, Villavicencio H, Colpi GM, Decobelli O, Salvioni R, Pizzocaro G, Rigatti P, Rocco F
J Urol 2007 Aug;178(2):507-11; discussion 511. Epub 2007 Jun 11 doi: 10.1016/j.juro.2007.03.108. PMID: 17561156
Value of frozen section analysis with suspected testicular malignancy.
Connolly SS, D'Arcy FT, Bredin HC, Callaghan J, Corcoran MO
Urology 2006 Jan;67(1):162-5. doi: 10.1016/j.urology.2005.07.041. PMID: 16413354

Diagnosis

SRY-Positive 46, XX Testicular Disorder of Sexual Development With Leydig Cell Tumor.
Osaka A, Ide H, Matsuoka K, Iwahata T, Kobori Y, Ban S, Okada H, Saito K
Am J Mens Health 2020 Sep-Oct;14(5):1557988320970071. doi: 10.1177/1557988320970071. PMID: 33131361Free PMC Article
Testicular Estrogen-Secreting Leydig Cell Tumor in 18F-FDG PET/CT: An Incidental Detection in a Patient Treated by Chemotherapy for Hodgkin Lymphoma.
Van Der Gucht A, Maged Z, Burruni R, Barras JL, Schaefer N
Clin Nucl Med 2018 Jan;43(1):41-43. doi: 10.1097/RLU.0000000000001905. PMID: 29166332
Leydig cell tumor of the spermatic cord in an adolescent affected by congenital adrenal hyperplasia.
Ferrari M, Raber M, Capitanio U, Russo G, Ferrario M, Rizzo N, Freschi M, Rigatti P, Montorsi F
Int J Urol 2012 Oct;19(10):954-6. Epub 2012 Jun 13 doi: 10.1111/j.1442-2042.2012.03074.x. PMID: 22691038
Leydig cell tumor and malignant lymphoma in a patient with nonclassical 21-hydroxylase deficiency.
Inaba H, Suzuki S, Shigematsu S, Shinomiya K, Ohfusa H, Shimojo Y, Uehara T, Hashizume K
Intern Med 2009;48(8):601-5. Epub 2009 Apr 15 doi: 10.2169/internalmedicine.48.1733. PMID: 19367056
Conservative surgical therapy for leydig cell tumor.
Carmignani L, Colombo R, Gadda F, Galasso G, Lania A, Palou J, Algaba F, Villavicencio H, Colpi GM, Decobelli O, Salvioni R, Pizzocaro G, Rigatti P, Rocco F
J Urol 2007 Aug;178(2):507-11; discussion 511. Epub 2007 Jun 11 doi: 10.1016/j.juro.2007.03.108. PMID: 17561156

Prognosis

Long-term followup after elective testis sparing surgery for Leydig cell tumors: a single center experience.
Giannarini G, Mogorovich A, Menchini Fabris F, Morelli G, De Maria M, Manassero F, Loggini B, Pingitore R, Cavazzana A, Selli C
J Urol 2007 Sep;178(3 Pt 1):872-6; quiz 1129. Epub 2007 Jul 16 doi: 10.1016/j.juro.2007.05.077. PMID: 17631320
Value of frozen section analysis with suspected testicular malignancy.
Connolly SS, D'Arcy FT, Bredin HC, Callaghan J, Corcoran MO
Urology 2006 Jan;67(1):162-5. doi: 10.1016/j.urology.2005.07.041. PMID: 16413354

Clinical prediction guides

Testicular Estrogen-Secreting Leydig Cell Tumor in 18F-FDG PET/CT: An Incidental Detection in a Patient Treated by Chemotherapy for Hodgkin Lymphoma.
Van Der Gucht A, Maged Z, Burruni R, Barras JL, Schaefer N
Clin Nucl Med 2018 Jan;43(1):41-43. doi: 10.1097/RLU.0000000000001905. PMID: 29166332
Conservative surgical therapy for leydig cell tumor.
Carmignani L, Colombo R, Gadda F, Galasso G, Lania A, Palou J, Algaba F, Villavicencio H, Colpi GM, Decobelli O, Salvioni R, Pizzocaro G, Rigatti P, Rocco F
J Urol 2007 Aug;178(2):507-11; discussion 511. Epub 2007 Jun 11 doi: 10.1016/j.juro.2007.03.108. PMID: 17561156
Value of frozen section analysis with suspected testicular malignancy.
Connolly SS, D'Arcy FT, Bredin HC, Callaghan J, Corcoran MO
Urology 2006 Jan;67(1):162-5. doi: 10.1016/j.urology.2005.07.041. PMID: 16413354

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