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Abnormal germ cell morphology

MedGen UID:
868310
Concept ID:
C4022704
Anatomical Abnormality
Synonyms: Abnormal shape of a reproductive cell; Abnormally shaped germ cell; Abnormally shaped reproductive cell
 
HPO: HP:0012862

Definition

Any structural anomaly of a reproductive cell. [from HPO]

Professional guidelines

PubMed

Cornelisse S, Zagers M, Kostova E, Fleischer K, van Wely M, Mastenbroek S
Cochrane Database Syst Rev 2020 Sep 8;9(9):CD005291. doi: 10.1002/14651858.CD005291.pub3. PMID: 32898291Free PMC Article
Spoor JA, Oosterhuis JW, Hersmus R, Biermann K, Wolffenbuttel KP, Cools M, Kazmi Z, Ahmed SF, Looijenga LHJ
Sex Dev 2018;12(1-3):106-122. Epub 2017 Nov 3 doi: 10.1159/000481757. PMID: 29131109
Simpson JL, Rechitsky S
J Steroid Biochem Mol Biol 2017 Jan;165(Pt A):124-130. Epub 2016 Apr 21 doi: 10.1016/j.jsbmb.2016.03.022. PMID: 27108943

Recent clinical studies

Etiology

La Vignera S, Vita R
Int J Immunopathol Pharmacol 2018 Jan-Dec;32:2058738418775241. doi: 10.1177/2058738418775241. PMID: 29737216Free PMC Article
Landero-Huerta DA, Vigueras-Villasenor RM, Yokoyama-Rebollar E, Arechaga-Ocampo E, Rojas-Castaneda JC, Jimenez-Trejo F, Chavez-Saldana M
Front Biosci (Landmark Ed) 2017 Mar 1;22(7):1073-1098. doi: 10.2741/4534. PMID: 28199193
King TF, Conway GS
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):504-10. doi: 10.1097/MED.0000000000000113. PMID: 25314337
Orbach D, Sarnacki S, Brisse HJ, Gauthier-Villars M, Jarreau PH, Tsatsaris V, Baruchel A, Zerah M, Seigneur E, Peuchmaur M, Doz F
Lancet Oncol 2013 Dec;14(13):e609-20. doi: 10.1016/S1470-2045(13)70236-5. PMID: 24275134
Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272

Diagnosis

Kumar N, Singh AK
Biol Reprod 2021 Mar 11;104(3):508-520. doi: 10.1093/biolre/ioaa213. PMID: 33238303
Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, Yang C, Zhai J, Tian R, Chen H, Luo J, Liu N, Deng Z, Lin X, Li N, Fang J, Sun J, Wang C, Zhou Z, Li Z
Nat Commun 2020 Nov 10;11(1):5683. doi: 10.1038/s41467-020-19414-4. PMID: 33173058Free PMC Article
Gatimel N, Moreau J, Parinaud J, Léandri RD
Andrology 2017 Sep;5(5):845-862. Epub 2017 Jul 10 doi: 10.1111/andr.12389. PMID: 28692759
King TF, Conway GS
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):504-10. doi: 10.1097/MED.0000000000000113. PMID: 25314337
Orbach D, Sarnacki S, Brisse HJ, Gauthier-Villars M, Jarreau PH, Tsatsaris V, Baruchel A, Zerah M, Seigneur E, Peuchmaur M, Doz F
Lancet Oncol 2013 Dec;14(13):e609-20. doi: 10.1016/S1470-2045(13)70236-5. PMID: 24275134

Therapy

Cornelisse S, Zagers M, Kostova E, Fleischer K, van Wely M, Mastenbroek S
Cochrane Database Syst Rev 2020 Sep 8;9(9):CD005291. doi: 10.1002/14651858.CD005291.pub3. PMID: 32898291Free PMC Article
Rubino P, Viganò P, Luddi A, Piomboni P
Hum Reprod Update 2016 Mar-Apr;22(2):194-227. Epub 2015 Nov 18 doi: 10.1093/humupd/dmv050. PMID: 26586241
Mongan NP, Tadokoro-Cuccaro R, Bunch T, Hughes IA
Best Pract Res Clin Endocrinol Metab 2015 Aug;29(4):569-80. Epub 2015 Apr 26 doi: 10.1016/j.beem.2015.04.005. PMID: 26303084
King TF, Conway GS
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):504-10. doi: 10.1097/MED.0000000000000113. PMID: 25314337
Low JJ, Ilancheran A, Ng JS
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):347-55. Epub 2012 Feb 1 doi: 10.1016/j.bpobgyn.2012.01.002. PMID: 22301054

Prognosis

Nikiforov D, Grøndahl ML, Hreinsson J, Andersen CY
Reprod Sci 2022 Oct;29(10):2768-2785. Epub 2021 Nov 23 doi: 10.1007/s43032-021-00723-y. PMID: 34816375
Liu C, Tu C, Wang L, Wu H, Houston BJ, Mastrorosa FK, Zhang W, Shen Y, Wang J, Tian S, Meng L, Cong J, Yang S, Jiang Y, Tang S, Zeng Y, Lv M, Lin G, Li J, Saiyin H, He X, Jin L, Touré A, Ray PF, Veltman JA, Shi Q, O'Bryan MK, Cao Y, Tan YQ, Zhang F
Am J Hum Genet 2021 Feb 4;108(2):309-323. Epub 2021 Jan 19 doi: 10.1016/j.ajhg.2021.01.002. PMID: 33472045Free PMC Article
Sapp SGH, Yabsley MJ, Bradbury RS
Emerg Infect Dis 2018 Aug;24(8):1407-1411. doi: 10.3201/eid2408.180560. PMID: 30014830Free PMC Article
King TF, Conway GS
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):504-10. doi: 10.1097/MED.0000000000000113. PMID: 25314337
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790

Clinical prediction guides

Nikiforov D, Grøndahl ML, Hreinsson J, Andersen CY
Reprod Sci 2022 Oct;29(10):2768-2785. Epub 2021 Nov 23 doi: 10.1007/s43032-021-00723-y. PMID: 34816375
Willems M, Gies I, Van Saen D
Am J Med Genet C Semin Med Genet 2020 Jun;184(2):356-370. Epub 2020 May 15 doi: 10.1002/ajmg.c.31787. PMID: 32412180
Sapp SGH, Yabsley MJ, Bradbury RS
Emerg Infect Dis 2018 Aug;24(8):1407-1411. doi: 10.3201/eid2408.180560. PMID: 30014830Free PMC Article
Tadokoro-Cuccaro R, Hughes IA
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):499-503. doi: 10.1097/MED.0000000000000107. PMID: 25354046
Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272

Recent systematic reviews

Nikiforov D, Grøndahl ML, Hreinsson J, Andersen CY
Reprod Sci 2022 Oct;29(10):2768-2785. Epub 2021 Nov 23 doi: 10.1007/s43032-021-00723-y. PMID: 34816375
Cornelisse S, Zagers M, Kostova E, Fleischer K, van Wely M, Mastenbroek S
Cochrane Database Syst Rev 2020 Sep 8;9(9):CD005291. doi: 10.1002/14651858.CD005291.pub3. PMID: 32898291Free PMC Article
Simon L, Emery B, Carrell DT
Adv Exp Med Biol 2019;1166:87-105. doi: 10.1007/978-3-030-21664-1_6. PMID: 31301048
Gunes S, Hekim GN, Arslan MA, Asci R
J Assist Reprod Genet 2016 Apr;33(4):441-54. Epub 2016 Feb 11 doi: 10.1007/s10815-016-0663-y. PMID: 26867640Free PMC Article
Rubino P, Viganò P, Luddi A, Piomboni P
Hum Reprod Update 2016 Mar-Apr;22(2):194-227. Epub 2015 Nov 18 doi: 10.1093/humupd/dmv050. PMID: 26586241

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